DE1222214B - Device for serial implementation of vaccinations - Google Patents

Description

FEDERAL REPUBLIC OF GERMANY

GERMAN

PATENT OFFICE

EDITORIAL

Int. α .:

A61m

German class: 30 k-3/02

Number: 1222 214

File number: H 40843IX d / 30 k

Filing date: November 3, 1960

Opening day: August 4, 1966

The invention relates to a device for serial implementation of vaccinations, one of has a storage container of refillable container for the substance to be administered, from which this substance becomes effective when an actuator is actuated by the operator of a path of adjustable length in association with the single doses to be administered Displacement piston is presented in the direction of the administering organ in order to deal with it Aid administered one after the other in the individual doses of the corresponding measured amounts to become.

In known arrangements of the type in question here, which are designed as needleless injection syringes is between the vaccine container and the injecting organ, which in this case is called Nozzle is formed, another container is provided in the form of a so-called drug chamber, which is in direct connection with the replaceable spray nozzle. The one to expel the to be administered, The displacement piston serving the substance is pushed forward by a strong spring, the ejection movement is triggered by pulling the trigger like a pistol. The piston can only be returned to the starting position with the help of special hydraulic means, because here the Effect of the strong spring is to be overcome. In this known arrangement, pressures must be generated which are at the height of 1400 at (at the beginning) and 210 at (in the second phase). Because of this However, "shooting in" the vaccine will shred the skin and prevent the vaccine from going into it desired »depot« can be controlled, as it is distributed immediately in the tissue due to the high pressure and also gets into tissue parts that it shouldn't get to. This known arrangement is above also much more complicated in construction, the many additional parts, such as additional hydraulic Drive etc., on the one hand, increase the manufacturing costs and, on the other hand, bring a substantial amount larger space requirements make handling the device more difficult and reduce it Transportability.

A vaccination device has also become known with which only individual vaccination operations are carried out and that's basically just a single syringe on top of a Tripod is arranged. The displacement movement takes place under the action of a spring, which, as with Known springs, constantly losing power on their way to work, so that the injection pressure with the

Device for serial implementation
of vaccinations

Applicant:

Christian Haber, Rangendingen via Hechingen

Named as inventor:

Christian Haber, Rangendingen via Hechingen

Injection time decreases. Incidentally, this is known Device, the metering device of which is extremely primitive and imprecise, is also very cumbersome serve. The aim of the invention is to remedy this situation, which is why the invention has set the task of creating a device in which, on the one hand, the pure inoculation process as possible is largely automated and, on the other hand, at the same time the advantages of hand vaccination are retained will.

According to the invention, in the new device, the in the container leads to the above-mentioned purpose Displacement piston guided for the substance to be administered, possibly loaded with weights the sliding movement between the starting position and the end position only under weight load and he places a number of the individual doses in the course of this shifting movement the series corresponding, individually successive path sections back, the beginning of each of the Release of the inflow of the substance to be administered to the organ to be administered through the in the active Position located and attacking the supply line immediately behind the administering organ Actuator and the end of each of the interruption of this inflow due to Impulse is assigned to the electrical monitoring of the exact dosage of the medium operated control device are sent out when the actuator is operated is set and their impulse determining the end of the relevant path section independently sends out from the actuator.

The new device makes it much easier for doctors to perform their tasks Serial vaccinations by making them more skilled in the execution of measures and operations.

609 608/21

This means that you can concentrate fully on your actual medical tasks. As the electrically or electromagnetically operated agitator element, the continuous stirring and mixing The doctor who carries out the serial vaccination must obtain the vaccine on his own initiative no longer check for yourself at certain time intervals how far they are in suspension Knocked down parts of the vaccine. The new device also has a quantity control device, with the help of this, after appropriate adjustment before the start, the serial vaccination is advantageous Electrically the dose of vaccine to be injected for each individual vaccination can be determined automatically, so that the doctor is no longer time-consuming and as before laboriously has to check whether the prescribed dose has been adhered to. While the doctor with the previously known vaccine syringes, e.g. the dose for five or ten individual Contain vaccinations, when vaccinating carefully must ensure that it is only the one in question Vaccination sprayed certain part of the syringe contents, this is the case with the new device the aforementioned quantity control organ provided. When using the new device, the doctor only has to pierce the cannula and then, by operating the actuator, inject the Initiate the vaccine and can also affect the patient and his or her behavior during the procedure watch. The new device thus helps the doctors save a lot of time and work, so that the vaccinations a vaccination appointment can be made in a much shorter period of time than before. In addition, the physicians are also less stressed physically and mentally. As the doctor at Use of the known syringes tired after some time, the z. B. from him later in the course the dosages carried out during the serial vaccination or examination are naturally more inaccurate, what not the case with the device according to the invention is. Another major advantage of the new device, especially with today's shortage to auxiliary staff in health care is important, is that when using the erfindüngsgemäße Arrangement of fewer steps to assist the doctor must be made and thus auxiliary staff can be saved. at the new device can control the injection pressure and thus the injection speed from the outset determined and automatically maintained during the vaccination operation without affecting the personality of the vaccinator and his physical and psychological characteristics have an influence as with use the well-known syringes exercise. The vaccination pressure and the vaccination speed can can also be increased and decreased as needed by displacing the vaccine Weighted piston serving the vaccine container by adding or removing weights or make it easier.

Furthermore, the device according to the invention is characterized by a simpler structure, the is associated with lower manufacturing costs. You can also use the device according to the invention let the vaccine flow in or flow in, so to speak, with only a slight overpressure required is. Infection through the syringe mouthpiece, which cannot always be ruled out with needleless vaccination devices does not occur in the present case, since the injection cannula is changed after each vaccination will.

For the sake of order, it is stated that the term "serial vaccinations" is also used at the same time the work is understood under the designation »serological or bacteriological serial examinations« are known. The device according to the invention is used in this case to the to spray individual samples, whereby an inoculation cannula is not required. For the sake of brevity but in the following only spoken of "serial vaccinations".

In the drawing, exemplary embodiments of the subject matter of the invention are shown. It shows

F i g. 1 shows a device according to the invention seen from the front in a perspective illustration,
FIG. 2 shows the device according to FIG. 1 in a front view, partially in section,

FIG. 3 shows the piston of the device according to FIG. 2 in a front view in an axial section,

4 shows a part of the device according to FIG. 2 in a section along the line IV-IV of FIG. 2, Fi g. 5 shows the vaccine container of the device according to FIG. 1 in a side view,

F i g. 6 the vaccination handpiece of the device according to the invention in a plan view in a horizontal Cut,

F i g. 7 shows a part of the vaccination handpiece according to FIG. 6 in a side view in a schematic representation,

F i g. 8 shows a modified embodiment of the stirring member of the device according to FIG. 1 in 'one Side view or in plan view,

F i g. 9 shows a further modified embodiment of the stirring member of the device according to FIG. 1 in a side view or in a top view,
10 shows the electrical circuit diagram of the device according to the invention,

11 shows the transport container for the detachable, removable parts to be sterilized of the device according to the invention in perspective Depiction,

12 shows a connection with the new one Device to be used cleaning device according to the invention in a side view partially in the Cut,

F i g. 13 the cleaning device according to FIG. 12 in a plan view,

F i g. 14 one for removing the vaccine from a storage container and for venting the storage container serving cannula in perspective view and

Fi g. 15 shows a cannula according to the invention with a corresponding gripping device in perspective Depiction.

The device according to the invention is used to carry out serial vaccinations or serological vaccinations or bacteriological screening. It has a to a refill container 1 with Vaccine connectable and from this, if necessary, to be refilled vaccine container 2 with a electrically or electromagnetically operated stirring member 3 for automatic stirring and mixing of the vaccine in the vaccine container and a vaccine handpiece 4, which is attached to the vaccine container 2 via a control unit influenced by

Flowed feed line 5 for the vaccine is in communication. The vaccination handpiece 4 has a holder for replaceable insertion of the vaccination cannula 6, which is supplied from the vaccine container via the supply line with Vaccine in adjustable, automatically measured amounts with the help of the volume control device is provided, and in the operative position, the inflow of the vaccine to the vaccination cannula releasing and this in the inoperative position interrupting actuator for the operator. The device according to the invention also has a control device with which With the help of the automatic sequence of the individual operations is determined in the desired order. The arrangement is made so that the individual parts coming into contact with the vaccine can be removed and sterilized individually.

The vaccine container 2 is in the form of an advantageously transparent material, for example glass existing cylinder, at one end of which leads to the refill container 1 line 7 and the Feed line 5 open to the vaccination handpiece 4 and in which a piston 8 is arranged so as to be movable back and forth, which when it moves from the mouth the connection line 7 sucked away vaccine into the vaccine container and when moving in the opposite direction vaccine from the vaccine container towards the vaccination handpiece too repressed. The cylindrical vaccine container 2 is arranged approximately vertically, the lines 5 and 7 open at its lower end wall, and the piston 8 is in the cylinder in the vertical direction and guided from moveable. The piston 8 can here with the help of a z. B. at one end 10 by hand to be actuated loading lever 9 or the like. In the container cylinder 2 are raised. Here he does the suction of vaccine by creating a negative pressure in the lower part of the container cylinder from the refill container 1. When moving backwards, under the action of his Running under its own weight, the piston displaces vaccine out of the vaccine container in the direction of towards the vaccination handpiece 4. An outwardly opening vent valve 11 is provided in the piston 8, with the help of the air present in the empty vaccine container 2 after sucking in Vaccine can be drained from the container. On the whole, the arrangement is made so that the Piston resting on the vaccine column in the vaccine container with the outlet open under the action of his Your own weight goes down at a steady pace and the vaccine is taken out of the Vaccine container displaced outwards while passing through the vaccine column with the outlet closed is held at the same level in the vaccine container. Here a control device monitors that the piston on its way from top to bottom during a series of vaccinations or withdrawals Always covers the same distance that the one from the vaccine container for a single vaccination with the respective dose correspond to the amount of vaccine to be displaced.

The piston 8 is provided with weights provided on both sides in a symmetrical arrangement 12, 13 connected to the fixed vertical Guide columns 14, 15 are slidably guided up and down, advantageously their upward Movement is limited by stops 16, 17 at the upper end of the guide columns.

As shown in FIG. 3 is the one in the vaccine container 2 displaceably guided pistons 8 with a vaccine container concentric to it from the outside surrounding cylinder jacket 18 z. B. with the help of a hollow, one through its inner bore Connection between the vent valve 11 in the piston and the rod 19 producing the outside air

ίο connected, and the cylinder jacket 18 has two to Coupling of the piston with the weights, parallel and ring-like, on its circumference encircling shoulders 20, 21, engage between the lugs 22 on the weights 12, 13.

In the embodiment shown in the drawing, a cone seat valve is used as the vent valve 11, which can be operated via a linkage 23, 24, 25. The crossbar 24 is at 130 on the jacket 18 rotatably mounted and connected to the rod 23 via the fork 131, which engages the nut 132, into which the rod 23 is screwed. The arrangement is made so that by appropriate Screwing the nut 132 on and off, the effective length of the valve rod 23 can be changed can. The lever 133 is on the one hand under the action of the spring 134 and on the other hand under the Effect of the eccentric lever 136 rotatably mounted at 135, when it is pivoted against the Clockwise the valve is closed against spring pressure and its stroke is limited by the special design of the surface 137.

The upright guide columns 14, 15 for the weights 12, 13 connected to the piston 8 are attached to the housing 27 and connected to each other at its upper end by a cross strut 28, the this simultaneously forms a handle for transporting the device.

The vaccine container 2 consists of a material, advantageously made of transparent material, e.g. B. made of glass, cylinder open at the top, which tapers at its lower end to a neck 29, which in a z. B. fork-like bracket 30 on the housing of the device can be releasably inserted and in this with the help a leaf or plate spring 31 or the like can be fixed and from which via the lower connection piece 32 on the one hand the connecting line 7 to the refill container 1 and on the other hand the feed line 5 to the vaccination handpiece 4 goes out.

With the piston 8 or a part attached to it moves in the area of the lower end of the piston stroke a contact piece 33 arranged outside the container cylinder, which in the course of its Downward movement actuates a limit switch 34 and thereby an electrical signal triggers, indicating that the vaccine container is running out of vaccine and there is only a certain, adjustable amount of vaccine left. When actuating the limit switch 34 a relay is switched that feeds the vaccine to the vaccination device for the next individual vaccination blocks, but the already initiated single inoculation with the set amount until its end expires. The limit switch 34 consists of a lower contact piece 35 and an on this under appropriate insulation with the aid of the spring 36 resiliently mounted upper contact piece 37. When the piston goes down, the contact piece 33 moving with it actuates the switch,

by applying the contacts 35 and 37 to one another, with a signal, e.g. B. a buzzer sounds. The operator now knows that there is only a small amount left in the container and that he has vaccine must refill.

The actuating element on the vaccination handpiece 4 consists of a clamp 38 which, when the electromagnet 39 is energized, is removed from the operative position in which it interrupts the line 5 coming from the vaccine container 2 and leading to the vaccination cannula 6, and which when it falls off of the magnet returns to the closed position. As can be seen, for example, from FIGS. 6 and 7, the clamp consists of a double lever pivoted approximately in the middle of its length at 40, one arm 41 of which in the closed position rests against the supply line 5 from the vaccine container to the vaccination cannula, with the supply line between squeezes itself and the opposing surface 42 and prevents the further passage of vaccine through the supply line to the vaccination channels, and its other arm 43 cooperates with an electromagnet 39, which is in a circuit to be closed by the operator's impulses, so that when the circuit is closed and when the electromagnet is excited, one arm of the double lever is attracted by the electromagnet and its other arm is removed from the closed position and when the circuit is opened, the two arms of the double lever move in the opposite direction under the action of the spring 44. To close the circuit controlling the electromagnet of the actuator, a switch 45 is provided which, for. B. is designed as a push button switch or as a slide button switch and can be operated by the person operating the vaccination cannula. The slide button switch has the advantage that inadvertent actuation is not possible, as is the case e.g. B. could occur when using a push button switch. The arrangement is such that the switch only accepts one command and only accepts the next command after the first command has been carried out. As shown in FIG. 6 and 7, the switch 45 is attached to one end of the double lever 141, 142, which at its other end actuates the snap switch 48 via the leaf spring 46 and the spring 47, which in turn closes the circuit controlling the electromagnet 39 of the actuator . The holder for the inoculation cannula 6 and the actuating element for the supply of the vaccine to the cannula are accommodated in a housing 49 into which the feed line 5 coming from the vaccine container 2 enters and to which the inoculation cannula can be attached and on the outer wall of which the switch 45 can be attached from the outside is operably attached, with the help of which the actuator can be brought into effect. The holder for the vaccination cannula 6 is here provided with a metal feed tube 50 which enters the interior of the vaccination handpiece 4 and onto which the front end 51 of the hose-like feed line 5 for the vaccine is pushed, the one for interrupting and releasing the vaccine feed for vaccination cannula serving clamp 38 is arranged immediately in front of the connection point between the metal feed tube and the hose-like feed line for the vaccine. In this way it is achieved that the hose-like supply line cannot expand as a result of the tissue pressure of the person being vaccinated.

The housing consists of two detachably connected parts 151, 152, one of which contains the elements of the handpiece to be sterilized, such as the cannula holder and the vaccine supply line, and the other the other parts, e.g. B. the electrical parts are housed.
In order to stir and mix the vaccine contained in the vaccine container, a magnetic stirring body 3, which is at least partially immersed in the vaccine, is provided, the portion of which is immersed in the vaccine and, under the action of an electromagnetically operated drive magnet 52, moves back and forth or up and down or rotates or Performs a circular motion, mixing and stirring the vaccine well. Here, the driving magnet is arranged outside the vaccine container with a relatively small distance on the outer wall of the vaccine container and the magnetic stirring body inside the vaccine container.
In the embodiment shown in the drawing, the driving magnet 52 is designed as an alternating current magnet and has the shape of an elongated plate or disc, preferably with a surface following the course of the outer wall of the container on part of its circumference, with its poles 53, 54 in one direction are offset from one another transversely to the longitudinal axis of the container. The magnetic stirring body 3 consists of a permanent magnet in the form of a cube and has two pairs of poles on opposite sides. A magnetic stirrer is used as a magnetic stirrer

• A stone is used that is resistant to attack by the sterilization fluids or media Coating, e.g. made from the plastics known under the trade name silicone rubber or Teflon is.

In an embodiment not shown in the drawing If the vaccine container is cylindrical, and a driving magnet is used for the container cylinder coaxial electromagnetic ring that surrounds it on the outside and at the same distance on all sides from the outer wall of the container. The magnetic one located inside the vaccine container Stirring body has an elongated resilient shape, e.g. B. in the manner of a leaf spring. Its an end is attached to a fixed point as far as possible off-center from the vaccine container, while the other end free to spring is immersed in the inoculation liquid and under the influence of the driving magnet performs a vibratory movement.

