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DE3752226D1 - Ein Verfahren zur Herstellung eines 1-Amino-1-Deoxyoligosaccharid-Derivats - Google Patents

Ein Verfahren zur Herstellung eines 1-Amino-1-Deoxyoligosaccharid-Derivats

Info

Publication number
DE3752226D1
DE3752226D1 DE3752226T DE3752226T DE3752226D1 DE 3752226 D1 DE3752226 D1 DE 3752226D1 DE 3752226 T DE3752226 T DE 3752226T DE 3752226 T DE3752226 T DE 3752226T DE 3752226 D1 DE3752226 D1 DE 3752226D1
Authority
DE
Germany
Prior art keywords
deoxyoligosaccharide
amino
derivative
producing
electrophilic reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3752226T
Other languages
English (en)
Other versions
DE3752226T2 (de
Inventor
John Marcus Risley
Etten Robert Lee Van
James R Rasmussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ETTEN ROBERT LEE VAN
Genzyme Corp
Original Assignee
ETTEN ROBERT LEE VAN
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ETTEN ROBERT LEE VAN, Genzyme Corp filed Critical ETTEN ROBERT LEE VAN
Publication of DE3752226D1 publication Critical patent/DE3752226D1/de
Application granted granted Critical
Publication of DE3752226T2 publication Critical patent/DE3752226T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE3752226T 1986-12-11 1987-12-10 Ein Verfahren zur Herstellung eines 1-Amino-1-Deoxyoligosaccharid-Derivats Expired - Fee Related DE3752226T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94057486A 1986-12-11 1986-12-11

Publications (2)

Publication Number Publication Date
DE3752226D1 true DE3752226D1 (de) 1998-11-12
DE3752226T2 DE3752226T2 (de) 1999-04-22

Family

ID=25475078

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3752226T Expired - Fee Related DE3752226T2 (de) 1986-12-11 1987-12-10 Ein Verfahren zur Herstellung eines 1-Amino-1-Deoxyoligosaccharid-Derivats

Country Status (6)

Country Link
US (1) US5283353A (de)
EP (2) EP0606925B1 (de)
JP (1) JPH01502266A (de)
AT (1) ATE171953T1 (de)
DE (1) DE3752226T2 (de)
WO (1) WO1988004323A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212298A (en) * 1989-08-16 1993-05-18 Monsanto Company Method for producing synthetic N-linked glycoconjugates
US5280113A (en) * 1989-08-16 1994-01-18 Monsanto Company Method for producing synthetic N-linked glycoconjugates
ATE122051T1 (de) * 1989-08-16 1995-05-15 Monsanto Co Verfahren zur herstellung von künstlichen n- verbundenen glycoconjugaten.
DE59107851D1 (de) * 1990-02-14 1996-07-04 Man Ceramics Gmbh Knochenimplantat
US5241072A (en) * 1990-05-25 1993-08-31 Genzyne Corporation Oligosaccharide oxazolines, oligosaccharide conjugates and methods of preparation thereof
DE4436164A1 (de) * 1994-10-10 1996-04-11 Hoechst Ag Neue Kohlenhydratkonjugate als Inhibitoren der Zelladhäsion
US6013634A (en) * 1996-11-08 2000-01-11 Synsorb Biotech, Inc. Solid support matrices containing a toxin binding oligosaccharide
US5846943A (en) * 1996-11-08 1998-12-08 Synsorb Biotech, Inc. Solid support matricles containing a toxin binding oligosaccharide
US7299805B2 (en) 2002-06-07 2007-11-27 Marctec, Llc Scaffold and method for implanting cells
US20070073385A1 (en) * 2005-09-20 2007-03-29 Cook Incorporated Eluting, implantable medical device
DE102006041829A1 (de) * 2006-09-06 2008-03-27 Poly-Clip System Gmbh & Co Kg Fertigungslinie zur Herstellung wurstförmiger Produkte
ES2608484T3 (es) 2008-02-04 2017-04-11 Prozyme, Inc. Compuestos y métodos para un marcaje rápido de N-glicanos
DE102013212179A1 (de) * 2012-07-31 2014-02-06 Agilent Technologies, Inc. Derivatisierung von PNGase F-freigesetzter Glykane auf einem HPLC-Chip
US9879097B2 (en) 2013-04-19 2018-01-30 Glytech, Inc. Method for producing activated sugar chain derivative and activated sugar chain derivative produced therefrom
ES2759503T3 (es) 2013-05-02 2020-05-11 Glykos Finland Oy Conjugados de una glicoproteína o un glicano con una carga útil tóxica
EP3682904A1 (de) 2014-06-30 2020-07-22 Glykos Finland Oy Saccharidderivat einer toxischen nutzlast und antikörperkonjugate davon

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB833263A (en) * 1956-01-20 1960-04-21 Ciba Ltd Amino-ketoses and process for their manufacture
US4175123A (en) * 1976-12-23 1979-11-20 Bayer Aktiengesellschaft Amino-sugar derivatives, process for their preparation and pharmaceutical composition thereof
US4948882A (en) * 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
US4719294A (en) * 1985-09-06 1988-01-12 Monsanto Company Isolation of unreduced oligosaccharides

Also Published As

Publication number Publication date
ATE171953T1 (de) 1998-10-15
EP0606925B1 (de) 1998-10-07
JPH01502266A (ja) 1989-08-10
US5283353A (en) 1994-02-01
EP0299007A1 (de) 1989-01-18
EP0299007A4 (de) 1990-03-08
EP0606925A3 (en) 1994-08-24
WO1988004323A1 (en) 1988-06-16
EP0606925A2 (de) 1994-07-20
DE3752226T2 (de) 1999-04-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee