DE3483508D1 - Physiologisch aktive substanz k-252, verfahren zu ihrer herstellung und eine pharmazeutische zusammensetzung die diese enthaelt. - Google Patents
Physiologisch aktive substanz k-252, verfahren zu ihrer herstellung und eine pharmazeutische zusammensetzung die diese enthaelt.Info
- Publication number
- DE3483508D1 DE3483508D1 DE8484305465T DE3483508T DE3483508D1 DE 3483508 D1 DE3483508 D1 DE 3483508D1 DE 8484305465 T DE8484305465 T DE 8484305465T DE 3483508 T DE3483508 T DE 3483508T DE 3483508 D1 DE3483508 D1 DE 3483508D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- pharmaceutical composition
- active substance
- physiologically active
- physiologically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/04—Actinomyces
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58147471A JPS6041489A (ja) | 1983-08-12 | 1983-08-12 | 新規生理活性物質k―252 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3483508D1 true DE3483508D1 (de) | 1990-12-06 |
Family
ID=15431133
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8484305465T Expired - Lifetime DE3483508D1 (de) | 1983-08-12 | 1984-08-10 | Physiologisch aktive substanz k-252, verfahren zu ihrer herstellung und eine pharmazeutische zusammensetzung die diese enthaelt. |
Country Status (4)
Country | Link |
---|---|
US (1) | US4555402A (de) |
EP (1) | EP0137632B1 (de) |
JP (1) | JPS6041489A (de) |
DE (1) | DE3483508D1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60217896A (ja) * | 1984-04-13 | 1985-10-31 | Kaken Pharmaceut Co Ltd | 新抗生物質6270物質及びその製造法 |
JPS62155284A (ja) * | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質k−252の誘導体 |
WO1988007045A1 (en) * | 1987-03-09 | 1988-09-22 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of physiologically active substance k-252 |
JPH07113027B2 (ja) * | 1987-12-24 | 1995-12-06 | 協和醗酵工業株式会社 | K−252誘導体 |
US5223637A (en) * | 1988-03-31 | 1993-06-29 | Kyowa Hakko Kogyo Co., Ltd. | KS-506 compounds |
US5142096A (en) * | 1988-03-31 | 1992-08-25 | Kyowa Hakko Kogyo Co., Ltd. | 2,4-dihydroxy-3,5,6-trimethylbenzoic acid compounds |
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
JPH07505124A (ja) | 1991-11-08 | 1995-06-08 | ザ ユニバーシティ オブ サザン カリフォルニア | ニューロトロフィン活性増強のためのk−252化合物を含む組成物 |
CA2123895A1 (en) * | 1992-09-21 | 1994-03-31 | Tatsuya Tamaoki | A therapeutic agent for thrombocytopenia |
US6306421B1 (en) | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6663881B2 (en) | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5981568A (en) * | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US7611533B2 (en) | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
ES2166071T3 (es) * | 1996-04-09 | 2002-04-01 | Kyowa Hakko Kogyo Kk | Procedimiento para purificar k-252a. |
NZ333441A (en) * | 1996-06-25 | 1999-05-28 | Cephalon Inc | Use of k-252a derivatives for the treatment of peripheral or central nerve disorders, and cytokine overproduction |
US6613083B2 (en) | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
US20060014165A1 (en) * | 2003-07-14 | 2006-01-19 | Decode Genetics Ehf. | Methods of diagnosis and treatment for asthma and other respiratory diseases based on haplotype association |
AU2003250150A1 (en) * | 2003-07-23 | 2005-02-25 | Creabilis Therapeutics S.R.L. | Topical use of tyrosine kinase inhibitors of microbial origin to prevent and treat skin disorders characterised by excessive cell proliferation |
WO2005082920A1 (en) * | 2004-02-27 | 2005-09-09 | H. Lundbeck A/S | Crystalline forms of a pharmaceutical compound |
MX2007001155A (es) * | 2004-07-29 | 2007-08-14 | Creabilis Therapeutics Spa | Uso de inhibidores de k-252a y de quinasa para la prevencion o el tratamiento de patologias asociadas con hmgb1. |
MX2007013071A (es) * | 2005-04-20 | 2008-01-14 | Abbott Lab | Extraccion de k-252a de caldo de fermentacion. |
US10231965B2 (en) | 2014-02-20 | 2019-03-19 | Ignyta, Inc. | Molecules for administration to ROS1 mutant cancer cells |
US10085979B2 (en) | 2014-12-02 | 2018-10-02 | Ignyta, Inc. | Combinations for the treatment of neuroblastoma |
CN108697661A (zh) | 2015-12-18 | 2018-10-23 | 亚尼塔公司 | 用于治疗癌症的组合 |
BR112020000793A2 (pt) | 2017-07-19 | 2020-07-14 | Ignyta, Inc. | composições farmacêuticas e formas de dosagem |
WO2019077506A1 (en) | 2017-10-17 | 2019-04-25 | Ignyta, Inc. | PHARMACEUTICAL COMPOSITIONS AND SOLID GALENIC FORMS |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5937952B2 (ja) * | 1977-09-12 | 1984-09-12 | 正 新井 | 抗生物質サフラマイシンa,b,c,d,eおよびその製造法 |
JPS5452797A (en) * | 1977-10-04 | 1979-04-25 | Meiji Seika Kaisha Ltd | Novel antibiotic substance bn-200, and its preparation |
US4317812A (en) * | 1981-01-15 | 1982-03-02 | Smithkline Corporation | Polynitroxin antibiotics produced by Nocardiopsis mutabilis Shearer sp. nov. ATCC 31520 |
-
1983
- 1983-08-12 JP JP58147471A patent/JPS6041489A/ja active Granted
-
1984
- 1984-08-10 DE DE8484305465T patent/DE3483508D1/de not_active Expired - Lifetime
- 1984-08-10 US US06/640,159 patent/US4555402A/en not_active Expired - Lifetime
- 1984-08-10 EP EP84305465A patent/EP0137632B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH0367073B2 (de) | 1991-10-21 |
EP0137632A2 (de) | 1985-04-17 |
JPS6041489A (ja) | 1985-03-05 |
EP0137632B1 (de) | 1990-10-31 |
US4555402A (en) | 1985-11-26 |
EP0137632A3 (en) | 1987-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |