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DE3688710D1 - Isolierung und pharmazeutische verwendung von hyaluronidase und diese enthaltende pharmazeutische und tieraerztliche praeparate. - Google Patents

Isolierung und pharmazeutische verwendung von hyaluronidase und diese enthaltende pharmazeutische und tieraerztliche praeparate.

Info

Publication number
DE3688710D1
DE3688710D1 DE8686301092T DE3688710T DE3688710D1 DE 3688710 D1 DE3688710 D1 DE 3688710D1 DE 8686301092 T DE8686301092 T DE 8686301092T DE 3688710 T DE3688710 T DE 3688710T DE 3688710 D1 DE3688710 D1 DE 3688710D1
Authority
DE
Germany
Prior art keywords
pharmaceutical
hyaluronidase
insulation
products containing
medicinal products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686301092T
Other languages
English (en)
Other versions
DE3688710T2 (de
Inventor
Roy Thomas Sawyer
Jeffrey Edwards
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of DE3688710D1 publication Critical patent/DE3688710D1/de
Application granted granted Critical
Publication of DE3688710T2 publication Critical patent/DE3688710T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE86301092T 1985-02-16 1986-02-17 Isolierung und pharmazeutische Verwendung von Hyaluronidase und diese enthaltende pharmazeutische und tierärztliche Präparate. Expired - Lifetime DE3688710T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858504025A GB8504025D0 (en) 1985-02-16 1985-02-16 Hyaluronidase

Publications (2)

Publication Number Publication Date
DE3688710D1 true DE3688710D1 (de) 1993-08-26
DE3688710T2 DE3688710T2 (de) 1993-11-18

Family

ID=10574607

Family Applications (1)

Application Number Title Priority Date Filing Date
DE86301092T Expired - Lifetime DE3688710T2 (de) 1985-02-16 1986-02-17 Isolierung und pharmazeutische Verwendung von Hyaluronidase und diese enthaltende pharmazeutische und tierärztliche Präparate.

Country Status (4)

Country Link
US (1) US4820516A (de)
EP (1) EP0193330B1 (de)
DE (1) DE3688710T2 (de)
GB (1) GB8504025D0 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988002261A1 (en) * 1986-09-30 1988-04-07 Biochemie Gesellschaft M.B.H. Use of hyaluronidase
US5279824A (en) * 1988-04-14 1994-01-18 Merck Patent Gmbh Pharmaceutical formulation containing heparin and endo-beta-glucuronidase, useful for the treatment of thrombosis
GB8808810D0 (en) * 1988-04-14 1988-05-18 Biopharm Clinical Research Ltd Heparin-containing formulations
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
ZA912770B (en) * 1990-04-16 1992-01-29 Bethesda Eye Inst Enzymatic disinsertion of vitreous body
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
DE4242655A1 (de) * 1992-12-17 1994-06-23 Behringwerke Ag Verwendung von Thrombin-Inhibitoren zur Inhibition okularer Fibrinbildung
US5747027A (en) * 1995-04-07 1998-05-05 The Regents Of The University Of California BH55 hyaluronidase
US5866120A (en) * 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US6610292B2 (en) 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
SE512633C2 (sv) * 1997-07-09 2000-04-17 Cecilia Johnsson Användning av hyaluronidas för reduktion av inflammatoriska cellinfiltrat
BR9910574A (pt) 1998-04-30 2001-09-11 Maruha Corp Compostos tendo derivado de ácido glicurÈnico e derivado de glicosamina em sua estrutura, método para a produção dos compostos, e uso dos compostos
JP2003502045A (ja) * 1999-06-12 2003-01-21 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング Ｈｉｒｕｄｉｎａｒｉａｍａｎｉｌｌｅｎｓｉｓ由来のヒアルロニダーゼ、その単離、精製および組換え製造方法
US20030199574A1 (en) 2000-03-02 2003-10-23 Vitreo-Retinal Technologies, Inc. Treatment of ophthalmic disorders using urea and urea derivatives
US6902548B1 (en) * 2001-03-19 2005-06-07 Ed Schuler Use of Streptomyces hyalurolyticus enzyme in ophthalmic treatments
US7807618B2 (en) * 2002-05-20 2010-10-05 The Board Of Regents Of The University Of Texas System Methods and compositions for delivering enzymes and nucleic acid molecules to brain, bone and other tissues
GB0228409D0 (en) * 2002-12-06 2003-01-08 Thromb X Nv Pharmacological vitreolysis
US6969514B2 (en) * 2003-02-05 2005-11-29 Soll David B Method for treating elevated intraocular pressure, including glaucoma
US7871607B2 (en) * 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
WO2004078140A2 (en) 2003-03-05 2004-09-16 Halozyme, Inc. SOLUBLE HYALURONIDASE GLYCOPROTEIN (sHASEGP), PROCESS FOR PREPARING THE SAME, USES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US20090123367A1 (en) * 2003-03-05 2009-05-14 Delfmems Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases
MXPA03011987A (es) 2003-12-19 2005-06-23 Osio Sancho Alberto Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal.
EP1781305A2 (de) * 2004-08-13 2007-05-09 Angiotech International Ag Zusammensetzungen und verfahren mit hyaluronsäure und hyaluronidase-inhibitoren
EP2316465A1 (de) * 2009-10-15 2011-05-04 Centre National De La Recherche Scientifique Verwendung von Extrakt von Blutegelspeichel als antibakterielles Mittel zur Herstellung unterschiedlicher Zusammensetzungen
WO2011097148A2 (en) * 2010-02-04 2011-08-11 Parsons Lowell C Use of oral heparin preparations to treat urinary tract diseases and conditions
BR112015002768B1 (pt) 2012-08-10 2022-05-03 Osio Corporation d/b/a Yolia Health Método para determinar um ajuste de uma lente de contato em um olho e lente de contato
EP3058084A4 (de) 2013-10-16 2017-07-05 Momenta Pharmaceuticals, Inc. Sialylierte glycoproteine
TWI788307B (zh) 2016-10-31 2023-01-01 美商艾歐凡斯生物治療公司 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
BR112019009925A2 (pt) 2016-11-17 2019-10-08 Iovance Biotherapeutics Inc método para preparar linfócitos infiltrantes de tumor remanescente para terapia de células t adotivas, e, método de tratamento de um câncer .
JP2023521059A (ja) 2020-04-02 2023-05-23 メッド プログレス，エルエルシー ヒアルロニダーゼの投与による目の損傷の低減又は抑制
US11890331B2 (en) 2020-04-02 2024-02-06 Med Progress, LLC Reducing or inhibiting ocular damage by hyaluronidase administration
CN114681595A (zh) * 2022-04-19 2022-07-01 宁波市第九医院 透明质酸酶在制备改善任意皮瓣血运的药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6033474B2 (ja) * 1978-05-11 1985-08-02 藤沢薬品工業株式会社 新規なヒアルロニダ−ゼｂｍｐ−８２３１およびその製造法
US4534967A (en) * 1982-08-03 1985-08-13 Boston Biomedical Research Institute Cell proliferation inhibitor and method of preparation

Also Published As

Publication number Publication date
EP0193330A3 (en) 1988-07-20
GB8504025D0 (en) 1985-03-20
EP0193330B1 (de) 1993-07-21
EP0193330A2 (de) 1986-09-03
DE3688710T2 (de) 1993-11-18
US4820516A (en) 1989-04-11

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