DE2150884A1 - BLOOD TEST AIDS - Google Patents
BLOOD TEST AIDSInfo
- Publication number
- DE2150884A1 DE2150884A1 DE19712150884 DE2150884A DE2150884A1 DE 2150884 A1 DE2150884 A1 DE 2150884A1 DE 19712150884 DE19712150884 DE 19712150884 DE 2150884 A DE2150884 A DE 2150884A DE 2150884 A1 DE2150884 A1 DE 2150884A1
- Authority
- DE
- Germany
- Prior art keywords
- blood
- glass
- blood test
- grains
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009534 blood test Methods 0.000 title claims description 6
- 208000030507 AIDS Diseases 0.000 title 1
- 239000011521 glass Substances 0.000 claims description 11
- 230000023555 blood coagulation Effects 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 9
- 239000000835 fiber Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 2
- 239000010419 fine particle Substances 0.000 claims 1
- 239000004033 plastic Substances 0.000 description 9
- 229920003023 plastic Polymers 0.000 description 9
- 239000002245 particle Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 239000008187 granular material Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 229920000426 Microplastic Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 239000011265 semifinished product Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/153—Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/15003—Source of blood for venous or arterial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
- A61B5/150061—Means for enhancing collection
- A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150236—Pistons, i.e. cylindrical bodies that sit inside the syringe barrel, typically with an air tight seal, and slide in the barrel to create a vacuum or to expel blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150244—Rods for actuating or driving the piston, i.e. the cylindrical body that sits inside the syringe barrel, typically with an air tight seal, and slides in the barrel to create a vacuum or to expel blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150259—Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
- A61B5/150381—Design of piercing elements
- A61B5/150503—Single-ended needles
- A61B5/150519—Details of construction of hub, i.e. element used to attach the single-ended needle to a piercing device or sampling device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Manufacturing & Machinery (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Ecology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Description
Dr. A. Menfael DipUng.W.DahikeDr. A. Menfael DipUng.W.Dahike
Ρί-tenlanwäiteΡί-tenlanwäite
«^:ti» bei Köln Oktober«^: Ti» near Cologne October
ror.kenforst 1o7 ^ror.kenforst 1o7 ^
Firma Walter Sarstedt Kunststoff-SpritzgußwerkWalter Sarstedt plastic injection molding plant
Nümbrecht / RommelsdorfNümbrecht / Rommelsdorf
"Hilfsmittel für Blutuntersuchung" Zusatz zu Patent P 20 34 457.4)"Aid for blood testing" addendum to patent P 20 34 457.4)
Im Hauptpatent wurde als Hilfsmittel für Blutuntersuchungen ein fester, granulatförmiger Träger und eine von diesem getragene, die Oberfläche der einzelnen Körner in einer dünnen Schicht bedeckende, die Blutgerinnung beeinflussende Substanz vorge β chla ge η.The main patent was used as an aid for blood tests a solid, granular carrier and one carried by this, A substance that covers the surface of the individual grains in a thin layer and affects blood coagulation proposed β chla ge η.
303816/0487303816/0487
Insbesondere war dabei vorgesehen, daß der Träger aus einem Kunststoff bestellt, dessen spezifisches Gewicht zwischen dem .des Serums bzw. des Plasmas einerseits und dem des Blutkuchens bzw. der sedimentierten Blutkörperchen andererseits liegt.In particular, it was provided that the carrier ordered from a plastic whose specific weight between the . of the serum or plasma on the one hand and that of the blood cake or sedimented blood cells on the other.
Wie im einzelnen im Hauptpatent ausgeführt wurde, kann es in einigen Fällen erwünscht sein, die Blutgerinnung in einem Ge- ^ fäß durch Zugabe von Körnern der genannten Art zu beschleunigen, in anderen Fällen dagegen, diese zu verlangsamen oder völlig zu verhindern. Es sind verschiedene chemische Substanzen bekannt, die, chemisch in den Blutgerinnungsprozeß eingreifend, diesen beschleunigen oder verlangsamen.As detailed in the main patent, it may be desirable in some cases to prevent blood clotting in a ^ accelerate the vessel by adding grains of the type mentioned, in other cases it is against slowing it down or preventing it entirely. They are different chemical substances known which, chemically intervening in the blood coagulation process, accelerate or slow it down.
Es ist aber auch bekannt, daß die Blutgerinnung ohne Eingriff in den Chemismus der Blutgerinnung, lediglich durch physikalische Mittel, beeinflußt werden kann, beispielsweise durch die Oberflächenspannung einer Grenzfläche zwischen der Substanz W des Behälters und dem Blut. So werden deutlich verlangsamte Blutgerinnungszeiten in Gefäßen aus thermoplastischen Kunststoffen, insbesondere aus Polyäthylen und Polypropylen, gegenüber Gefäßen aus Glas, beobachtet.However, it is also known that the blood coagulation can be influenced without interfering with the blood coagulation chemistry, merely by physical means, for example by the surface tension of an interface between the substance W of the container and the blood. Significantly slowed blood coagulation times are observed in vessels made of thermoplastics, in particular made of polyethylene and polypropylene, compared to vessels made of glass.
