DE10217808A1 - Food supplement combatting cartilage degradation in joints contains e.g. gelatine hydrolysate, water, vitamins, potassium sorbate, sodium benzoate and/or mandarin extract - Google Patents
Food supplement combatting cartilage degradation in joints contains e.g. gelatine hydrolysate, water, vitamins, potassium sorbate, sodium benzoate and/or mandarin extractInfo
- Publication number
- DE10217808A1 DE10217808A1 DE10217808A DE10217808A DE10217808A1 DE 10217808 A1 DE10217808 A1 DE 10217808A1 DE 10217808 A DE10217808 A DE 10217808A DE 10217808 A DE10217808 A DE 10217808A DE 10217808 A1 DE10217808 A1 DE 10217808A1
- Authority
- DE
- Germany
- Prior art keywords
- active ingredient
- ingredient combination
- combination according
- potassium sorbate
- combatting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 235000015872 dietary supplement Nutrition 0.000 title claims abstract 3
- 229920000159 gelatin Polymers 0.000 title claims description 7
- 235000019322 gelatine Nutrition 0.000 title claims description 7
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 title claims description 3
- 241001672694 Citrus reticulata Species 0.000 title claims description 3
- 235000010241 potassium sorbate Nutrition 0.000 title claims description 3
- 239000004302 potassium sorbate Substances 0.000 title claims description 3
- 229940069338 potassium sorbate Drugs 0.000 title claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims description 3
- 230000008355 cartilage degradation Effects 0.000 title abstract description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 title description 2
- 235000010234 sodium benzoate Nutrition 0.000 title description 2
- 239000004299 sodium benzoate Substances 0.000 title description 2
- 239000001828 Gelatine Substances 0.000 title 1
- 108010009736 Protein Hydrolysates Proteins 0.000 title 1
- 229960003885 sodium benzoate Drugs 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 241000124008 Mammalia Species 0.000 claims abstract 2
- 239000004480 active ingredient Substances 0.000 claims description 25
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- 108010010803 Gelatin Proteins 0.000 claims description 6
- 239000008273 gelatin Substances 0.000 claims description 6
- 235000011852 gelatine desserts Nutrition 0.000 claims description 6
- 210000000845 cartilage Anatomy 0.000 claims description 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 3
- 229930003268 Vitamin C Natural products 0.000 claims description 3
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- 235000019154 vitamin C Nutrition 0.000 claims description 3
- 239000011718 vitamin C Substances 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 229940046009 vitamin E Drugs 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- 239000007903 gelatin capsule Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 241000309551 Arthraxon hispidus Species 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- LCWXJXMHJVIJFK-UHFFFAOYSA-N Hydroxylysine Natural products NCC(O)CC(N)CC(O)=O LCWXJXMHJVIJFK-UHFFFAOYSA-N 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- 235000019393 L-cystine Nutrition 0.000 description 1
- 239000004158 L-cystine Substances 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- 102000016611 Proteoglycans Human genes 0.000 description 1
- 108010067787 Proteoglycans Proteins 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 description 1
- 229940124600 folk medicine Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- QJHBJHUKURJDLG-UHFFFAOYSA-N hydroxy-L-lysine Natural products NCCCCC(NO)C(O)=O QJHBJHUKURJDLG-UHFFFAOYSA-N 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003307 slaughter Methods 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Use is claimed of a combination as a food supplement active against cartilage degradation in joints, especially in humans or other mammals.
Description
Seit langer Zeit gilt in der Volksmedizin der Verzehr von Knochen und Knorpel, bzw. hieraus hergestelletn Zubereitungen als Heilmittel bei Erkrankungen und Beschwerden der Gelenke. Bereits bei Hildegard von Bingen finden sich Anleitungen zur Herstellung von Suppen aus Knochen und Knorpel zur Behandlung von Schmerzen in Gelenken und Gliedern. For a long time, folk medicine has been consuming bones and cartilage, or from them Manufactured preparations as a remedy for diseases and complaints of the joints. Instructions for making soups can already be found at Hildegard von Bingen Bones and cartilage for the treatment of pain in joints and limbs.
