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DE3680184D1 - Verfahren zur herstellung von arylpiperidincarbinol. - Google Patents

Verfahren zur herstellung von arylpiperidincarbinol.

Info

Publication number
DE3680184D1
DE3680184D1 DE8686306070T DE3680184T DE3680184D1 DE 3680184 D1 DE3680184 D1 DE 3680184D1 DE 8686306070 T DE8686306070 T DE 8686306070T DE 3680184 T DE3680184 T DE 3680184T DE 3680184 D1 DE3680184 D1 DE 3680184D1
Authority
DE
Germany
Prior art keywords
producing
arylpiperidine
carbinol
arylpiperidine carbinol
producing arylpiperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686306070T
Other languages
English (en)
Inventor
Faruk Erol Ali
Martin Roger Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858520153A external-priority patent/GB8520153D0/en
Priority claimed from GB868612579A external-priority patent/GB8612579D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE3680184D1 publication Critical patent/DE3680184D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8686306070T 1985-08-10 1986-08-06 Verfahren zur herstellung von arylpiperidincarbinol. Expired - Lifetime DE3680184D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858520153A GB8520153D0 (en) 1985-08-10 1985-08-10 Chemical process
GB868612579A GB8612579D0 (en) 1986-05-23 1986-05-23 Chemical process

Publications (1)

Publication Number Publication Date
DE3680184D1 true DE3680184D1 (de) 1991-08-14

Family

ID=26289644

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686306070T Expired - Lifetime DE3680184D1 (de) 1985-08-10 1986-08-06 Verfahren zur herstellung von arylpiperidincarbinol.

Country Status (17)

Country Link
US (1) US4902801A (de)
EP (1) EP0223334B1 (de)
JP (2) JPH0696551B2 (de)
AU (1) AU582456B2 (de)
BG (1) BG61319B2 (de)
CA (1) CA1310649C (de)
CY (1) CY1708A (de)
DE (1) DE3680184D1 (de)
DK (1) DK169730B1 (de)
ES (2) ES2000603A6 (de)
GR (1) GR862102B (de)
HK (1) HK69793A (de)
IE (1) IE58831B1 (de)
MX (1) MX171822B (de)
NZ (1) NZ217141A (de)
PT (1) PT83179B (de)
SG (1) SG27793G (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8714707D0 (en) * 1987-06-23 1987-07-29 Beecham Group Plc Chemical process
DK588289D0 (da) * 1989-11-22 1989-11-22 Ferrosan As Ny heterocyklisk kemi
JPH04288059A (ja) * 1991-03-14 1992-10-13 Nippon Paint Co Ltd 複素環化合物及びその製造法
GB9209687D0 (en) * 1992-05-06 1992-06-17 Smithkline Beecham Plc Novel process
US5258517A (en) * 1992-08-06 1993-11-02 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
GB9305175D0 (en) * 1993-03-13 1993-04-28 Smithkline Beecham Plc Novel process
GB9325644D0 (en) * 1993-12-15 1994-02-16 Smithkline Beecham Plc Novel formulation
US6444190B2 (en) 1995-08-03 2002-09-03 Fmc Corporation Reduction compositions and processes for making the same
AU4997096A (en) * 1995-08-03 1997-03-05 Fmc Corporation Reductions using hydrides
ES2121685B1 (es) * 1996-04-10 1999-09-16 Vita Invest Sa Procedimiento para la obtencion de (+)-trans-4(4-fluoro-fenil)-3-hidroximetil-1-metilpiperidina.
JP3446468B2 (ja) 1996-04-15 2003-09-16 旭硝子株式会社 ピペリジンカルビノール類の製造方法
US5936090A (en) * 1996-05-24 1999-08-10 Fmc Corporation Processes for the reduction of imide ester functionality
ES2331937T3 (es) 1996-06-13 2010-01-20 Sumitomo Chemical Company, Limited Derivados de piperidina como intermediarios para la preparacion de paroxetina y procedimiento de preparacion de los mismos.
US6638948B1 (en) 1996-09-09 2003-10-28 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
AU4651497A (en) * 1996-09-24 1998-04-17 Fmc Corporation Novel reduction compositions and processes for making the same
GB9623359D0 (en) * 1996-11-09 1997-01-08 Smithkline Beecham Plc Novel process
EP0975595B9 (de) * 1997-04-07 2009-09-16 Georgetown University Analoge von kokain
GB9710004D0 (en) * 1997-05-17 1997-07-09 Knoll Ag Chemical process
WO1998053824A1 (en) * 1997-05-29 1998-12-03 Smithkline Beecham Corporation Novel process
ATE200781T1 (de) 1997-06-10 2001-05-15 Synthon Bv 4-phenylpiperidin-derivate
EP0969002B1 (de) * 1998-06-29 2003-08-27 SUMIKA FINE CHEMICALS Co., Ltd. L-Tartrate von Trans-(-)-4-(4-Fluorphenyl)-3-Hydroxymethyl-Piperidin Verbindungen und Verfahren zu ihrer Herstellung
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
WO2000026187A1 (en) * 1998-11-02 2000-05-11 Synthon B.V. Process for producing 4-arylpiperidine-3-carbinols and related compounds
GB9915303D0 (en) * 1999-06-30 1999-09-01 Smithkline Beecham Plc Novel process
IT1313702B1 (it) * 1999-08-02 2002-09-09 Chemi Spa Processo per la preparazione di derivati 3-sostituiti di 4-fenil-piperidine.
GB9920147D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
GB9924855D0 (en) * 1999-10-20 1999-12-22 Smithkline Beecham Plc Novel processes
AU1037701A (en) * 1999-10-20 2001-04-30 Smithkline Beecham Plc Process for the preparation of 4-(fluorophenyl)piperidine esters
GB9924882D0 (en) * 1999-10-20 1999-12-22 Smithkline Beecham Plc Novel process
GB9930577D0 (en) * 1999-12-23 2000-02-16 Smithkline Beecham Plc Novel process
CZ20023694A3 (cs) * 2000-05-12 2003-05-14 Synthon B. V. Tosylátové soli 4-(p-fluorfenyl)-piperidin-3-methanolů
US6833458B2 (en) 2000-06-05 2004-12-21 Development Center For Biotechnology Practical syntheses of chiral trans-3, 4-disubstituted piperidines and the intermediates
AU2001211337A1 (en) * 2000-10-06 2002-04-15 Smithkline Beecham Plc Process for the preparation of aryl-piperidine carbinols and intermediates thereof
EP1347960B1 (de) * 2001-01-04 2004-11-17 Ferrer Internacional, S.A. Verfahren zur herstellung von (+)-trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidin
US6777554B2 (en) 2001-02-05 2004-08-17 Teva Pharmaceutical Industries Ltd. Preparation of N-methylparoxetine and related intermediate compounds
US20040073038A1 (en) * 2001-02-24 2004-04-15 Callewaert George Leo Process of preparing paroxetine and intermediates for use therein
AU2002318185A1 (en) 2001-06-13 2002-12-23 Teva Pharmaceutical Industries Ltd. Process for the preparation of paroxetine substantially free of alkoxy impurities
KR100477048B1 (ko) * 2002-07-05 2005-03-17 임광민 피페리딘 화합물의 새로운 제조방법
WO2004043921A1 (en) * 2002-11-11 2004-05-27 Natco Pharma Limited Novel process for the preparation of 4-aryl-3-hydroxymethyl-1-methylpiperidines.
US20050266082A1 (en) * 2004-05-26 2005-12-01 Patel Satishkumar A Preparation of stable paroxetine HC1 ER tablets using a melt granulation process
CN101205211B (zh) * 2006-12-19 2011-12-14 北京德众万全药物技术开发有限公司 一种盐酸帕罗西汀重要中间体的制备方法
WO2015071831A1 (en) * 2013-11-18 2015-05-21 Piramal Enterprises Limited An improved process for minimising the formation of dehalogenated byproducts
CN104262255A (zh) * 2014-09-22 2015-01-07 四川大学 一种不对称催化合成γ-硝基吡唑酰胺化合物的方法
CN104402800A (zh) * 2014-12-02 2015-03-11 千辉药业（安徽）有限责任公司 一种反式-4-(4-氟苯基)-3-羟甲基-1-甲基哌啶的制备方法
WO2022269643A1 (en) * 2021-06-25 2022-12-29 Vihita Chem Private Limited An improved process for the preparation of intermediate for paroxetine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE625656A (de) * 1961-12-05
NL125654C (de) * 1963-12-17 1900-01-01
US3666746A (en) * 1969-06-25 1972-05-30 Gaf Corp Pyrrolidonylphenyl azo dyestuffs
US3681327A (en) * 1970-07-01 1972-08-01 Exxon Research Engineering Co N-methylenethiophosphate derivatives of 1,3-thiazines and 1,4-thiazanes
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US3947460A (en) * 1974-06-27 1976-03-30 Sandoz, Inc. 5-Hydroxy-5-substituted phenyl-pyrrolidones and piperidinones
EP0047516B1 (de) * 1980-09-04 1984-01-04 Toray Industries, Inc. Propylaminderivate und Verfahren zu deren Herstellung
US4585777A (en) * 1984-02-07 1986-04-29 A/S Ferrosan (-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT

Also Published As

Publication number Publication date
CA1310649C (en) 1992-11-24
GR862102B (en) 1986-12-30
JPS6239566A (ja) 1987-02-20
EP0223334A1 (de) 1987-05-27
AU582456B2 (en) 1989-03-23
DK380986A (da) 1987-02-11
MX171822B (es) 1993-11-17
JPH07138228A (ja) 1995-05-30
PT83179B (pt) 1989-03-30
EP0223334B1 (de) 1991-07-10
NZ217141A (en) 1989-06-28
IE58831B1 (en) 1993-11-17
JPH08809B2 (ja) 1996-01-10
BG61319B2 (bg) 1997-05-30
ES2005745A6 (es) 1989-03-16
IE862135L (en) 1987-02-10
DK380986D0 (da) 1986-08-08
JPH0696551B2 (ja) 1994-11-30
DK169730B1 (da) 1995-01-30
HK69793A (en) 1993-07-30
SG27793G (en) 1993-05-21
US4902801A (en) 1990-02-20
AU6101286A (en) 1987-02-12
CY1708A (en) 1994-01-14
PT83179A (en) 1986-09-01
ES2000603A6 (es) 1988-03-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition