DE19638534A1 - Use of tocopheryl ferulate as skin bleaching agent - Google Patents

Abstract

Use of tocopheryl ferulate (I) as a skin bleaching agent is new.

Description

The present invention relates to the use of active substances known per se, for cosmetic and topical dermatological skin lightening or for Preventing the tanning of the skin, in particular that caused by UV radiation called skin tanning.

In a preferred embodiment, the present invention relates cosmeti cosmetic and dermatological preparations for prophylaxis and treatment dermal or dermatological lesions such. B. the undesirable Pigmentation, for example local hyper- and false pigmentation (e.g. as liver spots, freckles), but also for purely cosmetic Aufhel Larger, the individual skin type in itself quite appropriate pigmen derated skin areas.

Responsible for the pigmentation of the skin are the melanocytes, which are in the lowest layer of the epidermis, the stratum basale, in addition to the basal cells as - Depending on the skin type, either isolated or more or less frequent Tende pigment-forming cells are found. Melanocytes contain as cha characteristic cell organelles melanosomes that are excited by ultraviolet radiation increasingly form melanin. This is transported into the horny cells (keratinocytes) and gets a more or less pronounced brownish or brown skin color out.  

Melanin is formed as the final stage of an oxidative process in which tyrosine with the participation of the enzyme tyrosinase over 3,4-dihydroxyphenylalanine (Dopa), Dopa-quinone, leucodopachrom, dopachrome, 5,6-dihydroxyindole and indole-5,6- Finally, quinone is converted into melanin.

Problems with hyperpigmentation of the skin have many causes or are Concomitants of many biological processes, eg. B. UV radiation (eg, Som freckles, ephelides), genetic disposition, skin pigmentation wound healing or scarring or skin aging (eg Lentigines seni les).

There are known active ingredients and preparations which skin pigmentation counteract. In practical use are essentially preparations on the Basis of hydroquinone, which, however, partly after several weeks Application show their effect, their over-long use of others On the other hand, it is questionable for toxicological reasons. Also, the inhibition of Ty rosinase with substances such as kojic acid, ascorbic acid and azelaic acid and de ren derivatives is common, but has cosmetic and dermatological disadvantages.

To remedy this situation was the object of the present invention.

It is known that ferulic acid (4-hydroxy-3-methoxycinnamic acid, caffeic acid-3 methyl ether) has antioxidant properties. It is through the structural formula

characterized. It is widespread in plants and comes z. In turnips, Ge treid and the milky sap of the eponymous Umbelliferae Ferula asafoetida and Ferula nartex before. The E-form is a colorless-crystal under normal conditions liner solid, the Z-form is under normal conditions as a yellowish oil.

The tocopherols and their esters with vitamin E activity derive from the reason body tocol ((2-methyl-2- (4,8,12-trimethyltridecyl) chroman-6-ol) and are characterized by the following structures are marked:

In this case, K is either H or an acyl radical, R, R 'and R "are independently of one another H or a methyl group, eg. B .:
R = R '= R "= K = H: tocol
R = R '= R "= methyl, K = H: α-tocopherol
R = R "= methyl, R '= K = H: β-tocopherol
R '= R "= methyl, R = K = H: γ-tocopherol
R '' is methyl, R = R '= K = H: δ-tocopherol
R = methyl, R '= R "= K = H: ε-tocopherol
R = R '= methyl, R "= K = H: ζ-tocopherol
R '= methyl, R = R "= K = H: η-tocopherol.

Of course, the most abundant and important α-tocopherol comes the configuration 2R, 4'R, 8'R. It also occasionally becomes RRR-α-Toco called pherol.

Tocopheryl ferulate is characterized according to the isomeric forms of the femla acid or the various tocopherol basic body by the structural formulas

or.

where R, R 'and R "are as defined above.

The production of tocopheryl ferulate and its properties are described in the JP-OS Sho-60/222476 or in the associated JP-AS 86/052151 the Gesell Ichimaru Pharcos KK, Japan. In particular, is on am given places on the cosmetic usability of tocopheryl or noted its property as an antioxidant.

Rather, it was surprising and not foreseeable for the skilled person that the Use of tocopheryl ferulate against unwanted pigmentation of the skin or the use of cosmetic or dermatological preparations with egg effective content of tocopheryl ferulate against unwanted pigmentation the skin, the disadvantages of the prior art remedy.

Tocopheryl ferulate, hereinafter, whether a single substance or an isome mixture or a mixture of different tocopheryl ferulates, collectively also called "the active ingredient used in the invention", has been hervorra gender active ingredient against unwanted pigmentation, especially local hyper  pigmentation and against UV-induced skin tanning, both preventatively and in terms of treatment sen.

The inventively preferred α-tocopheryl ferulate (synonym: vitamin E Feru lat, chemical: 4-hydroxy-3-methoxycinnamic acid (2 ', 5', 7 ', 8'-tetramethyl-2' - (4 '', 8 '', 12 '' ') trimethyltridecyl) -6'-chromanyl ester, also 2,5,7,8-tetramethyl-2- (4 ', 8', 12'-trimethyl tridecyl) -6-Ch romanol (4 "-hydroxy-3" -methoxycinnamate) is disclosed in the Chemical Abstracts under the registry number 21290-29-9, formerly 17175-56-3, out.

Especially preferred is DL-α-tocopheryl ferulate. Equally advantageous are isomers with E and Z configuration on Ferulasäurerest.

If possibly in JP-OS Sho-60/222476 or in the associated JP-AS 86/052151 not for all conceivable, for the purposes of the present invention advantageous to use tocopheryl ferulate a concrete synthesis path be wanted to be written, the expert knows how he based on the information in those writings and, moreover, also because of his general expertise to the desired individuals, for example, by having in the relevant synthesis step the specifically disclosed tocopherol as starting material against a possibly not specifically disclosed tocopherol as starting material exchanges and otherwise proceeds in the same way.

According to the configuration of the Ferulasäurerestes arise for the inventions According to the preferred substances, the structures

or.

the configuration of the asymmetric centers on the tocopheryl radical is not taken into account was considered.

According to the invention, the content of active ingredient used in accordance with the invention may be in cosmetic or topical dermatological preparations 0.01-10 Wt .-%, preferably 0.1-5 wt .-%, in particular 0.2-2.0 wt .-% amount, based on the total weight of the preparations.

It has surprisingly been found that the invention ver used drug meets the underlying tasks of the invention. at Application of the active ingredient used according to the invention or cosmetic or topical dermatological preparations with an effective content Active ingredient used in the invention is an effective prophylaxis against unwanted pigmentation, so for example the prevention uner desired pigmentation by the action of UV radiation possible. But it is Also according to the invention extremely advantageous, the invention used Active substance or cosmetic or topical dermatological preparations with an effective content of active ingredient used according to the invention cosmetic or dermatological treatment of unwanted skin mentation, for example Lentigines seniles.

The prophylaxis or the cosmetic or dermatological treatment with the Active ingredient used according to the invention or with the cosmetic or topical dermatological preparations with an effective content of The active ingredient used in the usual way, namely in such a way that the active ingredient used according to the invention or the cosmetic or topical dermatological preparations with an effective content  Active ingredient used in the invention on the affected skin is applied.

Advantageously, the active ingredient used in the invention can be incorporated in conventional cosmetic and dermatological preparations, which in ver different forms may exist. So they can z. B. a solution, a Water-in-oil (W / O) or oil-in-water (O / W) type emulsion, or a multiple emulsions, for example of the water-in-oil-in-water type (W / O / W) or oil-in-water-in-oil (O / W / O), a hydrodispersion or Lipodis persion, a gel, a solid stick or even an aerosol.

According to the invention emulsions, z. B. in shape a cream, a lotion, a cosmetic milk are beneficial and included z. As fats, oils, waxes and / or other fatty substances, and water and a or more emulsifiers, as is customary for such a type of For be used.

It is also possible and advantageous within the meaning of the present invention, the inventions used according to the active ingredient in aqueous systems or Tensidzuberei to cleanse the skin and hair.

It is well known to those skilled in the art that sophisticated cosmetic applications compositions usually not without the usual auxiliaries and additives are conceivable. These include, for example, bodying agents, fillers, perfume, Dyes, emulsifiers, additional active ingredients such as vitamins or proteins, Light stabilizers, stabilizers, insect repellents, alcohol, water, salts, antimicrobial, proteolytic or keratolytic substances, etc.

Mutatis mutandis, corresponding requirements apply to the formulation medi Zinc preparations.

Medical topical compositions according to the present invention usually contain one or more drugs in effective concentration. For the sake of simplicity, a clear distinction between cosmetic and medical application and related products to the  referred to in the statutory provisions of the Federal Republic of Germany (eg Cosmetics Regulation Food and Drug Law).

It is also advantageous to use the active ingredient according to the invention as Add additive to preparations that already have other active ingredients for others Purposes included.

Accordingly, cosmetic or topical dermatological composition according to the present invention, depending on their structure, at For example, be used as Hautschutzcr'me, cleansing milk, sun protective lotion, nutrients, day or night creams, etc. It is optional possible and advantageous, the compositions of the invention as Basis for pharmaceutical formulations.

If appropriate, such cosmetic and dermatological additives are also favorable preparations which are in the form of a sunscreen. Preferably contain these in addition to the active ingredient used in the invention additionally at least one UVA filter substance and / or at least one UVB film tersubstanz and / or at least one inorganic pigment.

But it is also advantageous in the sense of the present inventions, such kosme tables and dermatological preparations, the main ones of which are The purpose is not to protect against sunlight, but Contains protective substances. For example, getting used to day crèmes incorporated UV-A or UV-B filter substances.

Advantageously, preparations according to the invention may contain substances which Absorb UV radiation in the UVB range, the total amount of the filterub punching z. B. 0.1 wt .-% to 30 wt .-%, preferably 0.5 to 10 wt .-%, in particular especially 1 to 6 wt .-%, based on the total weight of Zuberei obligations.

The UVB filters may be oil-soluble or water-soluble. As oil-soluble substances are z. To name, for example:

• - 3-Benzylidencampher and its derivatives, for. B. 3- (4-methylbenzylidene) cam pher,
• 4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;
• Esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamate;
• - Salicylic acid esters, preferably 2-ethylhexyl salicylate, salicylic acid (4-isopropylbenzyl) ester, salicylic acid homomenthyl ester;
• - Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophe non, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-meth oxybenzophenone;
• Esters of benzalmalonic acid, preferably 4-methoxybenzalmalone säuredi (2-ethylhexyl) ester;
• 2,4,6-trianilino (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine

As water-soluble substances are advantageous:

• - 2-phenylbenzimidazole-5-sulfonic acid and its salts, eg. For example, sodium, Ka lium or triethanolammonium salts,
• Sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4-meth oxybenzophenone-5-sulfonic acid and its salts;
• - Sulfonic acid derivatives of 3-Benzylidencamphers, such as. B. 4- (2-oxo-3-borny lidenmethyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bomylidenemethyl) sulfone acid and its salts.

The list of said UVB filters which can be used according to the invention of course, should not be limiting.

The invention also relates to the combination of an inventive UVA filters with a UVB filter or a cosmetic or cosmetic according to the invention dermatological preparation which also contains a UVB filter.

It may also be advantageous in formulations according to the invention UVA filters commonly used in cosmetic and / or dermatological applications are included. Such filter substances are present preferably derivatives of dibenzoylmethane, in particular 1- (4'-  tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione and 1-phenyl-3- (4'-iso propylphenyl) propan-1,3-dione. Also preparations containing these combinations contain, are the subject of the invention. It can be the same amounts UVA filter substances are used, which for UVB filter substances were called.

Cosmetic and / or dermatological preparations within the meaning of the present invention The invention may also include inorganic pigments commonly used in the art Cosmetics are used to protect the skin from UV rays. there are oxides of titanium, zinc, iron, zirconium, silicon, Manganese, aluminum, cerium and mixtures thereof, as well as modifications where the oxides are the active agents. It is particularly preferred pigments based on titanium dioxide. It can be for the above Combinations mentioned quantities can be used.

The cosmetic and dermatological preparations according to the invention can be contain cosmetic active ingredients, auxiliaries and / or additives, as is customary example be used in such preparations, for. B. Antioxidants, Kon Serving agents, bactericides, perfumes, substances for preventing Foaming, dyes, pigments that have coloring properties, thickening medium, surface-active substances, emulsifiers, softening, on moisturizing and / or moisturizing substances, fats, oils, waxes or others usual ingredients of a cosmetic or dermatological formulation such as Alcohols, polyols, polymers, foam stabilizers, electrolytes, organic Solvent or silicone derivatives.

It is also advantageous to the preparations according to the present inven add conventional antioxidants. According to the invention as cheap Antioxidants all for cosmetic and / or dermatological applications suitable or common antioxidants are used.

Advantageously, the antioxidants are selected from the group consisting of amino acids (eg, glycine, histidine, tyrosine, tryptophan) and their derivatives, imida zole (eg, urocanic acid) and derivatives thereof, peptides such as D, L-carnosine, D-car nosin, L-carnosine and their derivatives (eg anserine), carotenoids, carotenes (eg.  Carotene, β-carotene, lycopene) and their derivatives, lipoic acid and its derivatives (eg dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (e.g. Thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, Methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, Cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, Distearyl thiodipropionate, thiodipropionic acid and its derivatives (esters, ethers, Peptides, lipids, nucleotides, nucleosides and salts) as well as sulfoximine compounds (eg, buthionine sulfoximines, homocysteine sulfoximine, buthionine sulfones, penta-, Hexa-, heptathionine sulfoximine) in very low tolerated dosages (eg. pmol to μmol / kg), furthermore (metal) chelators (for example α-hydroxyfatty acids, Palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (eg citric acid, Lactic acid, malic acid), humic acid, bile acid, bile extracts, bilirubin, bili verdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives Derivatives (eg γ-linolenic acid, linoleic acid, oleic acid), folic acid and derivatives thereof, Alaninediacetic acid, flavonoids, polyphenols, catechins, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (eg ascorbyl palmitate, Mg-Ascor bylphosphate, ascorbyl acetate), tocopherols and derivatives (eg vitamin E acetate), and coniferyl benzoate of benzoin, rutinic acid and their derivatives, Feru and acid derivatives thereof, butylhydroxytoluene, butylhydroxyanisole, Nordihydro guaiacolic acid, nordihydroguiaretic acid, trihydroxybutyrophenone, uric acid and their derivatives, mannose and derivatives thereof, zinc and its derivatives (eg. ZnO, ZnSO₄) selenium and its derivatives (eg selenomethionine), stilbenes and de ren derivatives (eg stilbene oxide, trans-stilbene oxide) and the invention suitable derivatives (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these drugs.

The amount of antioxidants (one or more compounds) in the bait is preferably 0.001 to 30 wt .-%, particularly preferably 0.05-20 Wt .-%, in particular 1-10 wt .-%, based on the total weight of the Zube reitung.

If vitamin E and / or its derivatives are the antioxidant or antioxidants, is advantageous, their respective concentrations in the range of 0.001-10 Wt .-%, based on the total weight of the formulation to choose.  

If the cosmetic or dermatological preparation in the sense of present The invention is a solution or emulsion or dispersion can, as Solvents are used:

• - water or aqueous solutions
• - Oils, such as triglycerides of capric or caprylic acid, but preferably Castor oil;
• - Fats, waxes and other natural and synthetic fats, before preferably esters of fatty acids with lower C-number alcohols, e.g. B. with Isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with Alkanoic acids of low C number or with fatty acids;
• - Alcohols, diols or polyols low C number, and their ethers, preferably Example, ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or - monoethyl ether and analog products.

In particular, mixtures of the abovementioned solvents verwen det. For alcoholic solvents, water can be another ingredient.

The oil phase of the emulsions, oleogels or hydrodispersions or Lipodispersi Ones in the context of the present invention is advantageously selected from the group the ester of saturated and / or unsaturated, branched and / or unreacted branched alkanecarboxylic acids of a chain length of 3 to 30 carbon atoms and sown ei and / or unsaturated, branched and / or unbranched alcohols ei ner chain length of 3 to 30 carbon atoms, from the group of esters aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms. Such ester oils can then be advantageously selected from the group Isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, Isc nonyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2- Octyl dodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate and syn thetic, semi-synthetic and natural mixtures of such esters, e.g. B. jojoba oil.  

Furthermore, the oil phase can be advantageously selected from the group of ver Branched and unbranched hydrocarbons and waxes, of silicone oils, Dialkyl ethers, the group of saturated or unsaturated, branched or un branched alcohols, as well as the fatty acid triglycerides, namely the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched Al kancarbonsäuren a chain length of 8 to 24, in particular 12-18 C-atoms. The fatty acid triglycerides can be selected, for example, advantageously from Group of synthetic, semi-synthetic and natural oils, e.g. Olive oil, Sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, Palm kernel oil and the like more.

Any mixtures of such oil and wax components are advantageous to use for the purposes of the present invention. It can also be given if advantageous, waxes, for example cetyl palmitate, as the sole lipid component of the oil phase.

Advantageously, the oil phase is selected from the group consisting of 2-ethylhexyl isostearate, octyl dodecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C _12-15 alkyl benzoate, caprylic capric acid triglyceride, dicaprylyl ether.

Particularly advantageous are mixtures of C _12-15 -alkyl benzoate and 2-ethylhexyl isostearate, mixtures of C _12-15 -alkyl benzoate and Isotridecylisononanoat and mixtures of C _12-15 -alkyl benzoate, 2-Ethylhexylisostearat and Isotridecyliso nonanoate.

Of the hydrocarbons, paraffin oil, squalane and squalene are beneficial in the Use of the present invention.

Advantageously, the oil phase may further contain cyclic or linear silicates have or consist entirely of such oils, although is preferred, except the silicone oil or silicone oils an additional To use content of other oil phase components.

Cyclomethicone (octamethylcyclotetrasiloxane) is advantageous according to the invention used to be used silicone oil. But other silicone oils are beneficial  for the purposes of the present invention, for example Hexamethylcy clotrisiloxane polydimethylsiloxane, poly (methylphenylsiloxane).

Also particularly advantageous are mixtures of cyclomethicone and isotridecyl isononanoate, from cyclomethicone and 2-ethylhexyl isostearate.

Gels used according to the invention usually contain lower C alcohols. Number z. As ethanol, isopropanol, 1,2-propanediol, glycerol and water or a before standing oil in the presence of a thickener, the oily-alkoho gels preferably silica or an aluminum silicate, in aqueous-al or alcoholic gels, preferably a polyacrylate.

Fixed pins contain z. As natural or synthetic waxes, fatty alcohols or Fatty acid ester. Lip balm sticks and stick formulations are preferred Körperdesodorierung.

Usual raw materials, which are intended for use as cosmetic sticks in the sense of the present invention, liquid oils (e.g., paraffin oils, Ri cinus oil, isopropyl myristate), semi-solid components (eg petrolatum, lanolin), solid Ingredients (eg beeswax, ceresin and microcrystalline waxes or ozo kerit) and high-melting waxes (eg carnauba wax, candelilla wax).

As propellant for sprayable from aerosol containers cosmetic and / or the Matological preparations in the context of the present invention are the customary known volatile, liquefied propellant, for example Hydrocarbons (propane, butane, isobutane) suitable alone or in Mi can be used together. Also compressed air is beneficial too use.

Of course, the person skilled in the art knows that there are nontoxic propellants per se which basically for the realization of the present invention in the form of aera solpräparaten would be suitable, but nevertheless because of questionable effect the environment or other accompanying circumstances should be waived, esp hydrofluorocarbons and chlorofluorocarbons (CFCs).  

Cosmetic preparations according to the present invention can also be described as Gels are present, in addition to an effective content of Wirk Wirk substance and solvents commonly used for this purpose, preferably water, still organic thickeners, z. Gum arabic, xanthan gum, Na trium alginate, cellulose derivatives, preferably methylcellulose, hydroxymethylcel cellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellu loose or inorganic thickeners, e.g. B. aluminum silicates such as Bentonite, or a mixture of polyethylene glycol and polyethylene glycol stearate or distearate. The thickener is in the gel z. In in an amount between 0.1 and 30% by weight, preferably between 0.5 and 15% by weight, contain.

The following examples are intended to illustrate the present invention.

example 1 W / O cream

Wt.% Paraffin oil (DAB 9) 10.00 petrolatum 4.00 Wool alcohol 1.00 PEG-7 hydrogenated castor oil 3.00 aluminum stearate 0.40 DL-α-Tocopherylferulat 0.50 glycerin 2.00 Preservatives, dyes, perfume q.s. Water, ad 100.00

Example 2 W / O lotion

Wt.% Paraffin oil (DAB 9) 20.00 petrolatum 4.00 Glucosesesquiisostearat 2.00 aluminum stearate 0.40 DL-α-Tocopherylferulat 0.50 α-tocopheryl acetate 1.00 glycerin 5.00 Preservatives, dyes, perfume q.s. Water, ad 100.00

Example 3 O / W lotion

Wt.% Paraffin oil (DAB 9) 8.00 isopropyl palmitate 3.00 petrolatum 4.00, Cetylstearylalkohol 2.00 PEG 40 castor oil 0.50 sodium cetylstearyl 0.50 Sodium carbomer 0.40 DL-α-Tocopherylferulat 0.50 glycerin 3.00 α-tocopherol 0.20 octyl 5.00 butylmethoxydibenzoylmethane 1.00 Preservatives, dyes, perfume q.s. Water, ad 100.00

Example 4 O / W cream

Wt.% Paraffin oil (DAB 9) 7.00 avocado oil 4.00 glyceryl 2.00 DL-α-Tocopherylferulat 0.50 Titanium dioxide 1.00 sodium lactate 3.00 glycerin 3.00 Preservatives, dyes, perfume q.s. Water, ad 100.00

Example 5 Liposome-containing gel

Wt.% lecithin 6.00 shea butter 3.00 DL-α-Tocopherylferulat 0.50 α-tocopherol 0.20 biotin 0.08 sodium citrate 0.50 glycine 0.20 urea 0.20 Sodium PCA 0.50 Hydrolyzed collagen 2.00 Xanthan gum 1.40 sorbitol 3.00 Preservatives, dyes, perfume q.s. Water, ad 100.00

Example 6 Sunscreen Emulsion

Wt.% cyclomethicone 2.00 Cetyl dimethicone copolyol 0.20 PEG 22-dodecyl copolymer 3.00 Paraffin oil (DAB 9) 2.00 Caprylic / capric acid triglyceride 5.80 octyl 5.80 Butyl methoxydibenzoylmethane 4.00 DL-α-Tocopherylferulat 0.50 α-tocopheryl acetate 0.50 ZnSO₄ 0.70 Na₄EDTA 0.30 Preservatives, dyes, perfume q.s. Water, ad 100.00

Example 7 Sunscreen Emulsion

Wt.% cyclomethicone 2.00 Cetylstearyl alcohol + PEG 40-hydrogenated castor oil + sodium cetylstearylsulfate 2.50 glyceryl 1.00 Caprylic / capric acid triglyceride 0.10 Laurylmethicone copolyol 2.00 octyl 3.00 castor oil 4.00 glycerin 3.00 Acrylamide / sodium acrylate copolymer 0.30 hydroxypropyl methylcellulose 0.30 octyl 5.00 Butyl methoxydibenzoylmethane 0.50 DL-α-Tocopherylferulat 0.50 α-tocopheryl acetate 1.00 Na₃HEDTA 1.50 Preservatives, dyes, perfume q.s. Water, ad 100.00

Example 8 Sunscreen Emulsion

Wt.% Cyclomethicone 2.00 Cetylstearyl alcohol + PEG 40-hydrogenated castor oil + sodium cetylstearylsulfate 2.50 glyceryl 1.00 Caprylic / capric acid triglyceride 0.10 Laurylmethicone copolyol 2.00 octyl 3.00 castor oil 4.00 glycerin 3.00 Acrylamide / sodium acrylate copolymer 0.30 hydroxypropyl methylcellulose 0.30 octyl 5.00 Butyl methoxydibenzoylmethane 0.75 DL-α-Tocopherylferulat 0.50 Na₃HEDTA 1.50 Preservatives, dyes, perfume q.s. Water, ad 100.00

Example 9 spray formulation

Wt.% α-tocopherol 0.10 DL-α-Tocopherylferulat 0.50 ethanol 28,20 Preservatives, dyes, perfume q.s. Propane / butane 25/75, ad 100.00

Claims (4)

1. Use of Tocopherylferulaten against unwanted pigmentation of Skin. 2. Use according to claim 1, characterized in that the Tocopherylfe Rulaten in an effective content in cosmetic or dermatological Zube is available. 3. Use according to claim 1, characterized in that as Tocopherylfe the DL-α-Tocopherylferulat is selected. 4. Use according to claim 2, characterized in that the or the Ta copheryl ferulates in cosmetic or topical dermatological preparations in concentrations of 0.01-10 wt .-%, preferably 0.1-5 wt .-%, esp especially 0.2-2.0 wt .-% based on the total weight of the preparations, is present.