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DE2729007A1 - Medicine capsule with two chambers - comprises bottom part with caps pushed on both ends - Google Patents

Medicine capsule with two chambers - comprises bottom part with caps pushed on both ends

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Publication number
DE2729007A1
DE2729007A1 DE19772729007 DE2729007A DE2729007A1 DE 2729007 A1 DE2729007 A1 DE 2729007A1 DE 19772729007 DE19772729007 DE 19772729007 DE 2729007 A DE2729007 A DE 2729007A DE 2729007 A1 DE2729007 A1 DE 2729007A1
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Germany
Prior art keywords
capsule
base
lids
lid
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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DE19772729007
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German (de)
Inventor
Rainer Dr Med Liedtke
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Individual
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Individual
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Priority to DE19772729007 priority Critical patent/DE2729007A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)

Abstract

A medicine capsule with two separate chambers is used to for the controlled release of two medicinal preparations. The first chamber is formed by the bottom part of the capsule, with a cap pushed inside it. The second chamber is formed by a second cap, pushed on to meet the first. All parts are made of hard gelatine. By using materials of different solubility, the release of the medicine can be staggered. Incompatible medicines can be stored for long periods without deterioration.

Description

Arzneikapsel mit zwei KammernMedicinal capsule with two chambers

Die Erfindung betrifft eine Arzneikapsel mit zwei getrennten Kammern zur Herstellung aus Hartgelatine,insbesondere zur gesteuerten Arzneimittelfreigabe und zur Applikation physikalischchemisch und/oder pharmakokinetisch inkompatibler Arzneistoffe.The invention relates to a medicinal capsule with two separate chambers for production from hard gelatine, especially for controlled drug release and physicochemically and / or pharmacokinetically incompatible for application Medicinal substances.

Es ist bekannt,daß Hartgelatinekapseln für die Applikation von Arzneimitteln bereits eine Anzahl biopharmazeutischer Vorzüge in Bezug auf Stabilität der Wirkstoffe, Verträglichkeit, biologische Verfügbarkeit und Steuerung der Wirkungsdauer besitzen.It is known that hard gelatin capsules for the application of drugs already have a number of biopharmaceutical advantages in terms of stability of the active ingredients, Have tolerance, biological availability and control of the duration of action.

(Cordes,G.:Magensaftresistente Hartgelatinekapseln als Arzneiform für Fermentpräparate; Pharm., Ind. 31(1969)328 Czetsch-Lindenwand, H.v.: Über den Zerfall von Arzneikapseln; Pharm.Ind.24(1962)110 Czetsch-Lindenwald,H.v.,Fahrig,UJ.:Arzneikapseln,Edition Cantor, Aulendorf, 1962 Goldman,R.:Sustained release capsules;Drug Cosmetic Ind.107 (1970)52 Hagers Handbuch der pharmazeutischen Praxis,4.Neuausgabe,VII.(Cordes, G .: gastric juice-resistant hard gelatine capsules as a dosage form for ferment preparations; Pharm., Ind. 31 (1969) 328 Czetsch-Lindenwand, H.v .: About the Disintegration of drug capsules; Pharm.Ind.24 (1962) 110 Czetsch-Lindenwald, H.v., Fahrig, UJ .: Medicinal capsules, Edition Cantor, Aulendorf, 1962 Goldman, R .: Sustained release capsules; Drug Cosmetic Ind. 107 (1970) 52 Hager's Handbook of Pharmaceutical Practice, 4th New Edition, VII.

Band,Arzneiformen und Hilfsstoffe,Teil A:Arzneiformen;S.482-502,Kapseln,Springer Verlag 1971 Lehmann,K.:Programmierte Wirkstoffabgabe aus peroralen Arzneiformen;Pharma International 3(1971)452 Münzel.K.:Galöenische Formgebung und Arzneimittelwirkung; Progr.Volume, dosage forms and auxiliaries, part A: dosage forms; pp.482-502, capsules, Springer Verlag 1971 Lehmann, K.: Programmed drug delivery from peroral dosage forms; Pharma International 3 (1971) 452 Münzel.K.: Galöenische Formgebung and drug effect; Program

Drug Res.14(197U)2b9 Newton,J.M:The release of drugs from hard gelatin capsules Pharm.ieekblad 107(1972)485 Newton,J.M.,Rowley,G.:On the release of drug from hard gelatin capsules;J.Pharm.Pharmac.22( 1970)163 Newton,J.M.,Rowley,G.,Törnblom,J.F.V.:Further studies on the release of drug from hard gelatin capsules;J.Pharm.Pharmac.Drug Res. 14 (197U) 2b9 Newton, J.M: The release of drugs from hard gelatin capsules Pharm. Iekblad 107 (1972) 485 Newton, J.M., Rowley, G .: On the release of drug from hard gelatin capsules; J. Pharm. Pharmac. 22 (1970) 163 Newton, J.M., Rowley, G., Törnblom, J.F.V .: Further studies on the release of drug from hard gelatin capsules; J. Pharm. Pharmac.

23(1971)156S Neiton,J.rT.,Rowley,G.,Törnblom,J.F.V.:The effect of additives on the release of drug from hard gelatin capsules;J.Pharm.23 (1971) 156S Neiton, J.rT., Rowley, G., Törnblom, J.F.V .: The effect of additives on the release of drug from hard gelatin capsules; J. Pharm.

Pharmac.23(1971)452 Prescott,L.F.,Nimmo,J.:Generic inequivalence-Clinical observations;Acta Pharmacol.Toxicol.29(1971)280 Thoma,K.:Die Biopharmazie der Kapselpräparate;Schriftenreihe der Bundesapothekerkammer zur wissenschaftlichen Fortbildung, Band IV/Weine Reihe 1974 Thoma,K.:Die Bedeutung biopharmazeutischer Parameter für die Arzneimittelentwicklung, in: Probleme der Bioverfügbarkeit und des Wirkungsnachweises;Arznm.Forsch.(Drug Res.)26(1976)103) Die Stabilität inkompatibler WirkstofFe in der Kapsel,z.B.bei Vitamin-und Enzympräparationen muss jedoch durch spezielle pharmazeutisch-technologische Verfahren wie Einbettung der Stoffe in ölige Füllmassen oder Isolierung durch Einführung von Sperrschichten wie lackierte Granulate oder lackierte Mikrotabletten herbeigeführt werden,wodurch ein technologischer Aufwand unter Verwendung zusätzlicher Hilfsstoffe erforderlich ist.In Bezug auf die Steuerung der Wirkstoffreisetzung besitzen die derzeitigen Kapseln bisher lediglich die Möglichkeit,die enthaltenen Wirkstoffe mit Hilfe üblicher galenischer Verfahren wie Kationenaustacher-Resinaten, Diffusionspelltes, Einbettungspellets oder Ausbildung vnn Makrokristallen retardiert freizugeben oder durch Erzeugung magensaftresistenter Kapsel hüllen oder magensaftresistente Überziehung der enthaltenen Wirkstoffe den Freisetzungsort zu bestimmen.Pharmac. 23 (1971) 452 Prescott, L.F., Nimmo, J .: Generic inequivalence-Clinical observations; Acta Pharmacol.Toxicol. 29 (1971) 280 Thoma, K.: The biopharmacy of capsule preparations; series of publications of the Federal Chamber of Pharmacists for scientific advanced training, Volume IV / Wines series 1974 Thoma, K.: The importance of biopharmaceutical parameters for drug development, in: Problems of bioavailability and proof of effectiveness; Arznm.Forsch. (Drug Res.) 26 (1976) 103) The stability of incompatible active ingredients in the capsule, e.g. in Vitamin and enzyme preparations must, however, through special pharmaceutical-technological Processes such as embedding the substances in oily fillings or insulation by introduction caused by barrier layers such as coated granules or coated micro-tablets be, whereby a technological effort with the use of additional auxiliaries In terms of controlling drug release, the current capsules so far only the possibility of the contained active ingredients with the help of common galenic methods such as cation exchanger resinates, diffusion pelltes, Embedding pellets or formation of macrocrystals in a retarded manner or by producing enteric capsule shell or enteric coating to determine the place of release of the active substances contained.

Der Erfindung liegt llt aufgabe zugrunde, mit einem einheitlichen Kapseltyp die Möglichkeiten der Unterbringung und Anwendung physikalisch-chemisch und/oder biologisch inkompatibler Wirkstoffe zu verbessern sowie die Anzahl an Steuerungsmuglichkeiten des Freisetzungsvorganges für Kapseln zu erhöhen.The invention is based on the object with a uniform Capsule type the possibilities of accommodation and application physico-chemical and / or to improve biologically incompatible active ingredients as well as the number of control options to increase the release process for capsules.

Diese Aufgabe wird erfindungsmäßig t durch gelost,daß die Kapsel aus Kapselboden und Kapseldeckel und einem zusätzlich auf den Kapselboden oder Kapseldeckel aufgesteckten weiteren Kapseldeckel oder Kapselboden,durch welchen eine zweite Kammer gebildet wird, zusammengesetzt ist.According to the invention, this problem is solved by the fact that the capsule is made Capsule base and capsule lid and an additional one on the capsule base or capsule lid Attached further capsule lid or capsule base through which a second chamber is formed, is composed.

Um für die in den beiden Kammern enthaltenen Wirkstoffe einen unterschiedlichen Freigabezeitpunkt oder Freigabeort zu erzielen,werden,in einer weiteren Ausbildung der Erfindung,unterschiedlich lösliche Kapseldeckel und/oder Kapselböden verwandt.In order for the active ingredients contained in the two chambers to have a different Achieving the release time or release location will be in a further training related to the invention, differently soluble capsule lids and / or capsule bottoms.

Um eine versehentliche mechanische Losung von Kapseldeckel und Kapselboden zu verhindern,werden,in einer weiteren Ausbildung der Erfindung,die Kapseldeckel durch drei oder mehr kranzförmig angelegte komplementäre Ausbuchtungen in Kapselboden und Kapseldeckeln fixiert.To prevent accidental mechanical loosening of the capsule lid and base to prevent, in a further embodiment of the invention, the capsule lid by three or more ring-shaped complementary bulges in the capsule base and capsule lids fixed.

Um eine VergröBerung des durch den aufgesteckten Kapseldeckels abgegrenzten Raumes zu erreichen,wird,in einer weiteren Ausbildung der Erfindung,der Boden des Verschlussteiles flach, kegelförmig oder konkav ausgebildet.By an enlargement of the area delimited by the attached capsule lid To achieve space is, in a further embodiment of the invention, the bottom of the Closure part flat, conical or concave.

Um eine Kapsel mit drei Räumen zu erzielen,werden,in einer weiteren Ausbildung der Erfindung,gleichzeitig beidseitig je ein Kapseldeckel aufgesteckt.In order to achieve a capsule with three spaces, you need to place another Formation of the invention, at the same time a capsule lid attached to both sides.

Die mit der Erfindung erzielten Vorteile ergeben sich insbesondere dadurch,daB durch die mechanische Trennung verschiedener Wirkstoffe eine Wirkstoffgemisches physikalisch-chemische Inkompatibilitäten bei der Lagerung vermieden werden, ohne daß dies durch spezielle galenische Stabilisierungsmanahmen unter Verwendung zusätzlicher Hilfsstoffe geschieht, so daß sowohl eine Erhühung der Arzneimittelsicherheit als auch eine Verringerung des pharmazeutisch-technologischen Aufwandes erfolgt.Durch die Verwendung von Kapselhüllen unterschiedlicher Lösungscharakteristik kann'bei Unterbringung einer Ein-Wirkstoff Arzneiform eine zeitliche Verschiebung der Freisetzung von zwei Einzeldosen bei nur einmaliger Kapseleinnahme ermöglicht werden.Hei unterschiedlichen Wirkstoffen in den beiden Kammern kann,bei unterschiedlichen Freisetzungszeitpunkten oder Freisetzungsorten eine biologische Wechselwirkung am Resorptionsort verhindert,die Arzneimittelsicherheit somit erhöht werden.The advantages achieved with the invention result in particular by the fact that the mechanical separation of different active ingredients creates an active ingredient mixture Physico-chemical incompatibilities during storage can be avoided without that this is achieved by special galenic stabilization measures using additional Excipients happens so that both an increase in drug safety there is also a reduction in the pharmaceutical-technological effort the use of capsule shells with different solution characteristics can be used Accommodation of a single-active ingredient dosage form, a time shift in the release of two single doses with a single capsule intake, sometimes different Active ingredients in the two chambers can, at different release times or release sites a biological interaction at the point of absorption prevents the drug safety are thus increased.

Werden für die Füllung der Kammern unterschiedlich verarbeitete galenische Formulierungen verwendt, so kann die eigenständige Freisetzungscharakteristik der galenischen Formulierung durch die spezielle Ausbildung des Löslichkeitsverhaltens der Kapselhülle gezielt modifiziert werden.Die Zahl vor programmierbarer Freisetzungscharakteristiken lässt sich somit erhöhen.Different processed galenicals are used to fill the chambers Formulations used, the independent release characteristics of the galenic formulation due to the special development of the solubility behavior The number of programmable release characteristics can thus be increased.

Ausführungsbeispiele der Erfindung sind in den Zeichnungen dargestellt, wobei die Beispiele die Erfindung erläutern ohne sie zu beschränken. In Abbildung 1 ist der generelle Ausbau der Kapsel dargestellt. bei der aus Kapseldeckel (1) und Kapselhoden (2) zusammengesetzten Hartgelatinekapsel,ist Ober den Kapselboden ein weiterer Kapseldeckel (3) geschoben, welcher eine zweite zusätzliche getrennte Kammer (4) bildet. Abbildung 2 gibt eine Schnittzeichnung des gleichen Sachverhaltes wieder.In Abbildung 3 ist die Fixierung der Kapselldeckel an dem Mapselboden mittels der krenzförmigen komplementären Ausbuchtungen in Kapselboden und Kapseldeckeln (5) dargestellt. In Abbildung 4 ist zu Zecken der Raumvergrößerung der zuleiten Hammer der Kapselboden flach (6), in Abbildung 5 konkav gewölbt (7) dargestellt.Embodiments of the invention are shown in the drawings, The examples illustrate the invention without restricting it. In figure 1 shows the general expansion of the capsule. in the case of the capsule lid (1) and capsule testicle (2) composed hard gelatin capsule, is above the capsule base another capsule lid (3) pushed, which a second additional separate Chamber (4) forms. Figure 2 gives a sectional drawing of the same situation again.In Figure 3, the fixation of the capsule lid on the Mapselboden by means of the crown-shaped complementary bulges in the capsule base and capsule lids (5) shown. In Figure 4 the enlargement of the space is shown to the ticks Hammer the capsule base flat (6), shown in Figure 5 with a concave curve (7).

L e e r s e i t eL e r s e i t e

Claims (1)

Patentansprüche 1.Arzneikapsel mit zwei getrennten Kammern zur Herstellung aus Hartgelatine,insbesondere zur gesteuerten Arzneimittelfreigabe und zur Applikation physikalisch-chemisch und/oder pharmakokinetisch inkompatibler Arzneistoff, dadurch gekennzeichnet,daB die Kapsel aus Kapselboden und Kapseldeckel und einem zusätzlich auf den Kapselboden oder Kapseldeckel aufgesteckten weiteren Kapseldeckel oder Kapselboden,durch welchen eine zweite Kammer gebildet wird, zusammengesetzt ist(1,2) 2.Arzneikapsel nach Anspruch 1,dadurch gekennzeichnet,daB die Ausbildung der Kapsel statt mit Hartgelatine mit jedem der Hartgelatine biologisch und technisch gleichwertigen oder besseren Stoff oder Stoffgemisch erfolgt. Claims 1. Pharmaceutical capsule with two separate chambers for production Made of hard gelatine, especially for controlled drug release and application physico-chemical and / or pharmacokinetically incompatible drug, thereby marked that the capsule consists of the capsule base and capsule lid and one in addition on the capsule base or capsule lid attached further capsule lid or capsule base through which a second chamber is formed, is composed (1,2) 2nd drug capsule according to claim 1, characterized in that the capsule is formed instead of hard gelatin with each of the hard gelatine biologically and technically equivalent or better Substance or mixture of substances takes place. 3.Arzneikapsel nach Anspruch 1,dadurch gekennzeichnet,daB Kapselboden und Kapseldeckel oder die Kapseldeckel ein unterschiedliches Löslichkeitsverhalten zeigen.3. Medicinal capsule according to claim 1, characterized in that the capsule base and capsule lids or the capsule lids have different solubility behavior demonstrate. 4.Arzneikapsel nach Anspruch 1,dadurch gekennzeichnet,daß Kapselboden und Kapseldeckel durch Einfügung von drei oder mehr kranzförmig angelegten, punktförmigen, komplementären Ausbuchtungen in Kapselboden und Kapseldeckeln,fixiert werden. (3) 5.Arzneikapsel nach Anspruch 1,dadurch gekennzeichnet,daB der Hoden des den zweiten Kammerraum begrenzenden Verschlussteiles flach,kegelförmig oder konkav ausgebildet ist.(4,5) 6. Arzneikapsel nach Anspruch 1, dadurch gekennzeichnet, daß statt einseitig,gleichzeitig beidseitig ein Kapseldeckel aufgeschoben wird.4.Arzneikapsule according to claim 1, characterized in that the capsule base and capsule lids by inserting three or more point-shaped, complementary bulges in the capsule base and capsule lids. (3) 5. Medicinal capsule according to claim 1, characterized in that the testicle of the second Closing part delimiting the chamber space is flat, conical or concave is. (4,5) 6. Medicinal capsule according to claim 1, characterized in that instead of one-sided, simultaneously a capsule lid is pushed on on both sides.
DE19772729007 1977-06-28 1977-06-28 Medicine capsule with two chambers - comprises bottom part with caps pushed on both ends Pending DE2729007A1 (en)

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4373631A (en) * 1979-04-24 1983-02-15 Dr. Carl Hahn G.M.B.H. Tampon pack especially for a coated tampon containing medicaments
FR2572283A1 (en) * 1984-10-25 1986-05-02 Warner Lambert Co Pharmaceutical capsule comprising cylindrical body
US4601896A (en) * 1984-03-21 1986-07-22 Mark Nugent Pharmaceutical capsule compositions and structures for gastric sensitive materials
FR2586187A1 (en) * 1985-08-16 1987-02-20 Alza Corp SYSTEM FOR PROVIDING MATERIALS (AGENTS) TO AN ENVIRONMENT, INSTANTLY AND CONTINUOUSLY
EP0180543A3 (en) * 1984-10-25 1988-03-02 Warner-Lambert Company Method for sealing capsules
DE4443175A1 (en) * 1994-12-05 1996-06-13 Jenapharm Gmbh New pulsatile drug form
WO2003072088A1 (en) * 2002-02-26 2003-09-04 Natalie Herbon Capsule for the time-delayed dispensing of nutrients and/or active substances
EP1248595A4 (en) * 2000-01-20 2006-06-14 Delsys Pharmaceutical Corp Multi-step drug dosage forms
WO2008113368A1 (en) * 2007-03-21 2008-09-25 Kariem Ezzat Mahmoud A gelatin capsule with extra cap for combined therapies
WO2013050973A1 (en) * 2011-10-06 2013-04-11 Market Demand Trading 767 Proprietary Limited A method and apparatus for manufacturing a capsule
US9456987B2 (en) 2013-04-03 2016-10-04 Binutra, Inc. Capsule with internal diaphragm
CN109922791A (en) * 2016-10-27 2019-06-21 康宝卡普股份有限公司 A kind of edible capsule and its manufacturing method and apparatus

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4373631A (en) * 1979-04-24 1983-02-15 Dr. Carl Hahn G.M.B.H. Tampon pack especially for a coated tampon containing medicaments
US4601896A (en) * 1984-03-21 1986-07-22 Mark Nugent Pharmaceutical capsule compositions and structures for gastric sensitive materials
FR2572283A1 (en) * 1984-10-25 1986-05-02 Warner Lambert Co Pharmaceutical capsule comprising cylindrical body
EP0180543A3 (en) * 1984-10-25 1988-03-02 Warner-Lambert Company Method for sealing capsules
FR2586187A1 (en) * 1985-08-16 1987-02-20 Alza Corp SYSTEM FOR PROVIDING MATERIALS (AGENTS) TO AN ENVIRONMENT, INSTANTLY AND CONTINUOUSLY
DE4443175A1 (en) * 1994-12-05 1996-06-13 Jenapharm Gmbh New pulsatile drug form
EP1248595A4 (en) * 2000-01-20 2006-06-14 Delsys Pharmaceutical Corp Multi-step drug dosage forms
WO2003072088A1 (en) * 2002-02-26 2003-09-04 Natalie Herbon Capsule for the time-delayed dispensing of nutrients and/or active substances
WO2008113368A1 (en) * 2007-03-21 2008-09-25 Kariem Ezzat Mahmoud A gelatin capsule with extra cap for combined therapies
WO2013050974A1 (en) * 2011-10-06 2013-04-11 Market Demand Trading 767 Proprietary Limited A method and apparatus for manufacturing a capsule
WO2013050973A1 (en) * 2011-10-06 2013-04-11 Market Demand Trading 767 Proprietary Limited A method and apparatus for manufacturing a capsule
CN103987357A (en) * 2011-10-06 2014-08-13 生物胶囊药物和营养产品私人有限公司 Capsule manufacturing method and device
US9340004B2 (en) 2011-10-06 2016-05-17 Bio Capsule Pharmaceutical And Nutritional Products (Pty) Ltd. Method and apparatus for manufacturing a capsule
AU2012320099B2 (en) * 2011-10-06 2017-02-02 Combocap, Inc. A method and apparatus for manufacturing a capsule
CN104010617B (en) * 2011-10-06 2017-05-10 生物胶囊药物和营养产品私人有限公司 A method and apparatus for manufacturing a capsule
CN103987357B (en) * 2011-10-06 2017-12-12 康宝卡普股份有限公司 The manufacturing method and apparatus of capsule
US10046549B2 (en) 2011-10-06 2018-08-14 Combocap, Inc. Method and apparatus for manufacturing a capsule
US12043018B2 (en) 2011-10-06 2024-07-23 Combocap, Inc. Method and apparatus for manufacturing a capsule
US9456987B2 (en) 2013-04-03 2016-10-04 Binutra, Inc. Capsule with internal diaphragm
CN109922791A (en) * 2016-10-27 2019-06-21 康宝卡普股份有限公司 A kind of edible capsule and its manufacturing method and apparatus
EP3532032A4 (en) * 2016-10-27 2019-11-13 ComboCap, Inc. EDIBLE CAPSULE AND METHOD AND APPARATUS FOR MANUFACTURING THE SAME
JP2019535818A (en) * 2016-10-27 2019-12-12 コンボキャップ インコーポレイテッド Edible capsule and method and apparatus for manufacturing the same

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