DE60008642D1 - Verfahren zur Herstellung von optisch aktiven N-geschützten N-Methyl-phenylalanin-Derivaten - Google Patents
Verfahren zur Herstellung von optisch aktiven N-geschützten N-Methyl-phenylalanin-DerivatenInfo
- Publication number
- DE60008642D1 DE60008642D1 DE60008642T DE60008642T DE60008642D1 DE 60008642 D1 DE60008642 D1 DE 60008642D1 DE 60008642 T DE60008642 T DE 60008642T DE 60008642 T DE60008642 T DE 60008642T DE 60008642 D1 DE60008642 D1 DE 60008642D1
- Authority
- DE
- Germany
- Prior art keywords
- protected
- methyl
- optically active
- preparation
- halogenophenylalanine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title abstract 4
- -1 N-protected N-methyl-phenylalanine Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000008177 pharmaceutical agent Substances 0.000 abstract 2
- 150000003839 salts Chemical group 0.000 abstract 2
- XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical class C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
- C12P13/222—Phenylalanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/34—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/20—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/08—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11200014A JP2001031635A (ja) | 1999-07-14 | 1999-07-14 | 光学活性ｎ−保護−ｎ−メチル−フェニルアラニン誘導体の製造方法 |
| JP20001499 | 1999-07-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60008642D1 true DE60008642D1 (de) | 2004-04-08 |
| DE60008642T2 DE60008642T2 (de) | 2005-02-24 |
Family
ID=16417376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60008642T Expired - Fee Related DE60008642T2 (de) | 1999-07-14 | 2000-07-12 | Verfahren zur Herstellung von optisch aktiven N-geschützten N-Methyl-phenylalanin-Derivaten |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6342629B1 (de) |
| EP (1) | EP1069109B1 (de) |
| JP (1) | JP2001031635A (de) |
| AT (1) | ATE260888T1 (de) |
| DE (1) | DE60008642T2 (de) |
| ES (1) | ES2216825T3 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101109737B1 (ko) * | 2009-10-09 | 2012-02-15 | 미원상사주식회사 | 지방산 아미노에스테르 및 이를 함유하는 피부미백용 화장료 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS528821B1 (de) * | 1970-07-25 | 1977-03-11 | ||
| JPS5233194B2 (de) * | 1973-04-24 | 1977-08-26 | ||
| US4351763A (en) * | 1979-12-17 | 1982-09-28 | Eli Lilly And Company | Pharmacologically active peptides |
| US5248813A (en) * | 1992-10-14 | 1993-09-28 | Ethyl Corporation | Enantiomeric resolution |
| IL115685A (en) | 1994-11-16 | 2000-08-31 | Vertex Pharma | Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof |
| US5543423A (en) | 1994-11-16 | 1996-08-06 | Vertex Pharmaceuticals, Incorporated | Amino acid derivatives with improved multi-drug resistance activity |
| KR20000016204A (ko) | 1996-05-31 | 2000-03-25 | 한센 핀 베네드, 안네 제헤르 | 골다공증의 주기적(연계) 치료에 있어 성장호르몬 성분 및 뼈의항흡수 약물 |
-
1999
- 1999-07-14 JP JP11200014A patent/JP2001031635A/ja not_active Withdrawn
-
2000
- 2000-02-01 US US09/495,360 patent/US6342629B1/en not_active Expired - Fee Related
- 2000-07-12 EP EP00305894A patent/EP1069109B1/de not_active Expired - Lifetime
- 2000-07-12 ES ES00305894T patent/ES2216825T3/es not_active Expired - Lifetime
- 2000-07-12 DE DE60008642T patent/DE60008642T2/de not_active Expired - Fee Related
- 2000-07-12 AT AT00305894T patent/ATE260888T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001031635A (ja) | 2001-02-06 |
| US6342629B1 (en) | 2002-01-29 |
| EP1069109B1 (de) | 2004-03-03 |
| DE60008642T2 (de) | 2005-02-24 |
| ATE260888T1 (de) | 2004-03-15 |
| EP1069109A1 (de) | 2001-01-17 |
| ES2216825T3 (es) | 2004-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |