DE2111546A1 - Process for the treatment of medicinal plants or drugs - Google Patents

Description

DIPL-CHEM. DR.ELISABETH JUNG 8 MONKS 23. ^ - MsrZ 1971

DtPL-CHEM. DR. VOLKER VOSSIUS - ^ "SfSSi. ⁸ ,""* ⁰

DIPL-PHYS. DR. JÜRGEN SCHIRDEWAHN "lex 5 ^ 86 ^{ADDRESS: invent / monchen}

PATENT LAWYERS

uZ: P 94-3 G (Vo / we)
uase 2041

ϊοβΜζο SAKAMOTO and Kazuyasu SAKAMOTO 1166, Shimocrfcome, Oazu. Cöa-shi, Ohita-ken, Japan

"Method for the treatment of medicinal plants or drugs ⁿ priority: November 27, 1970, Japan, No. 104 639/70

The invention relates to an improved method for the production of dry powdered medicinal preparations and liquid ones Medicinal preparations made from raw medicinal plants or drugs, such as raw garlic.

Numerous plants are known to contain active ingredients or mixtures of substances that are used in medicine. These plants are after harvest by drying in a durable Form transferred, with the active ingredients to be largely retained. Among the common methods of preservation is drying the most important. The water is removed from the fresh plants, either naturally by letting it evaporate or

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by supplying dry, cold or warm air at normal pressure or under reduced pressure. The type of drying must be adapted to the sensitivity of the active ingredients. For the production of medicinal drug preparations are made from. the active ingredients extracted from the herbal drugs. For this purpose, solvents are used, which dissolve the active ingredients well.

The aforementioned methods have several disadvantages. Drying is a time consuming and cumbersome process There are numerous factors to consider in order to obtain good quality drugs. Natural drying requires exact Monitoring, and only when there is sufficient sunshine, this method can be used economically. the The quality of the drugs is determined by prolonged periods of fire exposure endangered. Artificial drying with warm air can only guarantee quality drugs for certain medicinal plants, because the action of atmospheric oxygen at elevated temperature causes a breakdown of the tannins and resinification of the essential ones Oils and other oxidative processes. Special drying process, such as so-called stabilization, vacuum drying, infrared drying and freeze drying, are either not generally applicable or too expensive.

In storage, too, there are the same possibilities for changing the drugs as in storage, albeit to a lesser extent Dry. If the drugs are stored for a long time, they can suffer a significant loss in quality.

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In the patent application P 20 10 210 »7 there is already a method for! ' Treatment of medicinal plants or »drugs have been suggested * that allows the active ingredients in medicinal plants to be preserved or extracted as gently as possible. This procedure is characterized! that fresh or dried drug plant is subjected in a rotary Destillationsbehäiter at pressures of 70 to 80 Torr and at temperatures of 50 to 25O ⁰ G for 15 minutes to 6 hours of dry distillation and the distillate from the separated residue halbverkohlt looking *

The semi-charred residue produced in this process represents the medicinal plant, which is covered by a charred coating is covered * This half-charred residue can be stored for a long time and used for the production of pharmaceutical preparations «Volatile active ingredient components of medicinal plants distill off together with water and are collected. This distillate can either be used directly as a medicinal product or for the production of medicinal drug products «

The method described above has the Jiaehpart that local overheating of the medicinal plants cannot be avoided can * because with this method the medicinal plants "like garlic," only move in the distillation container. will hold. As a result, along with the volatile -Active ingredients and water also tarry substances distill over * To separate these tarry constituents

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parts is therefore another distillation of the distillate or a treatment with activated carbon or absorbent exchange resins necessary. These measures complicate the process.

The object of the invention was to address the disadvantages of the above Process for the preparation of medicinal plants or ;. Drugs to avoid "

The subject of the invention is thus a method for the treatment of medicinal plants or drugs, which is characterized in that the raw drugs or medicinal plants are introduced in the uncomminuted state into a vacuum distillation vessel provided with an indirect heating device and equipped with a stirrer with cutting devices xmä. the drugs or medicinal plants are heated to moderate temperatures under reduced pressure and with stirring and cutting and a liquid distillate and a pulpy residue is obtained, which is further dried under reduced pressure.

According to the process of the invention succeeds ", 'the drug plants or Drogsn at low temperatures recycle. Preferable to operate at temperatures of 40 to 60 ⁰ C and at pressures of about 70 to 80 torr. Under these conditions no tar formation is observed. The The product resulting from the distillation can be used directly as a liquid medicinal preparation. The pulpy residue in the vacuum distillation vessel is not charred.

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preparation.

According to the method of the invention, the medicinal plants not oxidized as they are from the moment they are placed in the vacuum distillation vessel until they are broken off. are not exposed to air during treatment. '

Examples of the medicinal plants preferably used in the process of the invention are garlic, pearl barley, unpeeled rice,
Mugwort, wolfberry, arrowroot and mustard seeds,

In the drawing is an example of a vacuum distillation device reproduced for performing the method of the invention. The device comes with a liquid level meter (23) and a thermometer (25) and a jacket (2). Inside the distillation vessel is located a stirring blade (3) provided with cutting devices. The distillation vessel is closed with a cover plate (10). The stirrer (9) is attached to the cover plate (10) via an airtight socket (8) and is driven by an electric motor (7) driven. The cover plate (10) is also provided with a nozzle (6) for filling in the raw material. In the coat (2) is a heat transfer medium is filled in through the filler neck (5). The distillation vessel is heated by means of a heating source (4) heated. A thermometer (24) is used to control the heating temperature.

The cover plate (10) is with a line ("M) and (12) to one

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Connected cooler (13), which consists of a cooling pipe (14), a cooling water inlet (15) and a cooling water outlet (l6). The lower end of the cooler (13) is connected to a container (18) via a line (17). (19) is a peephole, (20) one Outlet line and (21) a line for removing distillate.

The bottom part of the distillation vessel (1) is provided with an extraction line (22) which is connected to a vacuum dryer (26).

The item to be treated, e.g. raw garlic, from which only the epidermis is peeled off, is inserted through the nozzle (6) into the Introduced the distillation vessel. To evacuate the distillation vessel, the line (20) is connected to a vacuum pump (not shown) tied together. When the prescribed pressure is reached, a heat transfer medium is introduced through the filler neck (5), like water, filled into the heating jacket (2) and heated by the heating source (4). The conditions prevailing in the heating jacket (2) are checked using the liquid level meter (23) and the thermometer (24).

The stirring blade (3), which is provided with a cutting device, is designed in such a way that the material to be treated is cut and

(9) can be crushed or ground. The stirrer / is driven by the Electric motor (7) »whose speed of rotation can be changed operated. The volatile components are im The cooler (13) condenses and is collected in the container (18). The pulpy residue in the distillation vessel gets through

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- 1 ~

2111548

the removal line (22) into the vacuum dryer (26) and i>: ird there dried to a powder under reduced pressure.

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Claims (2)

Claims 1. Process for the treatment of medicinal plants or drugs, characterized in that the raw Drugs or medicinal plants in a non-comminuted state in a vacuum distillation vessel equipped with an indirect heating device brings in, which is provided with a stirrer with cutting devices, and the drugs or medicinal plants under reduced pressure and heated to moderate temperatures with stirring and cutting and a liquid distillate and a Pasty residue wins, which is further dried under reduced pressure. 2. The method according to claim 1, characterized in that one at a temperature of 40 to 60 C and at a pressure of about 70 to 80 Torr. 3 · Method according to claim. 1, characterized in that one Garlic, pearl barley, unpeeled rice, mugwort, wolfberry, arrowroot or mustard seeds are used as medicinal plants. 209823/1076