χ In manchen Fällen ist diese Verzögerung der Blutgerinnung in ι Kunststoffbehältern ausgesprochen unerwünscht. In solchen Fällen hat man dann bisher auf die Verwendung von Kunststoffgefäßen anstelle von Glasgefäßen verzichtet. χ In some cases, this delay in blood clotting in plastic containers is extremely undesirable. In such cases, the use of plastic vessels instead of glass vessels has hitherto been dispensed with.
309816/0487309816/0487
Ausgehend von der Lehre des Hauptpatents und zur Lösung der dort gestellten Aufgabe für den vorstehend geschilderten besonderen Zweck wird erfindungsgemäß vorgeschlagen, daiB die auf der Oberfläche der Körner befindliche, die Blutgerinnung beeinflussende Substanz Glas in Gestalt feiner, in die oberflächennahen Schichten der Körner eingebetteter leuchen, vorzugsweise Fasern, ist.Based on the teaching of the main patent and to solve the problem set there for the special one described above Purpose is proposed according to the invention that the On the surface of the grains, the substance that affects blood coagulation is glass in a finer shape, in the near-surface Layers of the grains of embedded glow, preferably fibers, is.
Derartige Granulatkörner, insbesondere aus einem hochpolymereη thermoplastischen Kunststoff, die an ihrer Oberfläche mit Glasfasern oder feinen Glasteilchen in anderer Gestalt besetzt sind, bewirken, wenn sie mit Blut in Berührung gebracht v/erden, eine erheblich beschleunigte Blutgerinnung. Dabei besitzt dieses Hilfsmittel noch den besonderen Vorteil, daß es nicht in den eigentlichen Chemismus der Blutgerinnung als Reaktionspartner eingreift, sondern lediglich, wahrscheinlich aufgrund geänderter Oberflächenspannung, von Außen in diesen beschleunigend eingreift. Es können also Blutuntersuchungen jeder Art vorgenommen werden, ohne daß hinzugefügte chemische Substanzen dabei störend wirken*Such granules, in particular from a high polymer thermoplastic material, the surface of which is covered with glass fibers or fine glass particles in a different shape if they come into contact with blood, they cause a considerably accelerated coagulation of the blood. It owns this Aid still has the particular advantage that it does not intervene in the actual blood coagulation chemistry as a reaction partner, but only, probably due to changed surface tension, intervenes from the outside in an accelerating manner. So blood tests of any kind can be used can be carried out without added chemical substances having a disruptive effect *
V/esentlich für die Wirkung des erfindungsgemäß vorgeschlagenen Hilfsmittels ist es, daß die Glasteilchen aus der Oberfläche des sie tragenden Körnchens herausragen, ohne selbst durch die Substanz des Granulats eingehüllt und abgedeckt zu nein.V / aterial for the effect of the inventively proposed aid it is that the glass particles from the surface of the protrude supporting granule encased by the substance itself without the granules and covered to no.
309816/0487309816/0487
Besonders geeignet für diesen Zweck ist ein Kunststoffgranulat üblicher Korngröße, wie es zur Beschickung von kunststoffverarbeitenden Maschinen, beispielsweise Extrudern, verwendet wird. Es eignen sich grundsätzlich alle Kunststoffe, sofern sie nicht aus chemischen Gründen "bedenklich sind und die Blutunter-Buchung stören, für diesen Zweck. In den einzelnen Körnchen des Granulats sollen dann feine Glasteilchen, beispielsweise ™ kurze Pasern aus Glas, enthalten sein. Ein solches Kunststoffgranulat bzw. Halbfabrikate aus Kunststoff, die mit Glasfasern oder Glasteilchen verstärkt sind, sind schon bekannt. Sie sind aber nur dann als Hilfsmittel für Blutuntersuchungen im Sinne der Erfindung geeignet, wenn die Glasteilchen, beispielsweise die Enden der Fasern, aus der Oberfläche der Kunststoffteilchen nach außen vorstehen, und damit physikalisch wirksam werden. Bei der Herstellung eines solchen Granulats, das als Hilfsmittel für Blutuntersuchungen im vorgenannten Sinne geeignet ist, ist also darauf zu achten, daß die Glasteilchen oder zumindest einige derselben aus der Oberfläche nach außen vorstehen. Plastic granules are particularly suitable for this purpose usual grain size, as it is used for feeding plastics processing Machines such as extruders is used. In principle, all plastics are suitable, provided they are not for chemical reasons "are questionable and the blood under-booking bother for this purpose. Fine glass particles, for example ™ short leads made of glass. Such a plastic granulate or semi-finished products made of plastic, which are reinforced with glass fibers or glass particles, are already known. they are but only suitable as an aid for blood tests within the meaning of the invention if the glass particles, for example the ends of the fibers, protrude outward from the surface of the plastic particles, and thus become physically effective. In the production of such granules, which are suitable as an aid for blood tests in the aforementioned sense is, so make sure that the glass particles or at least some of them protrude from the surface to the outside.
