DE19837549A1 - Use of quaternary nitrogen compounds for treatment and prevention of atopic eczema - Google Patents

Abstract

Use of quaternary nitrogen compounds for the treatment and prevention of atopic eczema.

Description

The healthy human skin is made up of a variety of non-pathogenic microorganisms populated. This so-called microflora of the skin is not only harmless to them provides important protection against opportunistic or pathogenic germs represents.

In case of primary infection, d. h., the normal germ colonization of the skin, eintre tende new infection with high germ counts of one or more often physiological Er such as staphylococci, but often also unphysiological pathogens For example, Candida albicans, when encountering unfavorable influences, a "Superinfection" of the affected skin occur. The normal microflora of the skin (or of another body organ) is thereby literally over from the secondary exciter overgrown.

Such superinfections can, depending on the germ concerned, in favorable cases in unpleasant skin conditions (itching, unschö external appearance). In unfavorable cases they can but lead to extensive destruction of the skin, in the worst case even in the Culminate death of the patient.

Such superinfections are found in a variety of dermatological diseases especially atopic eczema, also neurodermatitis observed. The ato Eczema generally begins with itching, redness, scaling, and oozing Crust formation, wherein the infestation of the skin parts depending on the age of the patient assumes certain characteristic accumulations. Complications of appearance Pictures of atopic eczema often present superinfections with different kei  in particular Staphylococcus aureus, of which approximately 90% of all Atopiker with eczematous expression are affected.

Conventional treatments therefore include in addition to anti-inflammatory the active ingredients (eg hydrocortisone) also Externa as various antibiotics in the narrower sense or agents with antimicrobial or antimycotic properties in the wider sense (eg gentian violet).

The conventionally used agents but usually have the disadvantage that they either more or less serious side effects, resistance formation or incompatibilities, or that they have non-cosmetic sensations (eg severe skin discoloration with gentian violet).

So it is in some cases easily possible to super infections with antibiotics too combat, but usually such substances have the disadvantage unpleasant Side effects. For example, patients are often allergic to penicillins, Therefore, such treatment is prohibited in such a case would. Furthermore, topically administered antibiotics have the disadvantage that they Relieve skin flora not only from the secondary pathogen, but also in itself physiological skin flora severely impair and the natural healing process on this way is slowed down again.

The reduction of clinically pronounced atopic eczema, however, was with Wirk so far, if at all achievable, prior art materials and preparations bar - always associated with significant inconvenience.

The object of the present invention was to overcome the disadvantages of the prior art and substances and preparations containing such substances, to To make superinfections cured by using them can, wherein the physiological skin flora suffers no significant loss.

Moreover, it was an object of the present invention, substances and kosme tables or dermatological preparations containing such substances, for Ver to provide prophylactic against superinfections.  

It has surprisingly been found, and therein lies the solution of this problem that the Use of quaternary nitrogen compounds for the prophylaxis and treatment of Superinfected atopic dermatitis remedies the disadvantages of the prior art.

In the context of the disclosure of the present invention, the term "quaternary Ammonium compounds "occasionally synonymous with" quaternary nitrogen compounds "applied.

According to the invention, quaternary ammonium compounds or preparations, containing quaternary ammonium compounds, excellently suited, superinfi reduced atopic eczema or the symptoms of superinfected eczema to alleviate.

Quaternary ammonium compounds are characterized by at least one quaternary nitrogen atom and follow the following basic schemes:

Quaternary ammonium compounds having at least one long alkyl chain, such as for example distearyldimethylammonium chloride (DSDMA) have oberflä chenaktiven properties and are therefore used as cationic surfactants, eg. B. as a wetting agent, Emulsifiers, antistatic agents and used as a plasticizer. Mainly short-chain Quaternary ammonium compounds have microbicidal properties and fin Therefore, use in fungicidal and bactericidal disinfectants or as Algaecides.  

The quaternary ammonium compounds used according to the invention can are advantageously selected from the group of quaternary surfactants. Are advantageous for example, alkylbetaine, alkylamidopropylbetaine and alkyl-amidopropylhydroxy sulfain. The cationic surfactants used according to the invention can furthermore are preferably selected from the group of quaternary ammonium compounds, in particular Benzyltrialkylammoniumchloride or bromides, such as Ben cyldimethylstearylammonium chloride, further Alkyltrialkylammoniumsalze, beispielswei For example, cetyltrimethylammonium chloride or bromide, alkyldimethylhydro xyethylammonium chlorides or bromides, dialkyldimethylammonium chlorides or bromides, alkylamidoethyltrimethylammonium ether sulfates, alkylpyridinium salts For example, lauryl or cetylpyrimidinium chloride, imidazoline derivatives and Verbindun with cationic character such as amine oxides, for example Alkyldimethylaminoxi de or alkylaminoethyldimethylamine oxides. Cetyl trimes are particularly advantageous to use thylammonium salts, as well as polyaminoalkylbiguanides, z. B. poly aminopropylbiguanid.

The preparations according to the invention are particularly advantageously characterized records that the quaternary nitrogen compounds in concentrations of 0.001-99.00 wt%, preferably 0.01-50.00 wt%, more preferably 0.1-10.00 wt .-%, each based on the total weight of the composition before lie.

Dermatological preparations according to the invention may be in the form of aerosols, So from aerosol containers, squeeze bottles or by a pumping ver sprayable preparations or in the form of by means of roll-on devices Applicable liquid compositions, but also in the form of normal For bottles and containers, W / O or O / W emulsions, eg. B. creams or Lotions. Furthermore, the preparations may advantageously be in the form of tinctures, Shampoos, washing, shower or bath preparations or powders are present.

As usual cosmetic carriers for the preparation derma the invention In addition to water, ethanol and isopropanol, glycerol may also be used for tological preparations and propylene glycol skin-care fat or fat-like substances, such as oleic acid decyl esters, cetyl alcohol, cetylstearyl alcohol and 2-octyldodecanol, in those for such  Preparations are used in customary proportions and slime-forming Substances and thickeners, eg. Hydroxyethyl or hydroxypropyl cellulose, Polyacrylic acid, polyvinylpyrrolidone, but also in small quantities cyclic Silicone oils (polydimethylsiloxanes) as well as liquid polymethylphenylsiloxanes lower Viskosiät.

The lipid phase can advantageously be selected from the following substance group:

• - mineral oils, mineral waxes
• - Oils, such as triglycerides of capric or caprylic, but preferably Ri zinusöl;
• - Fats, waxes and other natural and synthetic fats, preferably example, esters of fatty acids with alcohols of low C number, z. B. with isopro panol, propylene glycol or glycerol, or esters of fatty alcohols with alkane acids of low C number or with fatty acids;
• - alkyl benzoate;
• - Silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixed forms thereof.

The oil phase of as oils, emulsions, oleogels or hydrodispersions or lipo dispersions present compositions according to the invention is advantageous ge selects from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohol len of a chain length of 3 to 30 carbon atoms, from the group of esters of aromati carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms. Such ester oils can then be advantageously selected from the group isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, Isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhe xyl laurate, 2-hexyldecyl stearate, 2-octyl dodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate and synthetic, semi-synthetic and natural mixtures sol cher ester, z. B. jojoba oil.

Furthermore, the oil phase can be advantageously selected from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ether,  the group of saturated or unsaturated, branched or unbranched alkoxy as well as the fatty acid triglycerides, namely the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a Chain length of 8 to 24, in particular 12-18 C atoms. The fatty acid triglycerides For example, they can be advantageously selected from the group of synthetic, semisynthetic and natural oils, e.g. As olive oil, sunflower oil, soybean oil, earth nut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like more, especially evening primrose oil and borage oil.

Any mixtures of such oil and wax components are advantageous in Use of the present invention. It may also benefit if necessary be liable, waxes, such as cetyl palmitate, as the sole lipid component of the oil phase.

Advantageously, the oil phase is selected from the group consisting of 2-ethylhexyl isostearate, octyldodanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C _12-15 alkyl benzoate, caprylic capric acid triglyceride, dicaprylyl ether.

Particularly advantageous are mixtures of C _12-15 alkyl benzoate and 2-Ethylhexyliso stearate, mixtures of C _12-15 alkyl benzoate and isotridecyl isononanoate and Mi mixtures of C _12-15 alkyl benzoate, 2-Ethylhexylisostearat and isotridecyl isononanoate.

