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DE3751389D1 - Verfahren zur Trennung von Proteinen. - Google Patents

Verfahren zur Trennung von Proteinen.

Info

Publication number
DE3751389D1
DE3751389D1 DE3751389T DE3751389T DE3751389D1 DE 3751389 D1 DE3751389 D1 DE 3751389D1 DE 3751389 T DE3751389 T DE 3751389T DE 3751389 T DE3751389 T DE 3751389T DE 3751389 D1 DE3751389 D1 DE 3751389D1
Authority
DE
Germany
Prior art keywords
value
ionic strength
gradually changing
maintaining
gels
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3751389T
Other languages
English (en)
Other versions
DE3751389T2 (de
Inventor
Thomas Prof Dr Vukovich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of DE3751389D1 publication Critical patent/DE3751389D1/de
Application granted granted Critical
Publication of DE3751389T2 publication Critical patent/DE3751389T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y10S530/831—Cohn fractions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE3751389T 1986-03-27 1987-03-26 Verfahren zur Trennung von Proteinen. Expired - Fee Related DE3751389T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0082786A AT399095B (de) 1986-03-27 1986-03-27 Verfahren zur auftrennung von proteinen mittels gradientenelution und vorrichtung zur durchführung des verfahrens

Publications (2)

Publication Number Publication Date
DE3751389D1 true DE3751389D1 (de) 1995-08-10
DE3751389T2 DE3751389T2 (de) 1996-03-21

Family

ID=3500677

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3751389T Expired - Fee Related DE3751389T2 (de) 1986-03-27 1987-03-26 Verfahren zur Trennung von Proteinen.

Country Status (7)

Country Link
US (1) US5112949A (de)
EP (1) EP0239565B1 (de)
JP (1) JP2511449B2 (de)
AT (2) AT399095B (de)
AU (1) AU596159B2 (de)
CA (1) CA1327674C (de)
DE (1) DE3751389T2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4664913A (en) * 1982-05-24 1987-05-12 Xoma Corporation Method for treating plasma for transfusion
US4810391A (en) * 1987-11-06 1989-03-07 Bio-Rad Laboratories, Inc. Separation of hemoglobin A2 from hemoglobin mixture
ATE114668T1 (de) * 1988-10-26 1994-12-15 American Cyanamid Co Verfahren zur verringerung des aggregatinhaltes in wachstumshormonen gleichenden stoffen.
US5110913A (en) * 1990-05-25 1992-05-05 Miles Inc. Antibody purification method
IT1262899B (it) * 1992-03-27 1996-07-22 Sclavo Spa Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano
EP0585504A1 (de) * 1992-09-04 1994-03-09 Pentapharm A.G. Phospholipidabhängiger Prothrombinaktivator und seine Anwendung in Lupusantikoagulanttesten
DK114392D0 (da) * 1992-09-17 1992-09-17 Kem En Tec As Isolering af biomolekyler
JP4383546B2 (ja) * 1997-04-28 2009-12-16 イーライ・リリー・アンド・カンパニー 活性化プロテインｃの改良プロセシング方法
AU769144B2 (en) * 1997-04-28 2004-01-15 Eli Lilly And Company Improved methods for processing activated protein C
US6630137B1 (en) 1997-04-28 2003-10-07 Eli Lilly And Company Activated protein C formulations
AT408613B (de) * 1998-06-17 2002-01-25 Immuno Ag Pharmazeutisches faktor vii-präparat
WO1999067277A1 (en) * 1998-06-23 1999-12-29 Shanbrom Technologies, Llc Method and apparatus for the production of purified plasma proteins
US7204981B2 (en) * 2000-03-28 2007-04-17 Eli Lilly And Company Methods of treating diseases with activated protein C
CA2410567A1 (en) 2000-05-24 2001-11-29 Eli Lilly And Company Formulations and use of activated protein c and protein c zymogen for treating hypercoagulable states
JP2005528351A (ja) * 2002-03-08 2005-09-22 イーライ・リリー・アンド・カンパニー 活性化プロテインｃ製剤
WO2005040787A1 (en) * 2003-10-17 2005-05-06 Ge Healthcare Bio-Sciences Ab Chromatography system, method and software for the separation of biomolecules
US20060057275A1 (en) * 2004-09-16 2006-03-16 Shaowen Wu Process for the preparation of glycinin-rich and beta-conglycinin-rich protein fractions
ES2374210T3 (es) * 2008-04-21 2012-02-14 Ge Healthcare Bio-Sciences Ab Preparación de mezclas líquidas.
WO2011037530A1 (en) * 2009-09-25 2011-03-31 Ge Healthcare Bio-Sciences Ab Method and system for preparation of liquid mixtures
US12227734B2 (en) 2011-03-08 2025-02-18 University Of Maryland, Baltimore County Microscale bioprocessing system and method for protein manufacturing from human blood
MX2017001433A (es) * 2014-07-31 2017-10-02 Rao Govind Sistema de bioprocesamiento a microescala y metodo para fabricacion de proteina a partir de sangre humana.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE392038B (sv) * 1971-09-08 1977-03-14 Kabi Ab Forfarande for isolering av antitrombin ur blod eller blodprodukter
CS162953B1 (de) * 1972-05-10 1975-07-31
AT336182B (de) * 1972-12-13 1977-04-25 Cutter Lab Verfahren zur herstellung eines prothrombinkomplexes
FR2210396A1 (en) * 1972-12-19 1974-07-12 Cutter Lab Blood coagulation complex - by extraction of plasma with sephadex
ATE15489T1 (de) * 1980-05-27 1985-09-15 Miles Lab Die blutkoagulation aktivierendes produkt und verfahren zu dessen herstellung.
US4447416A (en) * 1982-04-28 1984-05-08 American National Red Cross Plasma protein concentrates of reduced thrombogenicity and their use in clinical replacement therapy
FR2543448A1 (fr) * 1983-04-01 1984-10-05 Rhone Poulenc Spec Chim Procede de fractionnement du plasma
GB8327860D0 (en) * 1983-10-18 1983-11-16 Fujisawa Pharmaceutical Co Monoclonal antiprotein c antibody
GB8403473D0 (en) * 1984-02-09 1984-03-14 Special Trustees For St Thomas Purification of factor viii
US4721572A (en) * 1985-07-12 1988-01-26 Miles Laboratories, Inc. Purfication of blood clotting factors and other blood proteins on non-carbohydrate sulfated matrices
US4770781A (en) * 1986-03-03 1988-09-13 Merck & Co., Inc. Purification of human interleukin-1 species

Also Published As

Publication number Publication date
EP0239565B1 (de) 1995-07-05
EP0239565A2 (de) 1987-09-30
ATA82786A (de) 1989-09-15
JP2511449B2 (ja) 1996-06-26
CA1327674C (en) 1994-03-08
DE3751389T2 (de) 1996-03-21
AU596159B2 (en) 1990-04-26
JPS62246593A (ja) 1987-10-27
EP0239565A3 (en) 1989-07-26
AU7067287A (en) 1987-10-01
US5112949A (en) 1992-05-12
ATE124703T1 (de) 1995-07-15
AT399095B (de) 1995-03-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee