[go: up one dir, main page]

DE59107855D1 - METHOD FOR THE PRODUCTION OF N-PROTECTED (2S, 3S) -3-ETHYLASPARAGIC ACID DIALYST - Google Patents

METHOD FOR THE PRODUCTION OF N-PROTECTED (2S, 3S) -3-ETHYLASPARAGIC ACID DIALYST

Info

Publication number
DE59107855D1
DE59107855D1 DE59107855T DE59107855T DE59107855D1 DE 59107855 D1 DE59107855 D1 DE 59107855D1 DE 59107855 T DE59107855 T DE 59107855T DE 59107855 T DE59107855 T DE 59107855T DE 59107855 D1 DE59107855 D1 DE 59107855D1
Authority
DE
Germany
Prior art keywords
acid
pct
protected
ethylasparagic
dialyst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE59107855T
Other languages
German (de)
Inventor
Ulrich Heywang
Harry Schwartz
Michael Casutt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Application granted granted Critical
Publication of DE59107855D1 publication Critical patent/DE59107855D1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

PCT No. PCT/EP91/00332 Sec. 371 Date Nov. 6, 1991 Sec. 102(e) Date Nov. 6, 1991 PCT Filed Feb. 22, 1991 PCT Pub. No. WO91/13861 PCT Pub. Date Sep. 19, 1991.The invention relates to a process for the preparation of N-protected dialkyl (2S,3S)-3-ethylaspartates or their salts from unpurified (2S,3S)-3-ethylaspartic acid obtainable by enzymatic amination of ethylfumaric acid.
DE59107855T 1990-03-07 1991-02-22 METHOD FOR THE PRODUCTION OF N-PROTECTED (2S, 3S) -3-ETHYLASPARAGIC ACID DIALYST Expired - Fee Related DE59107855D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4007038A DE4007038A1 (en) 1990-03-07 1990-03-07 PROCESS FOR PREPARING N-PROTECTED (2S, 3S) -3-ETHYLASPARAGINSAEUREDIAL CYLINDERS
PCT/EP1991/000332 WO1991013861A1 (en) 1990-03-07 1991-02-22 Method for preparing n-protected (2s,3s)-3-ethylaspartic acid dialkyl esters

Publications (1)

Publication Number Publication Date
DE59107855D1 true DE59107855D1 (en) 1996-07-04

Family

ID=6401540

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4007038A Withdrawn DE4007038A1 (en) 1990-03-07 1990-03-07 PROCESS FOR PREPARING N-PROTECTED (2S, 3S) -3-ETHYLASPARAGINSAEUREDIAL CYLINDERS
DE59107855T Expired - Fee Related DE59107855D1 (en) 1990-03-07 1991-02-22 METHOD FOR THE PRODUCTION OF N-PROTECTED (2S, 3S) -3-ETHYLASPARAGIC ACID DIALYST

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE4007038A Withdrawn DE4007038A1 (en) 1990-03-07 1990-03-07 PROCESS FOR PREPARING N-PROTECTED (2S, 3S) -3-ETHYLASPARAGINSAEUREDIAL CYLINDERS

Country Status (11)

Country Link
US (1) US5275941A (en)
EP (1) EP0471809B1 (en)
JP (1) JP2968586B2 (en)
KR (1) KR0178960B1 (en)
AT (1) ATE138640T1 (en)
AU (1) AU646844B2 (en)
CA (1) CA2054715C (en)
DE (2) DE4007038A1 (en)
ES (1) ES2088000T3 (en)
HU (1) HU210953B (en)
WO (1) WO1991013861A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102381999A (en) * 2011-09-14 2012-03-21 杭州澳赛诺化工有限公司 Synthetic method of L-aspartate-4-methyl ester-1-benzyl ester

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4569911A (en) * 1984-01-19 1986-02-11 Uop Inc. Method of making aspartic acid and purifying aspartase
US4552846A (en) * 1984-01-19 1985-11-12 Uop Inc. Aspartase from a Bacillus subtilis

Also Published As

Publication number Publication date
KR0178960B1 (en) 1999-05-15
HUT60461A (en) 1992-09-28
WO1991013861A1 (en) 1991-09-19
AU7301491A (en) 1991-10-10
DE4007038A1 (en) 1991-09-12
KR920701126A (en) 1992-08-11
ES2088000T3 (en) 1996-08-01
JPH04505467A (en) 1992-09-24
AU646844B2 (en) 1994-03-10
US5275941A (en) 1994-01-04
CA2054715A1 (en) 1991-09-08
ATE138640T1 (en) 1996-06-15
CA2054715C (en) 2002-05-28
JP2968586B2 (en) 1999-10-25
HU210953B (en) 1995-09-28
EP0471809A1 (en) 1992-02-26
EP0471809B1 (en) 1996-05-29
HU913486D0 (en) 1992-01-28

Similar Documents

Publication Publication Date Title
DE59108707D1 (en) Process for the preparation of oxetanones
BR9407047A (en) Process for separating a protein from an aqueous protein solution
ATE226640T1 (en) METHOD FOR PRODUCING SUBSTITUTED ARYLMACTIC ACID CONTAINING CYCLODEPSIPEPTIDS WITH 24 RING ATOMS
ATE204905T1 (en) METHOD FOR PRODUCING ETHYL ALCOHOL
ATE216365T1 (en) METHOD FOR RACEMAT DECISION
DE69513847D1 (en) METHOD FOR PRODUCING SUBSTITUTED 3-AMINOBENZONITRILES
ATE301659T1 (en) METHOD FOR PRODUCING CAMPOTHECINE DERIVATIVES
ATE111734T1 (en) PROCESS FOR THE MANUFACTURE OF DIRECT-COMPRESSED TABLETS CONTAINING CEPHALOSPORANIC ACID DERIVATIVES.
ATE281434T1 (en) METHOD FOR PRODUCING BENZOPERHYDROISOINDOLES
DE59107855D1 (en) METHOD FOR THE PRODUCTION OF N-PROTECTED (2S, 3S) -3-ETHYLASPARAGIC ACID DIALYST
DE58902228D1 (en) METHOD FOR THE PRODUCTION OF 5-PIECE, NITROGEN-CONTAINING HETEROAROMATS.
DE59104516D1 (en) METHOD FOR PRODUCING AMINOMETHANEPHOSPHONIC ACID AND AMINOMETHYL PHOSPHINIC ACIDS.
DE69404454D1 (en) METHOD FOR PRODUCING AMINOMETHANPHOSPHONIC ACID
DE59404963D1 (en) METHOD FOR PRODUCING CAESUM SALTS FROM CAESUM ALUMINUM ALUMINUM
DE69032153D1 (en) Process for the preparation of butane tetracarboxylate
ATE218545T1 (en) METHOD FOR PRODUCING ENANTIOMERICALLY ENRICHED N-ACYLAZETIdine-2-CARBONIC ACIDS
ATE192437T1 (en) METHOD FOR PRODUCING 3-AMINO-2-CHLORINE-4-ALKYL OR 4-CYCLOALKYL-PYRIDINES
DE69514512D1 (en) METHOD FOR PRODUCING BENZOPYRANE DERIVATIVES
ATE77821T1 (en) PROCESS FOR THE PREPARATION OF PENICILLAN ACID DERIVATIVES.
ATE215071T1 (en) METHOD FOR PRODUCING PROSTAGLANDIN E1
ATE175968T1 (en) METHOD FOR PRODUCING CONDENSED CARBAPENEM DERIVATIVES
DE69104920D1 (en) METHOD FOR PRODUCING PYRIMID INTRION DERIVATIVES.
DE59611145D1 (en) METHOD FOR THE CONTINUOUS PRODUCTION OF BASIC, CYCLIC, OPTICALLY ACTIVE Alpha-AMINO ACIDS
ATE92108T1 (en) PROCESS FOR PRODUCTION OF L-PHOSPHINOTHRICINE BY TRANSAMINATION.
DE3867339D1 (en) METHOD FOR PRODUCING SALTS OF AMINOMALONIC ACID REDINITRILE.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee