DE29805613U1 - Miniaturized microtiter plate for HTS screening - Google Patents
Miniaturized microtiter plate for HTS screeningInfo
- Publication number
- DE29805613U1 DE29805613U1 DE29805613U DE29805613U DE29805613U1 DE 29805613 U1 DE29805613 U1 DE 29805613U1 DE 29805613 U DE29805613 U DE 29805613U DE 29805613 U DE29805613 U DE 29805613U DE 29805613 U1 DE29805613 U1 DE 29805613U1
- Authority
- DE
- Germany
- Prior art keywords
- microtiter plate
- miniaturized
- screening
- microtiter
- hts screening
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000012216 screening Methods 0.000 title description 5
- 239000011521 glass Substances 0.000 claims description 6
- 239000004033 plastic Substances 0.000 claims description 5
- 238000001704 evaporation Methods 0.000 claims description 3
- 230000008020 evaporation Effects 0.000 claims description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 238000013537 high throughput screening Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 238000007423 screening assay Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000004557 single molecule detection Methods 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
- B01J2219/00317—Microwell devices, i.e. having large numbers of wells
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Surface Acoustic Wave Elements And Circuit Networks Thereof (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Optical Measuring Cells (AREA)
Description
Hoechst Marion Roussel Deutschland GmbH HMR98/L013 Dr. WlHoechst Marion Roussel Germany GmbH HMR98/L013 Dr. Wl
Beschreibung
. 5 Miniaturisierte Mikrotiterplatte für das HTS-ScreeningDescription
. 5 Miniaturized microtiter plate for HTS screening
Die Erfindung betrifft eine miniaturisierte Mikrotiterplatte für das HTS-Screening (High Throughput Screening).The invention relates to a miniaturized microtiter plate for HTS screening (High Throughput Screening).
&iacgr;&ogr; Bei diesem Screening ist es wünschenswert, den Verbrauch von Assaykomponenten sowie von den Substanzen aus den Screening-Libraries möglichst niedrig zu halten und den Durchsatz von Screeningassays möglichst hoch. Dies kann durch eine Miniaturisierung von Screeningassays erreicht werden. Hierbei ist es jedoch notwendig, entsprechende Mikrotiterplatten zu befüllen, die ein Assayvolumen von etwa 1 bis 2 &mgr;&Igr; aufweisen. Verfügbar sind bisher erst wenige Prototypen, die nur von bestimmten Analysengeräten verarbeitet werden können. Benötigt werden jedoch Mikrotiterplatten, die eine Analyse mit sehr empfindlichen Detektoren (mit konvokaler Optik) ermöglichen und die die Befüllung mit „Nanodispensern" erlauben. Ferner wünschenswert ist zudem ein Verdunstungsschutz.&iacgr;&ogr; In this screening, it is desirable to keep the consumption of assay components and substances from the screening libraries as low as possible and the throughput of screening assays as high as possible. This can be achieved by miniaturizing screening assays. However, it is necessary to fill appropriate microtiter plates that have an assay volume of around 1 to 2 μλ. So far, only a few prototypes are available, which can only be processed by certain analytical devices. However, microtiter plates are required that enable analysis with very sensitive detectors (with convective optics) and that allow filling with "nanodispensers". Evaporation protection is also desirable.
) Bekannt sind Mikrotiterplatten der Fa. Greiner, 64943 Hirschberg, (Micro-Assay-Plate, 1536 wells). Hier ist das Arbeitsvolumen der Probenträger relativ hoch (4-8 &mgr;&Igr;) und sie erlauben keine „Single Molecule Detection". Das Arbeitsvolumen der Mikrotiterplatten von Corning Costar (Corning Costar Deutschland, 55924 Bodenheim) liegt zwar zwischen 1 bis 2 &mgr;&Igr;, allerdings ist der Rahmen der Mikrotiterplatten zu dünn, so daß übliche Robotersysteme die Mikrotiterplatten nicht transportieren können. Auch hier ist eine „Single Molecular Detection" nicht möglich.) Microtiter plates from Greiner, 64943 Hirschberg, (micro-assay plate, 1536 wells) are well known. Here, the working volume of the sample carrier is relatively high (4-8 μλ) and they do not allow for "single molecule detection". The working volume of the microtiter plates from Corning Costar (Corning Costar Germany, 55924 Bodenheim) is between 1 and 2 μλ, but the frame of the microtiter plates is too thin, so that conventional robot systems cannot transport the microtiter plates. Here, too, "single molecular detection" is not possible.
