DE3852636D1 - Peptid-analoge vom insulinähnlichen wachstums-faktor 1 (igf-1) oder faktor 2 (igf-2). - Google Patents

Peptid-analoge vom insulinähnlichen wachstums-faktor 1 (igf-1) oder faktor 2 (igf-2).

Info

Publication number: DE3852636D1
Authority: DE; Germany
Prior art keywords: growth factor; igf; acid residue; insulin; pct
Prior art date: 1987-12-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE3852636T

Other languages

English (en)

Other versions

DE3852636T2 (de

Inventor

Francis Ballard

John Wallace

Julian Richard Este Wells

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novozymes Biopharma AU Ltd

Original Assignee

Gropep Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-24

Filing date

1988-12-20

Publication date

1995-02-09

1988-12-20 Application filed by Gropep Ltd filed Critical Gropep Ltd

1995-02-09 Application granted granted Critical

1995-02-09 Publication of DE3852636D1 publication Critical patent/DE3852636D1/de

1995-05-04 Publication of DE3852636T2 publication Critical patent/DE3852636T2/de

2008-12-21 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 title abstract 3
102100037852 Insulin-like growth factor I Human genes 0.000 title abstract 3
102000048143 Insulin-Like Growth Factor II Human genes 0.000 title 1
108090001117 Insulin-Like Growth Factor II Proteins 0.000 title 1
125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 abstract 4
239000003102 growth factor Substances 0.000 abstract 2
101001076292 Homo sapiens Insulin-like growth factor II Proteins 0.000 abstract 1
102100025947 Insulin-like growth factor II Human genes 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DE3852636T 1987-12-24 1988-12-20 Peptid-analoge vom insulinähnlichen wachstums-faktor 1 (igf-1) oder faktor 2 (igf-2). Expired - Lifetime DE3852636T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPI606887		1987-12-24
PCT/AU1988/000485 WO1989005822A1 (en)	1987-12-24	1988-12-20	Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2)

Publications (2)

Publication Number	Publication Date
DE3852636D1 true DE3852636D1 (de)	1995-02-09
DE3852636T2 DE3852636T2 (de)	1995-05-04

Family

ID=3772677

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE3852636T Expired - Lifetime DE3852636T2 (de)	1987-12-24	1988-12-20	Peptid-analoge vom insulinähnlichen wachstums-faktor 1 (igf-1) oder faktor 2 (igf-2).

Country Status (7)

Country	Link
US (1)	US5164370A (de)
EP (1)	EP0346429B1 (de)
JP (1)	JP2507106B2 (de)
AT (1)	ATE116335T1 (de)
CA (1)	CA1341204C (de)
DE (1)	DE3852636T2 (de)
WO (1)	WO1989005822A1 (de)

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US5470828A (en) *	1987-12-24	1995-11-28	Gropep Pty. Ltd.	Peptide analogs of insulin-like growth factor II
US6723699B1 (en)	1989-06-05	2004-04-20	Cephalon, Inc.	Treating disorders by application of insulin-like growth factors and analogs
US5652214A (en) *	1989-06-05	1997-07-29	Cephalon, Inc.	Treating disorders by application of insulin-like growth factors and analogs
US6693076B1 (en)	1989-06-05	2004-02-17	Cephalon, Inc.	Treating disorders by application of insulin-like growth factors and analogs
EP0429586B1 (de) *	1989-06-09	1995-08-02	Gropep Pty. Ltd.	Wachstumshormonfusionsproteine
US5045531A (en) *	1989-12-18	1991-09-03	Magainin Sciences Inc.	Wound treatment employing biologically active ion channel forming peptides and proteins
CA2074166C (en) *	1990-02-13	2003-11-25	Francis J. Ballard	Method for treating intestinal diseases
US5679771A (en) *	1990-02-13	1997-10-21	Gropep Pty. Ltd.	Method for treating intestinal diseases
US5681814A (en) *	1990-06-07	1997-10-28	Genentech, Inc.	Formulated IGF-I Composition
SE9002732D0 (sv) *	1990-08-24	1990-08-24	Kabivitrum Ab	Product containing growth factor
SE9002731D0 (sv) *	1990-08-24	1990-08-24	Kabivitrum Ab	Product comprising growth factor
US5202119A (en) *	1991-06-28	1993-04-13	Genentech, Inc.	Method of stimulating immune response
US5744139A (en) *	1991-06-28	1998-04-28	University Of Tennessee Research Corporation	Insulin-like growth factor I (IGF-1) induced improvement of depressed T4/T8 ratios
WO1993003152A1 (en) *	1991-07-29	1993-02-18	British Bio-Technology Limited	Igf-ii analogues
AU661242B2 (en) *	1991-10-07	1995-07-13	Brigham And Women's Hospital	Method for enhancing gut absorption
US6310040B1 (en)	1991-11-08	2001-10-30	Cephalon, Inc.	Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs
WO1993023067A1 (en) *	1992-05-08	1993-11-25	Thomas Jefferson University	Igf-1 analogs
NZ243071A (en) *	1992-06-08	1994-09-27	Kabi Pharmacia Ab	Igf-2 (or analogue) compositions for pharmaceutical uses
EP0602210A1 (de) *	1992-06-08	1994-06-22	Pharmacia AB (reg.number 556131-9608)	Verwendung von wachstumsfaktor igf-i und/oder igf-ii
ES2140463T3 (es) *	1992-06-12	2000-03-01	Cephalon Inc	Prevencion y tratamiento de la neuropatia periferica.
US5420112A (en) *	1992-06-12	1995-05-30	Lewis; Michael E.	Prevention and treatment of peripheral neuropathy
US5444045A (en) *	1992-09-17	1995-08-22	Gropep, Pty. Ltd.	Method of administering IGF-1, IGF-2, and analogs thereof to birds
GB9310049D0 (en) *	1993-05-12	1993-06-30	Cancer Res Campaign Tech	Growth factor effects
ES2241906T3 (es) *	1993-09-20	2005-11-01	Celtrix Pharmaceuticals, Inc.	Tratamiento de trastornos inmunologicos y hematologicos con igfbp solo o asociado con igf.
AR048563A1 (es) *	1996-09-16	2006-05-10	Univ Dalhousie	Metodos para el tratamiento de la enfermedad renal poliquistica en un mamifero, la insuficiencia renal, el desarrollo glomerular y de los rinones y proteger de la toxicidad por hormonas esteroides y uso de la igf- i para la fabricacion de una composicion farmaceutica.
US6156728A (en) *	1996-11-01	2000-12-05	Genentech, Inc.	Treatment of inner ear hair cells
US6121416A (en)	1997-04-04	2000-09-19	Genentech, Inc.	Insulin-like growth factor agonist molecules
US6420518B1 (en)	1997-04-04	2002-07-16	Genetech, Inc.	Insulin-like growth factor agonist molecules
US6358916B1 (en)	1998-07-22	2002-03-19	Thomas T. Chen	Biological activity of IGF-I E domain peptide
US7118752B2 (en)	1998-07-22	2006-10-10	University Of Connecticut	Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I
US7700353B2 (en)	1998-07-22	2010-04-20	E-P Therapeutics, Inc.	Compositions and methods for inducing apoptosis in tumor cells
EP1141014B1 (de)	1999-01-06	2004-12-08	Genentech, Inc.	Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i)
EP1506972A1 (de) *	1999-01-06	2005-02-16	Genentech Inc.	Mutierte Varianten des Insulin-ähnlichen Wachstumsfaktor-I (IGF-I)
CA2356257C (en) *	1999-01-06	2012-10-16	Genentech, Inc.	Insulin-like growth factor (igf) i mutant variants
EP1165119B1 (de) *	1999-04-08	2003-10-08	Genentech, Inc.	Zusammensetzung auf basis gegensätzlich geladener polypeptide
WO2001087323A2 (en)	2000-05-16	2001-11-22	Genentech, Inc.	Method for treating cartilage disorders
PL374181A1 (en) *	2001-02-09	2005-10-03	Genentech, Inc.	Crystallization of igf-1
IL157705A0 (en) *	2001-03-14	2004-03-28	Genentech Inc	Igf antagonist peptides
US7041314B2 (en)	2001-05-24	2006-05-09	Neuren Pharmaceuticals Ltd.	GPE analogs and peptidominetics
US7605177B2 (en)	2001-05-24	2009-10-20	Neuren Pharmaceuticals Limited	Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration
US7714020B2 (en)	2001-05-24	2010-05-11	Neuren Pharmaceuticals Limited	Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate
US20030124091A1 (en) *	2001-10-26	2003-07-03	Large Scale Biology Corporation	Endothelial cell derived hematopoietic growth factor
AU2003273615B2 (en) *	2002-06-11	2010-07-29	Brigham And Women's Hospital	Neuroprotective synergy of erythropoietin and insulin-like growth factor
NZ545940A (en)	2003-09-12	2009-12-24	Tercica Inc	Methods for treatment of insulin-like growth factor-1 (IGF-1) deficiency
US7355018B2 (en) *	2003-09-30	2008-04-08	Regeneron Pharmaceuticals, Inc.	Modified IGF1 polypeptides with increased stability and potency
EP1670822A2 (de) *	2003-10-03	2006-06-21	Genentech, Inc.	Igf-bindende proteine
EP1674113A1 (de) *	2004-12-22	2006-06-28	F. Hoffmann-La Roche Ag	Konjugate von insulinähnlichem Wachstumfaktor-1 und Poly(Ethylenglykol)
US20080103457A1 (en) *	2005-01-11	2008-05-01	Heart Failure Technologies, Inc. University Enterprise Laboratories (Uel)	Method and System for Treating Heart Failure
TWI406870B (zh)	2005-02-21	2013-09-01	Chugai Pharmaceutical Co Ltd	A method of making a protein using hamster IGF-1
JO2968B1 (en)	2006-06-09	2016-03-15	نوفارتيس ايه جي	Polypeptides are a stable insulin-like growth factor
JP2012521750A (ja)	2009-03-27	2012-09-20	プロイェクト、デ、ビオメディシナ、シーマ、ソシエダッド、リミターダ	肝硬変及び肝線維症の治療のための方法及び組成物
ES2895676T3 (es)	2015-09-01	2022-02-22	Ncardia B V	Un método in vitro para diferenciar una población de células madre pluripotentes humanas en una población de células cardiomiocitas
US20210008172A1 (en)	2019-07-11	2021-01-14	Opko Biologics Ltd.	Long-acting igf-1 or igf-1 variants and methods of producing same
WO2024010727A2 (en) *	2022-07-05	2024-01-11	Terasaki Institute For Biomedical Innovation	Cell growth supplements using dairy-based materials

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WO1985000831A1 (en) *	1983-08-10	1985-02-28	Amgen	Microbial expression of insulin-like growth factor
US4745179A (en) *	1984-04-02	1988-05-17	Fujisawa Pharmaceutical Co., Ltd.	59 Valine insulin-like growth factor I and process for production thereof
SE8403479L (sv) *	1984-06-29	1986-01-29	Ssab Svenskt Stal Ab	Sett att framstella profilerade stenger
JPH0720993B2 (ja) *	1985-08-22	1995-03-08	グロペッププロプライエタリーリミテッド	生長因子
SE8505920D0 (sv) *	1985-12-13	1985-12-13	Kabigen Ab	New protein and its use
US4876242A (en) *	1987-09-21	1989-10-24	Merck & Co., Inc.	Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast
EP0379338A3 (de) *	1989-01-17	1991-07-24	Merck & Co. Inc.	Menschlicher insulinähnlicher Wachstumsfaktor und seine Herstellung in Hefe

1988
- 1988-12-20 WO PCT/AU1988/000485 patent/WO1989005822A1/en active IP Right Grant
- 1988-12-20 US US07/408,518 patent/US5164370A/en not_active Expired - Lifetime
- 1988-12-20 AT AT89900786T patent/ATE116335T1/de not_active IP Right Cessation
- 1988-12-20 DE DE3852636T patent/DE3852636T2/de not_active Expired - Lifetime
- 1988-12-20 JP JP1500684A patent/JP2507106B2/ja not_active Expired - Lifetime
- 1988-12-20 EP EP89900786A patent/EP0346429B1/de not_active Expired - Lifetime
- 1988-12-21 CA CA000586713A patent/CA1341204C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE3852636T2 (de)	1995-05-04
CA1341204C (en)	2001-03-13
EP0346429A1 (de)	1989-12-20
EP0346429A4 (en)	1990-10-10
WO1989005822A1 (en)	1989-06-29
ATE116335T1 (de)	1995-01-15
AU612776B2 (en)	1991-07-18
AU2900989A (en)	1989-07-19
JP2507106B2 (ja)	1996-06-12
EP0346429B1 (de)	1994-12-28
US5164370A (en)	1992-11-17
JPH02504279A (ja)	1990-12-06

Publication	Publication Date	Title
DE3852636D1 (de)	1995-02-09	Peptid-analoge vom insulinähnlichen wachstums-faktor 1 (igf-1) oder faktor 2 (igf-2).
EP0235205A4 (de)	1989-08-09	Peptidanalogedes insulinähnlichen wachstumsfaktors-1 bei säugetieren.
DE69016655D1 (de)	1995-03-16	Biologisch aktive polypeptide, die auf transformierten wachstumsfaktor-beta-sequenzen basieren.
NO905472L (no)	1991-03-20	Insulinanaloger fra menneske og blandinger som inneholderdem.
ATE121755T1 (de)	1995-05-15	Deletionsanaloga von magaininpeptiden.
DE69525544D1 (de)	2002-03-28	Peptidanaloge des menschlichen, basischen myelinproteins mit substitution an position 91 zur behandlung der multiplen sklerose
DE69029377D1 (de)	1997-01-23	Substituierungsanaloge von magaininpeptiden
MX167236B (es)	1993-03-11	Peptidos sinteticos de timosina -1 y metodo para su obtencion
DK162130C (da)	1992-03-02	Grf-analoge peptider, fremgangsmaade til fremstilling deraf, grf-analoge peptider som terapeutiske midler, anvendelse af grf-analoge peptider, fremgangsmaade til fremstilling af farmaceutiske praeparater indeholdende grf-analoge peptider samt parenterale farmaceutiske praeparater indeholdende grf-analoge peptider
ES2135398T3 (es)	1999-11-01	Compuesto y composiciones de inhibicion de la resorcion osea.
MY103251A (en)	1993-05-29	Biologically active molecules
AR004497A1 (es)	1998-12-16	Un análogo hexapéptido cíclico de somatostatina, procedimiento para prepararlos y las composiciones farmacéuticas que los contienen y el uso de dicho hexapéptido para la preparación de una composición farmacéutica.
EP0282318A3 (de)	1989-06-07	Analog des Rinderwachstumshormons
BR8807658A (pt)	1990-08-07	Peptideos tendo homologia estrutural, formulacao antigena farmaceutica e processo para alterar as caracteristicas de um vertebrado
KR890700673A (ko)	1989-04-26	돼지 성장호르몬 아날로그
NO901558L (no)	1990-04-05	Vasoaktive peptider.
ATE178073T1 (de)	1999-04-15	Superaktive analoga des wachstumshormon- releasingfaktors
GB1119353A (en)	1968-07-10	Peptides having an adrenocorticotropic hormone action and process for their manufacture
AR247473A1 (es)	1995-01-31	Una composicion que produce una respuesta lactogenica o crecimiento en ganado bovino, excluidas todas sus aplicaciones terapeuticas
JPS5750948A (en)	1982-03-25	Insulin analog and preparation
RU97117935A (ru)	1999-07-10	Свойства пептидов, стимулирующих рост
JPS5791965A (en)	1982-06-08	Preparation of polypeptide
TH21046B (th)	2006-12-08	ฮอร์โมนเทียมเพื่อการเจริญเติบโตของหมู

Legal Events

Date	Code	Title	Description
1996-02-01	8364	No opposition during term of opposition
2008-04-17	8327	Change in the person/name/address of the patent owner	Owner name: NOVOZYMES GROPEP LTD., ADELAIDE, AU
2009-05-28	8327	Change in the person/name/address of the patent owner	Owner name: NOVOZYMES BIOPHARMA AU LTD., ADELAIDE, AU