In a further embodiment shown in Fig. 8 of the drawing, the inside of the Vaccine container arranged magnetic stirring body from a central permanent magnet 57, preferably in a cube shape, and one for enlargement the circumference of the stirring body serving peripheral soft iron frame assembled, wherein to drive the agitator two from diametrically opposite sides from the outside of the container adjacent or almost adjacent pole pieces 58, 59 are used. The soft iron frame consists of two semicircular soft iron disks 60, 61, which are attached from opposite sides to the central, cube-shaped permanent magnets 57 are applied,

9 ίο

and the entire stirring body is with a mass of speaking from that of the lower bridge opposite the

an upper bridge secured against attack by sterilization fluids

resistant material, e.g. B. from the under the commercial depending on the from the vaccine container 2

named Teflon or silicone rubber existing plastic leaked amount of vaccine by electrical means

fabrics, as shown at 62. The edge 5 on the one hand the falling off of the magnet 39 for loading

this sheathing is at 63 along the circumference activating member and thus the interruption of the

serrated, toothed or knurled. A vaccine feed to the vaccination cannula 6 and on the other hand in this way

trained agitator can, for. B. with a falling of the or the holding magnets 66, 67 for

Alternating current from 50 Hz up to 3000 rpm run the upper bridge 65 and thus the sliding of the

and the prongs on the edge of the agitator body serve 10 upper bridge to rest against the lower bridge 64

to keep the vaccine liquid moving well and causing the frequency field to collapse,

set. In this way, the purpose of the stirring The frequency field between the upper and lower

body, a deposition of the loading _r in suspension bridge en influenced case the control relay 55,

Prevent sensitive particles of the inoculation liquid after responding as a result of the actuation of the switch

perfectly fulfilled. 15 45 when reaching a certain adjustable

Between the switch 45 on the vaccination handpiece, the strength of the frequency field drops and the terminal 38 for the supply line to the vaccination device holding magnets 66, 67 on the upper bridge 65 and a control relay 55 is switched which, when actuated, the terminal 38 on the vaccination Handpiece 4 zugeorddes push or slide button switch responds and Neten electromagnet 39 can drop. Be of the magnet 39 in-vaccination handpiece for loading _ao control relay 55-bringing into effect switch can agreed adjustable time regardless of the opinion operated when de-energized control relay, the switch lung excited holds and this only after this can with actuated limit switches 34 not flowing through a predetermined, controllable and brought into effect,
fall adjustable vaccine dose for Impfkanüle z _for determining the leaves from the vaccine cylinder. 2 The control relay 55 speaks upon actuation of the 35 per single vaccination to be excluded vaccine quantity switch 45 and brings the magnet in Jj ₃ J _1n the mapped _{from the} frequency field between the lower seed handpiece and thereby _un the ma- _(j of the upper bridge 64, 65 affected Steuergneten exciting switching relays 56th when _re i _a j _s 55 one of several capacitors reaching the set dose falls to effect the control relay _m j _t different, according to per single-55, and this also leaves the switching relay 56 for ₃₀ vaccination to be sprayed Vaccine doses are selected to fall off the magnet 39 in the vaccination handpiece 4. Capacities are assigned in such a way that the control relay 55 for dosing each individual withdrawal is then ineffective, the container at the beginning of the individual withdrawal _when the frequency field between the upper and the Marked starting position of the piston and then lower bridge depending on the distance between from this position the back of the piston _{35 sc} h _en these two bridges having the in each case measured to vergelegte way and reached on reaching the associated one of the sprayed dose value. provided dose corresponding value bringing a unintended When, for example, stopping the upper relay action which interrupts the feed of the bridge 65 by an externally acting mechanical vaccine for vaccination handpiece and _sc h _e force may in this case the control relay 55 except the same time the Starting position of the piston ₄₀ can be brought into effect. In this way, ver is marked for the following individual withdrawal. prevents someone standing in the way

With the piston 8 or with the stood with the piston or when the guides or tilted coupled weights 12, 13 is electrically unintentional by the operator lower bridge 64 connected, on which a ter way the upper bridge is held so that parallel to this, the upper bridge 65 loosely supports 45 the amount to be injected in a single vaccination, at one end or at both ends of the vaccine influenced from the outside and at least a hard magnet 66, 67 is attached which is changed.

In the non-excited state, a movement of the upper The bridge arranged on both sides of the piston 8, together with the lower bridge in vertical weights 12, 13 with the lower right-hand direction connecting them, and when excited by the flat bridge 64, form a structure in the form of cooperate with a fixed part of the device of a downwardly open U summarized, the upper bridge of which fixes in its respective position, so both legs formed by the weights to that the lower bridge when going down the upstanding guide columns 14, 15 for the piston of her in dependence on the expiring piston are slidably mounted up and down by z. B. Amount of vaccine removed. In this case, the adhesive 55 these columns will extend through longitudinal bores in the magnet when the actuating member becomes effective, with the lower 38 being excited and falling after a predetermined flat bridge 64, the upper bridge 65 loosely open, adjustable amount of vaccine from the vaccine - Is placed, at both ends of each one adhesive container from. When the actuating magnet 66, 67 is fixed in a housing 68, 69, when the actuating magnet 66, 67 becomes active, and thus when the upper 60 is fixed, the bridge 65 is in its respective position and when it is lowered, through which one each of the guide columns go to the lower bridge 64 with the piston 8 in 14, 15 for the piston 8 to pass through. The piston depending on the lowering of the level of the vaccine is in this case between the two legs of the U fluid in the vaccine container 2 builds up between ordered and coupled with these at their lower ends, the lower and upper bridges, a frequency field of 65 bar, as has already been described .
There are several capacitors in a strength that changes with the bridging, the number corresponding to the number of doses to be removed from the vaccine container 2 of a predetermined, adjustable value when different sizes are reached

lined up so that the operator uses the appropriate capacitor in the series The control relay 55 can be assigned to the control relay 55 by itself using a selector element 70.

The capacitors are accommodated with the control relay 55 in the housing 27 of the device the top of which is the vaccine container 2 with the upstanding guide columns 14, 15 for the piston 8 attached and the loading lever 9 mounted for lifting the piston in the cylinder 2 and with the Contact piece 33 is arranged on the piston interacting limit switch 34 and from which on the one hand the electrical connections 71 for connection to the network and on the other hand electrical Go out connecting lines 72 for the vaccination device. The guide columns 14, 15 are hollow on the inside and contain in their interior the electrical lead 73 for the upper bridge and also carry isolated therefrom and z. B. on the outside the electrical lead 74 for the lower bridge 64.

The holding magnets 66, 67 housed in the approximately cube-shaped housings 68, 69 at the ends of the upper bridge 65 are hammer-like and pivotably mounted at one end (at 74), while the other end is in the effective holding position against the through a hole in the magnet housing 68, 69 through guide column 14, 15 is applied. The holding magnets 66, 67 and the control magnet 39 for the clamp 38 on the vaccination handpiece 4 are electromagnets excited by direct current.

When the switch 45 on the vaccination handpiece 4 is operated, the control relay 55 is activated, on the one hand the relay 56 for controlling the electromagnet 39 of the terminal 38 in the vaccination handpiece 4 and on the other hand the relay 76 for controlling the holding magnets 66, 67 brings to effect. As a result, the inflow of inoculation liquid to the vaccination cannula 6 is released, and at the same time the holding magnets fix the upper bridge in the starting position for the individual vaccination in question on the guide pillars The lower bridge, which moves with the piston, builds up a frequency field whose frequency changes continuously according to the distance between the two bridges until the frequency is reached that corresponds to the selected capacitor from the series of capacitors. (One can, for example, take a series of ten capacitors, which corresponds to the dose series from 0.1 to 1.0 ml, and before the start of vaccination, the for example toggle-like selector element 70 is set to the number corresponding to the dose to be administered As can be seen from FIG. 1, the control relay 55 drops out at this point, so that the flow of vaccine to the inoculation cannula 6 is interrupted by the relay 56 dropping out, and the holding magnets 66, 67 as a result of the relay dropping out 76 loosen, the upper bridge 65 falls on the lower bridge 64 and the frequency field collapses. The individual inoculation is finished, a new inoculation operation can be initiated. When the limit switch 34 is actuated by the contact piece 33 at the lower end of the piston stroke, the control relay 55 is switched off so that the single inoculation that has already started is completed, but a new single inoculation can no longer be initiated because the control relay has been switched off until the piston reaches the A filling the container is lifted up again.

Instead of measuring the dose to be administered for each individual vaccination on the one described above One can also do such a measurement with a photocell and perform light source. For this purpose you can z. B. the light source and the photocell fixed to one of the two guide pillars, but adjustable according to the respective dose arrange. When the dose is reached, the descending piston interrupts the light beam between the light source and photocell, which can cause the control relay to drop out. You can also do that Photocell e.g. B. can be fixed on a guide column (e.g. by placing it on this column on a magnetic Paths stuck) and the light source along the other column with the piston down and lets go upstairs. Here, the arrangement is made so that when the light beam strikes the photocell is blocked by the control relay of the vaccine flow and the vaccination operation is interrupted will. To set the dose in this case the light source could be connected to one with reference to the Longitudinal axis of the guide column inclined plane can be adjusted so that the light beam earlier or later (at the same speed of the piston) hits the photocell. After completion After vaccination and expiry of the respective dose, the photocell will slide into the new starting position of the piston released. The operations follow one another as in the one described above and the arrangement shown in the drawing with an upper and a lower bridge.

The open feed line 5 leading from the vaccine container 2 to the vaccination handpiece 4 is provided with the aid a safety clamp 77 lockable, the z. B. when switching on the device by hand or under mediation an electromagnet can be closed. Here the arrangement is made so that both the supply line 5 and the connecting line 7 from a common fuse terminal 77 in the manner of a pivotably mounted in the middle between the two ends and on the one hand underneath the action of a magnet 78 and on the other hand under the opposite action of a spring 79 standing double lever is influenced, which shuts off the supply line 6 when the loading lever 9 is actuated and the connecting line 7 releases and is switched over when the loading lever is released. The loading lever is mounted and connected to the piston 8 so that when its one end 10 is actuated against the pressure of the spring 81 by depressing the piston with its other end 82 lifts up and moves a rocker 83, which closes a contact 84 and the magnet 78 the side of the supply line 5 to the vaccination handpiece 4 excited, which the corresponding end of the double lever the fuse terminal 77 attracts and these clamp the supply line 5 between itself and a counter surface leaves.

The device is provided with a control lamp 119, which shows that it is in operation. The control lamp 119 is connected to and controlled by a thermal relay, the switch is assigned to the vaccination handpiece by being switched on in its circuit and only after a certain start-up time since connection

the device to the mains and the actuation of the main switch when ready to vaccinate the control lamp light up and let the control relay come into effect when the vaccination handpiece is operated. This means that vaccinations will be carried out during the start-up period when the device is not yet operational is, thereby preventing the non-lighting of the lamp from the doctor's attention to this fact makes and that the control relay is not even then by pressing the switch on the vaccination handpiece can be brought into effect if the first-mentioned warning sign (indicator lamp not lit) should have been overlooked.

The piston 8, the cylindrical vaccine container 2 and the sterilizable part of the vaccination handpiece 4 are detachably and detachably attached to the housing 27 of the device and can be accommodated in a transport container 85, which is preferably sealed on all sides, on holders provided inside the container. For this purpose, a holding plate 86, possibly with support feet 118, is inserted into the transport container 85, removably in the longitudinal direction of the container, at the two axial ends of which protruding lugs 87 with latch-like brackets 88 are attached to the flap, on which the piston 8, the sterilizable Part of the vaccination handpiece 4 and the cylindrical vaccine container 2 and z. B. two emergency hand syringes 89 are attached to the underside of the holding plate 86 opposite the piston and the cylinder in a parallel arrangement. The parts coming into contact with the vaccine and thus to be sterilized - whereby the plunger and the vaccine container can be sterilized when pushed together - can be accommodated and easily transported in this way, and the presence of two hand syringes is at the same time provision for the Emergency met that the device fails due to force majeure.

The cannulas can be cleaned with the aid of the cleaning device shown in FIGS. 12 and 13, which is designed as a centrifuge. The cleaning device according to the invention consists of a container 115 with an outlet 116 and a drum 91 coupled to an electric motor 90 and set in circulation by this drum 91, in which layers of several cannulas arranged one above the other can be inserted immovably in their respective position, each in a common, legal _go lie at an angle to the longitudinal axis of the drum plane extending radially towards the center. The cannulas of a layer, which are shown at 93 , are each held in a flat plate-like magazine 92 extending radially to the center thereof. The magazines 92 are arranged one above the other in the drum running transversely to the drum's longitudinal axis. , Up to five magazines accommodate in a drum - and in its angular position with respect to the drum longitudinal axis through to DIE g ₀ ser parallel support rods 94 held, which are mounted in a uniform distribution on the circumference along the inner wall of the drum and between the from the edge of the magazine in the direction of the inner wall of the drum to protruding heads of two g. Grip adjacent cannulas of a magazine and are held at a distance from the drum wall by radial struts 95. The walls of the drum are slightly conical from the bottom inside to the top so that the water filled into the drum, which is partially pushed out through the bores of the cannulas by the centrifugal force when rotating, can rise up in the drum. The new centrifuge-like cleaning device is particularly suitable for cannulas of the type described in German patents 1004 344 and 1008 879, in which the bore is continuously cylindrical and has no conical enlargement at the plug-on end.

The connecting line 7 from the vaccine supply to the vaccine container 2 can be provided with a puncture and withdrawal cannula 96, the bore of which is in communication with the connecting line and which is surrounded on the outside by a venting cannula 97 arranged concentrically to it, the space 98 between these two cannulas with is in communication with the outside air. As shown in FIG. 14, the mounting head 99 of the removal cannula 96 is slotted in the longitudinal direction (see FIG. 100) and can be fitted onto the mounting head 101 of the venting cannula 97 with springs. The mounting and actuation device for the cannula is shown at 102. The new arrangement has the advantage that the removal and venting cannula form a unit and can be introduced together into the vaccine storage bottle or the refill container for the vaccine.

The holder for the cannula 103 has (Fig. See FIG. 15) has a fork-like grip 104, into which the cannula foot of the page's been used and the holder by a certain angle around its longitudinal axis rotatable in a bore 105 of the operating lever 106 and the action of a spring 107 acting on the end remote from the cannula is mounted displaceably in the longitudinal direction. The limited twisting motion of the claw is achieved by making its shank 117 cylindrical and flattening part of its length on one side, as shown at 108. Through this adjustable arrangement of the claw, the plane-parallel adjustment of the cannula base and the holder to one another is made possible in a simple manner and also ensures that the cannula can be easily ejected after use.

The replaceable cannula 103 has on its side facing away from the puncture end 109 a plate head 110 in the form of a flat cylinder, a relatively long neck 111 with a smaller diameter and then an upper stop collar 112 with a diameter corresponding to that of the plate head and finally an initially cylin drical and later conical transition part 113 to the cannula needle 114, the material distribution over the entire length of the cannula being made in such a way that the cannula falls down parallel to itself when it is thrown from the holder by shearing off.

The amount by which the gripping claw is displaceable in the longitudinal direction, and the type of distribution of the The dimensions of the cannula head are coordinated in such a way that the cannula is thrown from the Bracket always falls down parallel to itself by shearing off.

It was also found that one is known by the trade name "Teflon" Plastic coated magnetic stirrer

holds particularly well in stirring movement, if you except for the driving magnet described above outside of the vaccine container on its opposite side from the driving magnet two with reference to FIG A diameter of the vaccine container symmetrical permanent magnets in the shape of a cube or disk arranges.

Finally, the magnetic stirring body can also have the shape of a flat cylinder shown in FIG. 9 have, the surface of which goes out radially from the central area to the outside and thereby possibly Has widening recesses 160, which are used to the liquid contained in the cylinder mix well and swirl through.

In an exemplary embodiment not shown, they are arranged on both sides of the piston and with this coupled weights at the same time designed as magnets, which when energizing the holding magnets are ineffective during the course of the individual vaccinations and if the holding magnets fall off are energized and thereby the piston connected to them in its respective position to the Hold the guide pillars that correspond to the starting position for a new individual vaccination.

The embodiment of the device according to the invention shown in the drawing is used as has already been said above, for carrying out serial vaccinations. However, you can do the same can be used to carry out serial serological and bacteriological examinations.

Claims (4)

Patent claims: 1. Device for the serial implementation of vaccinations, one of a storage container from refillable container for the substance to be administered, from which this Substance each time an actuator is actuated by the operator and effective become a path section of adjustable length in association with the individual doses to be administered moving displacer towards the administering organ demonstrated with the help of which one after the other in the individual doses of the respective series to be administered in measured amounts, characterized in that the in the container (18) for the to be administered Substance-guided displacement piston (8) possibly loaded with weights, the displacement movement between the starting position and the end position only executes under weight load and in the course of this displacement movement a number of individual doses corresponding to the individual doses of the series Path sections covered, the beginning of which in each case the release of the inflow of the to be administered Substance to the administering organ through the in the operative position and actuating element acting on the supply line immediately behind the administering organ and the end of which is assigned to the interruption of this inflow due to pulses is electrically operated by a monitoring device that monitors the exact dosage of the medium Control device are sent out when the actuator is operated is set and their impulse determining the end of the relevant path section independently sends out from the actuator. 2. Device according to claim 1 for use in connection with an to be administered Substance which consists of a sedimentable liquid, characterized in that it an electromagnetically or electrically operated agitator (3) in the lower area of the container owns. 3. Apparatus according to claim 2, characterized in that the stirring member (3) consists of one permanent magnets provided in the interior of the container (18) for the substance to be administered in the form of a cube with two pairs of poles on opposite sides, the one Driving magnet (52) is assigned outside the container, which is designed as an alternating current magnet. forms and its two poles (53, 54) preferably one of the course of the outer wall of the Container have the following area on part of its circumference and in one direction are offset transversely to the longitudinal axis of the container. 4. Device according to one of claims 1 to 3, characterized in that as magnetic Stirring member (3) a magnetic stone is used, which is protected against attack by the sterilization fluids or media-resistant coating made of plastic is provided. 5. Apparatus according to claim 3 or 4, characterized in that the magnetic Agitator apart from the driving magnet on one side of the container outside of the same two further permanent magnets symmetrical with respect to a diameter of the container the outside of the container are assigned to the driving magnet approximately opposite one another. 6. Device according to one of claims 1 to 5, characterized in that the displacement piston (8) one to be operated by hand, approximately in the middle between semen ends on Housing pivotably mounted and engaging with its bent end (82) on the piston Loading lever (9) is assigned, with the help of which the piston in the cylinder for generating Negative pressure in the lower part of the same and for sucking up substance from the refill container (1) can be raised. 7. Device according to one of claims 1 to 6, characterized in that the displacement piston (8) an outwardly opening vent valve (11) is provided, with the help of which the air present in the empty container (2) after the material to be processed has been sucked in, it can be drained as a cone seat valve is designed, which can be opened from the outside against spring pressure (26). 8. Device according to one of claims 1 to 7, characterized in that the displacement piston (8) with weights provided on both sides in a symmetrical arrangement (12, 13) is connected, sliding up and down on fixed vertical guide columns are displaceably guided. 9. Apparatus according to claim 8, characterized in that the piston (8) with a den Container (2) from the outside surrounding cylinder jacket (18), through a hollow, over its inner Bore creates a connection between the vent valve in the piston and the outside air Rod is connected and the container (2) for coupling the piston with the weights serving, parallel, ring-like shoulders running around its circumference (20, 21) has, engage between the lugs (22) on the weights (12, 13), the guide columns (14,15) for the weights (12,13) connected to the piston (8) on the housing (27) attached to the device and at its upper end by a cross bar serving as a handle (28) are interconnected. 10. Device according to one of claims 1 to 9, characterized in that with the displacement piston (8) or a part fastened to it in the region of the lower end of the piston stroke, a contact piece (33) outside the container cylinder (33) participating in its up and down movement 2) is connected _ao , to which a limit switch (34) is assigned which, when actuated, switches a relay that blocks the inflow of the substance to be administered to the administering organ for the next single dose, but the already initiated single can with the set amount up to its The end can expire, possibly also triggering a signal electrically. 11. Device according to one of claims 1 to 10, characterized in that the container (2) consists of a cylinder which is advantageously made of transparent material and is open at the top, which tapers at its lower end to a neck (29) which is in a holder (30) on the Housing of the device can be used detachably and can be locked in this and from the one hand the connection line (7) to the refill container (1) and on the other hand the supply line (5) goes out to the administering organ (4). 12. Device according to one of claims 1 to 11, characterized in that the actuating member consists of a terminal (38) that when energized by an electromagnet (39) this is removed from the operative position in which it is from the container (2) for the to be administered The line (5) coming to the substance and leading to the administering organ (6) is interrupted, and which returns to the operative position when the magnet falls off. 13. The apparatus according to claim 12, characterized in that the clamp consists of an intermediate its ends pivotably mounted double lever, one arm (41) in the Closed position against the supply line (5) from the container (2) for the substance to be administered to administering organ (6) rests, in this case the supply line between itself and an opposing surface (42) squeezed together and the further passage through the supply line to the administered Organ prevents and its other arm ("43) with an electromagnet (39) in one by outgoing impulses to be closed by the operator interacts so that the Closing the circuit and, when the electromagnet is excited, one arm of the double lever is attracted by the electromagnet and its other arm is removed from the closed position and when the circuit is opened by the quantity control element, the two arms of the double lever move in the opposite direction. 14. Apparatus according to claim 13, characterized in that for opening and closing of the circuit controlling the electromagnet of the actuator, a switch (45) is provided is, which at one end of a double lever (141, 142) is attached, which at its other end via a suitable spring arrangement (46, 47) a snap switch (48) actuates, which in turn controls the electromagnet (39) of the actuator controlling circuit closes, the arrangement being made so that the switch receives only one command at a time and only resumes the next command after the first command has been executed. 15. Device according to one of claims 12 to 14, characterized in that the holder for the organ to be administered with a metallic element that enters the interior of the handpiece (4) Feed tube (50) is provided on which the front end (51) of the hose-like Feed line (5) for the substance to be administered is pushed out, and that the interruption and immediately releasing the delivery to the administering organ clamp (38) in front of the junction between the metallic feed pipe and the hose-like Supply line for the substance to be administered is arranged. 16. Device according to one of claims 1 to 15, characterized in that between the switch (45) on the handpiece and the clamp (38) for the supply line to the administered Organ a control relay (55) is switched, which when the push button or slide button switch is operated responds and the magnet (39) in the handpiece for a certain adjustable time keeps energized regardless of the position of the switch and this only after flowing through a predetermined, controllable and adjustable dose to the organ (6) to be administered leaves. 17. The device according to claim 16, characterized in that the control relay (55) at Actuation of the switch (45) responds and one associated with the magnet (39) in the handpiece (4) and this brings the solenoid energizing switching relay (56) into effect and at When the set dose is reached, so does the switching relay for the magnet drops in the handpiece. 18. Device according to one of claims 1 to 17, characterized in that for dosing each individual withdrawal from the container The starting position of the displacement piston is marked at the beginning of the respective individual removal or determines and then the distance covered by the piston from this position is measured and that when the value corresponding to the set dose is reached, a relay is brought into effect that the inflow of the substance to be administered to the handpiece interrupts and at the same time also the starting position of the piston marked or defined for the following individual removal. 609 608/21 19. The device according to claim 18, characterized in that with the displacement piston (8) at least indirectly an electrically conductive lower bridge that can be moved freely up and down (64) is connected, on which an upper bridge (65) running parallel thereto is loosely supported one end of which or at least one at both ends when the actuating member becomes effective (38) excited and after a predetermined adjustable amount has expired from the Container falling magnet (66,67) attached is, which in the de-energized state a movement of the upper bridge together with the lower one Bridge in the vertical direction and when excited by interacting with one fixed part of the device determines the upper bridge in its respective position. 20. The device according to claim 19, characterized in that when taking effect of the actuator £ 38) and thus when the upper bridge (65) is fixed in its respective position Position and at the same time lowering of the lower bridge (64) together with the displacement piston (8) depending on the drop in the level of the liquid in the container (2) between the lower and the upper bridge Alternating field builds up with a strength corresponding to the distance between the two bridges, when reaching a predetermined, adjustable value corresponding to that of the lower bridge compared to the established upper bridge and depending on the distance covered of the amount of liquid that has leaked out of the container (2) by electrical means, on the one hand, the falling of the magnet (39) for the actuator (38) and thus the interruption of the supply to the administering Organ (6) and on the other hand the falling off of the holding magnets (66, 67) for the upper bridge and thus causing the upper bridge to slide into contact with the lower bridge. 21. The device according to claim 20, characterized in that the alternating field between the lower and the upper bridge (64, 65) affects the control relay (55) so that it is after actuation of the switch (45) when a certain, adjustable strength of the alternating field is reached falls off and the holding magnets (66, 67) on the upper bridge and that of the clamp (38) on the handpiece (4) associated electrical 5 <> magnets (39) fall off, 22. The apparatus according to claim 21, characterized in that the control relay (55) for The effective switch (45) is only actuated when the control relay has dropped out and the control relay cannot be brought into effect when the limit switch (34) is actuated. 23. Apparatus according to claim 21 or 22, characterized in that for determining the The amount of liquid to be discharged from the container (2) per individual withdrawal is the same as that from the alternating field between the lower and the upper bridge (64, 65) influenced control relays (55) respectively one of several capacitors with different, according to the per individual withdrawal too Administering doses selected capacities can be assigned, so that the control relay is then ineffective when the alternating field between the upper and the lower bridge depending on the distance between the two bridges that of each has reached the value assigned to the dose to be administered. 24. Device according to one of claims 19 to 23, characterized in that when stopping the upper bridge (65) by an externally acting mechanical force the control relay (55) is rendered ineffective. 25. Device according to one of claims 19 to 24, characterized in that the to both Sides of the displacement piston (8) arranged weights (12,13) and the connecting them lower flat bridge (64) combined to form a structure in the form of a downwardly open U are, both of which are formed by the weights and those detachably coupled to them Piston between the legs contained in the through longitudinal bores in the weights upright guide columns (14,15) extending through it for the piston up and down are slidably mounted and that the holding magnets (66, 67) at the ends of the on the lower flat bridge running parallel to this, loosely placed upper bridge (65) in a housing (68, 69) are housed, which is provided with a transverse hole, through each of which one of the guide columns for the piston passes. 26. The device according to claim 25, characterized in that the approximately cube-shaped Housings (68, 69) housed at the ends of the upper bridge (65) and as with sliding current excited electromagnets designed holding magnets (66,67) designed like a hammer and at one end (at 74) are pivotably mounted, while the other end in the operative Locked position against the guide column passing through a hole in the magnet housing is present. 27. Device according to one of claims 1 to 26, characterized in that the from Container (2) leading to the handpiece (4) open supply line (5) with the help of a safety clamp (77) can be shut off at the same time to influence the connecting line (7) between the storage container (1) for the substance to be administered and the container (2) is used and after Kind of a pivoted in the middle between the two ends and on the one hand under the action of a magnet (78) and on the other hand under the opposite action a spring (79) standing double lever is formed, which upon actuation of the loading lever (9) Shuts off the supply line to the handpiece and releases the connection line to the storage container and is switched when the loading lever is released, this lever preferably being mounted in this way and is connected to the piston (8) so that when its one end (10) is actuated it against spring pressure (81) lifts the piston by pressing it down with its other end (82) and here a rocker (83) is adjusted, which closes a contact (84) and a magnet (78) on the side of the supply line (5) to the handpiece (4), which is the corresponding end of the Tighten the double lever of the safety clamp (77) and clamp the supply line to the handpiece between them and a mating surface leaves and counteracts a spring force. 28. Device according to one of claims 1 to 27, characterized in that the holder for the cannula (103) has a fork-like gripping claw (104) into which the cannula base can be inserted from the side and which is in a bore (105) of the The actuating lever (106) of the holder can be rotated through a certain angle and is mounted displaceably in the longitudinal direction under the action of a spring (107) acting on the end remote from the cannula. 29. Device according to one of claims 1 to 28, characterized in that the exchangeable cannula (103) on its side facing away from the puncture end (109) has a plate head (110) in the form of a flat cylinder, a relatively long neck (111) with a smaller one Diameter and then an upper stop ao collar (112) with a diameter corresponding to that of the plate head and finally an initially cylindrical and later conical transition part (113) to the cannula needle (114) and the material is distributed over the entire length of the cannula in such a way that the cannula falls down parallel to itself when it is thrown from the holder by shearing off. 30. Apparatus according to claim 28 or 29, characterized in that the measure to the the gripping claw is displaceable in the longitudinal direction, and the type of distribution of the mass of the cannula head are coordinated in such a way that the cannula is always parallel to itself when it is thrown from the holder by shearing off remaining falls down. Considered publications: German Patent No. 833 841; German exploratory documents No. 1 080 267,
327; French patents No. 1113 394,
293; U.S. Patent No. 2,735,431; Medizinal-Markt magazine, 4th year, no.2,
P. 52 and 53. 1 sheet of drawings 609 608/21 7.66 © Bundesdruckerei Berlin