DE122010000021I1 - In vivo assay zur prüfung der phänotypischen stabilität - Google Patents
In vivo assay zur prüfung der phänotypischen stabilitätInfo
- Publication number
- DE122010000021I1 DE122010000021I1 DE122010000021C DE122010000021C DE122010000021I1 DE 122010000021 I1 DE122010000021 I1 DE 122010000021I1 DE 122010000021 C DE122010000021 C DE 122010000021C DE 122010000021 C DE122010000021 C DE 122010000021C DE 122010000021 I1 DE122010000021 I1 DE 122010000021I1
- Authority
- DE
- Germany
- Prior art keywords
- chondrocytes
- vivo assay
- outcome
- phenotypic stability
- stability
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000005462 in vivo assay Methods 0.000 title abstract 2
- 210000001612 chondrocyte Anatomy 0.000 abstract 6
- 238000000018 DNA microarray Methods 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000006285 cell suspension Substances 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 238000010255 intramuscular injection Methods 0.000 abstract 1
- 239000007927 intramuscular injection Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000003908 quality control method Methods 0.000 abstract 1
- 238000010254 subcutaneous injection Methods 0.000 abstract 1
- 239000007929 subcutaneous injection Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0006—Skin tests, e.g. intradermal testing, test strips, delayed hypersensitivity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99203273 | 1999-10-06 | ||
| PCT/BE2000/000118 WO2001024833A2 (en) | 1999-10-06 | 2000-10-06 | In vivo assay for testing the phenotypic stability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE122010000021I1 true DE122010000021I1 (de) | 2012-09-06 |
Family
ID=8240723
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60017159T Expired - Lifetime DE60017159T2 (de) | 1999-10-06 | 2000-10-06 | In vivo assay zur prüfung der phänotypischen stabilität |
| DE122010000021C Pending DE122010000021I1 (de) | 1999-10-06 | 2000-10-06 | In vivo assay zur prüfung der phänotypischen stabilität |
| DE20023659U Expired - Lifetime DE20023659U1 (de) | 1999-10-06 | 2000-10-06 | Molekulare Marker zum Testen der phänotypischen Stabilität von Zellpopulationen und Zellpopulationen für die autologe Transplantation |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60017159T Expired - Lifetime DE60017159T2 (de) | 1999-10-06 | 2000-10-06 | In vivo assay zur prüfung der phänotypischen stabilität |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE20023659U Expired - Lifetime DE20023659U1 (de) | 1999-10-06 | 2000-10-06 | Molekulare Marker zum Testen der phänotypischen Stabilität von Zellpopulationen und Zellpopulationen für die autologe Transplantation |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7479367B1 (de) |
| EP (2) | EP1218037B1 (de) |
| AT (1) | ATE285797T1 (de) |
| AU (1) | AU7764200A (de) |
| CA (1) | CA2397610C (de) |
| CY (1) | CY2010007I2 (de) |
| DE (3) | DE60017159T2 (de) |
| DK (1) | DK1218037T3 (de) |
| ES (2) | ES2488240T1 (de) |
| LU (1) | LU91672I2 (de) |
| PT (1) | PT1218037E (de) |
| WO (1) | WO2001024833A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7482114B2 (en) | 1999-10-06 | 2009-01-27 | Tigenix N.V. | In vivo assay and molecular markers for testing the phenotypic stability of cell populations, and selected cell populations for autologous transplantation |
| EP1218037B1 (de) * | 1999-10-06 | 2004-12-29 | Tigenix N.V. | In vivo assay zur prüfung der phänotypischen stabilität |
| US6596855B2 (en) | 2000-06-14 | 2003-07-22 | Case Western Reserve University | Probes for chondrogenesis |
| AU2003254298A1 (en) * | 2002-08-02 | 2004-02-23 | Stratatech Corporation | Species specific dna detection |
| WO2007107330A2 (en) | 2006-03-20 | 2007-09-27 | Tigenix N.V. | Methods to maintain, improve and restore the cartilage phenotype of chondrocytes |
| JP5455219B2 (ja) * | 2006-11-24 | 2014-03-26 | ティゲニクス・ナムローゼ・フエンノートシャップ | 軟骨細胞表現型の安定性の確認および軟骨生成に影響を及ぼす因子のスクリーニングにおける使用のためのマーカー遺伝子 |
| CN101215565B (zh) * | 2008-01-11 | 2011-04-27 | 华中农业大学 | 一种作为猪标记辅助选择的与免疫性状相关的分子标记的克隆及应用 |
| GB0902793D0 (en) | 2009-02-20 | 2009-04-08 | Univ Gent | GDF15 as molecular tool to monitor and enhance phenotypic stability of articular chondrocytes |
| EP3872168A1 (de) * | 2020-02-28 | 2021-09-01 | Cline Scientific AB | Chondrozytendifferenzierung |
| CN116323666A (zh) | 2020-08-21 | 2023-06-23 | 建新公司 | Fgfr3抗体和使用方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5837258A (en) * | 1991-08-30 | 1998-11-17 | University Of South Florida | Induction of tissue, bone or cartilage formation using connective tissue growth factor |
| US5723331A (en) * | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
| US5902785A (en) * | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
| CA2223701C (en) | 1995-06-12 | 2010-02-16 | Yeda Research And Development Co., Ltd. | Fgf9 as a specific ligand for fgfr3 |
| AU742342B2 (en) | 1997-05-21 | 2001-12-20 | Clontech Laboratories, Inc. | Nucleic acid arrays |
| WO1998059035A2 (en) | 1997-06-25 | 1998-12-30 | The Goverment Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services, National Institutes Of Health | Serum-free cell growth medium |
| US7482114B2 (en) | 1999-10-06 | 2009-01-27 | Tigenix N.V. | In vivo assay and molecular markers for testing the phenotypic stability of cell populations, and selected cell populations for autologous transplantation |
| EP1218037B1 (de) * | 1999-10-06 | 2004-12-29 | Tigenix N.V. | In vivo assay zur prüfung der phänotypischen stabilität |
| AU7634400A (en) * | 1999-10-06 | 2001-05-10 | Tigenix N.V. | Isolation of precursor cells and their use for tissue repair |
-
2000
- 2000-10-06 EP EP00967443A patent/EP1218037B1/de not_active Expired - Lifetime
- 2000-10-06 DE DE60017159T patent/DE60017159T2/de not_active Expired - Lifetime
- 2000-10-06 DK DK00967443T patent/DK1218037T3/da active
- 2000-10-06 WO PCT/BE2000/000118 patent/WO2001024833A2/en active IP Right Grant
- 2000-10-06 ES ES04077642.9T patent/ES2488240T1/es active Pending
- 2000-10-06 AU AU77642/00A patent/AU7764200A/en not_active Abandoned
- 2000-10-06 ES ES00967443T patent/ES2234673T3/es not_active Expired - Lifetime
- 2000-10-06 DE DE122010000021C patent/DE122010000021I1/de active Pending
- 2000-10-06 PT PT00967443T patent/PT1218037E/pt unknown
- 2000-10-06 CA CA2397610A patent/CA2397610C/en not_active Expired - Lifetime
- 2000-10-06 EP EP20040077642 patent/EP1498146A3/de not_active Withdrawn
- 2000-10-06 AT AT00967443T patent/ATE285797T1/de active
- 2000-10-06 US US10/089,932 patent/US7479367B1/en not_active Expired - Fee Related
- 2000-10-06 DE DE20023659U patent/DE20023659U1/de not_active Expired - Lifetime
-
2008
- 2008-11-25 US US12/323,185 patent/US9089598B2/en not_active Expired - Fee Related
-
2010
- 2010-03-31 CY CY2010007C patent/CY2010007I2/el unknown
- 2010-04-02 LU LU91672C patent/LU91672I2/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20090162328A1 (en) | 2009-06-25 |
| US7479367B1 (en) | 2009-01-20 |
| EP1218037B1 (de) | 2004-12-29 |
| DE60017159D1 (de) | 2005-02-03 |
| DE60017159T2 (de) | 2006-05-04 |
| EP1218037A2 (de) | 2002-07-03 |
| ES2234673T3 (es) | 2005-07-01 |
| CY2010007I1 (el) | 2010-07-28 |
| EP1498146A3 (de) | 2007-01-24 |
| PT1218037E (pt) | 2005-05-31 |
| CA2397610A1 (en) | 2001-04-12 |
| WO2001024833A3 (en) | 2001-12-20 |
| DE20023659U1 (de) | 2005-07-07 |
| CY2010007I2 (el) | 2010-07-28 |
| ATE285797T1 (de) | 2005-01-15 |
| CA2397610C (en) | 2012-07-03 |
| EP1498146A2 (de) | 2005-01-19 |
| AU7764200A (en) | 2001-05-10 |
| WO2001024833A2 (en) | 2001-04-12 |
| US9089598B2 (en) | 2015-07-28 |
| LU91672I2 (fr) | 2010-06-02 |
| ES2488240T1 (es) | 2014-08-26 |
| DK1218037T3 (da) | 2005-04-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LU91672I2 (fr) | ChondroCelect | |
| Yamasaki et al. | Meniscal regeneration using tissue engineering with a scaffold derived from a rat meniscus and mesenchymal stromal cells derived from rat bone marrow | |
| DE69927512D1 (de) | Verwendung von op-1 zur herstellung einer pharmazeutischen zusammensetzung zur reparatur von nicht-gelenksknorpeldefekten eines säugers | |
| SE9303977D0 (sv) | Verfahren zur herstellung von implantatkeramikmaterial, insbesonders von hydroxylapatit aufweisenden implantatkeramikmaterial | |
| ATE213590T1 (de) | Fgf9 als spezifischer ligand für fgfr3 | |
| YU12201A (sh) | Metodi, instrumenti i materijali za transplantaciju ćelija hondrocita | |
| DE60028666D1 (de) | Verwendung von Fettgewebe-abgeleiteten Stromalen Zellen zur Differenzierung in Chondrozyten und ihre Verwendung zur Reparatur von Knorpelgewebe | |
| ATE484296T1 (de) | Präparate zur zeitbegrenzten markierung von biopsie-orten | |
| DE69733605D1 (de) | In vivo gentransfermethoden zur wundheilung | |
| ZA985507B (en) | Method for assessing disposable absorbent articles with improved skin dryness performance and with improved skin aeration | |
| BR9610357B1 (pt) | composição sinterizada artificial bioativa, estrutura microporosa cerámica aparente, dispositivo implantável, processo para o cultivo de células de ossos funcionais e kit para monitorar e quantificar a atividade das referidas células | |
| ATE432470T1 (de) | Verfahren zur unterscheidung des reizkolons von der entzündlichen darmerkrankung (inflammatory bowel disease, ibd) und zur überwachung von patienten mit ibd unter verwendung von endogenem gesamt-lactoferrin als marker | |
| DE69934179D1 (de) | Zusammensetzung enthaltend, ein Antigen, ein TH-1 induzierendes Adjuvans und eine im Wasser schwer lösliche Aminosäure, zur Verwendung in der Immunisierung | |
| DK1130394T3 (da) | In vitro-modeller af CNS-funktion og -dysfunktion | |
| FI923028A0 (fi) | Foerfarande foer detektering av ben- och andra bindvaevsskador i maenniskor och djur. | |
| DE69737460D1 (de) | Verfahren zur in vitro vorbehandlung von myoblasten in der transplantation | |
| ATE373083T1 (de) | Methode und zusammensetzungen zur identifizierung von morphogen-analogen | |
| DE60034672D1 (de) | Reporterverbindungen und verfahren zur bestimmung des lipidisierungsstatus einer zelle | |
| ATE452906T1 (de) | Therapeutische zusammenfassungen und verfahren zur modulierung von v3, eine isoform von versican | |
| Smith et al. | A new creativity test. | |
| DE59507162D1 (de) | Verfahren zur Befestigung von Hängen | |
| ATE320188T1 (de) | Nematizides mittel und verfahren zur biologischen bekämpfung von nematoden | |
| ATE455565T1 (de) | Verwendung eines biologischen materials mit dreidimensionalen gerüsten aus hyaluronsäure- derivaten | |
| ATE172028T1 (de) | Zytodiagnostisches verfahren unter verwendung von alstonin als selektivem marker und diesen marker enthaltender diagnostischer kit | |
| DE60026272D1 (de) | Verwendung eines Papillarfibroblast-spezifischen Antikörpers als Marker der Hautqualität |