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DE2810731A1 - Deep-drawn polyurethane blood pump - has chamber walls coated with blood-compatible polysiloxane or polyurethane-polysiloxane compsn. - Google Patents

Deep-drawn polyurethane blood pump - has chamber walls coated with blood-compatible polysiloxane or polyurethane-polysiloxane compsn.

Info

Publication number
DE2810731A1
DE2810731A1 DE19782810731 DE2810731A DE2810731A1 DE 2810731 A1 DE2810731 A1 DE 2810731A1 DE 19782810731 DE19782810731 DE 19782810731 DE 2810731 A DE2810731 A DE 2810731A DE 2810731 A1 DE2810731 A1 DE 2810731A1
Authority
DE
Germany
Prior art keywords
polyurethane
blood
polysiloxane
deep
drawn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19782810731
Other languages
German (de)
Inventor
Wolfhart Dr Rer Nat Dunkel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Licentia Patent Verwaltungs GmbH
Original Assignee
Licentia Patent Verwaltungs GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Licentia Patent Verwaltungs GmbH filed Critical Licentia Patent Verwaltungs GmbH
Priority to DE19782810731 priority Critical patent/DE2810731A1/en
Publication of DE2810731A1 publication Critical patent/DE2810731A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/06—Pumps having fluid drive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/247—Positive displacement blood pumps
    • A61M60/253—Positive displacement blood pumps including a displacement member directly acting on the blood
    • A61M60/268—Positive displacement blood pumps including a displacement member directly acting on the blood the displacement member being flexible, e.g. membranes, diaphragms or bladders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/841—Constructional details other than related to driving of balloon pumps for circulatory assistance
    • A61M60/843—Balloon aspects, e.g. shapes or materials
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/0009—Special features
    • F04B43/0054—Special features particularities of the flexible members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Geometry (AREA)
  • Physics & Mathematics (AREA)
  • External Artificial Organs (AREA)

Abstract

Parent patent claims mfr. of a blood pump where the inner wall of the blood chamber and its pump chamber membrane are deep-drawn from thermoplastics polyurethane. In this addn., a polyurethane is used in form of a polyurethane film laminate provided with a coating of blood-compatible plastics e.g. a polysiloxane or a polyurethane/siloxane blend. In a variant, the polyurethane/siloxane blend may be applied onto the polyurethane film laminate, as an interlayer which is finally coated with a polysiloxane.

Description

Verfahren zur llerstellung einer Blutpumpe Method for creating a blood pump

Die Erfindung bezieht sich auf ein Verfahren zur Ilerstellung einer Blutpumpe, deren Innenwandung der Blutkammer und deren Pumpenkammermembran aus einem thermoplastischen Polyurethan im Tiefziehverfahren hergestellt werden, nach Patent.........(Pat. Anm. P 25 09 006).The invention relates to a method for producing a Blood pump, its inner wall of the blood chamber and its pump chamber membrane from one thermoplastic polyurethane are produced in the deep-drawing process, according to patent ......... (Pat. Note P 25 09 006).

Nach dem Ilauptpatent werden die Innenwandung der Blutkammer und die Pumpenkammermembran aus einem thermoplastischen Polyurethan im Tiefziehverfahren hergestellt. Es hat sich jedoch gezeigt, daß die Polyurethanfolie bezüglich der Blutverträglichkeit nicht immer den gestellten Anforderungen genügen kann.According to the main patent, the inner wall of the blood chamber and the Pump chamber diaphragm made of a thermoplastic polyurethane in the deep-drawing process manufactured. However, it has been shown that the polyurethane film with respect to Blood tolerance cannot always meet the requirements.

Man hat schon versucht, die tiefgezogenen Membranteiie bzw. die Diutkammerteiie nachträglich mit einem besser blutverträglichen Kunststoff auf Silikonbasis oberflächlich zu beschichten.Attempts have already been made, the deep-drawn membrane parts or the diut chamber parts subsequently with a more blood-compatible silicone-based plastic on the surface to coat.

Wie die Erfahrung gezeigt hat, kann das nacbträgiiche Beschichten zu Schädigungen der tiefgezogenen Teile führen. Darüber hinaus wurde festgestellt, daß die haftfestigkeit so hergestellter Beschichtungen den hohen mechanischen Dauerbeanspruchungen einer kiinstlichen Blutpumpe nicht genügt, da die Beschichtung sich teilweise im Betrieb wieder ablöst.As experience has shown, this can be applied afterwards lead to damage to the deep-drawn parts. In addition, it was found that the adhesive strength of coatings produced in this way can withstand the high mechanical stresses and strains an artificial blood pump is not sufficient, as the coating is partially in the Operation takes over again.

Überraschenderweise wurde gefunden, daß diese Schwierigkeiten der Ablösungserscheinung der Beschihtung überwunden werden können, d-..h., daß die Haftfestigkeit wesentlich verbessert werden kann, wenn die fleschichtüng der Polyurethanfolie mit der blutverträglichten Polysiloxanschicht erfindungsgemäß vor dem Tifziehprozeß erfolgt und erst die Verbundfolie, d.h., die mit der Polysiloxanschicht versehene Polyurethanfolie einem Tiefziehprozeß zur Herstellung der Blutkammerteile unterworfen wird.Surprisingly, it has been found that these difficulties The peeling phenomenon of the coating can be overcome, i.e. the adhesive strength can be significantly improved if the polyurethane film is fleschichtüng with the blood-compatible polysiloxane layer according to the invention before the drawing process takes place and only the composite film, i.e. the one provided with the polysiloxane layer Polyurethane film subjected to a deep-drawing process for the production of the blood chamber parts will.

--In weiterer Ausbildung der Erfindung hat es sich als vorteilhaft erwiesen, vor dem Aufbringen der blutverträglichen Polysiloxanschicht eine als Haftvermittlerschicht wirkende Zwischenschicht aus einem Gemisch von Poiyurethan mit -Polysiloxan auf die Polyurethanfolie aufzubrigen.- In a further development of the invention, it has proven to be advantageous proved to be an adhesion promoter layer before the blood-compatible polysiloxane layer is applied acting intermediate layer made of a mixture of polyurethane with polysiloxane to apply the polyurethane film.

-In bestimmten Fällen haben sich auch Mischungen aus Polyurethan und Polysiloxan für eine blutverträgliche Beschichtung als geeignet erwies-en-.- Ein nachträglicher Tiefziehprozeß derartig beschichteter Polyurethanfolien führt ebenfalls zu einer deutlichen Verbesserung der Haftfestigkeit bei hinreichender Blutverträglichkeit.-In certain cases, blends of polyurethane and have also been used Polysiloxane proved to be suitable for a blood-compatible coating -.- A Subsequent deep-drawing process of polyurethane films coated in this way also leads to a significant improvement in the adhesive strength with adequate blood tolerance.

Folgendes Beispiel werdeutlicht die Erfindung: Während eine tiefgezogene- und nachträglich beschichtete fliutpumpen kammermembran auf einem Membrandauerprüfstand nach ca. 106 bis 107 Lastwechseln Ablösungserscheinungen zeigte, blieben nach der Erfindung hergestellte Membranen unter analogen Prüfbedingungen nach 30 x 107 Lastwechseln ohne Schädigungsmerkmale.The following example illustrates the invention: While a deep-drawn and subsequently coated fluid pump chamber diaphragm on a diaphragm endurance test stand after about 106 to 107 load changes showed signs of separation, remained after the Invention produced membranes under analog test conditions after 30 x 107 load changes without signs of damage.

Claims (4)

Patentansprüche 1) Verfahren zur Herstellung einer Blutpumpe, deren Itlnenwandung der Blutkammer und deren Pumpenkammermembran aus einem thermoplastischen Polyurethan im Tiefziehverfahren hergestellt werden, nach Patent . ... ... (Patentananmeldung P 25 09 006)-, dadurch gekennzeichnet, daß die Innenwandung und die Pumpenkammermembran aus einer Polyurethanverbundfolie tiefgezogen werden, die eine Beschichtung aus einem blutverträglichen Kunststoff aufweist. Claims 1) A method for producing a blood pump whose Inner wall of the blood chamber and its pump chamber membrane made of a thermoplastic Polyurethane can be manufactured in a deep-drawing process, according to patent. ... ... (patent application P 25 09 006) -, characterized in that the inner wall and the pump chamber membrane be deep-drawn from a polyurethane composite film that has a coating a blood-compatible plastic. 2) Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß eine Polyurethanverbundfolie tiefgezogen wird, die als blutverträgliche Beschichtung eine Polysiloxanbeschichtung aufweist.2) Method according to claim 1, characterized in that a polyurethane composite film is deep-drawn, the blood-compatible coating is a polysiloxane coating having. 3) Verfahren nach Anspruch 1 und 2, dadurch gekennzeichnet, daß die blutverträgliche Beschichtung aus einer Mischung aus einem Polyurethan und einem Siloxan hergestellt wird.3) Method according to claim 1 and 2, characterized in that the Blood-compatible coating made from a mixture of a polyurethane and a Siloxane is produced. 4) Verfahren nach Anspruch 3, dadurch gekennzeichnet, daß die Mischung aus Polyurethan und Polysiloxan als Zwischenschicht auf die Polyurethanfolie aufgebracht und diese mit einer Überzugsbeschichtung aus Polysiloxan versehen wird.4) Method according to claim 3, characterized in that the mixture made of polyurethane and polysiloxane as an intermediate layer applied to the polyurethane film and this is provided with a top coat of polysiloxane.
DE19782810731 1978-03-13 1978-03-13 Deep-drawn polyurethane blood pump - has chamber walls coated with blood-compatible polysiloxane or polyurethane-polysiloxane compsn. Withdrawn DE2810731A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19782810731 DE2810731A1 (en) 1978-03-13 1978-03-13 Deep-drawn polyurethane blood pump - has chamber walls coated with blood-compatible polysiloxane or polyurethane-polysiloxane compsn.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782810731 DE2810731A1 (en) 1978-03-13 1978-03-13 Deep-drawn polyurethane blood pump - has chamber walls coated with blood-compatible polysiloxane or polyurethane-polysiloxane compsn.

Publications (1)

Publication Number Publication Date
DE2810731A1 true DE2810731A1 (en) 1979-09-20

Family

ID=6034243

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782810731 Withdrawn DE2810731A1 (en) 1978-03-13 1978-03-13 Deep-drawn polyurethane blood pump - has chamber walls coated with blood-compatible polysiloxane or polyurethane-polysiloxane compsn.

Country Status (1)

Country Link
DE (1) DE2810731A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485928A1 (en) * 1980-07-04 1982-01-08 Pol Vincent Electromagnetically operated artificial heart - has magnetic zones embedded in elastomeric sidewalls with electric coils in central partition connected to AC source
EP3105272A4 (en) * 2014-02-14 2017-10-18 Sikorsky Aircraft Corporation Erosion resistant blade and blade coating

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485928A1 (en) * 1980-07-04 1982-01-08 Pol Vincent Electromagnetically operated artificial heart - has magnetic zones embedded in elastomeric sidewalls with electric coils in central partition connected to AC source
EP3105272A4 (en) * 2014-02-14 2017-10-18 Sikorsky Aircraft Corporation Erosion resistant blade and blade coating
US10336435B2 (en) 2014-02-14 2019-07-02 Sikorsky Aircraft Corporation Erosion resistant blade and blade coating

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