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DE60007848D1 - Herstellung von 2'-substitutierter rns - Google Patents

Herstellung von 2'-substitutierter rns

Info

Publication number
DE60007848D1
DE60007848D1 DE60007848T DE60007848T DE60007848D1 DE 60007848 D1 DE60007848 D1 DE 60007848D1 DE 60007848 T DE60007848 T DE 60007848T DE 60007848 T DE60007848 T DE 60007848T DE 60007848 D1 DE60007848 D1 DE 60007848D1
Authority
DE
Germany
Prior art keywords
preparation
substituted
rns
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60007848T
Other languages
English (en)
Other versions
DE60007848T2 (de
Inventor
Bernard Reese
Quanlai Song
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avecia Ltd
Original Assignee
Avecia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Ltd filed Critical Avecia Ltd
Application granted granted Critical
Publication of DE60007848D1 publication Critical patent/DE60007848D1/de
Publication of DE60007848T2 publication Critical patent/DE60007848T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60007848T 1999-03-19 2000-03-15 Herstellung von 2'-substitutierter rns Expired - Fee Related DE60007848T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9906328 1999-03-19
GBGB9906328.1A GB9906328D0 (en) 1999-03-19 1999-03-19 2-Substituted RNA preparation
PCT/GB2000/000965 WO2000056747A1 (en) 1999-03-19 2000-03-15 2'-substituted rna preparation

Publications (2)

Publication Number Publication Date
DE60007848D1 true DE60007848D1 (de) 2004-02-26
DE60007848T2 DE60007848T2 (de) 2004-12-30

Family

ID=10849939

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60007848T Expired - Fee Related DE60007848T2 (de) 1999-03-19 2000-03-15 Herstellung von 2'-substitutierter rns

Country Status (12)

Country Link
US (1) US6884881B1 (de)
EP (1) EP1165584B1 (de)
JP (1) JP2002540117A (de)
KR (1) KR20020013511A (de)
AT (1) ATE258187T1 (de)
AU (1) AU3181600A (de)
CA (1) CA2362714A1 (de)
DE (1) DE60007848T2 (de)
DK (1) DK1165584T3 (de)
ES (1) ES2215032T3 (de)
GB (1) GB9906328D0 (de)
WO (1) WO2000056747A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE312942T1 (de) * 2000-10-25 2005-12-15 Hoffmann La Roche Amplifizierung unter verwendung von modifizierten primern
KR100480498B1 (ko) * 2002-05-24 2005-04-06 학교법인 포항공과대학교 뉴클레오시드를 이용한 저분자 유기 젤레이터 및 그합성방법
CN102993255B (zh) * 2011-09-19 2016-02-10 上海兆维科技发展有限公司 2’-o-(2-甲氧乙基)-5-甲基尿苷和2’-o-(2-甲氧乙基)-5-甲基胞苷及其衍生物的制备及其纯化方法
CN114369124B (zh) * 2022-01-21 2024-03-26 北京瑞博奥医药科技有限公司 一种2`-位取代嘧啶类核苷的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090932A (en) 1994-06-22 2000-07-18 Proligo Llc Method of preparation of known and novel 2'-modified nucleosides by intramolecular nucleophilic displacement
US6222025B1 (en) * 1995-03-06 2001-04-24 Isis Pharmaceuticals, Inc. Process for the synthesis of 2′-O-substituted pyrimidines and oligomeric compounds therefrom

Also Published As

Publication number Publication date
ES2215032T3 (es) 2004-10-01
ATE258187T1 (de) 2004-02-15
AU3181600A (en) 2000-10-09
EP1165584B1 (de) 2004-01-21
JP2002540117A (ja) 2002-11-26
EP1165584A1 (de) 2002-01-02
KR20020013511A (ko) 2002-02-20
DE60007848T2 (de) 2004-12-30
GB9906328D0 (en) 1999-05-12
US6884881B1 (en) 2005-04-26
DK1165584T3 (da) 2004-05-17
CA2362714A1 (en) 2000-09-28
WO2000056747A1 (en) 2000-09-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee