DE4415087A1 - Lignin based compsn. for use in balneotherapy, cosmetics etc - Google Patents

Abstract

Product for use in balneotherapy, health care and cosmetics contains as basic active ingredient (A) lignin, or its sulphonic acids or sulphonates, opt. in chemically or (bio)technically modified forms, either as sole ingredient or as part of a mixt. of active ingredients.

Description

Field of application of the invention

The invention relates to agents as active ingredients or active ingredient mixtures for use in balneotherapy, Health care and cosmetics, and processes for their application and use in manufacture pharmaceutical products.

The agents according to the invention are characterized in particular by the fact that they are genuine alternative products to the traditionally used humic acids and humic substances, equal or are superior.

Characteristic of the known prior art

Balneotherapy and health care are becoming medical and health and cosmetic purposes as peat peat as a natural mud mud (Peloids) from moor deposits of different origins.

Likewise come for the purposes described above on a moor basis "manufactured and pharmaceutical products and preparations (preferably bath additives, medical disposable and Reusable packs, ointments, capsules, etc.) for a variety of medical and health care Indications and applications for use.

The composition of bath peat, generally recognized by experts, is shown in Fig. 1. The humic acids of bath peat or the humic colloids with a high water-binding capacity are considered to be relevant and recognized by experts. In addition to the humic acids and humic substances in Fig. 1, the constituents of bath peat are only considered by the experts for the purposes of balneotherapeutic, health-care and cosmetic measures as insignificant and in some cases also disturbing accompanying substances of bath peat.

Before the medical use of bath towels, a technical preparation is therefore carried out required and also carried out. This technical preparation is primarily aimed at Removal of foreign matter.

A technical drying process then often follows in order to produce the product for storage and application easier to make manageable. According to generally accepted information, naturally moist moor contains around 85 up to 95% by weight water; as a paste still 75-85% by weight.

92% of the solids in the peat consists of organic matter from the former bog vegetation as well as 8% from mineral substances.  

Humic acids for medical, health care, and cosmetic purposes are also used obtained from brown coal from different deposits or corresponding pharmaceutical Products based on this active ingredient.

However, the active ingredient or the mixture of active ingredients humic acids is not a uniform substance in the Define the meaning of classic chemistry or pharmaceutical quality testing and to classify. The molar masses of the humic acids are in the range from 10,000 to 200,000.

Chemically, they are high molecular weight phenolic polymers and have a variety of functional groups and are also natural substances with high sorption capacity and thus also excellent ion exchanger. Humic acids are predominantly colloidal in peat hydrated, swollen gels.

The quality of action of humic acids for use as natural remedies and health care products is very dependent on their origin. It is therefore a very crucial shortcoming that this Natural remedies cannot be obtained in approximately the same quality.

Another very critical shortcoming is that the natural moor deposits that make up Bath peat and humic acids are very limited, since they contain fossil raw materials represent and also not regrow. For reasons of nature conservation, certain moorlands are therefore allowed are no longer used to obtain bath tubs and humic acids.

In addition, well-known moor baths as spa facilities and healing facilities are forced to Maintenance of "moor bathing", bath peat and humic acids from foreign deposits or from the pharmaceutical-chemical industry because of their own traditional bog deposits are exhausted or the bath peat does not meet the quality requirements. It consists of the reasons outlined therefore the urgent need for medical facilities and for the pharmaceutical industry to develop an active ingredient base analogous to humic acids.

Humic acids extracted from brown coal can only meet these requirements and needs do justice to a very limited extent, as they mainly have significant quality fluctuations and thus subject to considerable pharmacological effects.

In conclusion, there is no suitable substance that is currently a real alternative to that Represents humic acids and humus colloids of bath peat and as a recent active ingredient for the future in unlimited amount is available.

Aim of the invention

It is the aim of the invention to show means and their possible uses, the alternative and superior to the humic acids and humic substances of the bath peat and the humic acids from the Lignite in the field of balneotherapy, health care and for cosmetic purposes can be used.

The funds according to the invention should be almost unlimited as recent, that is, continuously renewable Raw material sources are available and are obtained in a controllable, consistent quality can.

Quality fluctuations and the resulting pharmacological effects, such as the Humic acids from bath pots and lignite are to be avoided. The Agents according to the invention are intended for the above-mentioned substances in their pharmacological activity quality and superior to their large-scale producibility - but at least be on an equal footing.

State the nature of the invention

The inventive task is solved in that lignins and lignin derivatives as peers or superior substances to humic acids and humus colloids for use in balneotherapy, Health care, cosmetics and as raw materials for the manufacturing pharmaceutical industry be proposed.

Lignins, ligninsulfonic acids, ligninsulfonates and other lignin derivatives, as in the invention claims 2, 2.1., 2.2. and 2.3. are mentioned with regard to their material properties and large-scale production method described. (Ullmann's Encyclopedia of Chemical Engineering, 4th revised and expanded edition, volume 16, Verlag Chemie GmbH Weinheim, 1978).

As already shown in Fig. 1, lignins are also part of bath peat - i.e. substances of natural origin. Like humic acids, lignins are natural phenolic body polymers. High molecular fractions in particular have a high sorption capacity (ion exchanger) and low molecular fractions also have specific pharmacological properties. Lignins are the "framework" of wood and other biomass containing lignocellulose. Lignins, ligninsulfonic acids and ligninsulfonates are obtained in the industrial process in the wood pulping mainly for the purpose of cellulose production. In the so-called carbonization series of the natural material cycle, they are also essential starting materials for the formation of humic substances and ultimately intermediate products for the formation of brown coal. The pharmacological effects of the lignins and lignin derivatives are known to some extent in the specialist field (antiviral properties).

The professional community has so far overlooked it with blindness and ignored the fact that lignins, above all technically and biotechnologically processed lignins and lignin sulfonates analogous to humine Acids and humic substances as active ingredients and natural remedies in balneotherapy, health care and cosmetics can be used.

Information on the balneotherapeutic effects of lignins as components of bathing peat has so far been provided not mentioned and recognized. That is why experts have refrained from adding these substances isolate and use for therapeutic purposes.

This deficiency was recognized in an inventive manner and is also inventively described in An taken, substances and mixtures of substances according to the formulated claims for balneo therapeutic, health-care and cosmetic fields of application beat. High-molecular fractions of such substances and mixtures of substances, such as they can be obtained in exemplary embodiment 1.2., table 1, and exemplary embodiment 1.3., table 2 can. Particularly high molecular weight substances and substance mixtures with molecular masses of 10,000 to <130,000 have very strong sorption properties and are pharmacologically effective very similar to natural humic acids.

The pharmacological effects and quantities of action of high molecular weight (mol. Mass 10000 to <130000) and low molecular weight (mol. Masses 5000 to 10000) substances and mixtures, can by chemical modification according to claim 2.1., and 2.3. in your Impact quality can be varied.

The same statement applies to the use in special pharmaceutical preparations and pharma zeutischen products (claims 1 and 3). With suitable forms of application Both the quality of the effect and the quantity of the effect are influenced to a considerable degree.

Both low-molecular and high-molecular substances or mixtures of substances alone or in certain Mixing ratios can be used for the purposes of balneotherapy, health care and Cosmetics are used. This finding is not found in the relevant specialist literature.

In addition, an extensive search for property rights has shown that agents and pharmaceuticals Preparations and products according to the invention claims 1 to 3 are not known under protective law and therefore no corresponding claims are made.

Embodiments example 1 Production of lignins, ligninsulfonic acids or ligninsulfonates and modifications of the above Fabrics 1.1. Production of the starting substances

The production of lignins, ligninsulfonic acids and ligninsulfonates is known in the art. In this regard, reference is made to the explanations in Ullmann's Encyclopedia of Industrial Chemistry, 4. revised and expanded edition, volume 16, pp. 253 to 260, Verlag Chemie GmbH, Weinheim, 1978, referred. The production of corresponding chemical modifications according to the invention 2.1. is known prior art and can be carried out on an industrial scale.

1.2. Technical processing variants of the starting substances as under claim 1.2. called, Ultrafiltration

Technical processes of ultrafiltration are known prior art and can be carried out on an industrial scale. Large-scale fractionated lignins and lignin sulfonates are available as commercial products.

Fractionation and concentration became more fluid by the author of the present patent specification Lignin sulfonates using membrane filtration are described in the patent specification DD 2 44 908 A1. On the basis Liquid lignin sulfonates were membrane-filtered or Ultrafiltration and different variants worked up.

A mixed fraction (standard product) with an average mol. Mass of 13700 used and separated into individual fraction areas. The results are shown in Table 1 shown.

The fraction areas produced in Example 1 and Table 1 are intended only as examples for large-scale processing variants are available.

1.3. Biotechnological modification of the standard product through microbial metabolism

The results of the biotechnological modification of the standard product with an average mol. Masses of 13700 are shown in Table 2.  

Legend for table 2

The molecular weight distribution was determined using permeation chromatography on controlled pore Glass (CPG) determined. The molecular weight distribution in percent (%) gives the different proportions in the enriched faction. The mol. Masses of the standard or starting product (Standard-P) and those of the modified substances Mod. 1 and Mod. 2 are more natural with the molar masses Humic acids comparable. Provide the fermentation products of Mod. 3, Mod. 4 and Mod. 5 already very high molecular weight, sorptive substances and substance mixtures. The microbial Substance conversion of lignins and lignin derivatives according to example 1.3. and table 2 is just the principle the production of active substances and active substance mixtures by means of microbial metabolism in the represent industrial process. In principle, other microorganisms can be used than in Table 2 called, are used for the biotechnological material conversion of lignins and lignin derivatives.

Depending on the microorganism used, different management, the fermentation process and Processing of the culture substrates (fermenter content, culture liquid) gives active substances different pharmacological effects and quantities.

Example 2 Pharmacological effects and areas of application of lignins, ligninsulfonic acids or ligninsulfonates according to the invention claims 1, 2 and 3 analogous to natural humic acids and humic substances

With heat therapy with peloids, packs and baths as a supportive treatment for:

• 2.1. Subacute and chronic forms of rheumatic diseases of the musculoskeletal system and degenerative joint diseases;
  muscle relaxing effect after physical exertion
• 2.2. Supportive effect in diseases of internal organs, e.g. B. biliary and liver diseases as well as inflammation of the kidneys and ovaries.
• 2.3. Metabolic effects by influencing the control circuit of the endocrine radio tion and activating effect on granulocytes and leukocytes and thus also increased Defense of the body against infectious diseases.
• 2.4. Anti-inflammatory effects, vasodilator effects and anti-inflammatory effects.
• 2.5. By maintaining a substantial concentration differential between active ingredient application (e.g. in the form of peloids, full baths, packs, etc.) and skin coat is included an increased excretion of metabolic waste and body secretions can be expected,  due to the high sorption power, especially high molecular components of the active ingredient or the active ingredient mixtures are bound and made "harmless to the body".
• 2.6. Active substances or active substance mixtures based on lignin have according to claim 2 in addition to the aforementioned medical indications and cosmetic effects Can also be used as UV protection in sun protection products. Lignins absorb ultraviolet light with a wavelength of 205 nm to 280 nm.
• 2.7. The medical, cosmetic and health care effects of the agents and pharma Zeutische preparations and products according to claim 1 to 3 can be added or are supported by using the agents according to the invention in combination z. B. with essential oils, paraffins, siliceous fango, bentonites, salicylic acid derivatives vaten, Thiozynaten (-SCN), sulfur compounds, iodine compounds etc.

Example 3 Medical, health care and cosmetic forms of use, pharmaceutical preparations and products.

Under the term LIGNIN-containing preparations and products, substances and Active ingredients according to claim 2.1., 2.2. and 2.3. be understood.

3.1. Heat therapy with LIGNIN porridge as peloids (porridge full baths)

Basic fabric: LIGNIN fabrics
Optional auxiliaries:

• - fast-swelling special starches
• - cellulose and / or hemicellulose
• - sulfur compounds, salicylic acid derivatives, essential oils, thiocyanates (-SCN)
• - fango and / or bentonite

Approx. 70 to 90 kg of porridge are produced to prepare a LIGNIN porridge. The Peloid structure (mud-like structure) is achieved by adding water to a dry powder. The addition of e.g. B. fast-swelling special starches for LIGNIN base material causes the LIGNIN sludge as swollen gel is present. In this gel the LIGNIN raw materials and other active substances and Embedded auxiliaries cannot separate and therefore optimally their healing effects unfold. The heat retention capacity of the heated LIGNIN porridge peloids and the ability of one Even and intense heat transfer to the body leads to an increase in the body temperature and the desired balneotherapeutic and cosmetic effects.  

3.2. Heat therapy with LIGNIN suspended solid baths

Base material: finely ground LIGNIN powder
Optional auxiliaries: as under 3.1.

The LIGNIN fabrics are not used here as a peloid slurry, but as a LIGNIN suspended matter bath with approx. 70 to 100 g each 100 to 120 liters of water as a full bath (partial baths dosed accordingly). The Bathing temperature is preferably between 34 ° C and 40 ° C. The LIGNIN bath powder should Technologically prepared so that it can be used as a finely ground or atomized powder comes because it achieves an increase in surface area and an increase in the properties of the active ingredient becomes. The balneotherapeutic and cosmetic effect occurs analogously to the application as under 3.1. described a.

The excellent dispersing properties of LIGNIN raw materials enable preparation a bath in which the raw materials in the water do not sink to the bottom of the tub and sink do not separate the active ingredients and auxiliary substances optionally added to the LIGNIN base material.

3.3. LIGNIN medical packs

LIGNIN fabrics can be used as LIGNIN medicinal packs in the same way as Moor packs. Disposable packs for use in medical applications are customary for these types of use Facilities and consumer-friendly reusable packs for home use.

Disposable packs contain the LIGNIN base material and optionally added active substances and auxiliary substances, as under 3.1. called, as a peloid on a carrier (preferably plastic film) or in a fine mesh Textile cover that still allows an intensive contact of the active ingredient with the body. This peloid Packs are heated separately before use. The application on the patient can also combined with a heat transfer medium (e.g. resting on a strongly heated water cushion) so that a continuous and long-lasting heat transfer and active ingredient transfer to the body or corresponding body parts is guaranteed.

Reusable packs

Consumer-friendly reusable packs are primarily for medical and cosmetic Intended use at home.

The LIGNIN base material, optionally in combination with the supplementary active ingredients already mentioned and auxiliaries should therefore be processed in finished pharmaceutical products. The combination The active ingredient properties of the LIGNIN substances with heat therapy also form in these Application forms the basis for balneotherapeutic success and for cosmetic purposes.  

It is preferably proposed that the LIGNIN fabrics be embedded in permeable textile inlays, thus intensive contact of the active substances (LIGNINE and optionally other Additives) to the body surface is guaranteed.

The reusable packs are in the moist and heated state (e.g. heating in an oven or another heat donor). The addition of special starch products, Cellulose or hemicellulose products, fango and hard paraffin to the LIGNIN base material increase the therapeutic and cosmetic effect and is therefore advantageous and recommended.

Example 4 Medical, health-care and cosmetic application forms of LIGNIN products and pharmaceutical products based on the RETARD principle

The application of the RETARD principle of LIGNIN products with optional others already The active substances and auxiliary substances mentioned are used for all of the applications already described recommended.

The RETARD principle means that the LIGNIN active ingredients are dosed from a carrier and last longer to be released.

This principle is particularly important for reusable medical packs (usability for about 8 to 15 Applications) cosmetic masks and ointments etc. are recommended.

As an "active ingredient carrier" z. B. fast-swelling special starches with or without the addition of Cellulose products and hemicellulose products.

Rapidly swelling special starches in powder form form a gel-like, network structure when added to water. In the micropores of the gels can contain active ingredients, e.g. B. LIGNIN products are enclosed and deposited, in which LIGNIN products are mixed intensively with the starch gel. This "starch LIGNIN gel" will dried using suitable drying techniques (e.g. spray drying). Through water withdrawal the LIGNIN active ingredients are included in the special starch carrier.

These products can be stored and transported without any loss of quality.

When water is added to the LIGNIN starch powder again, special starches easily swell again Gel on and from the drug depot (micropores of the gel) the active ingredients (LIGNIN- Products alone or in combination with other active ingredients and adjuvants) in a well tolerated and released for longer periods of time for balneotherapeutic or cosmetic purposes.  

Embodiment 1.2

Table 1

Separation of the standard product into fractions and enrichment of certain fraction areas

Claims (3)

1. Agents and pharmaceutical products for use in balneotherapy, health care and cosmetics, characterized in that they contain lignins, lignin sulfonic acids or lignin sulfonates as well as chemical, technical and biotechnological modifications of the substances mentioned in pure form as a solitary ingredient or as active ingredient mixtures as the active ingredient base . 2. Composition according to claim 1, characterized in that the active substances or active substance mixtures or the pharmaceutical preparations and products produced on the basis of this active substance can be modified chemically, technically or biotechnologically, so that:

• 2.1. the chemical changes of the lignins, ligninsulfonic acids and ligninsulfonates are preferably aimed at the production of special salts. In addition to Na / Ca / Mg salts, lignin or lignosulfonic acid derivatives with NH₄, Fe⁺⁺, Fe⁺⁺⁺, Mn, Cn, Zn, Cr, Ba or rhodanized compounds (insertion of the functional group SCN) can preferably be used .
• 2.2. The technical processing variants or modifications of the above-mentioned substances are aimed at the separation and / or enrichment of certain fractions with the desired molar mass ranges (see exemplary embodiment 1.2. and Table 1), in order to use certain defined fractions, substances or substance mixtures with specific active substance properties to win.
• 2.3. the biotechnological changes or modifications are aimed at the biotechnological material conversion with suitable microorganisms, in order to gain preferential fermentative changes in the molecular weight ranges of the starting substances, substances or substance mixtures with special active substance effects (exemplary embodiment 1. 3. and Table 2).

3. Composition according to claim 1 and 2, characterized in that they alone or as a solitary ingredient in certain mixing ratios to each other or in a mixture with other pharma special substances as well as pharmaceutical raw materials and auxiliary substances in special pharmaceutical preparation forms and products based on the RETARD principle can come (embodiment 4).