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DE29714206U1 - Pipetting robot with improved temperature control device - Google Patents

Pipetting robot with improved temperature control device

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Publication number
DE29714206U1
DE29714206U1 DE29714206U DE29714206U DE29714206U1 DE 29714206 U1 DE29714206 U1 DE 29714206U1 DE 29714206 U DE29714206 U DE 29714206U DE 29714206 U DE29714206 U DE 29714206U DE 29714206 U1 DE29714206 U1 DE 29714206U1
Authority
DE
Germany
Prior art keywords
temperature control
control device
unset
pipetting
vol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE29714206U
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Hoechst Marion Roussel Deutschland GmbH
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE29714206U priority Critical patent/DE29714206U1/en
Application filed by Hoechst Marion Roussel Deutschland GmbH, Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Deutschland GmbH
Publication of DE29714206U1 publication Critical patent/DE29714206U1/en
Priority to DK98114306T priority patent/DK0895813T3/en
Priority to EP98114306A priority patent/EP0895813B1/en
Priority to DE59811623T priority patent/DE59811623D1/en
Priority to ES98114306T priority patent/ES2222538T3/en
Priority to PT98114306T priority patent/PT895813E/en
Priority to AT98114306T priority patent/ATE270151T1/en
Priority to US09/129,784 priority patent/US6558627B1/en
Priority to AU78869/98A priority patent/AU7886998A/en
Priority to JP10224014A priority patent/JPH11143551A/en
Priority to CA002245266A priority patent/CA2245266C/en
Priority to US10/387,477 priority patent/US20030170910A1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/02—Water baths; Sand baths; Air baths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G01N2035/00386—Holding samples at elevated temperature (incubation) using fluid heat transfer medium
    • G01N2035/00396—Holding samples at elevated temperature (incubation) using fluid heat transfer medium where the fluid is a liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Manipulator (AREA)
  • Temperature-Responsive Valves (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)

Description

Hoechst Marion Roussel Deutschland GmbH HMR 97/L 207 G Dr. WNHoechst Marion Roussel Deutschland GmbH HMR 97/L 207 G Dr. WN

Beschreibung
5Description
5

Pipettierroboter mit verbesserter TemperiervorrichtungPipetting robot with improved temperature control device

Die Erfindung betrifft eine plattenförmige Temperiervorrichtung für Pipettierroboter zur Aufnahme von Mikrotiterplatten.The invention relates to a plate-shaped temperature control device for pipetting robots for holding microtiter plates.

Temperiervorrichtungen für Pipettierroboter sind bekannt, beispielsweise von der Firma Beckmann Instruments GmbH, Frankfurter Ring 116, D-80810 München, die die Pipettierroboter unter dem Namen BIOMEK 2000 vertreibt. Auf diese Pipettierroboter wird in der vorliegenden Anmeldung ausdrücklich Bezug genommen. Solche Roboter werden in der pharmazeutischen Industrie beispielsweise zum Austesten von unbekannten Substanzen (Screening Tests) eingesetzt. Sie umfassen Temperiervorrichtungen für Behältnisse für die unbekannten Substanzen, die auf sogenannten Mikrotiterplatten angeordnet sind, sowie über Programmiersprachen bzw. Programmcodes ansteuerbare Pipettiervorrichtungen zum Befüllen dieser Behältnisse. Mit den Temperiervorrichtungen werden die unbekannten Substanzen bei den Screening Tests während des Pipettiervorganges auf konstanter Temperatur gehalten. Die bekannten Temperiervorrichtungen sind mittels Peltierelementen temperierbar, d.h. beheiz- oder kühlbar und weisen zwei Segmente zur Aufnahme von Mikrotiterplatten auf. Die bekannte Temperiervorrichtung hat die Nachteile, daß sie nur für Mikrotiterplatten eines bestimmten Formats geeignet ist und daß sie die zur Verfugung stehende Arbeitsfläche des Pipettierroboters, das ist die Fläche, die von der Pipettiervorrichtung erreichbar ist, nicht vollständig ausnutzt.Temperature control devices for pipetting robots are known, for example from the company Beckmann Instruments GmbH, Frankfurter Ring 116, D-80810 Munich, which sells the pipetting robots under the name BIOMEK 2000. This application expressly refers to these pipetting robots. Such robots are used in the pharmaceutical industry, for example, for testing unknown substances (screening tests). They include temperature control devices for containers for the unknown substances, which are arranged on so-called microtiter plates, as well as pipetting devices that can be controlled via programming languages or program codes for filling these containers. The temperature control devices are used to keep the unknown substances at a constant temperature during the pipetting process in the screening tests. The known temperature control devices can be temperature controlled using Peltier elements, i.e. can be heated or cooled, and have two segments for holding microtiter plates. The known temperature control device has the disadvantages that it is only suitable for microtiter plates of a certain format and that it does not fully utilize the available working area of the pipetting robot, i.e. the area that can be reached by the pipetting device.

Hier will die Erfindung eine Verbesserung vorgeben.This is where the invention aims to provide an improvement.

Diese Aufgabe wird erfindungsgemäß dadurch gelöst, daß die Temperiervorrichtung eine Rohrschlange für ein Temperiermedium aufweist und in mindestens drei Segmente zur Aufnahme der Mikrotiterplatten unterteilt ist.This object is achieved according to the invention in that the temperature control device has a pipe coil for a temperature control medium and is divided into at least three segments for receiving the microtiter plates.

Gegenstand der Erfindung ist daher eine plattenförmige Temperiervorrichtung für Pipettierroboter zur Aufnahme von Mikrotiterplatten, dadurch gekennzeichnet, daß die Temperiervorrichtung eine Rohrschlange für ein Temperiermedium aufweist und in mindestens drei Segmente zur Aufnahme der Mikrotiterpiatten unterteilt ist. 5The subject of the invention is therefore a plate-shaped temperature control device for pipetting robots for holding microtiter plates, characterized in that the temperature control device has a pipe coil for a temperature control medium and is divided into at least three segments for holding the microtiter plates. 5

Eine erste bevorzugte Ausgestaltung ist eine Temperiervorrichtung aufweisend ein Oberteil und einem Unterteil, die beide als rechteckige Platten ausgebildet sind, die aufeinandergelegt die Temperiervorrichtung bilden, dadurch gekennzeichnet, daß in das Oberteil in die Seite, die dem Unterteil gegenüberliegt, Nuten so eingearbeitet sind, daß diese Seite in mindestens drei Segmente zur Aufnahme von Mikrotiterplatten unterteilt ist. Eine zweite bevorzugte Ausgestaltung ist eine Temperiervorrichtung, aufweisend ein Oberteil und einem Unterteil, die beide als rechteckige Platten ausgebildet sind, die aufeinandergelegt die Temperiervorrichtung bilden, wobei die Oberfläche des Unterteils, die mit dem Oberteil in Kontakt ist, eine Rinne aufweist ist, die im zusammengebauten Zustand wie eine Rohrschlange wirkt.A first preferred embodiment is a temperature control device having an upper part and a lower part, both of which are designed as rectangular plates, which when placed one on top of the other form the temperature control device, characterized in that grooves are machined into the side of the upper part that is opposite the lower part, so that this side is divided into at least three segments for receiving microtiter plates. A second preferred embodiment is a temperature control device having an upper part and a lower part, both of which are designed as rectangular plates, which when placed one on top of the other form the temperature control device, wherein the surface of the lower part that is in contact with the upper part has a groove that acts like a pipe coil when assembled.

Oberteil und Unterteil können beispielsweise mit Schrauben oder anderen geläufigen Befestigungsmittein miteinander verbunden sein.The upper and lower parts can be connected to each other using screws or other common fastening elements.

Gegenstand der Erfindung ist auch ein Pipettierroboter, aufweisend eine erfindungsgemäße Temperiervorrichtung.The invention also relates to a pipetting robot comprising a temperature control device according to the invention.

Die bekannten programmierbaren Pipettierroboter können jedoch die erfindungsgemäße Temperiervorrichtung aufgrund ihrer Programmierung nicht vollständig nutzen, d.h. bedienen, so daß nicht alle Behältnisse von der Pipettiervorrichtung befüllt werden können.However, the known programmable pipetting robots cannot fully use, i.e. operate, the tempering device according to the invention due to their programming, so that not all containers can be filled by the pipetting device.

Der Erfindung lag daher zusätzlich die Aufgabe zugrunde, diesem Nachteil abzuhelfen.
30The invention was therefore also based on the object of remedying this disadvantage.
30

Gegenstand der Erfindung ist daher weiter ein programmierbarer Pipettierroboter, aufweisend eine erfindungsgemäße Temperiervorrichtung zur Aufnahme von Mikrotiterplatten, die Behältnisse für Flüssigkeiten aufweisen, sowie eine über eineThe subject of the invention is therefore a further programmable pipetting robot, having a temperature control device according to the invention for receiving microtiter plates which have containers for liquids, as well as a

Programmiersprache ansteuerbare Pipettiervorrichtung, wobei der Pipettierroboter so programmiert ist, daß, wenn die Temperiervomchtung und die Mikrotiterplatten bestimmungsgemäß angeordnet sind, mit der Pipettiervorrichtung in jedes der Behältnisse eine Flüssigkeit gefüiit werden kann.
5Pipetting device that can be controlled using a programming language, wherein the pipetting robot is programmed in such a way that, when the temperature control device and the microtiter plates are arranged as intended, a liquid can be filled into each of the containers using the pipetting device.
5

Im folgenden wird eine bevorzugte Ausgestaltung der erfindungsgemäßen Temperiervorrichtung anhand der Figur näher erläutert. Eine Beschränkung der Erfindung in irgendeiner Weise ist dadurch nicht beabsichtigt.A preferred embodiment of the temperature control device according to the invention is explained in more detail below with reference to the figure. This is not intended to limit the invention in any way.

Die bevorzugte Ausführungsform ist in der Figur perspektivisch dargestellt. Sie ist dadurch gekennzeichnet, daß die Temperiervorrichtung 1 aus einem Oberteil 2 und einem Unterteil 3 besteht, die beide als rechteckige Platten ausgebildet sind, die aufeinandergelegt die Temperiervomchtung 1 bilden, wobei in die Oberfläche 9 des Unterteils 3, die mit dem Oberteil 2 in Kontakt ist, eine Rinne 5 eingearbeitet ist, die im zusammengebauten Zustand wie eine Rohrschlange wirkt. Die Rohrschlange 5 hat einen Eingang 6 und einen Ausgang 7 für eine Heiz- oder Kühlmedum, je nach Anwendung. In das Oberteil 2 sind in die Seite 10, die dem Unterteil 3 gegenüberliegt, Nuten 4 so eingearbeitet sind, daß diese Seite 10 in drei Segmente 8 zur Aufnahme von Mikrotiterplatten unterteilt ist.The preferred embodiment is shown in perspective in the figure. It is characterized in that the temperature control device 1 consists of an upper part 2 and a lower part 3, both of which are designed as rectangular plates, which, when placed on top of one another, form the temperature control device 1, with a groove 5 being incorporated into the surface 9 of the lower part 3, which is in contact with the upper part 2, which acts like a pipe coil when assembled. The pipe coil 5 has an inlet 6 and an outlet 7 for a heating or cooling medium, depending on the application. Grooves 4 are incorporated into the side 10 of the upper part 2, which is opposite the lower part 3, in such a way that this side 10 is divided into three segments 8 for accommodating microtiter plates.

Eine weitere Unterteilung in mehr als drei Segmente 8 ist ohne weiteres möglich.A further subdivision into more than three segments 8 is easily possible.

Im folgenden wird ein beispielhaftes Programm zum erfindungsgemäßen Ansteuern eines Pipettierroboters vorgestellt. Es wurde in der Programmiersprache TCL geschrieben, die von der Fa. Beckmann für derartige Anwendungen vorgeschlagen wird und über das Internet zugänglich ist.An example program for controlling a pipetting robot according to the invention is presented below. It was written in the TCL programming language, which is recommended by Beckmann for such applications and is accessible via the Internet.

# Universal - TCL - Script zum einmaligen Abgeben von Voluminas. ## Universal - TCL - script for one-time delivery of volumes. #

#
# Beim Definieren von eigenen Variablen Bitte auf Gross/Klein-#
# When defining your own variables, please use uppercase/lowercase

# Schreibung achten !!!
## Pay attention to spelling!!!
#

## Soli ein Tip_touchSoli a Tip_touch erfolgentake place 0 = Nein0 = No ## Und wenn Ja wo ?And if so, where? ## Nur Quelle, nur Ziel oder beidesSource only, destination only or both ## 1 = Ja /1 = Yes / setset quelle_tip_touch 1source_tip_touch 1 setset ziel_tip_touch 1target_tip_touch 1 ##

# Ab hier kommen die gewuenschten Voluminas# From here come the desired volumes

set disp_vol 100 ' ■'■set disp_vol 100 ' ■'■

set bias_vol #set bias_vol #

# wenn deliver_voi dann kein blow_out # set deliver_vol # # blowout = 0 kein blowout!! # set blowout_voi 0 ## if deliver_voi then no blow_out # set deliver_vol # # blowout = 0 no blowout!! # set blowout_voi 0 #

# berrechne aufzunehmendes Volumen, wenn grosser m_vol # dann abbrechen des Scripts# calculate volume to be recorded, if large m_vol # then abort the script

if { $deliver_vol > 1 } {set blowout_vol 0} if { $blowout_voi > 1 } {set deiiver_vol 0} set asp_vol [expr $disp_voi+$bias_voi+$deliver_vol+$blow.out_vol] #if { $deliver_vol > 1 } {set blowout_vol 0} if { $blowout_voi > 1 } {set deiiver_vol 0} set asp_vol [expr $disp_voi+$bias_voi+$deliver_vol+$blow.out_vol] #

# Ab hier stehen die Pipetten Parameter# From here on the pipette parameters are

# Abhaengig von verwendeter Pipette# Depends on pipette used

# MP200 slope: 0.0838 / offset: 0.05 / m_voi set m_vol 240 set slope 0.0838 set offset 0.05# MP200 slope: 0.0838 / offset: 0.05 / m_voi set m_vol 240 set slope 0.0838 set offset 0.05

# Ab hier kommen die Koordinaten für das Queilgefaess# From here come the coordinates for the Quenching vessel

##

# Quelle : MTP auf Position B3 set quelle_x 77050 set quei!e_y 41401 set quelle_sicher_move 32000 5 set quelle_asp_high 30700 set quelie_disp_high 31000 set quelle_touch_x set quelle_touch_high 31200 ## Source: MTP at position B3 set source_x 77050 set quei!e_y 41401 set source_safe_move 32000 5 set source_asp_high 30700 set quelie_disp_high 31000 set source_touch_x set source_touch_high 31200 #

# Ab hier kommen die Koordinaten des Zielgefaesses# From here come the coordinates of the target vessel

# Ziel: Deep Well auf Position A4# Target: Deep Well at position A4

set ziel_x 90960 set ziel_y 26201 set ziel_sicher_move 32300 set ziei_disp_high 31000 set ziel_touch_x set ziel_touch_high 31600set target_x 90960 set target_y 26201 set target_safe_move 32300 set target_disp_high 31000 set target_touch_x set target_touch_high 31600

# Ab hier duerfen keine Veraenderungen mehr vorgenommen# From here on no further changes may be made

# werden!!!# become!!!

set sicher_move [expr $quelle_sicher_move*1 ] if {$que!!e_sicher_move < $zie!_sicher_move} { set sicher_move [expr $ziel_sicher_move*1 ]set safe_move [expr $source_safe_move*1 ] if {$que!!e_safe_move < $zie!_safe_move} { set safe_move [expr $target_safe_move*1 ]

# Umrechnen in die BIOMEK-Koordinaten ## Convert to BIOMEK coordinates #

set BIAS [expr int((($bias_vol*100*$slope+($offset*100))+0.5)*-1)] set DISPENSE [expr int((($disp_vol*100*$slope+($offset*100))+0.5)*-1)] set DELIVERO
if {$deliver_vol > 1}{
set DELIVER [expr int((($deliver_vol*100*$slope+($offset*100))+0.5)*-1)]set BIAS [expr int((($bias_vol*100*$slope+($offset*100))+0.5)*-1)] set DISPENSE [expr int((($disp_vol*100*$slope+($offset*100))+0.5)*-1)] set DELIVERO
if {$deliver_vol > 1}{
set DELIVER [expr int((($deliver_vol*100*$slope+($offset*100))+0.5)*-1)]

set BLOWOUT O
set GET_BLOWOUT 0
if {$blowout_vol > 1} {set BLOWOUT O
set GET_BLOWOUT 0
if {$blowout_vol > 1} {

set BLOWOUT [expr int((($blowout_vol*100*$slope+($offset*100))+0.5)*-1)] set GET_BLOWOUT [expr abs($BLOWOUT)]set BLOWOUT [expr int((($blowout_vol*100*$slope+($offset*100))+0.5)*-1)] set GET_BLOWOUT [expr abs($BLOWOUT)]

set ASPIRATE [ expr abs($DISPENSE)+abs($BiAS)+abs($DELIVER) ] #
# set speed upset ASPIRATE [ expr abs($DISPENSE)+abs($BiAS)+abs($DELIVER) ] #
# setspeedup

SX 650SX650

SY 650SY650

#
# move to destination labware#
# move to destination labware

MA 0 0 $sicher_moveMA 0 0 $safe_move

if {$b!owout_vol > 1} {MT $GET_BLOWOUT}if {$b!owout_vol > 1} {MT $GET_BLOWOUT}

MA $quelle_x $quel!e_y MA O O $quelle_asp_high #MA $source_x $source_y MA O O $source_asp_high #

# get volumen ## get volume #

MS TT 11 20 0 MT $ASPIRATE MS TT 11 20 0 MT $BIAS if {$quelle_tip_touch > 0} { MA 0 0 $quelie_touch_high MS TT 11 10 0 MV $quelle_touch_x 0 MS TT 11 20 0 MV [ expr $queile_touch_x * -1 ] 0MS TT 11 20 0 MT $ASPIRATE MS TT 11 20 0 MT $BIAS if {$quelle_tip_touch > 0} { MA 0 0 $quelie_touch_high MS TT 11 10 0 MV $quelle_touch_x 0 MS TT 11 20 0 MV [ expr $queile_touch_x * -1 ] 0

MA 0 0 $sicher_moveMA 0 0 $safe_move

# move to source ## movetosource #

MA $ziel_x $ziel_y MS TT 11 10 0 MA 0 0 $ziel_disp_high MS TT 11 20 0 MT$DiSPENSE if {$blowout_vol > 0} {MT $BLOWOUT} if {$ziel_tip_touch > 0} { MA 0 0 $ziel_touch_high MSTT11 100 MV $ziel_touch_x 0 MS TT 11 20 0 MV [ expr $zie!_touch_x * -1 J 0MA $ziel_x $ziel_y MS TT 11 10 0 MA 0 0 $ziel_disp_high MS TT 11 20 0 MT$DiSPENSE if {$blowout_vol > 0} {MT $BLOWOUT} if {$ziel_tip_touch > 0} { MA 0 0 $ziel_touch_high MSTT11 100 MV $ziel_touch_x 0 MS TT 11 20 0 MV [ expr $zie!_touch_x * -1 J 0

MS TT 11 10 0 MA 0 0 $sicher_move MA $quelle_x $quelle_y if {$deliver_vol > 0} { MSTT11 100 MA 0 0 $queile_disp_high MT $DELiVER MS TT 11 10 0 if {$quelle_tip_touch > 0} { MA 0 0 $quelle_touch_high MS TT 11 10 0 MV $quel!e_touch_x 0 MS TT 11 20 0 MV [ expr $quelle_touch_x * -1 ] 0 }MS TT 11 10 0 MA 0 0 $sicher_move MA $quelle_x $quelle_y if {$deliver_vol > 0} { MSTT11 100 MA 0 0 $queile_disp_high MT $DELiVER MS TT 11 10 0 if {$quelle_tip_touch > 0} { MA 0 0 $quelle_touch_high MS TT 11 10 0 MV $quel!e_touch_x 0 MS TT 11 20 0 MV [ expr $quelle_touch_x * -1 ] 0 }

MA 0 0 $sicher_moveMA 0 0 $safe_move

# speed down ##speeddown #

SX 500
SY 500
#SX500
SY500
#

# Alle initialisierten Variablen freigeben ## Release all initialized variables #

unset quelle_tip_touch unset ziel_tip_touch unset disp_vol unset bias_vol unset de!iver_vol unset blowout_vol unset asp_vol unset m volunset source_tip_touch unset target_tip_touch unset disp_vol unset bias_vol unset de!iver_vol unset blowout_vol unset asp_vol unset m vol

unset slopeunset slope

unset offsetunset offset

unset quelle_x unset quelle_y unset quelle_sicher_moveunset source_x unset source_y unset source_safe_move

unset queile_asp_highunset queile_asp_high

unset quelle_disp_highunset source_disp_high

unset quelle_touch_x unset quelle_touch_high unset ziel_xunset source_touch_x unset source_touch_high unset target_x

unset ziel_yunset target_y

unset ziei_sicher_moveunset ziei_sicher_move

unset ziel_disp_high unset ziel_touch_x unset ziel_touch_highunset target_disp_high unset target_touch_x unset target_touch_high

unset sicher_moveunset safe_move

unset BIASunset BIAS

unset DISPENSE unset DELIVER unset BLOWOUTunset DISPENSE unset DELIVER unset BLOWOUT

unset GET_BLOWOUTunset GET_BLOWOUT

unset ASPIRATEunset ASPIRATE

Claims (5)

10 Schutzansprüche10 Protection claims 1. Plattenförmige Temperiervorrichtung für Pipettierroboter zur Aufnahme von1. Plate-shaped temperature control device for pipetting robots for holding : Mikrotiterplatten, dadurch gekennzeichnet, daß die Temperiervorrichtung (1) : Microtiter plates, characterized in that the temperature control device (1) eine Rohrschlange (5) für ein Temperiermedium aufweist und in mindestens drei Segmente (8) zur Aufnahme der Mikrotiterplatten unterteilt ist.has a pipe coil (5) for a temperature control medium and is divided into at least three segments (8) for accommodating the microtiter plates. 2. Temperiervorrichtung nach Anspruch 1, aufweisend ein Oberteil (2) und einem Unterteil (3), die beide als rechteckige Platten ausgebildet sind, die aufeinandergelegt die Temperiervorrichtung (1) bilden, dadurch2. Temperature control device according to claim 1, comprising an upper part (2) and a lower part (3), both of which are designed as rectangular plates, which, when placed on top of one another, form the temperature control device (1), characterized ^ gekennzeichnet, daß in das Oberteil (2) in die Seite (6), die dem Unterteil (3)^ characterized in that in the upper part (2) in the side (6) which corresponds to the lower part (3) gegenüberliegt, Nuten (4) so eingearbeitet sind, daß diese Seite (6) ingrooves (4) are machined so that this side (6) in mindestens drei Segmente (8) zur Aufnahme von Mikrotiterplatten unterteilt ist. &igr;is divided into at least three segments (8) to accommodate microtiter plates. &igr; 3. Temperiervorrichtung nach Anspruch 1 oder 2, aufweisend ein Oberteil (2) und einem Unterteil (3), die beide als rechteckige Platten ausgebildet sind, die aufeinandergelegt die Temperiervorrichtung (1) bilden, wobei die Oberfläche (4) des Unterteils (3), die mit dem Oberteil (2) in Kontakt ist, eine Rinne (5) aufweist ist, die im zusammengebauten Zustand wie eine Rohrschlange wirkt.3. Temperature control device according to claim 1 or 2, comprising an upper part (2) and a lower part (3), both of which are designed as rectangular plates which, when placed on top of one another, form the temperature control device (1), wherein the surface (4) of the lower part (3) which is in contact with the upper part (2) has a channel (5) which, when assembled, acts like a pipe coil. 4. Pipettierroboter, aufweisend eine Temperiervorrichtung nach Anspruch 1.4. Pipetting robot comprising a temperature control device according to claim 1. 5. Programmierbarer Pipettierroboter, aufweisend eine Temperiervorrichtung zur Aufnahme von Mikrotiterplatten nach Anspruch 1, die Behältnisse für Flüssigkeiten aufweisen, sowie eine über eine Programmiersprache ansteuerbare Pipettiervorrichtung '5. Programmable pipetting robot, comprising a temperature control device for receiving microtiter plates according to claim 1, which have containers for liquids, and a pipetting device that can be controlled via a programming language.
DE29714206U 1997-08-08 1997-08-08 Pipetting robot with improved temperature control device Expired - Lifetime DE29714206U1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DE29714206U DE29714206U1 (en) 1997-08-08 1997-08-08 Pipetting robot with improved temperature control device
DK98114306T DK0895813T3 (en) 1997-08-08 1998-07-30 Pipetting robot with thermostatic device
EP98114306A EP0895813B1 (en) 1997-08-08 1998-07-30 Pipetting robot with thermostatic device
DE59811623T DE59811623D1 (en) 1997-08-08 1998-07-30 Pipetting robot with temperature control device
ES98114306T ES2222538T3 (en) 1997-08-08 1998-07-30 PIPETED ROBOT WITH THERMOSTATIC DEVICE.
PT98114306T PT895813E (en) 1997-08-08 1998-07-30 ROBOT OF PIPETACAO WITH TEMPERATURE IMPROVED ADJUSTMENT DEVICE
AT98114306T ATE270151T1 (en) 1997-08-08 1998-07-30 PIPETTING ROBOT WITH TEMPERATURE DEVICE
US09/129,784 US6558627B1 (en) 1997-08-08 1998-08-06 Temperature control apparatus and method for pipetting robot
CA002245266A CA2245266C (en) 1997-08-08 1998-08-07 Pipetting robot with an improved temperature-control apparatus
AU78869/98A AU7886998A (en) 1997-08-08 1998-08-07 Pipetting robot with an improved temperature-control apparatus
JP10224014A JPH11143551A (en) 1997-08-08 1998-08-07 Pipet robot having improved temperature controller
US10/387,477 US20030170910A1 (en) 1997-08-08 2003-03-14 Temperature control apparatus and method for pipetting robot

Applications Claiming Priority (1)

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DE29714206U DE29714206U1 (en) 1997-08-08 1997-08-08 Pipetting robot with improved temperature control device

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Cited By (1)

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US5061639A (en) * 1989-12-06 1991-10-29 E. I. Dupont De Nemours And Company Liquid dispenser accuracy verification method
EP0488769A2 (en) * 1990-11-29 1992-06-03 The Perkin-Elmer Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
DE4018734C2 (en) * 1990-06-12 1992-10-15 Spectrospin Ag, Faellanden, Zuerich, Ch
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DE1498929B2 (en) * 1964-06-10 1973-07-12 Eppendorf Gerätebau Netheler & Hinz GmbH, 2000 Hamburg PROCESSING DEVICE FOR PIPES OR CYLINDER-SHAPED VESSELS
DE3139479C2 (en) * 1980-10-10 1993-12-09 Perkin Elmer Ltd Device for concentrating a gas component contained in a gaseous, flowing carrier and forming a mixture therewith
US4554839A (en) * 1983-10-14 1985-11-26 Cetus Corporation Multiple trough vessel for automated liquid handling apparatus
DE3441179A1 (en) * 1984-11-10 1986-05-22 Dynatech Deutschland GmbH, 7306 Denkendorf Temperature-control device for microcell arrangements, in particular microtitration plates
US4775003A (en) * 1987-03-27 1988-10-04 Koh John K Laboratory materials and apparatus support and laminar flow thermal transfer device
EP0339710A2 (en) * 1988-04-29 1989-11-02 Rijksuniversiteit Utrecht Thermostatic device for sample supports
US5061630A (en) * 1988-05-13 1991-10-29 Agrogen Foundation, Seyffer & Co. & Ulrich C. Knopf Laboratory apparatus for optional temperature-controlled heating and cooling
US4950608A (en) * 1989-04-25 1990-08-21 Scinics Co., Ltd. Temperature regulating container
US5061639A (en) * 1989-12-06 1991-10-29 E. I. Dupont De Nemours And Company Liquid dispenser accuracy verification method
DE4018734C2 (en) * 1990-06-12 1992-10-15 Spectrospin Ag, Faellanden, Zuerich, Ch
EP0488769A2 (en) * 1990-11-29 1992-06-03 The Perkin-Elmer Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
US5255976A (en) * 1992-07-10 1993-10-26 Vertex Pharmaceuticals Incorporated Temperature gradient calorimeter
DE29515731U1 (en) * 1995-10-04 1995-12-07 ZTB Zentrum Technologietransfer Biomedizin Bad Oeynhausen GmbH, 32545 Bad Oeynhausen Storage device for laboratory vessels for storage in a refrigerator

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007057651A1 (en) * 2007-11-28 2009-06-18 Nickl, Julius, Dr. Temperature control system for cyclic heating up and cooling of e.g. chemical sample, has blocks heated up and/or cooled by tempering mechanisms e.g. electrically heating and cooling elements, that are in close thermal contact with blocks

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