DE489573C - Process for the preparation of complex organic vanadium compounds - Google Patents
Process for the preparation of complex organic vanadium compoundsInfo
- Publication number
- DE489573C DE489573C DEI30441D DEI0030441D DE489573C DE 489573 C DE489573 C DE 489573C DE I30441 D DEI30441 D DE I30441D DE I0030441 D DEI0030441 D DE I0030441D DE 489573 C DE489573 C DE 489573C
- Authority
- DE
- Germany
- Prior art keywords
- vanadium
- complex organic
- preparation
- vanadium compounds
- organic vanadium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 3
- 150000003682 vanadium compounds Chemical class 0.000 title claims description 3
- 239000002253 acid Substances 0.000 claims description 6
- QUEDYRXQWSDKKG-UHFFFAOYSA-M [O-2].[O-2].[V+5].[OH-] Chemical compound [O-2].[O-2].[V+5].[OH-] QUEDYRXQWSDKKG-UHFFFAOYSA-M 0.000 claims description 5
- 150000007513 acids Chemical class 0.000 claims description 5
- 125000003118 aryl group Chemical group 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 2
- 239000003929 acidic solution Substances 0.000 claims 1
- 229910052720 vanadium Inorganic materials 0.000 description 4
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 3
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 2
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 2
- CFVBFMMHFBHNPZ-UHFFFAOYSA-N [Na].[V] Chemical compound [Na].[V] CFVBFMMHFBHNPZ-UHFFFAOYSA-N 0.000 description 2
- 229960002510 mandelic acid Drugs 0.000 description 2
- 150000002894 organic compounds Chemical class 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- LXASOGUHMSNFCR-UHFFFAOYSA-D [V+5].[V+5].[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O Chemical class [V+5].[V+5].[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O.[O-]C(=O)C([O-])=O LXASOGUHMSNFCR-UHFFFAOYSA-D 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 150000004675 formic acid derivatives Chemical class 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 150000003873 salicylate salts Chemical class 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- -1 vanadyl tartrates Chemical class 0.000 description 1
- 231100000925 very toxic Toxicity 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/005—Compounds of elements of Group 5 of the Periodic Table without metal-carbon linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Darstellung von komplexen organischen Vanadin-Verbindungen Es wurde gefunden, daß man zu neuen komplexen organischen Verbindungen des dreiwertigen Vanadins dadurch gelangt, daß man Salze einbasischer aromatischer Oxycarbonsäuren mit Vanadintrioxyd V03 behandelt oder auf diese Säuren erst Vanadintrioxyd einwirken läBt und die erhältlichen Lösungen dann mit Alkalien oder Erdalkalien neutralisiert.Process for the preparation of complex organic vanadium compounds It has been found that new complex organic compounds of the trivalent Vanadins is obtained by using salts of monobasic aromatic oxycarboxylic acids treated with vanadium trioxide V03 or first act on these acids with vanadium trioxide and the available solutions are then neutralized with alkalis or alkaline earths.
Die neuen Produkte sind meistens gefärbte, feste Stoffe, die sich in Wasser mit fast neutraler Reaktion auflösen. Sie haben hervorragende therapeutische Bedeutung, da sie sehr kräftig gegen luetische Erkrankungen wirken und sich vor den bekannten Verbindungen des höherwertigen Vanadiums durch geringere Giftigkeit auszeichnen.The new products are mostly colored, solid fabrics that are Dissolve in water with an almost neutral reaction. You have excellent therapeutic Importance, as they have a very powerful effect against syphilitic diseases and prevent themselves the known compounds of higher quality vanadium due to their lower toxicity distinguish.
Komplexe organische Verbindungen des dreiwertigen Vanadins von so geringer Giftigkeit und so hohem therapeutischem Wert sind bisher noch nicht bekannt geworden. Gemäß den Angaben. in Beilstein, 4. Auflage, II (192o), Seite 520, und Chemisches Centralblatt z916, II, Seite 641, sind außer den sehr giftigen und daher therapeutisch wertlosen komplexen Vanadinoxalaten nur noch Formiate des dreiwertigen V anadins hergestellt worden. Letztere Säuren sind aber weder Oxysäuren, noch gehören sie der aromatischen Reihe an. An derselben Stelle des Chemischen Centralblattes ist allerdings die Absicht des Verfassers angedeutet worden, auch die Salicylate des dreiwertigen Vanadins darzustellen. Ihre Darstellung ist aber weder von diesem Autor noch von irgendeiner anderen Seite bisher erfolgt. Die weiterhin in der Literatur beschriebenen komplexen Vanadyltartrate (Barbieri, Chem. Centralblatt 1914, 1I, Seite 1427) leiten sich nicht vom dreiwertigen, sondern vom vierwertigen Vanadin ab, abgesehen davon, daB sie als Tartrate vollkommen verschieden sind von dem Gegenstand der vorliegenden Erfindung. Beispiels to Gewichtsteile Salicylsäure werden mit N atriumcarbonatlösung neutralisiert und mit 2 GewichtsteilenVanadintrioxyd-V20g einige Zeit erwärmt. Nach beendigter Reaktion wird die filtrierte Lösung zur Trockne verdampft, wobei .das komplexe Natriumvanadinsalz der Salicy1säure als hellgraue Masse zurückbleibt, die sich in Wasser mit grünlicher Farbe löst.Complex organic compounds of trivalent vanadium of such low toxicity and such high therapeutic value have not yet become known. According to the information. in Beilstein, 4th edition, II (192o), page 520, and Chemisches Centralblatt z916, II, page 641, in addition to the very toxic and therefore therapeutically worthless complex vanadium oxalates, only formates of trivalent vanadine have been produced. The latter acids are neither oxyacids nor do they belong to the aromatic series. At the same point in the Chemisches Centralblatt, however, the author's intention has been indicated to also present the salicylates of trivalent vanadium. However, it has not yet been presented by this author or by any other party. The complex vanadyl tartrates described in the literature (Barbieri, Chem. Centralblatt 1914, 11, page 1427) are not derived from trivalent but tetravalent vanadium, apart from the fact that, as tartrates, they are completely different from the subject of the present invention. Examples of parts by weight of salicylic acid are neutralized with sodium carbonate solution and heated for some time with 2 parts by weight of vanadine trioxide V20g. When the reaction is complete, the filtered solution is evaporated to dryness, the complex sodium vanadium salt of salicic acid remaining as a light gray mass which dissolves in water with a greenish color.
Beispiel e to Gewichtsteile Mandelsäure werden in 3,5 Gewichtsteilen wasserfreiem Natriumcarbonat und 6o Gewichtsteilen Wasser gelöst und mit 2,5 Gewichtsteilen Vanadintrioxyd - V20$ einige Zeit :erwärmt. Nach beendigter Reaktion wird die filtrierte Lösung zur Trockne verdampft, -wobei das komplexe Natriumvanadinsalz der Mandelsäure als graublaue Masse zurückbleibt, die sich in Wasser mit violetter Farbe auflöst.Example e to parts by weight of mandelic acid are in 3.5 parts by weight anhydrous sodium carbonate and 6o parts by weight of water and dissolved with 2.5 parts by weight Vanadium trioxide - V20 $ some time: heated. When the reaction is complete, the filtered one Solution evaporates to dryness, with the complex sodium vanadium salt of mandelic acid remains as a gray-blue mass that dissolves in water with a purple color.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEI30441D DE489573C (en) | 1923-01-06 | 1923-01-06 | Process for the preparation of complex organic vanadium compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEI30441D DE489573C (en) | 1923-01-06 | 1923-01-06 | Process for the preparation of complex organic vanadium compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE489573C true DE489573C (en) | 1930-01-18 |
Family
ID=7187623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEI30441D Expired DE489573C (en) | 1923-01-06 | 1923-01-06 | Process for the preparation of complex organic vanadium compounds |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE489573C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1015803B (en) * | 1951-08-23 | 1957-09-19 | Bataafsche Petroleum | Process for the production of cumene hydroperoxide by oxidation of pre-purified cumene |
-
1923
- 1923-01-06 DE DEI30441D patent/DE489573C/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1015803B (en) * | 1951-08-23 | 1957-09-19 | Bataafsche Petroleum | Process for the production of cumene hydroperoxide by oxidation of pre-purified cumene |
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