DE2212739A1 - Vaccine zur Immunisation gegen Zahncaries - Google Patents

Vaccine zur Immunisation gegen Zahncaries

Info

Publication number: DE2212739A1
Authority: DE; Germany
Prior art keywords: polyfructosans; strain; vaccine according; streptococcus; germs
Prior art date: 1971-03-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

DE19722212739

Other languages

German (de)

English (en)

Inventor

Kestenbaum Richard Charles

Abdul Gaffar

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Colgate Palmolive Co

Original Assignee

Colgate Palmolive Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-03-22

Filing date

1972-03-16

Publication date

1972-10-05

1972-03-16 Application filed by Colgate Palmolive Co filed Critical Colgate Palmolive Co

1972-10-05 Publication of DE2212739A1 publication Critical patent/DE2212739A1/de

Status Pending legal-status Critical Current

Links

229920000377 Sinistrin Polymers 0.000 claims description 37
208000002925 dental caries Diseases 0.000 claims description 29
229960005486 vaccine Drugs 0.000 claims description 24
241000194017 Streptococcus Species 0.000 claims description 15
230000003053 immunization Effects 0.000 claims description 13
238000002649 immunization Methods 0.000 claims description 12
229930006000 Sucrose Natural products 0.000 claims description 11
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 11
239000005720 sucrose Substances 0.000 claims description 11
239000000243 solution Substances 0.000 claims description 8
239000007788 liquid Substances 0.000 claims description 4
238000011534 incubation Methods 0.000 claims description 3
239000012266 salt solution Substances 0.000 claims description 2
238000010521 absorption reaction Methods 0.000 claims 1
244000052616 bacterial pathogen Species 0.000 description 27
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
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239000002609 medium Substances 0.000 description 10
238000000034 method Methods 0.000 description 9
230000015572 biosynthetic process Effects 0.000 description 8
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
239000000284 extract Substances 0.000 description 6
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 6
235000005911 diet Nutrition 0.000 description 5
230000037213 diet Effects 0.000 description 5
239000001963 growth medium Substances 0.000 description 5
235000015097 nutrients Nutrition 0.000 description 5
108090000623 proteins and genes Proteins 0.000 description 5
102000004169 proteins and genes Human genes 0.000 description 5
239000011780 sodium chloride Substances 0.000 description 5
238000002255 vaccination Methods 0.000 description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
241000194019 Streptococcus mutans Species 0.000 description 4
238000002347 injection Methods 0.000 description 4
239000007924 injection Substances 0.000 description 4
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WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
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241000894006 Bacteria Species 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
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RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
235000010469 Glycine max Nutrition 0.000 description 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
241000699673 Mesocricetus auratus Species 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
230000003115 biocidal effect Effects 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
229910002092 carbon dioxide Inorganic materials 0.000 description 2
239000001569 carbon dioxide Substances 0.000 description 2
230000008859 change Effects 0.000 description 2
238000011161 development Methods 0.000 description 2
-1 dextran polysaccharide Chemical class 0.000 description 2
239000000839 emulsion Substances 0.000 description 2
ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
238000002329 infrared spectrum Methods 0.000 description 2
210000000214 mouth Anatomy 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000000725 suspension Substances 0.000 description 2
238000012360 testing method Methods 0.000 description 2
108010050327 trypticase-soy broth Proteins 0.000 description 2
238000002604 ultrasonography Methods 0.000 description 2
PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
208000035473 Communicable disease Diseases 0.000 description 1
241000699800 Cricetinae Species 0.000 description 1
241000194032 Enterococcus faecalis Species 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
241000282596 Hylobatidae Species 0.000 description 1
241000563924 Mitu Species 0.000 description 1
241000186359 Mycobacterium Species 0.000 description 1
AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
229930182555 Penicillin Natural products 0.000 description 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical group N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
239000001888 Peptone Substances 0.000 description 1
108010080698 Peptones Proteins 0.000 description 1
206010035148 Plague Diseases 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
241000700159 Rattus Species 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
241000607479 Yersinia pestis Species 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
LUXUAZKGQZPOBZ-SAXJAHGMSA-N [(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (Z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O LUXUAZKGQZPOBZ-SAXJAHGMSA-N 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
239000008272 agar Substances 0.000 description 1
235000019270 ammonium chloride Nutrition 0.000 description 1
230000009604 anaerobic growth Effects 0.000 description 1
150000001450 anions Chemical class 0.000 description 1
230000002421 anti-septic effect Effects 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
238000009395 breeding Methods 0.000 description 1
230000001488 breeding effect Effects 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000006285 cell suspension Substances 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
230000006378 damage Effects 0.000 description 1
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239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical class CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
230000008014 freezing Effects 0.000 description 1
238000007710 freezing Methods 0.000 description 1
239000008103 glucose Substances 0.000 description 1
230000012010 growth Effects 0.000 description 1
210000003128 head Anatomy 0.000 description 1
230000036541 health Effects 0.000 description 1
150000002402 hexoses Chemical class 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
230000036039 immunity Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
229910021645 metal ion Inorganic materials 0.000 description 1
239000000203 mixture Substances 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
229940049954 penicillin Drugs 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
229940066779 peptones Drugs 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
230000008560 physiological behavior Effects 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
230000008569 process Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
210000003625 skull Anatomy 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
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238000009210 therapy by ultrasound Methods 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Birds (AREA)
Tropical Medicine & Parasitology (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Oral & Maxillofacial Surgery (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Mycology (AREA)
Pharmacology & Pharmacy (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Cosmetics (AREA)

DE19722212739 1971-03-22 1972-03-16 Vaccine zur Immunisation gegen Zahncaries Pending DE2212739A1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US12693371A	1971-03-22	1971-03-22

Publications (1)

Publication Number	Publication Date
DE2212739A1 true DE2212739A1 (de)	1972-10-05

Family

ID=22427441

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE19722212739 Pending DE2212739A1 (de)	1971-03-22	1972-03-16	Vaccine zur Immunisation gegen Zahncaries

Country Status (11)

Country	Link
JP (1)	JPS5549571B1 (xx)
AT (1)	AT320848B (xx)
AU (1)	AU464116B2 (xx)
BE (1)	BE781047A (xx)
CA (1)	CA990646A (xx)
CH (1)	CH562879A5 (xx)
DE (1)	DE2212739A1 (xx)
ES (1)	ES400957A1 (xx)
FR (1)	FR2130412B1 (xx)
GB (1)	GB1343755A (xx)
ZA (1)	ZA721479B (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3931398A (en) *	1973-06-20	1976-01-06	Colgate-Palmolive Company	Method for local immunization against dental caries

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2548848A (en) *	2016-03-30	2017-10-04	The Inst Of Food Res	Levan polysaccharide to modulate cell function

1972
- 1972-03-06 ZA ZA721479A patent/ZA721479B/xx unknown
- 1972-03-15 AU AU39988/72A patent/AU464116B2/en not_active Expired
- 1972-03-16 DE DE19722212739 patent/DE2212739A1/de active Pending
- 1972-03-16 GB GB1240872A patent/GB1343755A/en not_active Expired
- 1972-03-17 FR FR7209476A patent/FR2130412B1/fr not_active Expired
- 1972-03-20 ES ES400957A patent/ES400957A1/es not_active Expired
- 1972-03-21 CH CH418772A patent/CH562879A5/xx not_active IP Right Cessation
- 1972-03-21 CA CA137,688A patent/CA990646A/en not_active Expired
- 1972-03-21 AT AT238072A patent/AT320848B/de not_active IP Right Cessation
- 1972-03-22 JP JP2822372A patent/JPS5549571B1/ja active Pending
- 1972-03-22 BE BE781047A patent/BE781047A/xx unknown

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3931398A (en) *	1973-06-20	1976-01-06	Colgate-Palmolive Company	Method for local immunization against dental caries

Also Published As

Publication number	Publication date
FR2130412B1 (xx)	1976-04-16
JPS5549571B1 (xx)	1980-12-12
ZA721479B (en)	1973-10-31
ES400957A1 (es)	1975-01-16
FR2130412A1 (xx)	1972-11-03
AU3998872A (en)	1973-09-20
CA990646A (en)	1976-06-08
BE781047A (fr)	1972-07-17
GB1343755A (en)	1974-01-16
AT320848B (de)	1975-02-25
CH562879A5 (xx)	1975-06-13
AU464116B2 (en)	1975-07-31

