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DE10399011I1 - F}r Fakton-VIIIc kodierende DNA-Sequenzen und ver wandte DNA-Konstruktionen - Google Patents

F}r Fakton-VIIIc kodierende DNA-Sequenzen und ver wandte DNA-Konstruktionen

Info

Publication number
DE10399011I1
DE10399011I1 DE2003199011 DE10399011C DE10399011I1 DE 10399011 I1 DE10399011 I1 DE 10399011I1 DE 2003199011 DE2003199011 DE 2003199011 DE 10399011 C DE10399011 C DE 10399011C DE 10399011 I1 DE10399011 I1 DE 10399011I1
Authority
DE
Germany
Prior art keywords
factor viiic
protein
compsn
polypeptide
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE2003199011
Other languages
English (en)
Inventor
George Kuo
Frank R Masiarz
Martha Truett
Pablo Valenzuela
Mirella Ezban Rasmussen
Jennifer Favaloro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Novartis Vaccines and Diagnostics Inc
Original Assignee
Novo Nordisk AS
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27075219&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE10399011(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/570,062 external-priority patent/US5004804A/en
Application filed by Novo Nordisk AS, Chiron Corp filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of DE10399011I1 publication Critical patent/DE10399011I1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE2003199011 1984-01-12 1985-01-11 F}r Fakton-VIIIc kodierende DNA-Sequenzen und ver wandte DNA-Konstruktionen Pending DE10399011I1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/570,062 US5004804A (en) 1984-01-12 1984-01-12 Method and composition for preparation of factor VIIIC
US66491984A 1984-10-26 1984-10-26

Publications (1)

Publication Number Publication Date
DE10399011I1 true DE10399011I1 (de) 2003-10-23

Family

ID=27075219

Family Applications (6)

Application Number Title Priority Date Filing Date
DE2003199010 Pending DE10399010I1 (de) 1984-01-12 1985-01-11 F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen
DE2003199009 Pending DE10399009I1 (de) 1984-01-12 1985-01-11 F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen
DE3586402T Expired - Lifetime DE3586402T3 (de) 1984-01-12 1985-01-11 Proteinzusammensetzung mit Koagulations-wirkung und Verfahren zu ihrer Herstellung.
DE3588242T Expired - Lifetime DE3588242T2 (de) 1984-01-12 1985-01-11 Für Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen
DE2003199011 Pending DE10399011I1 (de) 1984-01-12 1985-01-11 F}r Fakton-VIIIc kodierende DNA-Sequenzen und ver wandte DNA-Konstruktionen
DE200412000028 Pending DE122004000028I1 (de) 1984-01-12 1985-01-11 F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen.

Family Applications Before (4)

Application Number Title Priority Date Filing Date
DE2003199010 Pending DE10399010I1 (de) 1984-01-12 1985-01-11 F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen
DE2003199009 Pending DE10399009I1 (de) 1984-01-12 1985-01-11 F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen
DE3586402T Expired - Lifetime DE3586402T3 (de) 1984-01-12 1985-01-11 Proteinzusammensetzung mit Koagulations-wirkung und Verfahren zu ihrer Herstellung.
DE3588242T Expired - Lifetime DE3588242T2 (de) 1984-01-12 1985-01-11 Für Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE200412000028 Pending DE122004000028I1 (de) 1984-01-12 1985-01-11 F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen.

Country Status (7)

Country Link
EP (3) EP0150735B2 (de)
JP (5) JPH0826078B2 (de)
AT (2) ATE78871T1 (de)
DE (6) DE10399010I1 (de)
DK (3) DK165506C (de)
LU (4) LU91014I2 (de)
NL (4) NL300119I1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657894A (en) * 1983-03-31 1987-04-14 Scripps Clinic & Research Foundation New factor VIII coagulant polypeptides
JPH07106156B2 (ja) * 1983-10-28 1995-11-15 ジェネティックス、インスティチュ−ト ファクタ−▲ｖｉｉｉ▼および関連生産物の製造
US7138505B1 (en) 1984-01-12 2006-11-21 Novartis Vaccines And Diagnostics, Inc. Factor VIII:C nucleic acid molecules
ZA852099B (en) * 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
IL74909A (en) * 1984-04-20 1992-01-15 Genentech Inc Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
EP0182448A3 (de) * 1984-08-24 1987-10-28 Genetics Institute, Inc. Verfahren zur Herstellung von Faktor VIII und verwandte Produkte
SE8501050D0 (sv) * 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
EP0218712B1 (de) * 1985-04-12 1992-02-26 Genetics Institute, Inc. Neue prokoagulierungsproteine
KR910006424B1 (ko) * 1985-08-21 1991-08-24 인코텍스 비.브이 편성브리프(brief) 제조방법
US5198349A (en) * 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
US5595886A (en) 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
FI98829C (fi) * 1986-01-27 1997-08-25 Chiron Corp Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
EP0251843A1 (de) * 1986-06-06 1988-01-07 Transgene S.A. Verfahren zur Herstellung von Faktor VIII aus Säugerzellen
DE3788944T2 (de) * 1986-06-24 1994-05-26 Novonordisk As Verfahren zur herstellung eines koagulationsaktiven komplexes vom faktor viii-fragment.
DE3769872D1 (de) 1986-07-11 1991-06-13 Miles Inc Herstellung von rekombinantem protein.
IL83192A (en) * 1986-07-18 1992-11-15 Gist Brocades Nv Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies
IL84168A0 (en) * 1986-10-15 1988-03-31 Rorer Int Overseas Human factor viii-c analogs,process for the preparation thereof and pharmaceutical compositions containing the same
WO1988005825A1 (en) * 1987-01-30 1988-08-11 Biogen N.V. A method for producing factor viii in high yield
CA1339946C (en) * 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
EP0690126B1 (de) 1987-06-12 2001-11-28 Baxter Aktiengesellschaft Proteine mit Faktor VIII Aktivität, Verfahren zu deren Herstellung unter Verwendung von genetisch modifizierten Zellen und diese enthaltende Zusammensetzungen
DE3737239A1 (de) * 1987-11-03 1989-10-12 Behringwerke Ag Gentechnische herstellung von anticoagulatorischem protein pp4
US6140111A (en) * 1987-12-11 2000-10-31 Whitehead Institute For Biomedical Research Retroviral gene therapy vectors and therapeutic methods based thereon
US6544771B1 (en) * 1987-12-11 2003-04-08 Cell Genesys, Inc. Retroviral gene therapy vectors and therapeutic methods based thereon
JPH05500512A (ja) * 1989-09-14 1993-02-04 バクスター　インターナショナル　インコーポレーテッド 薬学的組成物を製造するための方法および装置
US5610033A (en) * 1990-04-25 1997-03-11 Novo Nordisk A/S Method of producing proteins with FVIII activity and/or FVIII derivatives
DK53792D0 (da) * 1992-04-24 1992-04-24 Novo Nordisk As Fremgangsmaade til fremstilling af proteiner
US5910481A (en) * 1995-11-13 1999-06-08 Immuno Ag Hybrid proteins with modified activity
WO1998029453A1 (fr) * 1996-12-27 1998-07-09 Mochida Pharmaceutical Co., Ltd. Medicaments diriges vers la membrane cellulaire
ATE365052T1 (de) 1999-02-22 2007-07-15 Univ Connecticut Neue albuminfreie faktor viii formulierungen
EP1418810A4 (de) 2001-08-03 2006-08-02 Us Gov Health & Human Serv Orale behandlung von hämophilie
US7718787B2 (en) * 2002-10-18 2010-05-18 Lg Life Sciences Limited Gene families associated with cancers
EP1707634A1 (de) 2005-03-29 2006-10-04 Octapharma AG Verfahren zur Isolierung von rekombinant hergestellten Proteinen
EP1739179A1 (de) 2005-06-30 2007-01-03 Octapharma AG Serumfreie stabile Transfektion und Produktion von rekombinanten humanen Proteinen in humanen Zelllinien
ES2706296T3 (es) 2008-11-07 2019-03-28 Univ Connecticut Formulaciones de Factor VIII
WO2011095604A1 (en) 2010-02-04 2011-08-11 Octapharma Biopharmaceuticals Gmbh Half-life prolongation of proteins

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657894A (en) * 1983-03-31 1987-04-14 Scripps Clinic & Research Foundation New factor VIII coagulant polypeptides
FI841281L (fi) * 1983-03-31 1984-10-01 Scripps Clinic Res Ny faktor foer viii koagulenta polypeptider och deras monoklonala antikroppar.
US4663280A (en) * 1983-05-19 1987-05-05 Public Health Research Institute Of The City Of New York Expression and secretion vectors and method of constructing vectors
JPH07106156B2 (ja) * 1983-10-28 1995-11-15 ジェネティックス、インスティチュ−ト ファクタ−▲ｖｉｉｉ▼および関連生産物の製造
ZA852099B (en) * 1984-03-26 1985-12-24 Meloy Lab Recombinant factor viii-c.
IL74909A (en) * 1984-04-20 1992-01-15 Genentech Inc Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein
JPH0634760A (ja) * 1992-07-15 1994-02-10 Hamamatsu Photonics Kk 放射線計測装置及び核医学診断装置

Also Published As

Publication number Publication date
EP0466199B1 (de) 2002-09-18
LU91014I2 (fr) 2003-06-19
JPH04218399A (ja) 1992-08-07
JPH06105688A (ja) 1994-04-19
DK169724B1 (da) 1995-01-23
DK13585D0 (da) 1985-01-11
EP0466199A1 (de) 1992-01-15
DE3586402T2 (de) 1993-01-07
DE10399010I1 (de) 2003-10-23
LU91015I2 (fr) 2003-06-19
DE3586402T3 (de) 2004-12-23
DK169708B1 (da) 1995-01-16
ATE224445T1 (de) 2002-10-15
EP0150735A2 (de) 1985-08-07
EP1006182A2 (de) 2000-06-07
NL300118I1 (nl) 2003-06-02
EP0150735A3 (en) 1987-07-01
DK165506C (da) 1993-04-19
DK165506B (da) 1992-12-07
EP0150735B1 (de) 1992-07-29
EP1006182A3 (de) 2000-06-14
NL300120I1 (nl) 2003-06-02
JPH0634760B2 (ja) 1994-05-11
NL300119I1 (nl) 2003-06-02
DK13585A (da) 1985-09-11
DE3588242D1 (de) 2002-10-31
ATE78871T1 (de) 1992-08-15
DE122004000028I1 (de) 2004-09-30
DE3588242T2 (de) 2004-03-11
DE3586402D1 (de) 1992-09-03
JP2002186487A (ja) 2002-07-02
JPS60185723A (ja) 1985-09-21
EP0150735B2 (de) 2004-01-07
DK150992A (da) 1992-12-17
DE10399009I1 (de) 2003-10-23
DK38892D0 (da) 1992-03-25
NL300118I2 (nl) 2004-06-01
LU91087I2 (fr) 2004-08-26
DK38892A (da) 1992-03-25
NL300153I1 (nl) 2004-09-01
JP2000023670A (ja) 2000-01-25
LU91013I2 (fr) 2003-06-19
JPH0826078B2 (ja) 1996-03-13

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