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DE536191C - Process for obtaining female sex hormone from the urine of pregnant women - Google Patents

Process for obtaining female sex hormone from the urine of pregnant women

Info

Publication number
DE536191C
DE536191C DE1930536191D DE536191DD DE536191C DE 536191 C DE536191 C DE 536191C DE 1930536191 D DE1930536191 D DE 1930536191D DE 536191D D DE536191D D DE 536191DD DE 536191 C DE536191 C DE 536191C
Authority
DE
Germany
Prior art keywords
urine
sex hormone
female sex
pregnant women
hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1930536191D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chem & Pharm Patent Hold Ltd
Original Assignee
Chem & Pharm Patent Hold Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chem & Pharm Patent Hold Ltd filed Critical Chem & Pharm Patent Hold Ltd
Application granted granted Critical
Publication of DE536191C publication Critical patent/DE536191C/en
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)

Description

Verfahren zur Gewinnung von weiblichem Sexualhormon aus dem Harn von schwangeren Frauen Es ist bekannt, daß man aus dem Harn von schwangeren Frauen das weibliche Sexualhormon durch Behandlung des Harnes mit Äther, Chloroform usw. ' extrahieren kann.Process for the extraction of female sex hormone from the urine of Pregnant women It is known that this can be obtained from the urine of pregnant women female sex hormone by treating the urine with ether, chloroform, etc. ' can extract.

In den Abstracts of communications to the XIIIth International Physiological Congress held at Boston ist eine Methode beschrieben, nach welcher man dem Schwangerenharn das weibliche Sexualhormon durch Behandlung des Harns mit Olivenöl entziehen kann. Das hormonhaltige Olivenöl wird dann weiterverarbeitet.In the Abstracts of communications to the XIIIth International Physiological Congress held at Boston describes a method by which the pregnant woman's urine can be removed can remove the female sex hormone by treating the urine with olive oil. The hormone-containing olive oil is then processed further.

Es wurde nun gefunden, daß man dem Schwangerenharn das weibliche Sexualhormon leicht und vollständig entziehen kann, wenn man den Harn in der Wärme mit Stearinsäure, Walrat, Kakaobutter, Cetylalkohol oder anderen festen Fettsäuren oder deren Ester oder anderen festen Alkoholen behandelt.It has now been found that the female sex hormone can be found in pregnant woman's urine can be easily and completely withdrawn if the urine is heated with stearic acid, Whale rat, cocoa butter, cetyl alcohol or other solid fatty acids or their esters or other solid alcohols.

Die erwähnten Substanzen werden am besten dem Harn in heißgesättigter alkoholischer Lösung zugesetzt. Nach dem Abkühlen des Harns scheidet sich an der Oberfläche die angewendete Substanz in Form einer harten Kruste aus, aus welcher das Hormon mit Leichtigkeit durch einfache Umkristallisation aus Alkohol wieder quantitativ gewonnen werden kann.The substances mentioned are best added to the urine in hot water alcoholic solution added. After the urine cools down, it separates Surface the applied substance in the form of a hard crust from which recover the hormone with ease by simple recrystallization from alcohol can be obtained quantitatively.

Beispiel zoo Liter Schwangerenharn werden in der Wärme mit einer heißen gesättigten alkoholischen Lösung von 5 kg Walrat versetzt und r bis 2 Stunden lebhaft, am zweckmäßigsten mittels eines Rührwerkes, durchgearbeitet. Man läßt dann den Harn 24 Stunden stehen und entfernt die an der Oberfläche sich ausgeschiedene Kruste von Walrat, die das gesamte Hormon enthält. Man löst den Walrat in heißem Alkohol, läßt erkalten, nutscht die hormonhaltige Flüssigkeit ab, konzentriert sie und entfernt durch nochmalige Kristallisation die letzten Reste von Walrat.Example zoo liters of pregnant woman's urine are heated with a hot one saturated alcoholic solution of 5 kg whale rat added and lively for up to 2 hours, most expediently by means of an agitator, worked through. You then let the urine Stand for 24 hours and remove the crust that has separated on the surface of whale rat, which contains all of the hormone. Dissolve the whale rat in hot alcohol, lets it cool down, sucks off the hormone-containing liquid, concentrates it and removes it by repeated crystallization the last remains of Walrat.

Das alkoholische Filtrat wird weiter eingedampft, mit demselben Volumen Wasser versetzt und mit Petroläther ausgeschüttelt, dadurch werden die Verunreinigungen entfernt. Die wässerig alkoholische Lösung wird hierauf mit Chloroform mehrmals ausgeschüttelt, das Hormon geht in das Chloroform über. Die Chloroformlösung kann dann nach verschiedenen Methoden weiterbearbeitet werden, um ein hochkonzentriertes Sexualhormon zu gewinnen.The alcoholic filtrate is evaporated further, with the same volume Water is added and shaken out with petroleum ether, which removes the impurities removed. The aqueous alcoholic solution is then treated with chloroform several times Shaken out, the hormone is converted into chloroform. The chloroform solution can can then be further processed according to various methods to achieve a highly concentrated To attract sex hormone.

Claims (1)

PATENTANSPRUCIi: Verfahren zur Gewinnung von weiblichem Sexualhormon aus dem Harn von schwangeren Frauen, dadurch gekennzeichnet, da.ß der Schwangerenharn mit festen Fettsäuren oder deren Ester oder mit festen höheren Alkoholen behandelt wird und daß man diesen Stoffen das Hormon durch geeignete Lösungsmittel wieder entzieht.PATENT CLAIM: Process for obtaining female sex hormone from the urine of pregnant women, characterized in that the pregnant woman's urine treated with solid fatty acids or their esters or with solid higher alcohols and that one can restore the hormone to these substances by means of suitable solvents withdraws.
DE1930536191D 1930-01-28 1930-01-28 Process for obtaining female sex hormone from the urine of pregnant women Expired DE536191C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE536191T 1930-01-28

Publications (1)

Publication Number Publication Date
DE536191C true DE536191C (en) 1931-10-19

Family

ID=6557204

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1930536191D Expired DE536191C (en) 1930-01-28 1930-01-28 Process for obtaining female sex hormone from the urine of pregnant women

Country Status (1)

Country Link
DE (1) DE536191C (en)

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