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DE3686150D1 - Pyridopyrimidin-nukleotid-abkoemmlinge. - Google Patents

Pyridopyrimidin-nukleotid-abkoemmlinge.

Info

Publication number
DE3686150D1
DE3686150D1 DE8686905396T DE3686150T DE3686150D1 DE 3686150 D1 DE3686150 D1 DE 3686150D1 DE 8686905396 T DE8686905396 T DE 8686905396T DE 3686150 T DE3686150 T DE 3686150T DE 3686150 D1 DE3686150 D1 DE 3686150D1
Authority
DE
Germany
Prior art keywords
pyridopyrimidine
nucleotide combination
combination leather
leather
nucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686905396T
Other languages
English (en)
Other versions
DE3686150T2 (de
Inventor
Hideo Inoue
Eiko Ohtsuka
Akihiro Imura
Kenichi Masuda
Takashi Kamimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of DE3686150D1 publication Critical patent/DE3686150D1/de
Publication of DE3686150T2 publication Critical patent/DE3686150T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
DE8686905396T 1985-09-09 1986-08-28 Pyridopyrimidin-nukleotid-abkoemmlinge. Expired - Fee Related DE3686150T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19768985 1985-09-09
PCT/JP1986/000441 WO1987001373A1 (en) 1985-09-09 1986-08-28 Pyridopyrimidine nucleotide derivatives

Publications (2)

Publication Number Publication Date
DE3686150D1 true DE3686150D1 (de) 1992-08-27
DE3686150T2 DE3686150T2 (de) 1993-03-04

Family

ID=16378713

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686905396T Expired - Fee Related DE3686150T2 (de) 1985-09-09 1986-08-28 Pyridopyrimidin-nukleotid-abkoemmlinge.

Country Status (5)

Country Link
US (1) US4965350A (de)
EP (1) EP0235301B1 (de)
JP (1) JPH0725788B1 (de)
DE (1) DE3686150T2 (de)
WO (1) WO1987001373A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071974A (en) * 1986-10-31 1991-12-10 Amoco Corporation Compositions and methods for the synthesis of oligonucleotides having 5'-phosphorylated termini
US6005087A (en) * 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5852182A (en) * 1990-01-11 1998-12-22 Isis Pharmaceuticals Inc. Thiol-derivatized oligonucleosides
US5859221A (en) * 1990-01-11 1999-01-12 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US6395492B1 (en) * 1990-01-11 2002-05-28 Isis Pharmaceuticals, Inc. Derivatized oligonucleotides having improved uptake and other properties
EP1418179A3 (de) * 1990-01-11 2006-03-08 Isis Pharmaceuticals, Inc. Zusammensetzungen und Verfahren zum Detektieren und zur Modulation von RNA Aktivität und Genexpression
US6399754B1 (en) 1991-12-24 2002-06-04 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides
US5872232A (en) * 1990-01-11 1999-02-16 Isis Pharmaceuticals Inc. 2'-O-modified oligonucleotides
US5459255A (en) * 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
US6339066B1 (en) 1990-01-11 2002-01-15 Isis Pharmaceuticals, Inc. Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate βI, βII, γ, δ, Ε, ζ and η isoforms of human protein kinase C
US6114513A (en) * 1990-01-11 2000-09-05 Isis Pharmaceuticals, Inc. Thiol-derivatized oligonucleotides
ATE154246T1 (de) * 1990-07-27 1997-06-15 Isis Pharmaceuticals Inc Nuklease resistente, pyrimidin modifizierte oligonukleotide, die die gen-expression detektieren und modulieren
US6262241B1 (en) * 1990-08-13 2001-07-17 Isis Pharmaceuticals, Inc. Compound for detecting and modulating RNA activity and gene expression
US5965722A (en) 1991-05-21 1999-10-12 Isis Pharmaceuticals, Inc. Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
ATE244259T1 (de) * 1992-02-12 2003-07-15 Chromagen Inc Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen
US5652099A (en) * 1992-02-12 1997-07-29 Conrad; Michael J. Probes comprising fluorescent nucleosides and uses thereof
US6537973B1 (en) 1992-03-16 2003-03-25 Isis Pharmaceuticals, Inc. Oligonucleotide inhibition of protein kinase C
EP0669928A1 (de) * 1993-08-18 1995-09-06 Chromagen, Inc. Anwendung von fluoreszierenden n-nukleosiden und fluoreszierenden strukturanalogen von n-nukleosiden
US5591578A (en) * 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US5525711A (en) * 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
US6232465B1 (en) 1994-09-02 2001-05-15 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
GB2309968B (en) * 1996-02-01 2000-08-09 Amersham Int Plc Nucleoside analogues
GB9602025D0 (en) * 1996-02-01 1996-04-03 Amersham Int Plc Nucleoside analogues
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
GB9716231D0 (en) 1997-07-31 1997-10-08 Amersham Int Ltd Base analogues
US6232463B1 (en) 1997-10-09 2001-05-15 Isis Pharmaceuticals, Inc. Substituted purines and oligonucleotide cross-linking
US6335432B1 (en) * 1998-08-07 2002-01-01 Bio-Red Laboratories, Inc. Structural analogs of amine bases and nucleosides
UA72612C2 (en) * 2000-07-06 2005-03-15 Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
CN1274072C (zh) * 2000-08-03 2006-09-06 松下电器产业株式会社 无刷电机及其制造方法
EP1546344A4 (de) * 2002-09-18 2007-10-03 Isis Pharmaceuticals Inc Effiziente produktion von ziel-rnas mittels einzel- und doppelsträngiger oligomerverbindungen
AU2003290596B2 (en) 2002-11-05 2011-05-12 Isis Pharmaceuticals, Inc. Sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
WO2004063339A2 (en) 2003-01-08 2004-07-29 Lesley Davenport G-quadruplex binding assays and compounds therefor
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
US7842512B2 (en) * 2004-03-26 2010-11-30 Purdue Research Foundation Dyed microspheres for characterization of photochemical reactor behavior
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
EP1858889A1 (de) 2005-03-08 2007-11-28 Biota Scientific Management Pty. Ltd. Bicyclische nukleoside und nukleotide als therapeutische mittel
CN106957350B (zh) * 2017-02-28 2019-09-27 北京大学 5-醛基胞嘧啶的标记方法及其在单碱基分辨率测序中的应用
CN109678802B (zh) * 2019-01-28 2020-12-29 四川大学 衍生醛基嘧啶的方法、检测5-醛基胞嘧啶的方法以及醛基嘧啶衍生物的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1219824A (en) * 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same

Also Published As

Publication number Publication date
US4965350A (en) 1990-10-23
WO1987001373A1 (en) 1987-03-12
DE3686150T2 (de) 1993-03-04
EP0235301B1 (de) 1992-07-22
EP0235301A4 (de) 1989-10-12
JPH0725788B1 (de) 1995-03-22
EP0235301A1 (de) 1987-09-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee