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DE388669C - Process for the production of a silver salt of boronisalicylic acid - Google Patents

Process for the production of a silver salt of boronisalicylic acid

Info

Publication number
DE388669C
DE388669C DESCH66366D DESC066366D DE388669C DE 388669 C DE388669 C DE 388669C DE SCH66366 D DESCH66366 D DE SCH66366D DE SC066366 D DESC066366 D DE SC066366D DE 388669 C DE388669 C DE 388669C
Authority
DE
Germany
Prior art keywords
acid
silver salt
production
boronisalicylic
silver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DESCH66366D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OTTO FRITZ SCHULZ DR
PAUL JOERRENS
Original Assignee
OTTO FRITZ SCHULZ DR
PAUL JOERRENS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OTTO FRITZ SCHULZ DR, PAUL JOERRENS filed Critical OTTO FRITZ SCHULZ DR
Priority to DESCH66366D priority Critical patent/DE388669C/en
Application granted granted Critical
Publication of DE388669C publication Critical patent/DE388669C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • C07C65/10—Salicylic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Description

Verfahren zur Herstellung eines Silbersalzes der Bordisalicylsäure._ Versucht man auf unmittelbarem Wege durch Einwirkung äquivalenter Mengen Silbernitrat, Borsäure: und Salicylsäure in heißer wässeriger Lösung aufeinander zu dem Silbersalz der Bordisalicylsäure zu gelangen, so wirkt die bei der Reaktion freiwerdende Salpetersäure sowohl spaltend als auch oxydierend auf das Reaktionsprodukt ein.Process for the production of a silver salt of boron disalicylic acid. If one tries directly through the action of equivalent amounts of silver nitrate, Boric acid: and salicylic acid in hot aqueous solution on top of each other to form the silver salt To reach the boronisalicylic acid, the nitric acid released during the reaction acts both cleaving and oxidizing on the reaction product.

Es wurde jedoch festgestellt, daß beim Arbeiten in verdünnter Lösung diese hinderlichen Erscheinungen nicht eintreten, und daß sich ein rein weißes, gut kristallisiertes Produkt abscheidet, das die gleiche Zusammensetzung und. dieselben Eigenschaften aufweist, wie die von Jahns (vgl. Archiv der Pharmazie 2r2 [1878], S. 222 unten) durch doppelte Umsetzung von bordisalicylsaurem Natrium mit Silbersalzen hergestellte Verbindung. Abgesehen von der wesentlich einfacheren Arbeitsweise weist das vorliegende Verfahren gegenüber dem bekannten Verfahren den Vorteil auf, daB das Sübersalz keine störenden Verunreinigungen durch anorganische Salze, wie Natriumnitrat, enthält; mithin ein Umkristallisieren der labilen komplexen Silberverbindung vermieden werden kann.However, it has been found that when working in dilute solution these obstructive phenomena do not occur, and that a pure white, well crystallized product separates which has the same composition and. same Has properties like those of Jahns (cf. Archiv der Pharmazie 2r2 [1878], P. 222 below) by double conversion of sodium boron disalicylic acid with silver salts established connection. Apart from the much simpler way of working, it has the present process has the advantage over the known process that the suber salt does not have any disruptive impurities from inorganic salts such as sodium nitrate, contains; therefore recrystallization of the labile complex silver compound is avoided can be.

Beispiel Die heiße konzentrierte Lösung von Borsäure (r Molj und Salicylsäure (2 Mol.) versetzt man mit r Mol: heiß gelösten, Silbernitrats: Die Konzentration der Lösung muß so bemessen sein, daß auf einen Gewichtsteil der gesamten drei festen Komponenten mindestens die zehnfache Gewichtsmenge an Lösungsmittel (Wasser) kommt.Example The hot concentrated solution of boric acid (r Molj and salicylic acid (2 mol.) Are added r mol: hot dissolved silver nitrate: the concentration the solution must be so dimensioned that to one part by weight of the entire three solid Components at least ten times the amount by weight of solvent (water).

Es scheidet sich ein rein weißes kristallinisches Produkt ab, das unter dem Mikroskop prismatische Nadelstruktur zeigt und bis Zoo ° nicht schmilzt. In der Nähe dieser Temperatur beginnt gelbe bzw. braune Färbung; bei weiterer Temperaturerhöhung tritt Zersetzung ein. Die mehrfachen Analysen ergaben, daß das gebildete Produkt ein Silbersalz der Bordisalicylsäure darstellt; dem die Formel zuzuschreiben ist.A pure white crystalline product is deposited which shows a prismatic needle structure under the microscope and does not melt until Zoo °. In the vicinity of this temperature, yellow or brown color begins; if the temperature is increased further, decomposition occurs. The multiple analyzes showed that the product formed is a silver salt of boron disalicylic acid; which the formula is attributable.

Der Körper löst sich in lauwarmem Wasser im Verhältnis von r : 500, leichter in Ammoniak, er ist dagegen unlöslich in den gebräuchlichen organischen Lösungsmitteln. Er zeigt geringe Löslichkeit in. einem Alkohol-Äther-Gemisch und wird von Tetralin zersetzt. .The body dissolves in lukewarm water in the ratio of r: 500, lighter in ammonia, but it is insoluble in common organic substances Solvents. It shows poor solubility in an alcohol-ether mixture and is decomposed by tetralin. .

Beim anhaltenden Kochen in wässeriger Lösung tritt ebenfalls Zersetzung ein.Decomposition also occurs on prolonged boiling in aqueous solution a.

Im Sonnenlicht ist die wässerige Lösung nur wenige Stunden haltbar. Es tritt Hydrolyse eint. Metallisches Silber flockt aus. In brauner Flasche im Dunkeln aufbewahrt, .zeigt sich die wässerige Lösung wochenlang haltbar.In the sunlight the aqueous solution is only few Lasts for hours. Hydrolysis occurs. Metallic silver flakes out. In brown If the bottle is kept in the dark, the aqueous solution can be kept for weeks.

Das Produkt schmeckt bitter; wirkt baktericid, besonders gegenüber Coccen, und kann als .Antiseptikum therapeutische Verwendung fin-. den.The product tastes bitter; has a bactericidal effect, especially against Cocci, and can be used therapeutically as an antiseptic. the.

Claims (1)

.. PATENT-ANSPIZÜC,o. Verfahren zur Herstellung eines Silbersalzes der Bordisalicylsäure, dadurch gekennzeichnet, daß man die verdünnten heißen, wässerigen Lösungen äquivalenter "-Mengen Silbernitrat, Borsäure und Sahcylsäure aufeinander wirken läßt... PATENT INSPECTION, o. Process for the production of a silver salt of boron disalicylic acid, characterized in that the dilute hot, aqueous Solutions of "equivalent" amounts of silver nitrate, boric acid and acetylic acid on top of one another works.
DESCH66366D 1922-11-17 1922-11-17 Process for the production of a silver salt of boronisalicylic acid Expired DE388669C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DESCH66366D DE388669C (en) 1922-11-17 1922-11-17 Process for the production of a silver salt of boronisalicylic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DESCH66366D DE388669C (en) 1922-11-17 1922-11-17 Process for the production of a silver salt of boronisalicylic acid

Publications (1)

Publication Number Publication Date
DE388669C true DE388669C (en) 1924-01-17

Family

ID=7438841

Family Applications (1)

Application Number Title Priority Date Filing Date
DESCH66366D Expired DE388669C (en) 1922-11-17 1922-11-17 Process for the production of a silver salt of boronisalicylic acid

Country Status (1)

Country Link
DE (1) DE388669C (en)

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