DE3852589D1 - Verfahren zur O-Alkylierung von N-(Hydroxy)aralkylphenylethanolamin. - Google Patents
Verfahren zur O-Alkylierung von N-(Hydroxy)aralkylphenylethanolamin.Info
- Publication number
- DE3852589D1 DE3852589D1 DE3852589T DE3852589T DE3852589D1 DE 3852589 D1 DE3852589 D1 DE 3852589D1 DE 3852589 T DE3852589 T DE 3852589T DE 3852589 T DE3852589 T DE 3852589T DE 3852589 D1 DE3852589 D1 DE 3852589D1
- Authority
- DE
- Germany
- Prior art keywords
- formula
- compound
- alkylation
- group
- denotes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000010934 O-alkylation reaction Methods 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8711498A FR2619379B1 (fr) | 1987-08-12 | 1987-08-12 | Procede pour la o-alkylation de n-(hydroxy) aralkyl-phenylethanolamines |
| FR8807948A FR2632637B1 (fr) | 1988-06-14 | 1988-06-14 | Ethers de la 2-amino-7-hydroxytetraline |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3852589D1 true DE3852589D1 (de) | 1995-02-09 |
| DE3852589T2 DE3852589T2 (de) | 1995-08-10 |
Family
ID=26226167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3852589T Expired - Lifetime DE3852589T2 (de) | 1987-08-12 | 1988-08-11 | Verfahren zur O-Alkylierung von N-(Hydroxy)aralkylphenylethanolamin. |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US4927955A (de) |
| EP (1) | EP0303546B1 (de) |
| JP (2) | JP2611816B2 (de) |
| AT (1) | ATE116284T1 (de) |
| DE (1) | DE3852589T2 (de) |
| ES (1) | ES2067483T3 (de) |
| GR (1) | GR3015632T3 (de) |
| HK (1) | HK1000963A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2648042B1 (fr) * | 1989-06-13 | 1994-06-10 | Midy Spa | Utilisation de phenylethanolaminotetralines pour la preparation de medicaments pour le traitement des affections oculaires |
| FR2669821A1 (fr) * | 1990-12-04 | 1992-06-05 | Sanofi Sa | Utilisation de phenylethanolaminotetralines pour la preparation de medicaments destines au traitement de la depression. |
| GB9107827D0 (en) * | 1991-04-12 | 1991-05-29 | Fujisawa Pharmaceutical Co | New ethanolamine derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
| EP0627407A1 (de) * | 1993-05-28 | 1994-12-07 | MIDY S.p.A. | (7S)-7-(2R)-2(3-Chlorophenyl)-2-hydroxethylamino-5,6,7,8-Tetrahydronaphthalen-2-yloxy-Essigsäure, ihre pharmazeutisch akzeptablen Salze, mit Beta-3-adrenergischer agonistischer Aktivität und diese enthaltende pharmazeutische Zusammensetzung |
| EP0845451A4 (de) * | 1995-07-26 | 1999-10-13 | Ono Pharmaceutical Co | Naphthyloxoessigsäure-derivate und medikamente die diese als aktive bestandteile enthalten |
| US6197993B1 (en) | 1996-07-02 | 2001-03-06 | Ono Pharmaceutical Co., Ltd. | Naphthyloxyacetic acid derivatives and a pharmaceutical composition comprising them as an active ingredient |
| FR2826651B1 (fr) * | 2001-06-28 | 2005-09-02 | Sanofi Synthelabo | Forme cristalline d'une phenylethanolamine, sa preparation et compositions pharmaceutiques la contenant |
| US7544841B2 (en) * | 2004-10-20 | 2009-06-09 | Mitsubishi Tanabe Pharma Corporation | Production method of phenylethanolamine compound, and its intermediate |
| US7122690B1 (en) | 2006-02-14 | 2006-10-17 | E. I. Du Pont De Nemours And Company | Process to prepare metal complex of N,N-bis(2-hydroxyethyl)glycine |
| WO2014108449A1 (en) | 2013-01-08 | 2014-07-17 | Atrogi Ab | A screening method, a kit, a method of treatment and a compound for use in a method of treatment |
| GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714740D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB202205895D0 (en) | 2022-04-22 | 2022-06-08 | Atrogi Ab | New medical uses |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2230383C3 (de) * | 1971-10-01 | 1981-12-03 | Boehringer Mannheim Gmbh, 6800 Mannheim | Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben |
| JPS6021576B2 (ja) * | 1977-09-05 | 1985-05-28 | 保土谷化学工業株式会社 | α−（フエノキシまたはナフトキシ）有機酸エステル類の製造法 |
| US4338333A (en) * | 1979-06-16 | 1982-07-06 | Beecham Group Limited | Ethanamine derivatives their preparation and use in pharmaceutical compositions |
| US4275219A (en) * | 1979-09-24 | 1981-06-23 | Interx Research Corporation | Novel process and intermediates useful in the preparation of sympathomimetic amines |
| GB2096988B (en) * | 1980-11-20 | 1984-08-01 | Beecham Group Ltd | Aromatic hydroxyamines |
| ZA821436B (en) * | 1981-03-06 | 1983-02-23 | Beecham Group Plc | Secondary amines |
| ZA824902B (en) * | 1981-07-11 | 1983-04-27 | Beecham Group Plc | Secondary amines |
| GB8329490D0 (en) * | 1983-11-04 | 1983-12-07 | Beecham Group Plc | Compounds |
| IL79323A (en) * | 1985-07-10 | 1990-03-19 | Sanofi Sa | Phenylethanolaminotetralines,their preparation and pharmaceutical compositions containing them |
| DE3719924A1 (de) * | 1986-12-22 | 1988-06-30 | Bayer Ag | 8-substituierte 2-aminotetraline |
-
1988
- 1988-08-11 AT AT88402095T patent/ATE116284T1/de not_active IP Right Cessation
- 1988-08-11 US US07/230,860 patent/US4927955A/en not_active Expired - Lifetime
- 1988-08-11 EP EP88402095A patent/EP0303546B1/de not_active Expired - Lifetime
- 1988-08-11 DE DE3852589T patent/DE3852589T2/de not_active Expired - Lifetime
- 1988-08-11 ES ES88402095T patent/ES2067483T3/es not_active Expired - Lifetime
- 1988-08-12 JP JP63202621A patent/JP2611816B2/ja not_active Expired - Lifetime
-
1990
- 1990-03-05 US US07/488,137 patent/US5041606A/en not_active Expired - Lifetime
-
1993
- 1993-09-01 US US08/114,190 patent/US5347037A/en not_active Expired - Lifetime
-
1995
- 1995-03-27 GR GR950400710T patent/GR3015632T3/el unknown
-
1996
- 1996-06-07 JP JP8145620A patent/JP2818763B2/ja not_active Expired - Lifetime
-
1997
- 1997-12-24 HK HK97102622A patent/HK1000963A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0303546A2 (de) | 1989-02-15 |
| ES2067483T3 (es) | 1995-04-01 |
| DE3852589T2 (de) | 1995-08-10 |
| EP0303546B1 (de) | 1994-12-28 |
| US5347037A (en) | 1994-09-13 |
| HK1000963A1 (en) | 1998-05-15 |
| GR3015632T3 (en) | 1995-06-30 |
| US4927955A (en) | 1990-05-22 |
| EP0303546A3 (en) | 1990-10-17 |
| JP2611816B2 (ja) | 1997-05-21 |
| US5041606A (en) | 1991-08-20 |
| JPH09110811A (ja) | 1997-04-28 |
| JPS6466152A (en) | 1989-03-13 |
| JP2818763B2 (ja) | 1998-10-30 |
| ATE116284T1 (de) | 1995-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: SANOFI-SYNTHELABO, PARIS, FR |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: SANOFI-AVENTIS, PARIS, FR |