Hier will die Erfindung Abhilfe schaffen.This is where the invention aims to remedy the situation.
2
Erfindungsgemäß geschieht dies durch eine miniaturisierte Mikrotiterplatte mit einer
Größe von 12,7 &khgr; 8,5 cm, die dadurch gekennzeichnet ist, daß die Mikrotiterplatte
(Körper aus Kunststoff, Boden aus Glas), 1536 runde Gefäße (Wells) hat, der
Durchmesser der Gefäße (Wells) ungefähr 1,2 bis 1,5 mm ist, der Boden der
Mikrotiterplatte aus Glas besteht und eine Schichtdicke von 0,07 - 0,2 mm, bevorzugt 0,14 mm, aufweist und die Mikrotiterplatte einen Deckel als
Verdunstungsschutz hat. 2
According to the invention, this is done by means of a miniaturized microtiter plate with a size of 12.7 x 8.5 cm, which is characterized in that the microtiter plate (body made of plastic, bottom made of glass) has 1536 round vessels (wells), the diameter of the vessels (wells) is approximately 1.2 to 1.5 mm, the bottom of the microtiter plate is made of glass and has a layer thickness of 0.07 - 0.2 mm, preferably 0.14 mm, and the microtiter plate has a lid as evaporation protection.
Bei der Herstellung von Mikrotiterplatten ist es wichtig, das richtige Material zu &iacgr;&ogr; verwenden. Der Körper der Mikrotiterplatte besteht aus Kunststoff, wie z.B. Polystyrol, Polypropylen, Polycarbonat, Vectra, Hostalen. Die Mikrotiterplatten werden in der Regel im Spritzgußverfahren hergestellt. Nach dem Spritzen kühlt der Kunststoff ab. Dabei kann sich die Mikrotiterplatte verbiegen (da die Abkühlung lokal unterschiedlich schnell erfolgt). Somit ist es günstig ein Material zu verwenden, das nur eine sehr geringe „Verkrümmung" erzeugt.When manufacturing microtiter plates, it is important to use the right material. The body of the microtiter plate is made of plastic, such as polystyrene, polypropylene, polycarbonate, Vectra, Hostalen. The microtiter plates are usually manufactured using an injection molding process. After injection molding, the plastic cools down. This can cause the microtiter plate to bend (since cooling occurs at different speeds locally). It is therefore advisable to use a material that only produces very little "warping".
Der Deckel der Mikrotiterplatte ist ebenfalls aus Kunststoff und sitzt auf der Mikrotiterplatte formschlüssig auf. Die Schichtdicke des Bodens (Material: Glas) der Mikrotiterplatte (0,07 - 0,20 mm) als auch der Durchmesser der Gefäße (ca. 1,2 -1,5 mm) erlauben die Analyse der Mikrotiterplatte mit Hilfe einer konvokalen Optik. Die Verwendung einer konvokalen Optik hat folgende Vorteile:The lid of the microtiter plate is also made of plastic and sits on the microtiter plate in a form-fitting manner. The layer thickness of the base (material: glass) of the microtiter plate (0.07 - 0.20 mm) as well as the diameter of the vessels (approx. 1.2 -1.5 mm) allow the analysis of the microtiter plate using convective optics. The use of convective optics has the following advantages:
) 1. Die Sensitivität ist sehr hoch (im Vergleich zu nicht konvokalen Optiken), da u. U. sogar einzelne Moleküle detektiert werden können (Single Molecule Detection)) 1. The sensitivity is very high (compared to non-conductive optics), since even individual molecules can be detected (single molecule detection)
2. Aufgrund der hohen Sensitivität kann die Meßzeit niedriger sein und somit die gesamte Analysegeschwindigkeit einer Mikrotiterplatte erhöht werden (im Vergleich zu vielen nicht konvokalen Optiken).2. Due to the high sensitivity, the measurement time can be shorter and thus the overall analysis speed of a microtiter plate can be increased (compared to many non-conductive optics).
3. Da der Focus einer konvokalen Optik sehr klein ist (meist deutlich unter 10 pm), ist die Detektion von Hintergrundsignalen stark reduziert und somit das Signal/Rauschverhältnis besser (im Vergleich zu nicht konvokalen Optiken).3. Since the focus of a convective optic is very small (usually well below 10 pm), the detection of background signals is greatly reduced and thus the signal-to-noise ratio is better (compared to non-convective optics).
