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DE3686470D1 - Verfahren zur herstellung des alpha-1-proteinase-inhibitors. - Google Patents

Verfahren zur herstellung des alpha-1-proteinase-inhibitors.

Info

Publication number
DE3686470D1
DE3686470D1 DE8686114461T DE3686470T DE3686470D1 DE 3686470 D1 DE3686470 D1 DE 3686470D1 DE 8686114461 T DE8686114461 T DE 8686114461T DE 3686470 T DE3686470 T DE 3686470T DE 3686470 D1 DE3686470 D1 DE 3686470D1
Authority
DE
Germany
Prior art keywords
alpha
proteinase inhibitor
resin
producing
aqueous solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686114461T
Other languages
English (en)
Other versions
DE3686470T2 (de
Inventor
Michael H Coan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Application granted granted Critical
Publication of DE3686470D1 publication Critical patent/DE3686470D1/de
Publication of DE3686470T2 publication Critical patent/DE3686470T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S210/00—Liquid purification or separation
    • Y10S210/902—Materials removed
    • Y10S210/903—Nitrogenous
    • Y10S210/905—Protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y10S530/831—Cohn fractions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE8686114461T 1985-11-01 1986-10-18 Verfahren zur herstellung des alpha-1-proteinase-inhibitors. Expired - Lifetime DE3686470T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/793,807 US4697003A (en) 1985-11-01 1985-11-01 Method of preparing alpha-1-proteinase inhibitor

Publications (2)

Publication Number Publication Date
DE3686470D1 true DE3686470D1 (de) 1992-09-24
DE3686470T2 DE3686470T2 (de) 1993-01-21

Family

ID=25160853

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686114461T Expired - Lifetime DE3686470T2 (de) 1985-11-01 1986-10-18 Verfahren zur herstellung des alpha-1-proteinase-inhibitors.

Country Status (8)

Country Link
US (1) US4697003A (de)
EP (1) EP0221426B1 (de)
JP (1) JPH0764750B2 (de)
AT (1) ATE79633T1 (de)
AU (1) AU591397B2 (de)
CA (1) CA1286848C (de)
DE (1) DE3686470T2 (de)
ES (1) ES2051684T3 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629567A (en) * 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
DE3612137A1 (de) * 1986-04-10 1987-10-15 Biotest Pharma Gmbh Steriles plasmaaustauschmittel
US4808314A (en) * 1987-09-18 1989-02-28 Scripps Clinic And Research Foundation Method for reducing bacterial endotoxin contamination in solutions of macromolecules
US5151358A (en) * 1989-06-13 1992-09-29 Genencor International, Inc. Processes for the recovery of naturally produced chymosin
US5139943A (en) * 1989-06-13 1992-08-18 Genencor International, Inc. Processes for the recovery of microbially produced chymosin
US5328841A (en) * 1990-10-05 1994-07-12 Genencor International, Inc. Methods for isolating EG III cellulase component and EG III cellulase in polyethylene glycol using inorganic salt and polyethylene glycol
CA2093422C (en) * 1990-10-05 2001-04-03 DETERGENT COMPOSITIONS CONTAINING LOW CBH I CONTENT CELLULASE COMPOSITIONS
US5290474A (en) * 1990-10-05 1994-03-01 Genencor International, Inc. Detergent composition for treating cotton-containing fabrics containing a surfactant and a cellulase composition containing endolucanase III from trichoderma ssp
DE4407837C1 (de) * 1994-03-09 1995-08-17 Octapharma Ag Verfahren zur Gewinnung von hochreinem, virusinaktiviertem alpha¶1¶-Antitrypsin mittels Anionenaustauscher-Chromatographie
US5616693A (en) * 1996-07-01 1997-04-01 Alpha Therapeutic Corporation Process for seperating alpha-1-proteinase inhibitor from COHN IV1 +1V4 paste
GB2318732A (en) 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
AT407114B (de) * 1997-06-10 2000-12-27 Immuno Ag Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung
US6093804A (en) * 1998-09-24 2000-07-25 American National Red Cross Method for purification of alpha-1 proteinase inhibitor
US6887678B2 (en) * 1998-12-02 2005-05-03 Cindy L. Bristow Method for the quantitative determination of proteinase inhibitors
US6462180B1 (en) 1999-11-24 2002-10-08 Bayer Corporation Method of preparing α-1 proteinase inhibitor
PT1343809E (pt) 2000-12-14 2015-09-22 Grifols Therapeutics Inc Método de preparação de inibidor de proteinase alfa-1
US7777006B2 (en) 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
SI1664123T2 (sl) * 2003-09-22 2012-03-30 Kamada Ltd Priprava inhibitorja alfa proteinaze v velikem merilu in njegova uporaba
GB0524432D0 (en) * 2005-11-30 2006-01-11 Nhs Blood & Transplant Method
US20090304604A1 (en) * 2006-02-09 2009-12-10 Kamada Ltd. Pulmonary delivery of alpha-1 proteinase inhibitor
US8436152B2 (en) 2007-08-17 2013-05-07 Csl Behring Gmbh Methods for purification of alpha-1-antitrypsin andapolipoprotein A-1
CN102180966B (zh) * 2011-01-28 2013-04-03 哈尔滨派斯菲科生物制药股份有限公司 一种规模化生产人α1-抗胰蛋白酶的方法
MX351189B (es) 2011-12-30 2017-10-04 Grifols Sa Inhibidor de alfa1-proteinasa para demorar el comienzo o progresión de exacerbaciones pulmonares.
WO2017066683A1 (en) 2015-10-15 2017-04-20 Plasma Technologies, Llc Methods for extracting proteins from blood plasma
EP3411383A4 (de) 2016-02-03 2019-08-14 Plasma Technologies, LLC Verfahren zur extraktion von proteinen aus blutbasiertem material
US10815270B1 (en) 2019-09-20 2020-10-27 Plasma Technologies, Llc Compositions and methods for high efficiency protein precipitation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL286954A (de) * 1962-01-03
US3869436A (en) * 1971-06-01 1975-03-04 Statens Bakteriologiska Lab Method for fractionating plasma proteins using peg and ion-exchangers
US4100149A (en) * 1975-08-28 1978-07-11 Rhone-Poulenc Industries Method of separating proteins by ion exchange
US4379087A (en) * 1982-06-17 1983-04-05 Cutter Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4656254A (en) * 1985-12-02 1987-04-07 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor and antithrombin III
US4629567A (en) * 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification

Also Published As

Publication number Publication date
AU591397B2 (en) 1989-11-30
JPS62108821A (ja) 1987-05-20
CA1286848C (en) 1991-07-23
EP0221426A2 (de) 1987-05-13
ATE79633T1 (de) 1992-09-15
DE3686470T2 (de) 1993-01-21
EP0221426A3 (en) 1989-02-08
EP0221426B1 (de) 1992-08-19
ES2051684T3 (es) 1994-07-01
AU6462486A (en) 1987-05-07
US4697003A (en) 1987-09-29
JPH0764750B2 (ja) 1995-07-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BAYER CORP. (N.D.GES.D. STAATES INDIANA), PITTSBUR