DE3864257D1 - NEW N-1 SUBSTITUTED BETA LACTAME AS AN ANTIBIOTIC. - Google Patents
NEW N-1 SUBSTITUTED BETA LACTAME AS AN ANTIBIOTIC.Info
- Publication number
- DE3864257D1 DE3864257D1 DE8888901670T DE3864257T DE3864257D1 DE 3864257 D1 DE3864257 D1 DE 3864257D1 DE 8888901670 T DE8888901670 T DE 8888901670T DE 3864257 T DE3864257 T DE 3864257T DE 3864257 D1 DE3864257 D1 DE 3864257D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- hydrogen
- compounds
- antibiotic
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Novel 2-azetidinone compounds of formula (I), wherein R10 and R15 are the same or different and are a) hydrogen, b) (C1-C12) alkyl, c) (C2-C8) alkenyl, d) (C2-C8) alkynyl, e) -CH2OCO-CH2NHR4, f) -CH2OCO2R30, g) -CH2F, or h) -CHF2; wherein R4 is hydrogen or -COH; wherein R30 is (C1-C8) alkyl; wherein R20 is an acyl group derived from a carboxylic acid; wherein A is oxygen or sulfur; and wherein R70 is a) hydrogen, b) (C1-C8) alkyl, c) phenyl, d) -OH, or e) -SH; where each member of b or c may optionally be substituted by 1 to 2 substituents selected from the group consisting of halogen, hydroxy, and amino. These compounds are useful as antibacterial agents to eradicate or control susceptible microbes. Intermediates and processes for making these compounds are also disclosed.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1340187A | 1987-02-11 | 1987-02-11 | |
| PCT/US1988/000049 WO1988006156A1 (en) | 1987-02-11 | 1988-01-15 | NOVEL N-1 SUBSTITUTED beta-LACTAMS AS ANTIBIOTICS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3864257D1 true DE3864257D1 (en) | 1991-09-19 |
Family
ID=21759779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8888901670T Expired - Fee Related DE3864257D1 (en) | 1987-02-11 | 1988-01-15 | NEW N-1 SUBSTITUTED BETA LACTAME AS AN ANTIBIOTIC. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0344197B1 (en) |
| JP (1) | JPH02502378A (en) |
| KR (1) | KR890700588A (en) |
| AT (1) | ATE66225T1 (en) |
| AU (1) | AU602067B2 (en) |
| CA (1) | CA1317302C (en) |
| DE (1) | DE3864257D1 (en) |
| DK (1) | DK564788A (en) |
| WO (1) | WO1988006156A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9285011B2 (en) | 2008-09-26 | 2016-03-15 | Tenneco Automotive Operating Company Inc. | High velocity compression damping valve |
| AU2009329169B2 (en) | 2008-12-19 | 2012-06-28 | Pfizer Inc. | Monocarbams |
| JP7366746B2 (en) | 2017-08-31 | 2023-10-23 | 北興化学工業株式会社 | 1-(N,N-disubstituted carbamoyl)4-(substituted sulfonyl)triazolin-5-one derivatives, 4-(N,N-disubstituted carbamoyl)1-(substituted sulfonyl)triazolin-5-one derivatives, and the like Herbicide containing as an active ingredient |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2539128A1 (en) * | 1983-01-10 | 1984-07-13 | Roussel Uclaf | NOVEL 3-AMINO 2-OXOAZETIDINE DERIVATIVES HAVING IN POSITION 1 A HETEROCYCLIC NITROGENIC RADICAL, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS AND THE INTERMEDIATE PRODUCTS NECESSARY FOR THEIR PREPARATION |
| EG18314A (en) * | 1985-09-26 | 1993-02-28 | Squibb & Sons Inc | Process for preparing of 2-oxo-1((substituted sulfonyl)amino)carbonyl)-azitidines |
| EP0308416A1 (en) * | 1986-05-23 | 1989-03-29 | The Upjohn Company | N-1 substituted sulfonylaminocarbonyl, c-4 substituted monobactams |
| CA1317298C (en) * | 1987-03-03 | 1993-05-04 | Upjohn Company (The) | Antibiotic sulfonylaminocarbonyl activated .beta.-lactams |
-
1988
- 1988-01-15 AU AU13470/88A patent/AU602067B2/en not_active Expired - Fee Related
- 1988-01-15 EP EP88901670A patent/EP0344197B1/en not_active Expired - Lifetime
- 1988-01-15 JP JP63502104A patent/JPH02502378A/en active Pending
- 1988-01-15 AT AT88901670T patent/ATE66225T1/en not_active IP Right Cessation
- 1988-01-15 DE DE8888901670T patent/DE3864257D1/en not_active Expired - Fee Related
- 1988-01-15 WO PCT/US1988/000049 patent/WO1988006156A1/en active IP Right Grant
- 1988-01-15 KR KR1019880701264A patent/KR890700588A/en not_active Application Discontinuation
- 1988-01-26 CA CA000557365A patent/CA1317302C/en not_active Expired - Fee Related
- 1988-10-10 DK DK564788A patent/DK564788A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0344197B1 (en) | 1991-08-14 |
| JPH02502378A (en) | 1990-08-02 |
| KR890700588A (en) | 1989-04-25 |
| AU602067B2 (en) | 1990-09-27 |
| EP0344197A1 (en) | 1989-12-06 |
| DK564788D0 (en) | 1988-10-10 |
| WO1988006156A1 (en) | 1988-08-25 |
| CA1317302C (en) | 1993-05-04 |
| DK564788A (en) | 1988-10-10 |
| AU1347088A (en) | 1988-09-14 |
| ATE66225T1 (en) | 1991-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |