DE2034198C3 - Process for the manufacture of sealed gelatin capsules filled with dry material to just below the edge of the capsule - Google Patents
Process for the manufacture of sealed gelatin capsules filled with dry material to just below the edge of the capsuleInfo
- Publication number
- DE2034198C3 DE2034198C3 DE2034198A DE2034198A DE2034198C3 DE 2034198 C3 DE2034198 C3 DE 2034198C3 DE 2034198 A DE2034198 A DE 2034198A DE 2034198 A DE2034198 A DE 2034198A DE 2034198 C3 DE2034198 C3 DE 2034198C3
- Authority
- DE
- Germany
- Prior art keywords
- capsule
- gelatin
- filled
- dry material
- capsules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002775 capsule Substances 0.000 title claims description 48
- 239000000463 material Substances 0.000 title claims description 9
- 238000000034 method Methods 0.000 title claims description 9
- 238000004519 manufacturing process Methods 0.000 title claims 4
- 239000007903 gelatin capsule Substances 0.000 title claims 3
- 229920000159 gelatin Polymers 0.000 claims description 17
- 235000019322 gelatine Nutrition 0.000 claims description 17
- 108010010803 Gelatin Proteins 0.000 claims description 15
- 239000008273 gelatin Substances 0.000 claims description 15
- 235000011852 gelatine desserts Nutrition 0.000 claims description 15
- 239000001828 Gelatine Substances 0.000 claims description 2
- 239000000155 melt Substances 0.000 claims description 2
- 238000007711 solidification Methods 0.000 claims description 2
- 230000008023 solidification Effects 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims 4
- 230000004927 fusion Effects 0.000 claims 3
- 238000007789 sealing Methods 0.000 claims 2
- 230000006835 compression Effects 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 230000001066 destructive effect Effects 0.000 claims 1
- 238000005538 encapsulation Methods 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 238000003860 storage Methods 0.000 claims 1
- 230000006378 damage Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B7/00—Closing containers or receptacles after filling
- B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
- B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S206/00—Special receptacle or package
- Y10S206/828—Medicinal content
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S220/00—Receptacles
- Y10S220/34—Anti-tamper pharmaceutical capsules, e.g. tamper indicating or resistant
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mechanical Engineering (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Seasonings (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
vor dem Aufbringen der geschmolzenen Gelatine das In einer aus einem Behälter 27 mit geschmolzenerBefore applying the melted gelatin, in one of a container 27 with melted
trockene Material in der Kapsel zu rütteln. Dadurch Gelatine führenden Leitung 25 ist ein Ventil 24 vor-to shake dry material in the capsule. Line 25 carrying gelatin through this is provided with a valve 24
034 198034 198
· f die offenen Enden bzw.F the open ends resp.
gesehen. Das Ventil 24 kann ähnlich wie eine lnjek- schmolzene Gelatme au K lkörper ig auf-seen. The valve 24 may be similar to a molten lnjek- Gelatme au K lkörper ig up
tionsspritze gebaut sein, die synchron mit dem Vor- Kapselrander 18 der % ^^ emfache Ein tion syringe be built, which is synchronized with the front edge of the capsule 18 of% ^^ simple one
rücken der noch nicht abgedichteten Kapselkörper zubringen. Es *?"Q „ Verschiießen von wenigstens 15 aktiviert wird, so daß automatisch eine ganz be- ™htung nun' öicme einzigen Reihe verstimmte Menge geschmolzener Gelatine aufgebracht 5 lOOKapseln pro Mmute^ o^du^könnenmove the not yet sealed capsule body. Is it *? "Q" Various ii e SEN activated by at least 15, so that automatically loading a very ™ Pla melted gelatin applied 5 lOOKapseln per Mmute ^ o ^ ^ You can now 'öicme single row detuned amount
W1Die gefüllten und abgedichteten Kaprsln 11 wer- Reihen von ^Ρ^Ρ^,οΟ Kapseln pro Minute W1 The filled and sealed Kaprsln 11 are rows of ^ Ρ ^ Ρ ^, οΟ capsules per minute
den auf der Fördereinrichtung 21 belassen, bis der ^rden wodurchj^fn /Der THockenzyklus die.Leave the on the conveyor 21 until the ^ rd e n w od ur chj ^ f n / Der T H ockenzyklus die .
Ver^hluß 17 vollständig verfestigt und ausreichend «bßef ^t werfeη konn beschleunigt werde. ,Ver ^ STATEMENTS 17 completely solidified and sufficient "bßef ^ t werfeη could ACC i g t will. ,
getrocknet ist, so daß ein Verkleben mit anderen ge- ίο ^r abgedichteten ^Ps*n Strom aus entfeuchteteris dried, so that a sticking with other ge ίο ^ r sealed ^ P s * n stream from dehumidified
füllten und abgedichteten Kapseln 11 vermieden ^^"^oStimmten Temperatur daruber-Filled and sealed capsules 11 avoided ^^ "^ o Appropriate temperature above-
wird. BeLTi Trocknen des Verschlusses 17 schmilzt . Luft mit einer vorowill. BeLTi drying the closure 17 melts. Air with a voro
der erweichte Kapselrand 18 des Kapselkörpers IS 5ΐΓ^ηβη,^Γεη nach der Erfindung ist^ auf allethe softened capsule edge 18 of the capsule body IS 5ΐΓ ^ ηβη , ^ Γεη according to the invention is ^ on all
und schrumpft dicht auf den Verschluß 17 auf, wo- Das Verfanrej' na Nachdem man den Gradand shrinks tightly onto the closure 17, where- Das Verfanrej ' na After one the degree
durch eine einheitliche Kapsel 11 gebildet wird, die 15 Κ2Ρ^™^ηΓ^ Kapselkörpers bestimmteris formed by a unitary capsule 11, the 15 Κ2 Ρ ^ ™ ^ ηΓ ^ capsule body certain
nicht ohne Zerstörung geöffnet werden kann. Der der Sch™"g£« 6^ kaSn eine vorbestimmtecannot be opened without destruction. The Sch ™ "g £« 6 ^ ka Sn a predetermined
Kapselrand 18 wird beim Schrumpfen nach innen ge- Große ^Jg™ n Gdatine Von den Injektions-Capsular rim 18 is on shrinking inward overall Large ^ Jg ™ s Gdatine V on the injection
ZOg1Cn und die innere Oberfläche des Verschlusses 17 Menge g^^^den, um ein glatt kontunertesZOg 1 Cn and the inner surface of the breech 17 set g ^^^ den to a smoothly contoured
wölbt sich infolge des Schrumpfvorganges während sprUzen abgegeben werd ^ ^ ^^ ^^^bulges as a result of the shrinkage process while spraying is dispensed ^ ^ ^^ ^^^
der Verfestigung der geschmolzenen Gelatine nach »o End?zu^r everschluß 17 kthe solidification of the melted gelatine after »o End ? to ^ r e ve r conclusion 17 k
ferner aus einer un-also from an un-
sehen Injektionsspritzen verwendet werden, um ge- mansee hypodermic syringes used to get man
Hierzu 1 Blatt Zeichnungen1 sheet of drawings
Claims (2)
latinetropfen und Kapselrand erzeugt wird. F i g. 4 in schematischer Ansicht einer Veran-fens or from drops of a temperature on- io F i g. 3 one of the F i g. 2 corresponding longitudinally, the loosening of the capsule edge cut through the capsule according to F i g. 1 causes radial shrinkage after filling, so that when oiling with dry material, but before sealing solidification, a fusion bond
Latin drops and capsule rim is generated. F i g. 4 in a schematic view of a
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84104469A | 1969-07-11 | 1969-07-11 |
Publications (3)
Publication Number | Publication Date |
---|---|
DE2034198A1 DE2034198A1 (en) | 1971-12-09 |
DE2034198B2 DE2034198B2 (en) | 1973-05-24 |
DE2034198C3 true DE2034198C3 (en) | 1973-12-06 |
Family
ID=25283872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2034198A Expired DE2034198C3 (en) | 1969-07-11 | 1970-07-09 | Process for the manufacture of sealed gelatin capsules filled with dry material to just below the edge of the capsule |
Country Status (8)
Country | Link |
---|---|
US (1) | US3653500A (en) |
BE (1) | BE753194A (en) |
CA (1) | CA924239A (en) |
CH (1) | CH508398A (en) |
DE (1) | DE2034198C3 (en) |
ES (1) | ES381678A1 (en) |
FR (1) | FR2055048A5 (en) |
GB (1) | GB1267304A (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2722807A1 (en) * | 1977-05-20 | 1978-11-23 | Capsugel Ag | PROCESS FOR MANUFACTURING A VISCOSE-FILLED CAPSULE |
DE2722806C2 (en) * | 1977-05-20 | 1984-12-13 | Capsugel AG, Basel | Capsule body for a push-fit capsule for drugs or other substances to be packaged in portions, as well as a process for its production |
USD285837S (en) | 1982-12-20 | 1986-09-23 | Warner-Lambert Company | Pharmaceutical capsule |
US4576284A (en) * | 1983-12-02 | 1986-03-18 | Warner-Lambert Company | Closing of filled capsules |
CH664938A5 (en) * | 1983-10-20 | 1988-04-15 | Warner Lambert Co | PRINTED ARTICLES. |
US5074426A (en) * | 1986-11-13 | 1991-12-24 | Warner-Lambert Company | Dividable capsule |
DE10128779A1 (en) † | 2001-06-13 | 2003-01-02 | Boehringer Ingelheim Pharma | Process for cleaning hard gelatin capsules |
EP1459725B1 (en) * | 2003-03-21 | 2007-10-17 | Warner-Lambert Company LLC | Apparatus for and method of sealing capsules |
DE102010028125A1 (en) * | 2010-04-22 | 2011-10-27 | Robert Bosch Gmbh | Device for filling and closing capsules filled with at least one filling substance |
USD684253S1 (en) * | 2011-02-24 | 2013-06-11 | Moldex-Metric, Inc. | Cylinder earplug |
KR20120107793A (en) * | 2011-03-22 | 2012-10-04 | 엘지이노텍 주식회사 | Display device and light conversion member |
CN110471318B (en) * | 2019-06-26 | 2022-05-10 | 康美药业股份有限公司 | Intelligent control system of pharmacy heating furnace |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US464121A (en) * | 1891-12-01 | Capsule | ||
US1256307A (en) * | 1917-06-26 | 1918-02-12 | Margaret Grant | Process and container for canning or preserving jellies and the like. |
US1792010A (en) * | 1929-04-24 | 1931-02-10 | Lake Erie Chemical Company | Gelatin-composition container |
US1846052A (en) * | 1929-06-12 | 1932-02-23 | Grant Margaret | Container and method for sealing jelly or preserves |
US1911020A (en) * | 1929-06-12 | 1933-05-23 | Grant Margaret | Method for sealing jelly, preserves, or the like in containers, and product for such use |
US2031660A (en) * | 1932-11-26 | 1936-02-25 | Gen Fire Extinguisher Co | Method of sealing charged glass bulbs |
US2046367A (en) * | 1934-03-16 | 1936-07-07 | Columbus Dental Mfg Co | Method of packing homogeneous mixtures of pulverized heterogeneous materials |
US2028241A (en) * | 1934-06-15 | 1936-01-21 | United States Radium Corp | Method of making self-luminous element |
US2046609A (en) * | 1935-10-23 | 1936-07-07 | Clark Grover | Container and method of sealing |
US2046366A (en) * | 1936-01-06 | 1936-07-07 | Columbus Dental Mfg Co | Granular material package and method of producing the same |
US2329928A (en) * | 1942-02-02 | 1943-09-21 | Blue Line Chemical Co | Sterilizing medicinal pellets or the like |
US2379342A (en) * | 1942-03-21 | 1945-06-26 | Frank J Cozzoli | Method of sealing filled tubes |
US3078629A (en) * | 1960-01-08 | 1963-02-26 | Upjohn Co | Method for sealing hard filled capsules |
US3162000A (en) * | 1962-06-04 | 1964-12-22 | Cooper Tinsley Lab Inc | Method of sealing two-piece gelatin capsules |
US3324902A (en) * | 1965-05-26 | 1967-06-13 | Bartelt Engineering Co Inc | Method of filling capsules |
US3505775A (en) * | 1966-06-08 | 1970-04-14 | Andersen Prod H W | Method of managing a volatile substance |
US3518340A (en) * | 1968-04-15 | 1970-06-30 | Dow Corning | Method of forming silicone rubber drug carriers |
-
1969
- 1969-07-11 US US841044A patent/US3653500A/en not_active Expired - Lifetime
-
1970
- 1970-07-02 CA CA087069A patent/CA924239A/en not_active Expired
- 1970-07-09 DE DE2034198A patent/DE2034198C3/en not_active Expired
- 1970-07-09 BE BE753194D patent/BE753194A/en unknown
- 1970-07-09 CH CH1040970A patent/CH508398A/en not_active IP Right Cessation
- 1970-07-10 GB GB33590/70A patent/GB1267304A/en not_active Expired
- 1970-07-10 ES ES381678A patent/ES381678A1/en not_active Expired
- 1970-07-10 FR FR7025814A patent/FR2055048A5/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
BE753194A (en) | 1971-01-11 |
CH508398A (en) | 1971-06-15 |
US3653500A (en) | 1972-04-04 |
CA924239A (en) | 1973-04-10 |
ES381678A1 (en) | 1972-12-01 |
FR2055048A5 (en) | 1971-05-07 |
DE2034198A1 (en) | 1971-12-09 |
GB1267304A (en) | 1972-03-15 |
DE2034198B2 (en) | 1973-05-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C3 | Grant after two publication steps (3rd publication) |