Publication	Publication Date	Title
DE3539202C2 (xx)	1989-01-12
DE69329693T2 (de)	2001-06-28	Verwendung von Bakterienhüllen der Ordnung Beggiatoales oder der Gattung Vitreoscilla als Wirkstoff eines Medikamentes, das für die Anregung der nichtspezifischen Immunität bestimmt ist
DE3686158T2 (de)	1993-02-25	Impfstoff gegen mastitis.
DE3024282A1 (de)	1981-01-08	Vakzinierende glycopeptid-antigenfraktion mit grosser immunisierungsfaehigkeit, isoliert aus kulturen pathogener keime, verfahren zur isolierung dieser fraktion und diese enthaltende vakzinen
DE69026371T2 (de)	1996-08-01	Heilmittel und verfahren zur inhibierung der vaskularisierung von tumoren
DE2833545A1 (de)	1979-02-15	Hochmolekulare meningokokken- gruppe c-vaccine und verfahren zu ihrer herstellung
DE2926406A1 (de)	1980-01-10	Praeparat zur behandlung maligner neoplasien und verfahren zu seiner herstellung
DD202623A5 (de)	1983-09-28	Verfahren zur herstellung von sporen-polyosiden
DE4447677C2 (de)	1998-07-23	Verfahren zur Herstellung eines Impfserums zur Immunisierung gegen Pseudomonas Aeruginosa-Infektionen
DE3541044A1 (de)	1987-05-21	Neues, allgemein anwendbares antigen (psc-a) gegen pseudomonas aeruginosa, das als mittel zum schutz gegen pseudomonas aeruginosa-infektion wirkt
DE4324859A1 (de)	1994-01-27	Oral verabreichbare Zusammensetzung zur Behandlung periodontaler Erkrankungen
DE3427477C2 (xx)	1988-11-17
DE2212739A1 (de)	1972-10-05	Vaccine zur Immunisation gegen Zahncaries
DE3504940C2 (de)	1997-11-06	Multipotente Paramunitätsmediatoren, Verfahren zu ihrer Herstellung und diese Mediatoren enthaltende Arzneimittel
DE3122669A1 (de)	1982-02-11	"verfahren zur herstellung von neuen mutanten von herpes simplex-viren typ 1 und typ 2"
DE4007315A1 (de)	1991-09-12	Verwendung von zink-calciumhydroxid, lecithin und pao zur adjuvierung von antigenloesungen und auf diese weise adjuvierte antigenloesungen
DE2152112C3 (de)	1979-10-11	Impfstoff gegen Pseudomonas aeruginosa
DE2829975A1 (de)	1979-01-25	Antitumor wirksame substanz, deren herstellung und verwendung
CH657989A5 (de)	1986-10-15	Biologisch aktive substanz, verfahren zur herstellung der substanz, sowie die substanz enthaltende, immunoaktive zusammensetzung.
DE2737060C2 (de)	1986-07-31	Escherichia coli-Neurotoxin
DD143729A5 (de)	1980-09-10	Verfahren zur herstellung eines immunbiotherapeutischen arzneimittels gegen infektionen der atemwege
DE2727236C3 (de)	1981-02-05	Verfahren zum Herstellen von Lösungen filtrierter Lysate und darauf basierendes, oral applizierbares Arzneimittel zum Vorbeugen gegen und Bekämpfen von Zahnkaries und Paradentoseerkrankungen
DE2921829C2 (xx)	1987-08-13
DE1115888B (de)	1961-10-26	Verfahren zur Herstellung eines Streptokinase-Praeparates
DE2165401C3 (de)	1979-10-31	Inaktivierter Kombinationsimpfstoff zum Immunisieren von Geflügel gegen Infektion der Atmungsorgane

DE2212739A1 - Vaccine zur Immunisation gegen Zahncaries - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (1)

Publications (1)

Family

ID=22427441

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