DE20204843U1 - Micronutrient combination product, suitable for nutritional supplementation when there is an increased need for micronutrients, especially in patients with diabetes and / or cardiovascular diseases - Google Patents

Description

Düsseldorf ■ Munich · Hamburg

Patent attorneys

Dr. Walter Maiwald (Munich) Dr. Volker Hamm (Hamburg) Dr. Stefan Michalski (Düsseldorf) Dr. Regina Neuefeind (Munich) Dipl.-Ing. Univ. Udo Preuss (Munich)

Lawyer

Stephan N. Schneller (Munich)

In co-operation with:

Dr. Schmidt-Felzmann & Kozianka

Lawyers

(Hamburg)

Parr ■ Dive ■

Leutheusser-Schnarrenberger Attorneys at Law (Munich · Starnberg)

Reference number Our reference

New registration WD 40005 / SAM

WEBER & WEBER GMBH & CO. KG

Dusseldorf, 26 March 2002

Weber & Weber GmbH & Co. KG

Herrschinger Strasse 33
82266 Inning / Ammersee

Micronutrient combination product, suitable for nutritional supplementation in cases of increased micronutrient requirements, especially in patients with diabetes and/or cardiovascular diseases

The present invention relates to a micronutrient combination product which is also suitable for diabetics.

It is well known that vitamins, trace elements and minerals are important components of our food and act as cofactors of enzymes. To replace the

Metabolism and enzymes subject to wear and tear, the human organism is completely

SAM:sa

Achenbachstrasse 43 ■ 40237 Düsseldorf

Tel. +49 (0)211 669 698 40 ■ Fax +49 (0)211 669 698 60 · http://www.maiwald.de ■ mail@maiwald.de

Managing Director: Dr. Walter MaMjIdCW Voller*WarrTm.Ur. Stefan i/lichaliß'-.l-JfcB N?.*4*rJ413 · '

&ngr;&ogr;&eegr; depends on an exogenous intake of certain micronutrients. Experience shows that an inadequate intake of the aforementioned substances leads to deficiency symptoms in the organism.

The vitamin preparations known to the state of the art contain a wide variety of vitamin compositions, which are generally not tailored to a specific disease or its prophylaxis, but often combine different vitamins according to their group affiliation. For example, there are vitamin B or vitamin D preparations. In parallel, there are products that offer a supplement to the mineral supply but do not contain any vitamins. A few forms of administration combine at least group B vitamins with folic acid, but do not take into account other heart-specific vitamins or vitaminoids, such as ubiquinone, whose decreasing concentration is known, particularly in the heart, in connection with chronic heart disease.

In most cases, it is up to the consumer to choose the right combination of preparations for their personal needs. This leads to arbitrarily chosen combinations that do not contain all of the necessary ingredients or at least in combinations that inevitably lead to under- or overdosing of the individual components, since neither an exact dosage of the individual components nor a sensible combination of different combination preparations is possible. Optimal care is impossible if the consumer is left to sort through a wide variety of products, since these cannot be matched to one another in a sensible way, i.e. according to a clinical picture or a desired prophylaxis.

Due to their limited nutritional situation, diabetics are particularly dependent on a balanced intake of essential vitamins, vitaminoids and trace elements. Although the proportion of diabetics, caused by a lack of exercise and

Malnutrition is constantly increasing, and the special needs of this group in terms of micronutrient supply are not taken into account. The vitamin preparations known from the state of the art are neither tailored to specific age groups nor to the coordinated supplementation of disease-related deficiencies.

In particular, there is an increasing number of people whose diabetes in old age is accompanied by the onset of age-related heart problems or who wish to have appropriate prophylaxis. It is particularly important for this group, whose number will continue to rise in the future, to counteract the existing situation of suboptimal care, as incorrect dosages can lead to long-term deficiency symptoms due to the long-term therapy required for diabetics.

The absorption of vitamins, trace elements and minerals in the intestine as well as their metabolism is hindered by many pharmaceuticals. In particular, long-term treatment with drugs, as is necessary for chronic complaints such as cardiovascular diseases, can lead to a deficiency in micronutrients, which in turn can have negative effects on the clinical picture for the reasons mentioned above.

There is therefore a need for a product that offers prevention of heart disease by supplying vitamins from group B and folic acid in a scientifically based composition. In addition, there is a need for a product that does not cause any harmful side effects and can be used safely to prevent vitamin deficiencies and also to meet increased needs in the case of deficiency symptoms, such as through drug treatment of existing diseases. There is also a need for a product that, in addition to preventing heart disease, also offers a special

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nutritional situation of people with diabetes and is tailored to specific age groups and takes into account their metabolic needs.

It is therefore the object of the present invention to provide a means which overcomes the aforementioned disadvantages of the prior art. In particular, it is the object of the present invention to provide a means which allows prevention of heart disease by lowering the homocysteine level in the blood by supplying vitamins B(, and Bn and folic acid and which is suitable for diabetics.

This task is solved by a micronutrient combination product, optimized in terms of its components, suitable for nutritional supplementation in diabetes, whereby the product, based on a daily dose, comprises the active ingredients:

a. 0.4-15 mg, preferably 0.5 - 5 mg, preferably 1.0 - 2.5 mg folic acid;

b. 5 - 250 mg, preferably 10-100 mg, preferably 25 - 50 mg vitamin B12;

c. 0.05 - 2 mg, preferably 0.1-1.2 mg, preferably 0.4 - 0.8 mg vitamin B^;

d. 2.5 - 50 mg, preferably 5-30 mg, preferably 10-20 mg lutein;

e. optionally 10 - 300 mg, preferably 15 - 120 mg, more preferably 30 - 60 mg coenzyme Q10;

f. optionally 100 - 5000 mg, preferably 150 - 2000 mg, more preferably 350 - 700 mg magnesium;

g. optionally 50 - 1000 mg, preferably 150 - 800 mg, more preferably 300 - 600 mg grape seed extract;

h. optionally 10 - 500 mg, preferably 50 - 450 mg, preferably 148 - 300 mg OPC

from cocoa;
i. optionally 2 - 200 mg, preferably 3-50 mg, preferably 12.5 - 25 mg vitamin

_B1 ;
j. optionally 0.01-1 mg, preferably 0.05 - 0.3 mg, more preferably 0.1 - 0.2 mg chromium;

k. optionally 5 - 500 mg, preferably 25 - 200 mg, preferably 50-100 mg

vanadium;
1. optionally 10 - 500 mg, preferably 50 - 250 mg, more preferably 125-175 mg of isoflavones, in particular from soya extract;

m. optionally 1 - 30 g, preferably 3 - 15 g, more preferably 8 - 10 g arginine; n. optionally 0.3-10 g, preferably 0.5 - 5 g, more preferably 1 - 3 g carnitine.

The micronutrient combination product suitable for diabetics can help reduce the risk factor homocysteine, prevent damage to cells and tissue, improve the energy supply to the heart muscle, improve cardiac performance and have a positive effect on the development of heart disease through an adequate supply of the cardiac-active micronutrients.

It has surprisingly been shown that the use of natural cocoa, grape seed and soy extracts has a positive effect on the bioavailability of the polyphenols with antioxidant properties, particularly flavonoids, contained therein, compared to the use of synthetic substances. The advantageous properties result from the selection of the individual components and their weight contents, which are specifically selected to reduce the risk factor homocysteine and improve the energy supply to the heart muscle. It is particularly advantageous that the dosages of the components of the micronutrient combination product according to the invention, suitable for diabetics, do not cause any side effects and are suitable for preventing vitamin deficiencies and as a dietary supplement in the drug treatment of existing heart diseases to reduce a drug-related vitamin deficiency situation.

The composition of the individual vitamins according to the invention is limited to the components required for an indication of heart disease, so that a combination

of the agent according to the invention with vitamin preparations for other indications is made possible without the consumer running the risk of producing a heart-damaging overdose of non-essential vitamins.

Antioxidants for supplementary dietary treatment have a preventive effect on heart disease by intercepting free radicals present in the body. Oral intake of beta-carotenoids can lead to damage in connection with medication, particularly in smokers. However, the lutein used in the invention does not serve as a precursor for vitamin A, unlike beta-carotenoids. The micronutrient combination product according to the invention also includes cocoa, grape seed and soy extracts rich in flavonoids and isoflavones, which can protect the cardiovascular system by reducing the risk of thrombosis.

A heart disease-preventing effect of a diet rich in flavonoids, such as wine or cocoa, as has been suspected on the basis of epidemiological studies on a possible connection between moderate consumption of red wine and a reduced risk of heart attack, may be achieved by reducing the risk of thrombosis. The plant polyphenols contained in the products, which include oligomeric proanthocyanidins (OPC), have antioxidant properties. The health benefits of these antioxidants can be achieved through the inventive use of the cocoa, grape seed and soy extracts and the mixture of polyphenols with antioxidant properties contained therein, in particular flavonoids and isoflavones, without excluding certain groups of consumers who must also consider the risks of very limited alcohol consumption or weight gain when consuming foods containing cocoa.

It has surprisingly been shown that by using the amino acids in combination with polyphenols and isoflavones contained in natural extracts with

Antioxidant and phytoestrogenic properties significantly improve the holistic quality of the micronutrient combination product.

Due to the advantageous properties of the active ingredients of the micronutrient combination product suitable for diabetics, it can also be used as a food supplement as part of dietary nutritional advice. In particular, the micronutrient combination product can be used as a nutritional supplement, accompanying or supportive treatment and/or treatment for diabetes.

The micronutrient combination product can be in solid, liquid and/or gel form, preferably the micronutrient combination product is in preparation forms selected from the group comprising tablets, capsules, powder, granules, solutions, effervescent tablets and/or spray, particularly preferably in the form of 0-10 tablets, capsules, effervescent tablets and/or granules with the same or different composition.

In a preferred embodiment, the micronutrient combination product is in the form of 0-10 tablets, preferably 1-5 tablets, preferably 1-4 tablets, particularly preferably 1-3 tablets and very particularly preferably 1-2 tablets, 0-10 capsules, preferably 1-5 capsules, preferably 1-4 capsules, particularly preferably 1-3 capsules and very particularly preferably 1-2 capsules, 0-10 effervescent tablets, preferably 1-5 effervescent tablets, preferably 1-4 effervescent tablets, particularly preferably 1-3 effervescent tablets and very particularly preferably 1-2 effervescent tablets and/or 0-10 granules, preferably 1-5 granules, preferably 1-4 granules, particularly preferably 1-3 granules and very particularly preferably 1-2 granules. In particular, the capsules can comprise non-animal material, preferably plant material, wherein the capsules are preferably gelatin capsules.

♦♦♦**

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Another beneficial effect of the micronutrient combination product is the possibility of administering the active ingredients contained in separate preparation forms in several separate doses. In particular, the omega-3 fatty acids can be administered in one or more capsules separately from the other active ingredients or together with selected active ingredients.

The micronutrient combination product can be in the form of at least one preparation form, in particular at least two separate preparation forms, preferably in the form of at least three separate preparation forms, particularly preferably in the form of at least four separate preparation forms and very particularly preferably in the form of at least five separate preparation forms with the same or different active ingredient composition. In particular, the micronutrient combination product can have separate preparation forms with different compositions of active ingredients and/or active ingredient weight contents.

In a preferred embodiment, the micronutrient combination product comprises, based on a daily dose, the active ingredients:

a. 1.0 mg folic acid;

b. 25 mg vitamin B12;

c. 0.4 mg vitamin B^;

d. lOmgLutein;

e. 30mgCoenzymeQ10;

f. 350 mg magnesium;

G. 12.5 mg vitamin Bi; H. 100 µg chromium.

In another suitable embodiment, the micronutrient combination product comprises, based on a single dose, the active ingredients:

a. 0.5 mg folic acid;

b. 12.5 mg vitamin B12;

c. 0.2 mg vitamin B^;

d. 5 mg lutein;

e. 15 mg coenzyme Q10;

f. 175 mg magnesium;

G. 6.25 mg vitamin B ?; H. 50 µg chromium.

Preferably, the micronutrient combination product comprises, based on a daily dose, the active ingredients:

a. 1.0 mg folic acid;

b. 25 mg vitamin B12;

c. 0.4 mg vitamin B^;

d. 10 mg lutein;

e. 30 mg coenzyme Q10;

f. 350 mg magnesium;

g. 300 mg grape seed extract; h. 148 mg OPC from cocoa;

i. 12.5 mg vitamin B12;

j. 100 μg chromium;

k. 50 mg vanadium;

1. 82.5 mg isoflavones, particularly from soya extract;

m. 4.5 g arginine;

n. 1 g carnitine.

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In a further preferred embodiment, the micronutrient combination product comprises, based on a single dose, the active ingredients:

a. 0.5 mg folic acid;

b. 12.5 mg vitamin B12;

c. 0.2 mg vitamin B^",

d. 5 mg lutein;

e. 15mgCoenzyme Q10;

f. 175 mg magnesium;

g. 150 mg grape seed extract; h. 74 mg OPC from cocoa;

i. 6.25 mg vitamin B12;

j. 50 μg chromium;

k. 25 mg vanadium;

1. 41.25 mg isoflavones, particularly from soya extract;

m. 2.25 g arginine;

n. 0.5 g carnitine.

The daily dose and/or individual dose is preferably distributed over several identical or different preparation forms, whereby the preparation forms may contain identical or different active ingredients and/or active ingredient weight contents.

The micronutrient combination product may optionally comprise, based on a daily dose, 0.25 - 20 g of omega-3 fatty acids, in particular eicosapentaenoic acid and/or docosahexaenoic acid, wherein the omega-3 fatty acids are preferably contained in at least one or more capsules.

Omega-3 fatty acids have a positive effect due to their anti-inflammatory properties and the reduction of the synthesis of inflammatory substances.

· ■

Supplementing the agent according to the invention with omega-3 fatty acids results in a significant improvement in the properties of the micronutrient combination product in the prophylaxis of cardiovascular disorders.

Examples of micronutrient combination products suitable for diabetics are given below:

It goes without saying that the preparation forms, selected from the group comprising tablets, capsules, powder, granules, solutions, effervescent tablets and/or spray, contain the usual excipients used to formulate the respective preparation forms, so that only the active ingredients contained are listed in the examples.

example 1

Micronutrient combination product comprising 1 capsule with the following active ingredients:

0.5 mg folic acid; 12.5 mg vitamin B^;

0.2 mg vitamin B^; 5 mg lutein; 15 mg coenzyme QlO; 175 mg magnesium;

6.25 mg vitamin B&igr;; 50 µg chromium.

Example 2

Micronutrient combination product comprising 1 capsule with the following active ingredients:

1.0 mg folic acid;

25 mg vitamin B,

*■;

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0.4 mg vitamin B12; 10 mg lutein; 30 mg coenzyme QlO; 350 mg magnesium;

- 12.5 mg vitamin B12;

- 100 μg chromium.

Example 3

Milironutrient combination product comprising 1 effervescent tablet with the following active ingredients:

2.0 mg folic acid; 50 mg vitamin B12; 0.8 mg vitamin B12; 20 mg lutein; 60 mg coenzyme Q10; 700 mg magnesium;

- 25 mg vitamin B12;

- 200 μg chromium.

Example 4

Micronutrient combination product comprising 1 capsule with the following active ingredients:

1.0 mg folic acid; 25 mg vitamin B12; 0.4 mg vitamin B12; 10 mg lutein; 30 mg coenzyme Q10; 350 mg magnesium; 12.5 mg vitamin B12.

•&ngr;;;·

Example 5

Micronutrient combination product comprising 1 effervescent tablet with the following active ingredients:

- 2.0 mg folic acid;
50 mg vitamin &$;
0.8 mg vitamin B^;

- 20 mg lutein;

60 mg coenzyme QlO; 700 mg magnesium; 25 mg vitamin Bi.

Example 6

Micronutrient combination product comprising 1 capsule with the following active ingredients:

0.5 mg folic acid;

12.5 mg Vitamin Bo; 0.2 mg vitamin B^;

- 5 mg lutein;

15 mg coenzyme QlO; 175 mg magnesium; 6.25 mg vitamin Bi.

Example 7

Micronutrient combination product comprising 1 capsule with the following active ingredients:

1.0 mg folic acid;

25 mg vitamin B,

0.4 mg vitamin B^; 10 mg lutein.

Example 8

Micronutrient combination product comprising 1 capsule with the following active ingredients:

2.0 mg folic acid;

50 mg vitamin B^, - 0.8 mg vitamin Bi ₂ ; 20 mg lutein.

Example 9

Milao nutritional combination product comprising 1 capsule with the following active ingredients:

1.0 mg folic acid; 25 mg vitamin B12, 0.4 mg vitamin B12; 10 mg lutein; 30 mg coenzyme Q10.

Example 10

Micronutrient combination product comprising 1 capsule with the following active ingredients:

2.0 mg folic acid; 50 mg vitamin B12; 0.8 mg vitamin B12; 20 mg lutein; 60 mg coenzyme Q10.

Example 11

Micronutrient combination product comprising 1 capsule with the following active ingredients: 1.0 mg folic acid;

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25 mg vitamin 0.4 mg vitamin lOmgLutein;

- 30 mg coenzyme QlO; 350 mg magnesium.

Example 12

Micronutrient combination product comprising 1 capsule with the following active ingredients: 2.0 mg folic acid;

- 50 mg of vitamin B; 0.8 mg vitamin B12; 20 mg lutein; 60 mg coenzyme QlO; 700 mg magnesium.

Example 13

Micronutrient combination product comprising 1 capsule with the following active ingredients:

1.0 mg folic acid; 25 mg vitamin B12,

- 0.4 mg vitamin B12; 10 mg lutein; 30 mg coenzyme QlO; 350 mg magnesium; 300 mg grape seed extract.

Example 14

Micronutrient combination product comprising 1 granule with the following active ingredients:

2.0 mg folic acid; 50 mg vitamin B 0.8 mg vitamin 20 mg lutein; 60 mg coenzyme Q10; 700 mg magnesium; 600 mg grape keratin extract.

Example 15

Müa-onutrient combination product comprising 1 capsule with the following active ingredients:

1.0 mg folic acid; 25 mg vitamin B12; 0.4 mg vitamin B12; 10 mg lutein; 30 mg coenzyme Q10; 350 mg magnesium;

300 mg grape seed extract; - 148 mg OPC from cocoa.

Example 16

Micronutrient combination product comprising 1 granule with the following active ingredients:

2.0 mg folic acid; 50 mg vitamin B12; 0.8 mg vitamin B12; 20 mg lutein; 60 mg coenzyme Q10; 700 mg magnesium;

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600 mg grape seed extract;

- 296 mg OPC from cocoa.

Example 17

Miloronutrient combination product comprising 1 capsule with the following active ingredients: 1.0 mg folic acid;

- 25 mg vitamin B ₆ ; 0.4 mg vitamin Bi ₂ ; 10 mg lutein; 30 mg coenzyme Q10; 350 mg magnesium; 300 mg grape seed extract;

- 148 mg OPC from cocoa;

- 12.5 mg vitamin B12.

Example 18

Micronutrient combination product comprising 1 granule with the following active ingredients:

2.0 mg folic acid; 50 mg vitamin B ₆ ; 0.8 mg vitamin B n; 20 mg lutein; 60 mg coenzyme Q10; 700 mg magnesium; 600 mg grape seed extract;

- 296 mg OPC from cocoa; 25 mg vitamin Bj.

Example 19

Micronutrient combination product comprising 1 capsule with the following active ingredients:

1.0 mg folic acid; 25 mg vitamin B12, 0.4 mg vitamin B2; 1.0 mg lutein;

- 30mgCoenzymeQ10;

- 350 mg magnesium;

300 mg grape seed extract;

- 148 mg OPC from cocoa;

- 12.5 mg vitamin B12,

- 100 μg chromium.

Example 20

Micronutrient combination product comprising 1 granule with the following active ingredients:

2.0 mg folic acid; 50 mg vitamin B12; 0.8 mg vitamin B13; 20 mg lutein; 60 mg coenzyme Q10; 700 mg magnesium; 600 mg grape seed extract;

- 296 mg OPC from cocoa; 25 mg vitamin B ₁ ;

- 200 μg chromium.

Example 21

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Micronutrient combination product comprising 1 capsule with the following active ingredients: 1.0 mg folic acid; 25 mg vitamin B ₆ ; 0.4 mg vitamin B^; lOrngLutein;

- 30mg Coenzyme Q10; 350 mg magnesium; 300 mg grape seed extract;

- 148 mg OPC from cocoa;

- 12.5 mg vitamin B12;

- 100 µg chromium; 50 mg vanadium.

Example 22

Micronutrient combination product comprising 1 granule with the following active ingredients:

2.0 mg folic acid; 50 mg vitamin B ₆ ; 0.8 mg vitamin B^; 20 mg lutein; 60 mg coenzyme Q10; 700 mg magnesium; 600 mg grape seed extract;

- 296 mg OPC from cocoa; 25 mg vitamin Bi;

- 200 µg chromium; 100 mg vanadium.

Example 23

Micronutrient combination product comprising 1 granule with the following active ingredients:

1.0 mg folic acid; 25 mg vitamin B12; 0.4 mg vitamin B12; 10 mg lutein; 30 mg coenzyme Q10; 350 mg magnesium; 300 mg grape seed extract;

- 148 mg OPC from cocoa;

- 12.5 mg vitamin _B1 ;

- 100 μg chromium; 50 mg vanadium; 82.5 mg isoflavones, particularly from soy extract.

Example 24

Micronutrient combination product comprising 1 granule with the following active ingredients:

2.0 mg folic acid; 50 mg vitamin B12; 0.8 mg vitamin B12; 20 mg lutein;

- 60 mg coenzyme Q10; 700 mg magnesium; 600 mg grape seed extract;

- 296 mg OPC from cocoa;

- 25 mg vitamin B12;

- 200 μg chromium;

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100 mg vanadium; 165 mg isoflavones, particularly from soy extract.

Example 25

Micronutrient combination product comprising 1 granule with the following active ingredients:

1.0 mg folic acid; 25 mg vitamin B12; 0.4 mg vitamin B12; 10 mg lutein;

- 30mg Coenzyme Q10; 350 mg magnesium; 300 mg grape seed extract;

- 148 mg OPC from cocoa;

- 12.5 mg vitamin _B1 ;

- 100 μg chromium; 50 mg vanadium; 82.5 mg isoflavones, particularly from soy extract; 4.5 g arginine.

Example 26

Micronutrient combination product comprising 1 granule with the following active ingredients:

2.0 mg folic acid; 50 mg vitamin B12; 0.8 mg vitamin B12; 20 mg lutein; 60 mg coenzyme Q10; 700 mg magnesium;

- 600 mg grape seed extract;

- 296 mg OPC from cocoa; 25 mg vitamin Bi;

- 200 μg chromium;

100 mg vanadium; 165 mg isoflavones, particularly from soy extract; 9 g arginine.

Example 27

Milk nutrient combination product comprising 1 granule with the following active ingredients:

1.0 mg folic acid; 25 mg vitamin B12; 0.4 mg vitamin B12; 10 mg lutein; 30 mg coenzyme Q10; 350 mg magnesium; 300 mg grape seed extract;

- 148 mg OPC from cocoa; 12.5 mg vitamin Bi;

- 100 μg chromium; 50 mg vanadium; 82.5 mg isoflavones, particularly from soya extract;

- 4.5 g arginine; 1 g carnitine.

Example 28

Micronutrient combination product comprising 1 granule with the following active ingredients:

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2.0 mg folic acid; 50 mg vitamin B12; 0.8 mg vitamin B13; 20 mg lutein; 60 mg coenzyme Q10; 700 mg magnesium; 600 mg grape seed extract;

- 296 mg OPC from cocoa;

- 25 mg vitamin B12;

- 200 μg chromium; 100 mg vanadium; 165 mg isoflavones, particularly from soya extract; 9 g arginine;
2 g carnitine.

Example 29

Micronutrient combination product comprising 1 granule with the following active ingredients:

0.5 mg folic acid; 12.5 mg vitamin B1, 0.2 mg vitamin B12; 5 mg lutein; 15 mg coenzyme Q10; 175 mg magnesium; 150 mg grape seed extract;

- 74 mg OPC from cocoa; 6.25 mg vitamin Bi; 50 µg chromium;

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25 mg vanadium; 41.25 mg isoflavones, particularly from soy extract;

- 2.25 g of arginine; 0.5g carnitine.

Example 30

Micronutrient combination product comprising 1 capsule with the following active ingredients:

1.0 mg folic acid; 25 mg vitamin B^, 0.4 mg vitamin B12; 10 mg lutein; 30 mg coenzyme Q10; 350 mg magnesium; 300 mg grape seed extract; 12.5 mg vitamin Bf, 82.5 mg isoflavones, particularly from soya extract.

Example 31

Micronutrient combination product comprising 1 capsule with the following active ingredients:

1.0 mg folic acid; 25 mg vitamin B12; 0.4 mg vitamin B12; 10 mg lutein;

- 30 mg coenzyme Q10; 350 mg magnesium; 300 mg grape seed extract;

- 12.5 mg vitamin B12;

:: ·«I I &bgr;*"

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82.5 mg isoflavones, particularly from soy extract;
100 μg chromium.

Claims (11)

1. Micronutrient combination product suitable for nutritional supplementation in diabetes, characterized in that the micronutrient combination product comprises, based on a daily dose, the active ingredients: a) 0.4-15 mg, preferably 0.5-5 mg, preferably 1.0-2.5 mg folic acid; b) 5-250 mg, preferably 10-100 mg, preferably 25-50 mg vitamin B ₆ ; c) 0.05-2 mg, preferably 0.1-1.2 mg, preferably 0.4-0.8 mg vitamin B ₁₂ ; d) 2.5-50 mg, preferably 5-30 mg, preferably 10-20 mg lutein; e) optionally 10-300 mg, preferably 15-120 mg, preferably 30-60 mg coenzyme Q10; f) optionally 100-5000 mg, preferably 150-2000 mg, preferably 350-700 mg magnesium; g) optionally 50-1000 mg, preferably 150-800 mg, preferably 300-600 mg grape seed extract; h) optionally 10-500 mg, preferably 50-450 mg, preferably 148-300 mg OPC from cocoa; i) optionally 2-200 mg, preferably 3-50 mg, more preferably 12.5-25 mg vitamin B ₁ ; j) optionally 0.01-1 mg, preferably 0.05-0.3 mg, preferably 0.1-0.2 mg chromium; k) optionally 5-500 mg, preferably 25-200 mg, preferably 50-100 mg vanadium; l) optionally 10-500 mg, preferably 50-250 mg, preferably 125-175 mg of isoflavones, in particular from soya extract; m) optionally 1-30 g, preferably 3-15 g, preferably 8-10 g arginine; n) optionally 0.3-10 g, preferably 0.5-5 g, more preferably 1-3 g carnitine. 2. Micronutrient combination product according to claim 1, characterized in that the micronutrient combination product is in solid, liquid and/or gel form, preferably the micronutrient combination product is in preparation forms selected from the group comprising tablets, capsules, powder, granules, solutions, effervescent tablets and/or spray, particularly preferably in the form of 0-10 tablets, capsules, effervescent tablets and/or granules with the same or different composition. 3. Micronutrient combination product according to one of the preceding claims, characterized in that the micronutrient combination product is in the form of at least one preparation form, in particular at least two separate preparation forms, preferably in the form of at least three separate preparation forms, particularly preferably in the form of at least four separate preparation forms and very particularly preferably in the form of at least five separate preparation forms with the same or different active ingredient composition. 4. Micronutrient combination product according to one of the preceding claims, characterized in that the micronutrient combination product comprises separate preparation forms with different compositions of active ingredients and/or active ingredient weight contents. 5. Micronutrient combination product according to one of the preceding claims, characterized in that the capsules comprise non-animal material, preferably vegetable material, wherein the capsules are preferably gelatin capsules. 6. Micronutrient combination product according to one of the preceding claims, characterized in that the micronutrient combination product optionally comprises, based on a daily dose, 0.25-20 g of omega-3 fatty acids, in particular eicosapentaenoic acid and/or docosahexaenoic acid, wherein the omega-3 fatty acids are preferably contained in at least one capsule. 7. Micronutrient combination product according to one of the preceding claims, characterized in that the micronutrient combination product, based on a daily dose, comprises the active ingredients: a) 1.0 mg folic acid; b) 25 mg vitamin B ₆ ; c) 0.4 mg vitamin B ₁₂ ; d) 10 mg lutein; e) 30 mg coenzyme Q10; f) 350 mg magnesium; g) 12.5 mg vitamin _B1 ; h) 100 µg chromium. 8. Micronutrient combination product according to one of the preceding claims, characterized in that a single dose of the micronutrient combination product comprises the active ingredients: a) 0.5 mg folic acid; b) 12.5 mg vitamin B ₆ ; c) 0.2 mg vitamin B ₁₂ ; d) 5 mg lutein; e) 15 mg coenzyme Q10; f) 175 mg magnesium; g) 6.25 mg vitamin _B1 ; h) 50 µg chromium. 9. Micronutrient combination product according to one of the preceding claims, characterized in that the micronutrient combination product, based on a daily dose, comprises the active ingredients: a) 1.0 mg folic acid; b) 25 mg vitamin B ₆ ; c) 0.4 mg vitamin B ₁₂ ; d) 10 mg lutein; e) 30 mg coenzyme Q10; f) 350 mg magnesium; g) 300 mg grape seed extract; h) 148 mg OPC from cocoa; i) 12.5 mg vitamin _B1 ; j) 100 µg chromium; k) 50 mg vanadium; (l) 82.5 mg isoflavones, in particular from soya extract; m) 4.5 g arginine; n) 1 g carnitine. 10. Micronutrient combination product according to one of the preceding claims, characterized in that a single dose of the micronutrient combination product comprises the active ingredients: a) 0.5 mg folic acid; b) 12.5 mg vitamin B ₆ ; c) 0.2 mg vitamin B ₁₂ ; d) 5 mg lutein; e) 15 mg coenzyme Q10; f) 175 mg magnesium; g) 150 mg grape seed extract; h) 74 mg OPC from cocoa; i) 6.25 mg vitamin _B1 ; j) 50 µg chromium; k) 25 mg vanadium; (l) 41.25 mg of isoflavones, in particular from soya extract; m) 2.25 g arginine; n) 0.5 g carnitine. 11. Foodstuffs, in particular food supplements, comprising active ingredients according to one of the preceding claims.