Of the hydrocarbons, paraffin oil, squalane and squalene are beneficial in the sin ne of the present invention.

Advantageously, the oil phase may further contain cyclic or linear silicone have oils or consist entirely of such oils, although before is added, except the silicone oil or silicone oils to an additional content of to use their oil phase components.

Advantageously, cyclomethicone (octamethylcyclotetrasiloxane) is used as the invention used silicone oil. But other silicone oils are also beneficial For purposes of the present invention, for example Hexamethylcyclotrisi loxan, polydimethylsiloxane, poly (methylphenylsiloxane).  

Furthermore, mixtures of cyclomethicone and isotridecyliso are particularly advantageous nonanoate, from cyclomethicone and 2-ethylhexyl isostearate.

The aqueous phase of the preparations according to the invention optionally contains advantageous alcohols, diols or polyols low C number, and their ethers, preferably Example, ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol Mo noethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or mono butyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products, furthermore lower C number alcohols, e.g. As ethanol, isopropanol, 1,2-propanediol, glycerol and in particular one or more thickening agents, which or which advantage can be selected from the group silicon dioxide, aluminum silicates, poly saccharides or their derivatives, for. Hyaluronic acid, xanthan gum, hydroxypropene pylmethylcellulose, particularly advantageous from the group of polyacrylates, preferred a polyacrylate from the group of so-called carbopols, for example Car bopols of types 980, 981, 1382, 2984, 5984, each individually or in combination.

Solid pins used according to the invention contain z. Natural or synthetic Waxes, fatty alcohols or fatty acid esters.

As a propellant for inventive dermatolo sprayable from aerosol containers gische preparations are the usual known volatile, liquefied Propellants, for example hydrocarbons (propane, butane, isobutane) suitable, which can be used alone or mixed with each other. Also compressed air is advantageous to use.

Of course, the expert knows that there are nontoxic propellants per se, the reason addition would be suitable for the present invention, but because of questionable effect on the environment or other accompanying circumstances especially chlorofluorocarbons (CFCs).

As emulsifiers for the preparation of dermatological Zubere invention nonionic types such as polyoxyethylene fatty alcohol ethers, e.g. B. Cetylstearyl alcohol polyethylene glycol ethers with 12 or 20 attached ethylene oxide Units per molecule, cetostearyl alcohol and sorbitan esters and sorbitan esters Ethylene oxide compounds (e.g., sorbitan monostearate and polyoxyethylene sorbitan  monostearate) and long-chain higher molecular weight waxy polyglycol ethers as proved suitable.

Cleaning agents may also be advantageous embodiments of the present invention represent. This is particularly advantageous because some quaternary nitrogen compounds have surfactant properties.

Surfactants are amphiphilic substances that dissolve organic, nonpolar substances in water sen. They provide, due to their specific molecular structure with minde at least one hydrophilic and one hydrophobic moiety, for a reduction the surface tension of the water, the wetting of the skin, the relief Dirt removal and solution, a gentle rinse and - as desired - for foam regulation.

The hydrophilic portions of a surfactant molecule are usually polar functional groups, for example -COO ^- , -OSO3 ^2- , -SO ₃ ^- , while the hydropho ben parts are generally nonpolar hydrocarbon radicals. Surfactants are generally classified according to the nature and charge of the hydrophilic part of the molecule. Here four groups can be distinguished:

• - anionic surfactants,
• - cationic surfactants,
• Amphoteric surfactants and
• - nonionic surfactants.

Anionic surfactants generally have carboxylate, sulfate or sulfonate groups as functional groups. In aqueous solution, they form negatively charged organic ions in the acidic or neutral state. Cationic surfactants are almost exclusively characterized by the presence of a quaternary ammonium group. In aqueous solution they form positive gela dene organic ions in an acidic or neutral medium. Amphoteric surfactants contain both anionic and cationic groups and therefore behave in aqueous solution depending on the pH as anionic or cationic surfactants. They have a positive charge in a strongly acidic environment and a negative charge in an alkaline environment. In the neutral pH range, however, they are zwitterionic, as the following example is intended to illustrate:

RNH ₂ ⁺ CH ₂ CH ₂ COOH X ^- (at pH = 2) X = any anion, e.g. B. Cl ^-
RNH ₂ ⁺ CH ₂ CH ₂ COO ^- (at pH = 7)
RNHCH ₂ CH ₂ COO ^- B ⁺ (at pH = 12) B ⁺ = any cation, eg. Na ⁺

Typical of non-ionic surfactants are polyether chains. Nonionic surfactants bil no ions in aqueous medium.

A. Anionic surfactants

These are usually difficult to be compatible with cationic surfactants, therefore their co-use according to the present invention difficult, although, z. B. in small quantities, is not excluded. Advantageously used anionic surfactants are
Acylamino acids (and their salts), such as

• 1. Acylglutamates, for example sodium acylglutamate, di-TEA-palmitoyl aspartate and sodium caprylic / capric glutamate,
• 2. Acyl peptides, for example palmitoyl-hydrolyzed milk protein, sodium coco yl-hydrolyzed soy protein and sodium / potassium cocoyl-hydrolyzed collagen gene,
• 3. sarcosinates, for example myristoyl sarcosine, TEA lauroyl sarcosinate, Natri umlauroyl sarcosinate and sodium cocoyl sarcosinate,
• 4. taurates, for example sodium lauroyl taurate and sodium methyl cocoyl taurate,
• 5. Acyl lactylate, lauroyl lactylate, caproyl lactylate
• 6. alaninates

Carboxylic acids and derivatives, such as

• 1. Carboxylic acids, for example lauric acid, aluminum stearate, magnesium alka nolate and zinc undecylenate,
• 2. Ester carboxylic acids, for example calcium stearoyl lactylate, laureth-6 citrate and sodium PEG-4 lauramide carboxylate,
• 3. Ether carboxylic acids, for example sodium laureth-13 carboxylate and sodium PEG-6 cocamide carboxylate,
  Phosphoric acid esters and salts such as DEA-oleth-10-phosphate and di-laureth-4-phosphate,

Sulfonic acids and salts, such as

• 1. Acyl-isethionates, z. B. sodium / ammonium cocoyl isethionate,
• 2. alkylarylsulfonates,
• 3. alkyl sulfonates, for example sodium coconut monoglyceride sulfate, sodium C _12-14 olefin sulfonate, sodium lauryl sulfoacetate and magnesium PEG-3 cocamide sulfate,
• 4. Sulfosuccinates, for example dioctyl sodium sulfosuccinate, disodium laurethsul fosuccinate, disodium lauryl sulphosuccinate and disodium undecylenamido MEA sulfosuccinate

such as
Sulfuric acid esters, such as

• 1. alkyl ether sulfate, for example sodium, ammonium, magnesium, MIPA, TIPA laureth sulfate, sodium myreth sulfate and sodium C _12-13 pareth sulfate,
• 2. Alkyl sulfates, for example sodium, ammonium and TEA lauryl sulfate.

B. Cationic surfactants

Advantageously to use cationic surfactants

• 1. alkylamines,
• 2. Alkylimidazoles,
• 3. Ethoxylated amines.

The large remaining group of quaternary nitrogen surfactants is characterized by the Represents invention underlying drug group.

C. Amphoteric surfactants

Advantageously used amphoteric surfactants

• 1. acyl / dialkylethylenediamine, for example, sodium acylamphoacetate, disodium acylamphodipropionate, disodium alkylamphodiacetate, sodium acylamphohydro xypropylsulfonate, disodium acylamphodiacetate and sodium acylamphopropionate,
• 2. N-alkyl amino acids, for example Aminopropylalkylglutamid, Alkylaminopropi onsäure, Natriumalkylimidodipropionat and Lauroamphocarboxyglycinat.

D. Nonionic surfactants

Advantageously used nonionic surfactants are

• 1. Alcohols,
• 2. alkanolamides, such as cocamide MEA / DEA / MIPA,
• 3. amine oxides, such as cocoamidopropylamine oxide,
• 4. Esters obtained by esterification of carboxylic acids with ethylene oxide, glycerol, Sor bitane or other alcohols,
• 5. Ethers, for example ethoxylated / propoxylated alcohols, ethoxylated / propoxy esters, ethoxylated propoxylated glycerol esters, ethoxylated / propoxylated esters Cholesterols, ethoxylated propoxylated triglyceride esters, ethoxylated propoxy lanolin, ethoxylated / propoxylated polysiloxanes, propoxylated POE ethers and alkyl polyglycosides such as lauryl glucoside, decyl glycoside and cocoglycoside.
• 6. sucrose ester, ether
• 7. Polyglycerol esters, diglycerol esters, monoglycerol esters
• 8. Methyl glucose esters, esters of hydroxy acids

According to the invention, it is particularly advantageous to use a combination of quaternary nitrogen compounds with one or more amphoteric surfactants and / or with one or more nonionic surfactants.

Depending on the compatibility of the non-cationic surfactants with the inventive Quaternary nitrogen compound can be used in accordance with their concentration in preparations of the invention up to 80 wt .-%, based on the total weight of the Zube TION.

In addition to the ingredients mentioned derma the invention tological preparations whose pH preferably z. B. by conventional Puf Fememic to 4.0 to 7.5, in particular 5.0 to 6.5, is adjusted, perfume, color substances, antioxidants, suspending agents, buffer mixtures or other conventional cosmeti or basic dermatological substances.

According to the invention as cheap antioxidants all for cosmetic and / or dermatological applications suitable or common antioxidants ver be used.

It is also advantageous to add antioxidants to the preparations according to the invention. The antioxidants are advantageously selected from the group consisting of amino acids (eg glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg urocaninic acid) and derivatives thereof, peptides such as D, L-carnosine, D Carnosine, L-carnosine and their derivatives (eg anserine), carotenoids, carotenes (eg α-carotene, β-carotene, lycopene) and derivatives thereof, chlorogenic acid and its derivatives, lipoic acid and derivatives thereof ( eg dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (eg thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodi propionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and Sulfoximine compounds (eg, buthionine sulfoximines, homocysteine sulfoximine, buthioni sulfones, penta, hexa, heptathionine sulfoximine) in very low tolerated dosages (eg. Pmol to μmol / kg), furthermore (metal) chelators (for example α-hydroxyfatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (for example citric acid, lactic acid, malic acid), humic acid, bile acid , Bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (eg γ-linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (For example, ascorbyl palmitate, Mg-ascorbyl phosphate, As corbylacetat), tocopherols and derivatives (eg., Vitamin E acetate), vitamin A and Deri vate (vitamin A palmitate) and Koniferylbenzoat of Benzoeharzes, rutinic acid and their Derivatives, α-glycosylrutin, ferulic acid, furfurylideneglucitol, carnosine, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiacetic acid, nordihydroguajaric acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives (eg ZnO, ZnS O ₄ ) selenium and its derivatives (e.g. B. selenium methionine), stilbenes and their derivatives (eg stilbene oxide, trans-stilbene oxide) and the inventively suitable derivatives (salts, esters, ethers, sugars, Nukleoti de, nucleosides, peptides and lipids) of these drugs.

The amount of antioxidants (one or more compounds) in the preparation is preferably from 0.001 to 30% by weight, particularly preferably from 0.05 to 20% by weight, in particular 1-10% by weight, based on the total weight of the preparation.

If vitamin E and / or its derivatives are the antioxidant (s) advantageous, their respective concentrations in the range of 0.001-10 wt .-%, based on the total weight of the formulation to choose.  

If vitamin A, or vitamin A derivatives, or carotenes or their derivatives the or which are antioxidants is advantageous, their respective concentrations of in the range of 0.001-10% by weight based on the total weight of the formulation to choose.

It is advantageous for the present invention that the pH of the inventive dermatological preparations is less than 8. pH values that are slightly higher as 7, but smaller than 7.5 can be tolerated in general. Anyway for a given fatty acid mixture in a particular case by simple trial and error, without inventive effort, easy to determine which exact upper pH limit to note is.

Advantageously, the pH of the formulations of the invention in the acid to very weakly alkaline range less than 8, preferably 4.0-7.5, more preferably from 5.0 to 6.5.

The amounts to be used in each case auxiliary auxiliaries and carriers and give Perfume may vary depending on the type of product Professional can be easily determined by simple trial and error.

The production of the dermatological preparations according to the invention takes place from seen from special preparations which in the examples separately ver are noticed in the usual way, usually by simply mixing with stirring, optionally with slight warming. It offers no difficulties. For Emulsions become fat phase and the water phase z. B. separately, if necessary prepared with heating and then emulsified.

Otherwise, the usual measures for putting together galenic Observe formulations that are familiar to the expert.

If the combinations according to the invention are to be incorporated in powder, then Kings NEN the suspension bases are advantageously selected from the group  Silica gels (eg those available under the tradename Aerosil®), Diatomaceous earth, talc, modified starch, titanium dioxide, silk powder, nylon powder, poly ethylene powder and related substances.

Following are advantageous embodiments of the present invention. The quantities Information always refers to% by weight, unless stated otherwise.  

example 1 W / O cream

Wt .-% Paraffin oil (DAB 9) 10.00 petrolatum 4.00 Wool alcohol 1.00 PEG-7 hydrogenated castor oil 3.00 aluminum stearate 0.40 polyaminopropylbiguanide 0.20 glycerin 2.00 Preservatives, dyes, perfume q.s. water ad 100.00

Example 2 W / O lotion

Wt .-% Pafaffin oil (DAB 9) 20.00 petrolatum 4.00 Glucosesesquiisostearat 2.00 aluminum stearate 0.40 cetyltrimethylammonium 0.10 α-tocopheryl acetate 1.00 glycerin 5.00 Preservatives, dyes, perfume q.s. water ad 100.00

Example 3 O / W lotion

Wt .-% Paraffin oil (DAB 9) 8.00 isopropyl palmitate 3.00 petrolatum 4.00 Cetylstearylalkohol 2.00 PEG-40 castor oil 0.50 sodium cetylstearyl 0.50 Sodium carbomer 0.40 polyaminopropylbiguanide 0.20 glycerin 3.00 α-tocopherol 0.20 octyl 5.00 butylmethoxydibenzoylmethane 1.00 Preservatives, dyes, perfume q.s. water ad 100.00

Example 4 O / W cream

Wt .-% Paraffin oil (DAB 9) 7.00 avocado oil 4.00 glyceryl 2.00 cetyltrimethylammonium 0.10 Titanium dioxide 1.00 sodium lactate 3.00 glycerin 3.00 Preservatives, dyes, perfume q.s. water ad 100.00

Example 5 O / W cream

Wt .-% Quaternium-5 3.50 Paraffin oil, subliquidum 10.00 cetearyl 2.00 Hydrogenated coconut fatty acid glycerides 0.50 Dimethicone 0.75 glycerin 20.00 tocopherol 0.50 polyaminopropylbiguanide 0.20 Preservatives, dyes, perfume q.s. water ad 100.00

Example 6 O / W cream

Wt .-% Quartemium-5 3.50 Paraffin oil, subliquidum 10.00 cetearyl 2.00 Hydrogenated coconut fatty acid glycerides 0.50 Dimethicone 0.75 glycerin 20.00 tocopherol 0.50 Preservatives, dyes, perfume q.s. water ad 100.00

Example 7 Liposome-containing gel

Wt .-% lecithin 6.00 shea butter 3.00 cetyltrimethylammonium 0.10 α-tocopherol 0.20 biotin 0.08 sodium citrate 0.50 glycine 0.20 urea 0.20 Sodium PCA 0.50 Hydrolyzed collagen 2.00 Xanthan gum 1.40 sorbitol 3.00 Preservatives, dyes, perfume q.s. water ad 100.00

Example 8 gel

Wt .-% Carbopol 934 P 2.00 triethanolamine 3.00 polyaminopropylbiguanide 0.20 α-tocopheryl acetate 0.20 Polyoxyethylene sorbitan fatty acid ester (Tween 20) 0.50 glycerin 2.00 Sodium PCA 0.50 Hydrolyzed collagen 2.00 Preservatives, dyes, perfume q.s. water ad 100.00

Claims (2)

1. Use of quaternary nitrogen compounds for prophylaxis and treatment of superinfected atopic dermatitis. 2. Use according to claim 1, characterized in that the quaternary Nitrogen compounds in concentrations of 0.01-99.00 wt .-%, preferably 0.05-50.00 wt .-%, particularly preferably 0.1-10.00 wt .-%, each based on the Total weight of the composition, are present.