DE60014103D1 - Verfahren zur herstellung von debromohymenialdisin und deren analogen - Google Patents
Verfahren zur herstellung von debromohymenialdisin und deren analogenInfo
- Publication number
- DE60014103D1 DE60014103D1 DE60014103T DE60014103T DE60014103D1 DE 60014103 D1 DE60014103 D1 DE 60014103D1 DE 60014103 T DE60014103 T DE 60014103T DE 60014103 T DE60014103 T DE 60014103T DE 60014103 D1 DE60014103 D1 DE 60014103D1
- Authority
- DE
- Germany
- Prior art keywords
- compound
- dbh
- analogs
- converted
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- JYRJOQGKGMHTOO-VURMDHGXSA-N (4z)-4-(2-amino-4-oxo-1h-imidazol-5-ylidene)-1,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one Chemical compound N1C(N)=NC(=O)\C1=C/1C(C=CN2)=C2C(=O)NCC\1 JYRJOQGKGMHTOO-VURMDHGXSA-N 0.000 title abstract 7
- JYRJOQGKGMHTOO-UHFFFAOYSA-N Debromohymenialdisine hydrochloride Natural products N1C(N)=NC(=O)C1=C1C(C=CN2)=C2C(=O)NCC1 JYRJOQGKGMHTOO-UHFFFAOYSA-N 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- LLQCRTZROWMVOL-DYDIJXKYSA-N (3as,6s,6ar,9as,9br)-6a-hydroxy-6,9a-dimethyl-3-methylidene-4,5,6,9b-tetrahydro-3ah-azuleno[8,7-b]furan-2,9-dione Chemical compound C[C@H]1CC[C@H]2C(=C)C(=O)O[C@H]2[C@]2(C)C(=O)C=C[C@]12O LLQCRTZROWMVOL-DYDIJXKYSA-N 0.000 abstract 2
- WZZBNLYBHUDSHF-DHLKQENFSA-N 1-[(3s,4s)-4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanone Chemical compound CC1=NC2=CN=C3C=C(F)C(C=4C(=CC(OC=5N=CC=CN=5)=CC=4)Cl)=CC3=C2N1[C@H]1CCN(C(=O)CO)C[C@@H]1F WZZBNLYBHUDSHF-DHLKQENFSA-N 0.000 abstract 2
- 229940125773 compound 10 Drugs 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- MRMGABUTBNWSLA-UHFFFAOYSA-N hymenine Natural products N1C(N)=NC(C2C=3C(Br)=C(Br)NC=3C(=O)NCC2)=C1 MRMGABUTBNWSLA-UHFFFAOYSA-N 0.000 abstract 2
- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 abstract 2
- LLQCRTZROWMVOL-UHFFFAOYSA-N parthenin Natural products CC1CCC2C(=C)C(=O)OC2C2(C)C(=O)C=CC12O LLQCRTZROWMVOL-UHFFFAOYSA-N 0.000 abstract 2
- SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical compound O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 abstract 1
- GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 abstract 1
- NPRYCHLHHVWLQZ-TURQNECASA-N 2-amino-9-[(2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-ynylpurin-8-one Chemical compound NC1=NC=C2N(C(N(C2=N1)[C@@H]1O[C@@H]([C@H]([C@H]1O)F)CO)=O)CC#C NPRYCHLHHVWLQZ-TURQNECASA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229940125797 compound 12 Drugs 0.000 abstract 1
- 229940126543 compound 14 Drugs 0.000 abstract 1
- 150000001993 dienes Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/357,687 US6211361B1 (en) | 1999-07-20 | 1999-07-20 | Method for making debromohymenialdisine and analogs thereof |
| PCT/US2000/019704 WO2001005794A2 (en) | 1999-07-20 | 2000-07-19 | Method for making debromohymenialdisine and analogs thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60014103D1 true DE60014103D1 (de) | 2004-10-28 |
Family
