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DE60012165D1 - Verfahren zur herstellung von alendron-säure - Google Patents

Verfahren zur herstellung von alendron-säure

Info

Publication number
DE60012165D1
DE60012165D1 DE60012165T DE60012165T DE60012165D1 DE 60012165 D1 DE60012165 D1 DE 60012165D1 DE 60012165 T DE60012165 T DE 60012165T DE 60012165 T DE60012165 T DE 60012165T DE 60012165 D1 DE60012165 D1 DE 60012165D1
Authority
DE
Germany
Prior art keywords
alendronic acid
producing
reacting
group
iodo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60012165T
Other languages
English (en)
Other versions
DE60012165T2 (de
Inventor
Ramy Lidor-Hadas
Revital Lifshitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of DE60012165D1 publication Critical patent/DE60012165D1/de
Publication of DE60012165T2 publication Critical patent/DE60012165T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE60012165T 1999-02-17 2000-02-11 Verfahren zur herstellung von alendron-säure Expired - Fee Related DE60012165T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25163499A 1999-02-17 1999-02-17
US251634 1999-02-17
PCT/US2000/003586 WO2000049026A1 (en) 1999-02-17 2000-02-11 Novel process for preparing alendronic acid

Publications (2)

Publication Number Publication Date
DE60012165D1 true DE60012165D1 (de) 2004-08-19
DE60012165T2 DE60012165T2 (de) 2005-08-25

Family

ID=22952795

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60012165T Expired - Fee Related DE60012165T2 (de) 1999-02-17 2000-02-11 Verfahren zur herstellung von alendron-säure

Country Status (29)

Country Link
US (2) US6201148B1 (de)
EP (1) EP1169326B1 (de)
JP (1) JP3930251B2 (de)
KR (1) KR100665633B1 (de)
AT (1) ATE271057T1 (de)
AU (1) AU770312B2 (de)
BG (1) BG64851B1 (de)
BR (1) BR0010112A (de)
CA (1) CA2363317C (de)
CZ (1) CZ296921B6 (de)
DE (1) DE60012165T2 (de)
DK (1) DK1169326T3 (de)
EA (1) EA003861B1 (de)
EE (1) EE04593B1 (de)
ES (1) ES2222188T3 (de)
HK (1) HK1041004B (de)
HR (1) HRP20010606B1 (de)
HU (1) HUP0200342A3 (de)
IL (1) IL144941A0 (de)
IS (1) IS6050A (de)
MX (1) MXPA01008332A (de)
NO (1) NO20013984L (de)
NZ (1) NZ513551A (de)
PL (1) PL350126A1 (de)
PT (1) PT1169326E (de)
SK (1) SK285163B6 (de)
WO (1) WO2000049026A1 (de)
YU (1) YU59401A (de)
ZA (1) ZA200106816B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA01008332A (es) * 1999-02-17 2003-01-08 Teva Pharma Proceso novedoso para preparar acido alendronico.
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
WO2003057136A2 (en) * 2001-12-24 2003-07-17 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
WO2007083240A2 (en) * 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US562A (en) * 1838-01-09 Scale beam and weight
US22A (en) * 1836-09-05 Spbcificatioh
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4621107A (en) * 1982-08-12 1986-11-04 Lagow Richard J Fluorinated elastomeric materials
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US5039819A (en) * 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
GB2248063A (en) * 1990-09-18 1992-03-25 Merck & Co Inc Phthalimido alkanoyl phosphonates
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
MXPA01008332A (es) * 1999-02-17 2003-01-08 Teva Pharma Proceso novedoso para preparar acido alendronico.

Also Published As

Publication number Publication date
KR20010102162A (ko) 2001-11-15
EP1169326A4 (de) 2002-05-22
JP2002537303A (ja) 2002-11-05
ATE271057T1 (de) 2004-07-15
HUP0200342A3 (en) 2005-02-28
NO20013984D0 (no) 2001-08-16
EA003861B1 (ru) 2003-10-30
HUP0200342A2 (en) 2002-06-29
KR100665633B1 (ko) 2007-01-10
BG64851B1 (bg) 2006-06-30
WO2000049026A1 (en) 2000-08-24
AU3488600A (en) 2000-09-04
YU59401A (sh) 2004-05-12
SK11862001A3 (sk) 2002-02-05
HK1041004A1 (en) 2002-06-28
CZ296921B6 (cs) 2006-07-12
IL144941A0 (en) 2002-06-30
EA200100894A1 (ru) 2002-04-25
NO20013984L (no) 2001-10-17
EE200100436A (et) 2002-12-16
ZA200106816B (en) 2002-08-19
EP1169326A1 (de) 2002-01-09
US6201148B1 (en) 2001-03-13
CZ20012942A3 (cs) 2002-01-16
EP1169326B1 (de) 2004-07-14
AU770312B2 (en) 2004-02-19
HK1041004B (en) 2005-01-21
BG105825A (en) 2002-04-30
EE04593B1 (et) 2006-02-15
ES2222188T3 (es) 2005-02-01
MXPA01008332A (es) 2003-01-08
IS6050A (is) 2001-08-16
NZ513551A (en) 2003-02-28
PT1169326E (pt) 2004-10-29
JP3930251B2 (ja) 2007-06-13
BR0010112A (pt) 2001-12-26
DE60012165T2 (de) 2005-08-25
SK285163B6 (sk) 2006-07-07
US20020052527A1 (en) 2002-05-02
CA2363317A1 (en) 2000-08-24
CA2363317C (en) 2008-04-29
HRP20010606B1 (en) 2005-08-31
HRP20010606A2 (en) 2002-10-31
PL350126A1 (en) 2002-11-04
DK1169326T3 (da) 2004-10-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee