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DE3886222D1 - Verwendung von 4-[1-oxoalkyl]-2,5-oxazolidindionen zur selektiven stereospezifischen bildung von biologisch wirkenden beta-lactamen. - Google Patents

Verwendung von 4-[1-oxoalkyl]-2,5-oxazolidindionen zur selektiven stereospezifischen bildung von biologisch wirkenden beta-lactamen.

Info

Publication number
DE3886222D1
DE3886222D1 DE88906377T DE3886222T DE3886222D1 DE 3886222 D1 DE3886222 D1 DE 3886222D1 DE 88906377 T DE88906377 T DE 88906377T DE 3886222 T DE3886222 T DE 3886222T DE 3886222 D1 DE3886222 D1 DE 3886222D1
Authority
DE
Germany
Prior art keywords
indions
oxazolide
oxoalkyl
selective
biologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88906377T
Other languages
English (en)
Other versions
DE3886222T2 (de
Inventor
Richard Day
John Wallace
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Cincinnati
Original Assignee
University of Cincinnati
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Cincinnati filed Critical University of Cincinnati
Application granted granted Critical
Publication of DE3886222D1 publication Critical patent/DE3886222D1/de
Publication of DE3886222T2 publication Critical patent/DE3886222T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/44—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE3886222T 1987-06-16 1988-06-10 Verwendung von 4-[1-oxoalkyl]-2,5-oxazolidindionen zur selektiven stereospezifischen bildung von biologisch wirkenden beta-lactamen. Expired - Fee Related DE3886222T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/062,856 US4855419A (en) 1987-06-16 1987-06-16 Application of 4-[1-oxoalkyl]-2,5-oxazolidinediones in selective stereospecific formation of biologically active α-lactams
PCT/US1988/001996 WO1988010256A1 (en) 1987-06-16 1988-06-10 Application of 4-[1-oxoalkyl]-2,5-oxazolidinediones in selective stereospecific formation of biologically active beta-lactams

Publications (2)

Publication Number Publication Date
DE3886222D1 true DE3886222D1 (de) 1994-01-20
DE3886222T2 DE3886222T2 (de) 1994-05-26

Family

ID=22045282

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3886222T Expired - Fee Related DE3886222T2 (de) 1987-06-16 1988-06-10 Verwendung von 4-[1-oxoalkyl]-2,5-oxazolidindionen zur selektiven stereospezifischen bildung von biologisch wirkenden beta-lactamen.

Country Status (5)

Country Link
US (1) US4855419A (de)
EP (1) EP0385999B1 (de)
AU (1) AU1983788A (de)
DE (1) DE3886222T2 (de)
WO (1) WO1988010256A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006661A (en) * 1987-06-16 1991-04-09 University Of Cincinnati Selective stereospecific biologically active beta-lactams
EP0381472A1 (de) * 1989-01-31 1990-08-08 Takeda Chemical Industries, Ltd. Saccharoascorbinsäure-Derivate und deren Herstellung

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2480466A (en) * 1946-03-23 1949-08-30 Merck & Co Inc Production of penicilin-g
GB960896A (en) * 1961-09-26 1964-06-17 Lepetit Spa Production of penicillins
US3658788A (en) * 1969-06-06 1972-04-25 Salk Inst For Biological Studi Aminooxazolines and products thereof and processes for synthesizing same
GB1273241A (en) * 1969-08-21 1972-05-03 Bristol Myers Co Heterobicyclic amino acids
US3989685A (en) * 1972-06-29 1976-11-02 Shinogi & Co., Ltd. Process for making a 2'-halopenicillin
US4020077A (en) * 1972-07-21 1977-04-26 Glaxo Laboratories Limited Antibiotics
GB1459999A (en) * 1972-12-27 1976-12-31 Novo Industri As Penicillin and cephalosporin intermediates
DE2336718A1 (de) * 1973-07-19 1975-02-06 Basf Ag Verfahren zur herstellung von substituierten oxazolinon-(5)-verbindungen
US4051132A (en) * 1974-01-23 1977-09-27 Merck & Co., Inc. Process for epimerizing beta-lactam antibiotic compounds by means of an acid quench
GB1565656A (en) * 1975-12-13 1980-04-23 Beecham Group Ltd Preparation of substituted penicillin acid esters
US4167630A (en) * 1975-12-24 1979-09-11 Merck & Co., Inc. Process for epimerizing beta-lactam antibiotic compounds, and related products
DE2619247C2 (de) * 1976-04-30 1986-04-03 Eckert, Heiner, Dipl.-Chem. Dr., 8000 München Verfahren zum Schutze reaktionsfähiger Amino-, Hydroxyl- und/oder Carboxylgruppen
JPS5576886A (en) * 1978-12-07 1980-06-10 Mitsubishi Chem Ind Ltd Synthetic method of penicillin
US4248966A (en) * 1979-05-17 1981-02-03 Massachusetts Institute Of Technology Synthesis of isopenicillin derivatives in the absence of living cells
US4307192A (en) * 1979-05-17 1981-12-22 Massachusetts Institute Of Technology Cell-free synthesis of deacetoxycephalosporin C
US4320055A (en) * 1980-04-07 1982-03-16 Eli Lilly And Company Process for penicillin epimerization
US4314062A (en) * 1980-04-15 1982-02-02 Ciba-Geigy Corporation Process for production of dicyanopiperazine
US4301282A (en) * 1980-09-17 1981-11-17 Eli Lilly And Company 1-Oxa-β-lactam antibiotics
US4452796A (en) * 1982-06-14 1984-06-05 Pfizer Inc. 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
US4536393A (en) * 1983-06-06 1985-08-20 Pfizer Inc. 6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor
US4508921A (en) * 1984-06-28 1985-04-02 Merck & Co., Inc. Process for preparation of alpha-alkyl amino acids

Also Published As

Publication number Publication date
AU1983788A (en) 1989-01-19
EP0385999A1 (de) 1990-09-12
WO1988010256A1 (en) 1988-12-29
EP0385999B1 (de) 1993-12-08
DE3886222T2 (de) 1994-05-26
US4855419A (en) 1989-08-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee