DE2838736A1 - Wound-covering medicament powder base - of hydroxyethyl starch for improved absorbence and inherent purity - Google Patents
Wound-covering medicament powder base - of hydroxyethyl starch for improved absorbence and inherent purityInfo
- Publication number
- DE2838736A1 DE2838736A1 DE19782838736 DE2838736A DE2838736A1 DE 2838736 A1 DE2838736 A1 DE 2838736A1 DE 19782838736 DE19782838736 DE 19782838736 DE 2838736 A DE2838736 A DE 2838736A DE 2838736 A1 DE2838736 A1 DE 2838736A1
- Authority
- DE
- Germany
- Prior art keywords
- powder base
- hydroxyethyl starch
- wound
- absorbence
- improved
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000843 powder Substances 0.000 title claims abstract description 11
- 229920001612 Hydroxyethyl starch Polymers 0.000 title claims abstract description 6
- 229940050526 hydroxyethylstarch Drugs 0.000 title claims abstract description 6
- 239000003814 drug Substances 0.000 title abstract 2
- 206010048629 Wound secretion Diseases 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 abstract description 4
- 229920002472 Starch Polymers 0.000 abstract description 3
- 235000019698 starch Nutrition 0.000 abstract description 3
- 206010052428 Wound Diseases 0.000 abstract description 2
- 208000027418 Wounds and injury Diseases 0.000 abstract description 2
- 239000000377 silicon dioxide Substances 0.000 abstract description 2
- 239000008107 starch Substances 0.000 abstract description 2
- 239000000454 talc Substances 0.000 abstract description 2
- 229910052623 talc Inorganic materials 0.000 abstract description 2
- 229910052681 coesite Inorganic materials 0.000 abstract 1
- 229910052906 cristobalite Inorganic materials 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 235000012239 silicon dioxide Nutrition 0.000 abstract 1
- 229910052682 stishovite Inorganic materials 0.000 abstract 1
- 229910052905 tridymite Inorganic materials 0.000 abstract 1
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Hydroxyethyl starch (I) is used as a powder base for medicaments used to cover wounds. Irrespective of its mo. wt. (I) absorbs secretions better than known bases based on starch etc. and is not microbially infected like inorganic bases (e.g. talc, TiO2, SiO2, etc.).
Description
Verwendung von Hydroxyäthylestärke als Pudergrundlage Use of hydroxyethyl starch as a powder base
Bekanntlich sind Pudergrundlagen äußerlich anzuwendende pulverförmige Arzneimittel, die entweder als solche angewendet werden oder in Form von Gemischen mit Wirkstoffen. Als Pudergrundlagen haben sie dabei eine Eigenwirkung vor allem im Sinne einer Feuchtigkeitsufnahmefähigkeit gegenüber Wundsekreten. Als Pudergrundlagen kommen verschiedene Stärkearten zur Anwendung aber auch Talcum, hochdisperse Kieselsäure, Zinkoxid, Titandioxid oder auch andere organische oder anorganische Substanzen.It is well known that powder bases are powder-form to be used externally Medicinal products that are used either as such or in the form of mixtures with active ingredients. As a powder base, they have an effect of their own, above all in terms of moisture absorption against wound secretions. As powder bases different types of starch are used but also talc, highly dispersed silica, Zinc oxide, titanium dioxide or other organic or inorganic substances.
Allen bisher bekannten Pudergrundlagen haften jedoch vielfach schwerwiegende Nachteile an. So sind beispielsweise anorganische Pundergrundlagen vielfach mikrobiell verunreinigt. Das klifsaugevermögen von Stärl-en gegenüber Wundsekret ist nur begrenzt.However, all of the powder bases known so far have often serious ones Disadvantages. For example, inorganic powder bases are often microbial contaminated. The ability of starches to absorb wounds from wound secretions is only limited.
Überraschenderweise wurde nun gefunden, daß Hydroxyäthylstärke der verschiedensten Molekulargewichte über vorzügliche Äufsaugevermögen gegenüber Wundsekreten verfügt und infolgedessen als Pudergrundlage ausgezeichnet geeignet ist. Das Aufsaugevermögen wird zwar von dem Molekulargewicht der Hydroxyäthylstärke beeinflußt, ohne jedoch den grundsätzlichen Effekt zu verändern.Surprisingly, it has now been found that the hydroxyethyl starch various molecular weights over excellent suction capacity for wound secretions and is therefore ideally suited as a powder base. The absorption capacity is influenced by the molecular weight of the hydroxyethyl starch, but without to change the basic effect.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782838736 DE2838736A1 (en) | 1978-09-06 | 1978-09-06 | Wound-covering medicament powder base - of hydroxyethyl starch for improved absorbence and inherent purity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782838736 DE2838736A1 (en) | 1978-09-06 | 1978-09-06 | Wound-covering medicament powder base - of hydroxyethyl starch for improved absorbence and inherent purity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2838736A1 true DE2838736A1 (en) | 1980-03-20 |
Family
ID=6048748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19782838736 Withdrawn DE2838736A1 (en) | 1978-09-06 | 1978-09-06 | Wound-covering medicament powder base - of hydroxyethyl starch for improved absorbence and inherent purity |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE2838736A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1980002374A1 (en) * | 1979-05-10 | 1980-11-13 | American Hospital Supply Corp | Hydroxyalkyl starch drug carrier |
| EP2203053A1 (en) | 2008-01-14 | 2010-07-07 | Starch Medical Inc. | Modified starch material of biocompatible hemostasis |
-
1978
- 1978-09-06 DE DE19782838736 patent/DE2838736A1/en not_active Withdrawn
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1980002374A1 (en) * | 1979-05-10 | 1980-11-13 | American Hospital Supply Corp | Hydroxyalkyl starch drug carrier |
| EP0028641A4 (en) * | 1979-05-10 | 1981-09-01 | American Hospital Supply Corp | Hydroxyalkyl starch drug carrier. |
| EP0019403A3 (en) * | 1979-05-10 | 1981-10-07 | American Hospital Supply Corporation | Hydroxyalkyl-starch drug carrier and method of administering a biologically active compound to an animal |
| EP2203053A1 (en) | 2008-01-14 | 2010-07-07 | Starch Medical Inc. | Modified starch material of biocompatible hemostasis |
| JP2011509932A (en) * | 2008-01-14 | 2011-03-31 | スターチ メディカル インコーポレーテッド | Biocompatible hemostasis, adhesion prevention, fusion promotion, surgically sealable modified starch material |
| EP2203053B1 (en) * | 2008-01-14 | 2017-09-20 | Xin Ji | Modified starch material of biocompatible hemostasis |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8139 | Disposal/non-payment of the annual fee | ||
| 8180 | Miscellaneous part 1 |
Free format text: WIEDEREINSETZUNG IN DEN VORHERGEHENDEN STAND |
|
| 8139 | Disposal/non-payment of the annual fee |