Die Anzahl der Gefäße (Wells) der miniaturisierten Mikrotiterplatte kann auch variieren.The number of wells in the miniaturized microtiter plate can also vary.
Im folgenden werden mögliche Ausgestaltungen der erfindungsgemäßen Mikrotiterplatte anhand der Figuren 1 bis 3 näher beschrieben.Possible embodiments of the microtiter plate according to the invention are described in more detail below with reference to Figures 1 to 3.
Fig. 1: Perspektivische Darstellung der Mikrotiterplatte mit abgehobenem Deckel Fig. 2: Schnitt gemäß Ebene M-Il aus Fig. 1Fig. 1: Perspective view of the microtiter plate with the lid removed Fig. 2: Section along plane M-II of Fig. 1
Fig. 3: Schnitt gemäß Ebene Ill-Ill aus Fig. 1Fig. 3: Section along plane III-III of Fig. 1
In Fig. 1 ist die Mikrotiterplatte mit den Gefäßen (3) perspektivisch dargestellt. Der Rahmen (1) hat eine Länge von a = 127 mm und eine Breite von b = 85 mm. Der Deckel (4) mit den Vorsprüngen (5) ist in abgehobenem Zustand gezeigt.In Fig. 1, the microtiter plate with the vessels (3) is shown in perspective. The frame (1) has a length of a = 127 mm and a width of b = 85 mm. The lid (4) with the projections (5) is shown in the lifted off state.
In Fig. 2 ist ein Schnitt gemäß Ebene H-Il dargestellt. Der Glasboden (2) ist unter der Mikrotiterplatte befestigt. Der Randabstand (al) beträgt 3-8 mm, bevorzugt 6 mm, und der Abstand (a2) 6-11 mm, bevorzugt 9,5 mm. Der entsprechende Randabstand (b1) in Fig. 3 beträgt ebenfalls 3-8 mm, bevorzugt 6 mm, und der Abstand (b2) 4-9 mm, bevorzugt 6,5 mm. Die Rahmenhöhe der MikrotiterplatteIn Fig. 2, a section according to plane H-II is shown. The glass bottom (2) is attached under the microtiter plate. The edge distance (al) is 3-8 mm, preferably 6 mm, and the distance (a2) is 6-11 mm, preferably 9.5 mm. The corresponding edge distance (b1) in Fig. 3 is also 3-8 mm, preferably 6 mm, and the distance (b2) is 4-9 mm, preferably 6.5 mm. The frame height of the microtiter plate
beträgt c = 6 -15 mm, bevorzugt 6 mm, und die Innenhöhe c1 3-12 mm, bevorzugt ) 3 mm. Der Gefäßdurchmesser (d) liegt zwischen 1,0 und 1,5 mm, bevorzugt bei 1,3 mm, der Gefäßabstand (a3) bei 2,25 mm und die Gefäßhöhe (h) zwischen 2,0 und 7,0 mm.is c = 6 -15 mm, preferably 6 mm, and the internal height c1 3-12 mm, preferably ) 3 mm. The vessel diameter (d) is between 1.0 and 1.5 mm, preferably 1.3 mm, the vessel spacing (a3) is 2.25 mm and the vessel height (h) is between 2.0 and 7.0 mm.
Claims (1)
gekennzeichnet, daß die Mikrotiterplatte (Körper aus Kunststoff, Boden aus Glas),
1536 runde Gefäße (Wells) (3) hat, der Durchmesser der Gefäße (Wells) (d) 1,2 bis 1,5 mm ist, der Boden der Mikrotiterplatte (2) aus Glas besteht und eine
Schichtdicke von 0,07 - 0,2 mm aufweist und die Mikrotiterplatte einen Deckel (4) als1. Miniaturized microtiter plate with a size of 12.7 x 8.5 cm, thereby
characterized in that the microtiter plate (body made of plastic, bottom made of glass),
1536 round wells (3), the diameter of the wells (d) is 1.2 to 1.5 mm, the bottom of the microtiter plate (2) is made of glass and a
layer thickness of 0.07 - 0.2 mm and the microtiter plate has a lid (4) as
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE29805613U DE29805613U1 (en) | 1998-03-27 | 1998-03-27 | Miniaturized microtiter plate for HTS screening |
| DE19818481A DE19818481A1 (en) | 1998-03-27 | 1998-04-24 | Micro-titration plate with glass base and plastic body |
| CA002326107A CA2326107C (en) | 1998-03-27 | 1999-03-17 | Miniaturized microtiter plate for high throughput screening |
| DE59903746T DE59903746D1 (en) | 1998-03-27 | 1999-03-17 | MINIATURIZED MICROTITER PLATE FOR HIGH-PERFORMANCE SCREENING |
| JP2000540932A JP4499918B2 (en) | 1998-03-27 | 1999-03-17 | Miniaturized microtiter plate for high-throughput screening |
| EP99915629A EP1066112B1 (en) | 1998-03-27 | 1999-03-17 | Miniaturized microtiter plate for high throughput screening |
| PCT/EP1999/001729 WO1999049973A1 (en) | 1998-03-27 | 1999-03-17 | Miniaturized microtiter plate for high throughput screening |
| AU34134/99A AU3413499A (en) | 1998-03-27 | 1999-03-17 | Miniaturized microtiter plate for high throughput screening |
| AT99915629T ATE229373T1 (en) | 1998-03-27 | 1999-03-17 | MINIATURIZED MICROTITER PLATE FOR HIGH-THROUGHPUT SCREENING |
| ES99915629T ES2184434T3 (en) | 1998-03-27 | 1999-03-17 | MINIATURIZED MICROTITULATION PLATE FOR EXPLORATION OF HIGH PERFORMANCE. |
| DK99915629T DK1066112T3 (en) | 1998-03-27 | 1999-03-17 | Miniature microtiter plate for high capacity screening |
| PT99915629T PT1066112E (en) | 1998-03-27 | 1999-03-17 | MINIATURIZED MICROTITULATION PLATE FOR SELECTING HIGH DEBIT |
| US11/121,536 US20050255580A1 (en) | 1998-03-27 | 2005-05-02 | Miniaturized microtiter plate for HT-screening |
| US12/127,965 US7951337B2 (en) | 1998-03-27 | 2008-05-28 | Miniaturized microtiter plate for HT-screening |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE29805613U DE29805613U1 (en) | 1998-03-27 | 1998-03-27 | Miniaturized microtiter plate for HTS screening |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE29805613U1 true DE29805613U1 (en) | 1998-05-28 |
Family
ID=8054897
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE29805613U Expired - Lifetime DE29805613U1 (en) | 1998-03-27 | 1998-03-27 | Miniaturized microtiter plate for HTS screening |
| DE19818481A Withdrawn DE19818481A1 (en) | 1998-03-27 | 1998-04-24 | Micro-titration plate with glass base and plastic body |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19818481A Withdrawn DE19818481A1 (en) | 1998-03-27 | 1998-04-24 | Micro-titration plate with glass base and plastic body |
Country Status (1)
| Country | Link |
|---|---|
| DE (2) | DE29805613U1 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE29919861U1 (en) | 1999-11-11 | 2000-02-24 | Studiengesellschaft Kohle mbH, 45481 Mülheim | Spot plate for parallelized crystallization and X-ray diffractometric analysis of solids |
| DE19852947A1 (en) * | 1998-11-12 | 2000-05-18 | Univ Schiller Jena | Micro-liter automatic dispensing apparatus comprises needle moving vertically to penetrate cover over micro-titration plate, to dispense liquid into cells |
| DE19943443A1 (en) * | 1999-09-11 | 2001-04-12 | Inst Mikrotechnik Mainz Gmbh | Device and method for the planarization of titer plates in screening and synthesis systems |
| US6821787B2 (en) | 2000-11-17 | 2004-11-23 | Thermogenic Imaging, Inc. | Apparatus and methods for infrared calorimetric measurements |
| US6835574B2 (en) | 2000-11-17 | 2004-12-28 | Flir Systems Boston, Inc. | Apparatus and methods for infrared calorimetric measurements |
| US6982431B2 (en) | 1998-08-31 | 2006-01-03 | Molecular Devices Corporation | Sample analysis systems |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE20100345U1 (en) | 2001-01-09 | 2002-05-23 | EVOTEC BioSystems AG, 22525 Hamburg | sample carrier |