ID=23406630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60014103T Expired - Lifetime DE60014103D1 (de) | 1999-07-20 | 2000-07-19 | Verfahren zur herstellung von debromohymenialdisin und deren analogen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6211361B1 (de) |
| EP (1) | EP1200438B1 (de) |
| JP (1) | JP2003505392A (de) |
| AT (1) | ATE277051T1 (de) |
| AU (1) | AU6112800A (de) |
| BR (1) | BR0012599A (de) |
| CA (1) | CA2379847A1 (de) |
| DE (1) | DE60014103D1 (de) |
| IL (1) | IL147728A0 (de) |
| MX (1) | MXPA02000706A (de) |
| WO (1) | WO2001005794A2 (de) |
| ZA (1) | ZA200201159B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1572682A4 (de) * | 2002-12-20 | 2008-01-23 | Pharmacia Corp | Acyclische pyrazolverbindungen |
| WO2004098520A2 (en) * | 2003-05-01 | 2004-11-18 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| US7385055B2 (en) * | 2003-05-19 | 2008-06-10 | Board Of Trustees Of Michigan State University | Preparation of hymenialdisine derivatives and use thereof |
| US8304408B2 (en) * | 2007-05-24 | 2012-11-06 | The Regents Of The University Of California | Wnt signaling inhibitors, and methods for making and using them |
| DE102017124284A1 (de) * | 2016-10-19 | 2018-04-19 | Steering Solutions Ip Holding Corporation | In eine controllerplatine integrierter drehmomentsensor und eps-system, das diese enthält |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3375131B2 (ja) * | 1992-02-24 | 2003-02-10 | スミスクライン・ビーチャム・コーポレイション | プロテインキナーゼｃ阻害剤 |
| JP3714685B2 (ja) * | 1994-05-18 | 2005-11-09 | 第一サントリーファーマ株式会社 | ハイメニアルディシン及びその誘導体並びにそれらの合成中間体の製造法並びにその合成中間体 |
| US5591740A (en) * | 1995-06-07 | 1997-01-07 | Osteoarthritis Sciences, Incorporated | Use of debromohymenialdisine for treating osteoarthritis |
-
1999
- 1999-07-20 US US09/357,687 patent/US6211361B1/en not_active Expired - Fee Related
-
2000
- 2000-07-19 MX MXPA02000706A patent/MXPA02000706A/es unknown
- 2000-07-19 WO PCT/US2000/019704 patent/WO2001005794A2/en active IP Right Grant
- 2000-07-19 AU AU61128/00A patent/AU6112800A/en not_active Abandoned
- 2000-07-19 CA CA002379847A patent/CA2379847A1/en not_active Abandoned
- 2000-07-19 AT AT00947544T patent/ATE277051T1/de not_active IP Right Cessation
- 2000-07-19 EP EP00947544A patent/EP1200438B1/de not_active Expired - Lifetime
- 2000-07-19 IL IL14772800A patent/IL147728A0/xx unknown
- 2000-07-19 JP JP2001511453A patent/JP2003505392A/ja active Pending
- 2000-07-19 BR BR0012599-7A patent/BR0012599A/pt not_active Application Discontinuation
- 2000-07-19 DE DE60014103T patent/DE60014103D1/de not_active Expired - Lifetime
-
2002
- 2002-02-11 ZA ZA200201159A patent/ZA200201159B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2379847A1 (en) | 2001-01-25 |
| JP2003505392A (ja) | 2003-02-12 |
| ATE277051T1 (de) | 2004-10-15 |
| WO2001005794A3 (en) | 2001-07-19 |
| EP1200438A2 (de) | 2002-05-02 |
| WO2001005794A2 (en) | 2001-01-25 |
| EP1200438B1 (de) | 2004-09-22 |
| MXPA02000706A (es) | 2002-07-02 |
| ZA200201159B (en) | 2003-08-27 |
| BR0012599A (pt) | 2002-09-17 |
| IL147728A0 (en) | 2002-08-14 |
| US6211361B1 (en) | 2001-04-03 |
| AU6112800A (en) | 2001-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |