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DE3684819D1 - Choline-ester-salze enthaltende pharmazeutische zusammensetzung zur erhoehung der absorption der magen-darmwege. - Google Patents

Choline-ester-salze enthaltende pharmazeutische zusammensetzung zur erhoehung der absorption der magen-darmwege.

Info

Publication number
DE3684819D1
DE3684819D1 DE8686401414T DE3684819T DE3684819D1 DE 3684819 D1 DE3684819 D1 DE 3684819D1 DE 8686401414 T DE8686401414 T DE 8686401414T DE 3684819 T DE3684819 T DE 3684819T DE 3684819 D1 DE3684819 D1 DE 3684819D1
Authority
DE
Germany
Prior art keywords
gastic
choline
arrows
absorption
increasing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686401414T
Other languages
English (en)
Inventor
Jose Alexander
Joseph A Fix
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3684819D1 publication Critical patent/DE3684819D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE8686401414T 1985-06-28 1986-06-26 Choline-ester-salze enthaltende pharmazeutische zusammensetzung zur erhoehung der absorption der magen-darmwege. Expired - Fee Related DE3684819D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/749,696 US4729989A (en) 1985-06-28 1985-06-28 Enhancement of absorption of drugs from gastrointestinal tract using choline ester salts

Publications (1)

Publication Number Publication Date
DE3684819D1 true DE3684819D1 (de) 1992-05-21

Family

ID=25014792

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686401414T Expired - Fee Related DE3684819D1 (de) 1985-06-28 1986-06-26 Choline-ester-salze enthaltende pharmazeutische zusammensetzung zur erhoehung der absorption der magen-darmwege.

Country Status (4)

Country Link
US (1) US4729989A (de)
EP (1) EP0206947B1 (de)
JP (1) JPH0710779B2 (de)
DE (1) DE3684819D1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3805523A1 (de) * 1988-02-22 1989-10-05 Schur Pharmazeutika Gmbh & Co Pharmazeutische praeparate zur transdermalen applikation von heparin
DE3806852A1 (de) * 1988-03-03 1989-09-14 Knoll Ag Neue (alpha)-aminodicarbonsaeure-derivate, ihre herstellung und verwendung
US5167947A (en) * 1989-10-26 1992-12-01 Southwest Research Institute Enhancement of absorption of radioprotective drugs
IT1263755B (it) * 1991-09-16 1996-08-29 Fidia Spa Uso di esteri della colina con polisaccaridi acidi come agenti antiulcera e gastroprotettivi
US6576636B2 (en) 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US5977174A (en) * 1997-11-26 1999-11-02 Neuromedica, Inc. Cholinergic compositions and uses thereof
US6153653A (en) * 1997-11-26 2000-11-28 Protarga, Inc. Choline compositions and uses thereof
US6221378B1 (en) 1998-02-10 2001-04-24 Generex Pharmaceuticals Incorporated Mixed micellar delivery system and method of preparation
US6017545A (en) * 1998-02-10 2000-01-25 Modi; Pankaj Mixed micellar delivery system and method of preparation
US7070799B1 (en) * 1998-02-10 2006-07-04 Generex Pharmaceuticals, Inc. Method for administering insulin to the buccal region
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
EP1427407A4 (de) * 2001-03-23 2005-05-11 Luitpold Pharm Inc Fettamin-arzneimittel-konjugate
ES2387562T3 (es) * 2001-03-23 2012-09-26 Luitpold Pharmaceuticals, Inc. Conjugados alcohol graso-medicamento
WO2004041837A1 (en) * 2002-10-31 2004-05-21 Metabasis Therapeutics, Inc. Novel cytarabine monophosphate prodrugs
AU2004285533A1 (en) * 2003-10-31 2005-05-12 Alza Corporation Compositions and dosage forms for enhanced absorption
CN103772259B (zh) * 2006-08-08 2016-08-31 于崇曦 具有快速皮肤穿透速度的带正电荷的芳基和杂芳基乙酸类前药
CN103772258B (zh) * 2006-08-08 2016-09-28 于崇曦 具有快速皮肤穿透速度的带正电荷的芳基和杂芳基乙酸类前药
ES2702798T3 (es) * 2010-10-25 2019-03-05 Stepan Co Esteraminas y derivados de la metátesis del aceite natural
CN114404427A (zh) 2014-02-13 2022-04-29 配体药物公司 前药化合物及其用途
WO2016003812A1 (en) 2014-07-02 2016-01-07 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
EP3737676B1 (de) 2018-01-09 2024-03-06 Ligand Pharmaceuticals, Inc. Acetalverbindungen und therapeutische verwendungen davon
CN119564753A (zh) * 2025-01-23 2025-03-07 南昌大学第一附属医院 胆碱类低共熔溶剂在提高车前草萃取物口服吸收的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2554453A1 (de) * 1974-12-18 1976-06-24 Experimentales Et Cliniques De Medikament zur glykaemieregulierung
US4171353A (en) * 1978-05-16 1979-10-16 Ryan Wayne L Immunization of animals using choline esters as an immunological adjuvant
NZ196349A (en) * 1980-03-07 1984-08-24 Interx Research Corp Enhancement of absorption rate of orally administered polar bioactive agents
DE3109188A1 (de) * 1981-03-11 1982-09-23 NATEC Institut für naturwissenschaftlich-technische Dienste GmbH, 2000 Hamburg Antimikrobielles konservierungsmittel und seine verwendung
US4425337A (en) * 1981-12-30 1984-01-10 Merck & Co., Inc. Adjuvants for rectal delivery of drug
JPS5976024A (ja) * 1982-10-25 1984-04-28 Eisai Co Ltd インシユリン吸着防止組成物および方法
US4749694A (en) * 1984-04-26 1988-06-07 Merck & Co., Inc. Novel lysine esters used as absorption

Also Published As

Publication number Publication date
EP0206947A3 (en) 1989-05-17
US4729989A (en) 1988-03-08
EP0206947A2 (de) 1986-12-30
JPH0710779B2 (ja) 1995-02-08
JPS624238A (ja) 1987-01-10
EP0206947B1 (de) 1992-04-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee