DE60034770D1 - Stabile fumagillin-formulierung - Google Patents
Stabile fumagillin-formulierungInfo
- Publication number
- DE60034770D1 DE60034770D1 DE60034770T DE60034770T DE60034770D1 DE 60034770 D1 DE60034770 D1 DE 60034770D1 DE 60034770 T DE60034770 T DE 60034770T DE 60034770 T DE60034770 T DE 60034770T DE 60034770 D1 DE60034770 D1 DE 60034770D1
- Authority
- DE
- Germany
- Prior art keywords
- fumagillin
- formulation
- stable
- treating
- relates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NGGMYCMLYOUNGM-UHFFFAOYSA-N (-)-fumagillin Natural products O1C(CC=C(C)C)C1(C)C1C(OC)C(OC(=O)C=CC=CC=CC=CC(O)=O)CCC21CO2 NGGMYCMLYOUNGM-UHFFFAOYSA-N 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title abstract 2
- NGGMYCMLYOUNGM-CSDLUJIJSA-N fumagillin Chemical compound C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O)C[C@@]21CO2 NGGMYCMLYOUNGM-CSDLUJIJSA-N 0.000 title abstract 2
- 229960000936 fumagillin Drugs 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 206010022678 Intestinal infections Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9902401 | 1999-02-26 | ||
| FR9902401A FR2790200B3 (fr) | 1999-02-26 | 1999-02-26 | Formulation stable contenant de la fumagilline |
| FR9909702 | 1999-07-27 | ||
| FR9909702A FR2796842B3 (fr) | 1999-07-27 | 1999-07-27 | Formulation stable contenant de la fumagilline |
| PCT/FR2000/000424 WO2000050084A1 (fr) | 1999-02-26 | 2000-02-21 | Formulation stable contenant de la fumagilline |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60034770D1 true DE60034770D1 (de) | 2007-06-21 |
| DE60034770T2 DE60034770T2 (de) | 2008-04-30 |
Family
ID=26234836
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60034770T Expired - Lifetime DE60034770T2 (de) | 1999-02-26 | 2000-02-21 | Stabile fumagillin-formulierung |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6528539B1 (de) |
| EP (1) | EP1156829B1 (de) |
| JP (1) | JP2002537358A (de) |
| AT (1) | ATE361757T1 (de) |
| AU (1) | AU2811400A (de) |
| CY (1) | CY1106807T1 (de) |
| DE (1) | DE60034770T2 (de) |
| DK (1) | DK1156829T3 (de) |
| ES (1) | ES2286998T3 (de) |
| HU (1) | HU228857B1 (de) |
| PT (1) | PT1156829E (de) |
| WO (1) | WO2000050084A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2302233C2 (ru) * | 2001-09-10 | 2007-07-10 | Ф.Хоффманн-Ля Рош Аг | Масляные тиксотропные композиции |
| CA2549115C (en) * | 2002-09-26 | 2013-07-16 | Vita-Herb Nutriceuticals, Inc. | Prebiotic and preservative uses of oil-emulsified probiotic encapsulations |
| DE102005055385A1 (de) * | 2004-12-09 | 2006-06-14 | Bayer Healthcare Ag | Arzneimittel zur hygienischen Applikation im Ohr |
| DE102007055341A1 (de) * | 2007-11-19 | 2009-05-20 | Bayer Animal Health Gmbh | Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren |
| WO2009073445A2 (en) * | 2007-11-28 | 2009-06-11 | Mersana Therapeutics, Inc. | Biocompatible biodegradable fumagillin analog conjugates |
| JP5873375B2 (ja) * | 2012-04-03 | 2016-03-01 | 中日本カプセル 株式会社 | ソフトカプセル及びソフトカプセルの製造方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4918103A (en) | 1988-07-25 | 1990-04-17 | Formulations Development Labs | Liquid oral pharmaceutical compositions of non-steroidal anti-inflammatory drugs |
| DE69311278T2 (de) | 1992-12-16 | 1997-10-30 | Takeda Chemical Industries Ltd | Stabile pharmazeutische Zubereitung mit Fumagillolderivaten |
| US5900431A (en) | 1995-03-27 | 1999-05-04 | Sanofi | Use of fumagillol and derivatives thereof for preparing medicaments against intestinal infections |
| EP0799616A1 (de) * | 1996-04-01 | 1997-10-08 | Takeda Chemical Industries, Ltd. | Orale Zubereitung enthaltend ein Fumagillolderivat |
| JPH1081621A (ja) * | 1996-04-01 | 1998-03-31 | Takeda Chem Ind Ltd | 経口投与用医薬組成物 |
| US20010025046A1 (en) * | 1999-06-24 | 2001-09-27 | Rong(Ron) Liu | Self-emulsifying systems containing anticancer medicament |
| US6267985B1 (en) * | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
-
2000
- 2000-02-21 EP EP00906438A patent/EP1156829B1/de not_active Expired - Lifetime
- 2000-02-21 DK DK00906438T patent/DK1156829T3/da active
- 2000-02-21 HU HU0202151A patent/HU228857B1/hu unknown
- 2000-02-21 WO PCT/FR2000/000424 patent/WO2000050084A1/fr active IP Right Grant
- 2000-02-21 PT PT00906438T patent/PT1156829E/pt unknown
- 2000-02-21 US US09/913,547 patent/US6528539B1/en not_active Expired - Lifetime
- 2000-02-21 ES ES00906438T patent/ES2286998T3/es not_active Expired - Lifetime
- 2000-02-21 JP JP2000600694A patent/JP2002537358A/ja active Pending
- 2000-02-21 DE DE60034770T patent/DE60034770T2/de not_active Expired - Lifetime
- 2000-02-21 AT AT00906438T patent/ATE361757T1/de active
- 2000-02-21 AU AU28114/00A patent/AU2811400A/en not_active Abandoned
-
2007
- 2007-08-08 CY CY20071101062T patent/CY1106807T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60034770T2 (de) | 2008-04-30 |
| HUP0202151A2 (en) | 2002-10-28 |
| HU228857B1 (en) | 2013-06-28 |
| AU2811400A (en) | 2000-09-14 |
| DK1156829T3 (da) | 2007-09-10 |
| JP2002537358A (ja) | 2002-11-05 |
| EP1156829A1 (de) | 2001-11-28 |
| WO2000050084A1 (fr) | 2000-08-31 |
| ATE361757T1 (de) | 2007-06-15 |
| CY1106807T1 (el) | 2012-05-23 |
| US6528539B1 (en) | 2003-03-04 |
| PT1156829E (pt) | 2007-08-17 |
| HUP0202151A3 (en) | 2005-02-28 |
| EP1156829B1 (de) | 2007-05-09 |
| ES2286998T3 (es) | 2007-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |