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DE447161C - Process for the production of solutions for sleeping pills - Google Patents

Process for the production of solutions for sleeping pills

Info

Publication number
DE447161C
DE447161C DEF59903D DEF0059903D DE447161C DE 447161 C DE447161 C DE 447161C DE F59903 D DEF59903 D DE F59903D DE F0059903 D DEF0059903 D DE F0059903D DE 447161 C DE447161 C DE 447161C
Authority
DE
Germany
Prior art keywords
sleeping pills
solutions
production
solvents
pills
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEF59903D
Other languages
German (de)
Inventor
Dr Max Bockmuehl
Dr Karl Ludwig Lautenschlaeger
Dr Rudolf Schwabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IG Farbenindustrie AG
Original Assignee
IG Farbenindustrie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IG Farbenindustrie AG filed Critical IG Farbenindustrie AG
Priority to DEF59903D priority Critical patent/DE447161C/en
Application granted granted Critical
Publication of DE447161C publication Critical patent/DE447161C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids
    • C07D239/64—Salts of organic bases; Organic double compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung von Lösungen von Schlafmitteln. In der Patentschrift 446 290 ist beschrieben, daß wasserlösliche Äther und Ester mehrwertiger Alkohole, beispielsweise die Äther des Glycerins und des Glykols, ausgezeichnete Lösungsmittel für Kampfer darstellen.Process for the preparation of solutions for sleeping pills. Patent specification 446 290 describes that water-soluble ethers and esters of polyhydric alcohols, for example the ethers of glycerol and glycol, are excellent solvents for camphor.

Bei weiterer Erforschung der Eigenschaften dieser Lösungsmittel wurde nun gefunden, daß sie gleichfalls hervorragendes Lösungsvermögen für Schlafmittel aller Art, insbesondere der Barbitursäurederivate, besitzen. Man kennt bisher für Schlafmittel keine Lösungsmittel, welche einerseits die Schlafmittel in genügender Konzentration lösen; andererseits indifferenter Natur sind, also sich, ohne das Gewebe zu reizen und ohne Intoxikationen hervorzurufen, injizieren lassen.Further research into the properties of these solvents was made now found that they also have excellent dissolving power for sleeping pills of all kinds, especially the barbituric acid derivatives. One knows so far for Sleeping pills do not contain solvents, which on the one hand make sleeping pills sufficient Solve concentration; on the other hand are of an indifferent nature, i.e. themselves, without that To irritate tissue and without causing intoxication, have it injected.

Beispiele. i. i Teil Diäthylallylacetamid (vgl. Patentschrift 412 82o) wird in --Teilen Glycerindiäthyläther gelöst. Die Lösung stellt eine klare, wasserhelle Flüssigkeit dar.Examples. i. i Diäthylallylacetamid part (. see Patent 82o 412) is in - dissolved Glycerindiäthyläther parts. The solution is a clear, water-white liquid.

a. i Teil Diäthylallylacetamid wird mit 2 Teilen Glykolmonoäthyläther digeriert. Es tritt sehr bald Lösung ein.a. i part of diethylallylacetamide is mixed with 2 parts of glycol monoethyl ether digested. There will be a solution very soon.

3. i Teil Allylisopropylbarbitursäure wird in 9 Teilen Glycerindiäthyläther unter schwachem Erwärmen gelöst.3. i part of allylisopropylbarbituric acid is added to 9 parts of glycerol diethyl ether dissolved with gentle heating.

Die so gewonnenen Lösungen können durch Erhitzen sterilisiert werden und sind dauernd haltbar.The solutions obtained in this way can be sterilized by heating and are durable.

Claims (1)

PATRNTANSPRUCH: Verfahren zur Herstellung von Lösungen von Schlafmitteln, wie Barbitursäurederivaten und anderen Säureamiden, gemäß Patent 446 29o, dadurch gekennzeichnet, daß wasserlösliche Äther und Ester mehrwertiger Alkohole als Lösungsmittel für die betreffenden Schlafmittel verwendet werden.PATRNT CLAIM: Process for the production of solutions for sleeping pills, such as barbituric acid derivatives and other acid amides, according to patent 446 29o, thereby characterized in that water-soluble ethers and esters of polyhydric alcohols as solvents be used for the sleeping pills in question.
DEF59903D 1925-09-29 1925-09-29 Process for the production of solutions for sleeping pills Expired DE447161C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEF59903D DE447161C (en) 1925-09-29 1925-09-29 Process for the production of solutions for sleeping pills

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF59903D DE447161C (en) 1925-09-29 1925-09-29 Process for the production of solutions for sleeping pills

Publications (1)

Publication Number Publication Date
DE447161C true DE447161C (en) 1927-07-16

Family

ID=7108928

Family Applications (1)

Application Number Title Priority Date Filing Date
DEF59903D Expired DE447161C (en) 1925-09-29 1925-09-29 Process for the production of solutions for sleeping pills

Country Status (1)

Country Link
DE (1) DE447161C (en)

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