| DE10117723A1 (en) * | 2001-04-09 | 2002-10-17 | Evotec Ag | Carrier for biological or synthetic samples has a sample holding plate with reservoirs and a dosing plate with projections, fitted with membranes, of an optically transparent material with trouble-free light beam transparency |
| DE102004041941B4 (en) * | 2004-08-30 | 2007-01-11 | P.A.L.M. Microlaser Technologies Ag | Method for obtaining biological objects with a recording unit |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4824230A (en) * | 1985-12-13 | 1989-04-25 | E. I. Du Pont De Nemours And Company | Visualization device |
| DE19628178C1 (en) * | 1996-07-12 | 1997-09-18 | Bruker Franzen Analytik Gmbh | Loading matrix-assisted laser desorption-ionisation sample plate for mass spectrometric analysis |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2633293A1 (en) * | 1976-07-23 | 1978-01-26 | Bayer Ag | Dispersions of polyaddition prods. of polyisocyanates in hydroxy cpds. - useful as polyol components for prodn. of polyurethanes, by reaction with polyisocyanates |
| US4725388A (en) * | 1982-10-12 | 1988-02-16 | Dynatech Laboratories, Inc. | Non-fluorescent vessels for holding test samples in fluorescent assays |
| EP0449434A3 (en) * | 1990-03-30 | 1992-03-04 | Beckman Instruments, Inc. | Multi-cell module for spectrophotometry |
| US5487872A (en) * | 1994-04-15 | 1996-01-30 | Molecular Device Corporation | Ultraviolet radiation transparent multi-assay plates |
-
1998
- 1998-03-27 DE DE29805613U patent/DE29805613U1/en not_active Expired - Lifetime
- 1998-04-24 DE DE19818481A patent/DE19818481A1/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4824230A (en) * | 1985-12-13 | 1989-04-25 | E. I. Du Pont De Nemours And Company | Visualization device |
| DE19628178C1 (en) * | 1996-07-12 | 1997-09-18 | Bruker Franzen Analytik Gmbh | Loading matrix-assisted laser desorption-ionisation sample plate for mass spectrometric analysis |
Non-Patent Citations (2)
| Title |
|---|
| LEMMO,Anthony V., et.al.: Characterization of an Inkjet Chemical Microdispenser for Combinatorial Library Synthesis. In: Anal. Chem. 1997, 69, S.543-551 * |
| Prospekt: Specialist Micro Titer Plates & Accessories der Fa. Radleys, 1997 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6982431B2 (en) | 1998-08-31 | 2006-01-03 | Molecular Devices Corporation | Sample analysis systems |
| DE19852947A1 (en) * | 1998-11-12 | 2000-05-18 | Univ Schiller Jena | Micro-liter automatic dispensing apparatus comprises needle moving vertically to penetrate cover over micro-titration plate, to dispense liquid into cells |
| DE19943443A1 (en) * | 1999-09-11 | 2001-04-12 | Inst Mikrotechnik Mainz Gmbh | Device and method for the planarization of titer plates in screening and synthesis systems |
| DE29919861U1 (en) | 1999-11-11 | 2000-02-24 | Studiengesellschaft Kohle mbH, 45481 Mülheim | Spot plate for parallelized crystallization and X-ray diffractometric analysis of solids |
| US6821787B2 (en) | 2000-11-17 | 2004-11-23 | Thermogenic Imaging, Inc. | Apparatus and methods for infrared calorimetric measurements |
| US6835574B2 (en) | 2000-11-17 | 2004-12-28 | Flir Systems Boston, Inc. | Apparatus and methods for infrared calorimetric measurements |
| US6991765B2 (en) | 2000-11-17 | 2006-01-31 | Flir Systems Boston, Inc. | Apparatus and methods for infrared calorimetric measurements |
Also Published As
| Publication number | Publication date |
|---|---|
| DE19818481A1 (en) | 1999-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R207 | Utility model specification |
Effective date: 19980709 |
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| R163 | Identified publications notified |
Effective date: 19980702 |
|
| R150 | Utility model maintained after payment of first maintenance fee after three years |
Effective date: 20010321 |
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| R151 | Utility model maintained after payment of second maintenance fee after six years |
Effective date: 20040513 |
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| R081 | Change of applicant/patentee |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE Free format text: FORMER OWNER: HOECHST MARION ROUSSEL DEUTSCHLAND GMBH, 65929 FRANKFURT, DE Effective date: 20060313 |
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| R152 | Utility model maintained after payment of third maintenance fee after eight years |
Effective date: 20060413 |
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| R071 | Expiry of right |