• - 5 309818/0487 • - 5 309818/0487
Claims (1)
Priority Applications (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE789954D BE789954A (en) | 1970-03-07 | BLOOD COLLECTION DEVICE | |
| DE2010830A DE2010830C3 (en) | 1970-03-07 | 1970-03-07 | Device for taking blood |
| DE19702034457 DE2034457A1 (en) | 1970-03-07 | 1970-07-11 | Tools for blood tests |
| DE19717111793U DE7111793U (en) | 1970-03-07 | 1971-03-27 | STOPPER FOR BLOOD COLLECTION DEVICE |
| DE19712150884 DE2150884C3 (en) | 1971-10-13 | Tools for blood tests | |
| GB5361271A GB1390621A (en) | 1970-03-07 | 1972-02-27 | Device for the extraction of blood |
| DE2245584A DE2245584C3 (en) | 1970-03-07 | 1972-09-16 | Device for taking blood |
| CH1477572A CH548765A (en) | 1970-03-07 | 1972-10-10 | Device for collecting blood. |
| CA154,125A CA1012023A (en) | 1970-03-07 | 1972-10-12 | Device for the extraction of blood |
| NL7213918A NL7213918A (en) | 1970-03-07 | 1972-10-13 | |
| FR7236318A FR2157471A5 (en) | 1970-03-07 | 1972-10-13 | |
| US297219A US3886928A (en) | 1970-03-07 | 1972-10-13 | Device for the extraction of blood |
| JP10194672A JPS575541B2 (en) | 1970-03-07 | 1972-10-13 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2010830A DE2010830C3 (en) | 1970-03-07 | 1970-03-07 | Device for taking blood |
| DE19702034457 DE2034457A1 (en) | 1970-03-07 | 1970-07-11 | Tools for blood tests |
| DE19712150884 DE2150884C3 (en) | 1971-10-13 | Tools for blood tests | |
| DE2245584A DE2245584C3 (en) | 1970-03-07 | 1972-09-16 | Device for taking blood |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2150884A1 true DE2150884A1 (en) | 1973-04-19 |
| DE2150884B2 DE2150884B2 (en) | 1975-12-11 |
| DE2150884C3 DE2150884C3 (en) | 1976-07-15 |
Family
ID=
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3036220A1 (en) * | 1979-10-04 | 1981-04-23 | Ken Heistad Heimreid | METHOD AND DEVICE FOR EXAMINING UNCLOTNED BLOOD |
| US4477575A (en) * | 1980-08-05 | 1984-10-16 | Boehringer Mannheim Gmbh | Process and composition for separating plasma or serum from whole blood |
| US4883764A (en) * | 1987-07-20 | 1989-11-28 | Kloepfer Mary A | Blood test strip |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3036220A1 (en) * | 1979-10-04 | 1981-04-23 | Ken Heistad Heimreid | METHOD AND DEVICE FOR EXAMINING UNCLOTNED BLOOD |
| US4477575A (en) * | 1980-08-05 | 1984-10-16 | Boehringer Mannheim Gmbh | Process and composition for separating plasma or serum from whole blood |
| US4883764A (en) * | 1987-07-20 | 1989-11-28 | Kloepfer Mary A | Blood test strip |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2157471A5 (en) | 1973-06-01 |
| CH548765A (en) | 1974-05-15 |
| GB1390621A (en) | 1975-04-16 |
| DE7111793U (en) | 1971-07-01 |
| DE2245584B2 (en) | 1979-04-26 |
| DE2010830B2 (en) | 1977-09-22 |
| DE2245584C3 (en) | 1980-01-03 |
| JPS575541B2 (en) | 1982-01-30 |
| DE2245584A1 (en) | 1974-03-21 |
| BE789954A (en) | 1973-02-01 |
| CA1012023A (en) | 1977-06-14 |
| DE2010830A1 (en) | 1971-09-16 |
| DE2034457A1 (en) | 1972-02-17 |
| DE2010830C3 (en) | 1978-05-11 |
| US3886928A (en) | 1975-06-03 |
| DE2150884B2 (en) | 1975-12-11 |
| NL7213918A (en) | 1973-04-17 |
| JPS4847191A (en) | 1973-07-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| E77 | Valid patent as to the heymanns-index 1977 | ||
| 8339 | Ceased/non-payment of the annual fee |