Gelatine wird aus kollagenreichem Ausgangsmatrial, im Wesentlichen Knochen und Häuten von Schlachttieren, gewonnen. Es handelt sich um ein Protein von geringer biologischer Wertigkeit aber mit einem hohen Anteil an Hydroxyprolin, Hydroxylysin und Arginin. Zusammen mit der schwefelhaltigen Aminosäure L-Cystin bilden diese Aminosäuren die wesentlichen Ausgangssubstanzen für die Synthese von Kollagen und Proteoglykanen im Knorpelgewebe. Es kann davon ausgegangen werden, dass ein optimales Angebot innerhalb einer bestimmten Wirkstoffkombination dem Knorpelabbau bei der Arthrose entgegenwirkt. Aus zahlreichen Veröffentlichungen geht hervor, dass schon allein der langfristige Verzehr von Gelatine grundsätzlich die Stabilität und mechanische Belastbarkeit proteinreicher Strukturen steigern kann. Gelatin is made from a collagen-rich starting material, essentially bones and skins from slaughter animals. It is a protein of less biological Quality with a high proportion of hydroxyproline, hydroxylysine and arginine. Together with the sulfur-containing amino acid L-cystine, these amino acids form the essential starting substances for the synthesis of collagen and proteoglycans in Cartilage tissue. It can be assumed that an optimal offer within counteracts a specific combination of active ingredients to reduce cartilage in osteoarthritis. Numerous publications show that long-term consumption alone of gelatin basically the stability and mechanical resilience high protein Structures can increase.
Aufgabe dieser Erfindung ist es, eine Wirkstoffkombination einzusetzen, die in optimaler Weise dem schleichenden Knorpelabbau entgegenzuwirken. The object of this invention is to use an active ingredient combination which is optimal Way to counteract the creeping cartilage degradation.
Es ist aus mehreren klinischen Studien bereits bekannt, dass der tägliche Bedarf an kollagenem Eiweiss bei ca. 15 g liegt. Ca. 5 g werden bei einer durchschnittlichen Ernährung aufgenommen. Bei einer Zufuhr von den täglich "fehlenden" 10 g über mehrere Wochen allein an Gelatinehydrolysat sind entsprechende positive Ergebnisse dokumentiert. It is already known from several clinical studies that the daily needs collagen protein is approx. 15 g. Approximately 5 g are with an average diet added. When the daily "missing" 10 g is supplied over several weeks Corresponding positive results are documented on gelatin hydrolyzate alone.
Dabei werden neben Gelatinehydrolysat Vitamin E und Vitamin C sowie Aromastoffe zur
Geschmacksverbesserung in einem bestimmten Verhältnis zueinander rezeptiert:
Die Wirkstoffkombination kann in Kunststoff oder Glasflaschen 10-1000 ml abgefüllt sein. Es sind auch andere Anwendungsformen beispielsweise als Pulver oder in Gelatinekapseln möglich. The active ingredient combination can be filled in plastic or glass bottles 10-1000 ml. There are also other forms of use, for example as a powder or in gelatin capsules possible.
Gelenkbeschwerden sind bei allen Altersgruppen besonders bei aufsteigendem Alter festzustellen. Die Wirkstoffkombination kann bedenkenlos für lange Zeit eingenommen werden, da sie natürlichen Ursprungs und rein biologisch ist. Joint complaints are common to all age groups, especially with increasing age determine. The active ingredient combination can be taken safely for a long time because it is of natural origin and purely organic.
Claims (11)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10217808A DE10217808A1 (en) | 2002-04-22 | 2002-04-22 | Food supplement combatting cartilage degradation in joints contains e.g. gelatine hydrolysate, water, vitamins, potassium sorbate, sodium benzoate and/or mandarin extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10217808A DE10217808A1 (en) | 2002-04-22 | 2002-04-22 | Food supplement combatting cartilage degradation in joints contains e.g. gelatine hydrolysate, water, vitamins, potassium sorbate, sodium benzoate and/or mandarin extract |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE10217808A1 true DE10217808A1 (en) | 2003-11-13 |
Family
ID=29224633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE10217808A Ceased DE10217808A1 (en) | 2002-04-22 | 2002-04-22 | Food supplement combatting cartilage degradation in joints contains e.g. gelatine hydrolysate, water, vitamins, potassium sorbate, sodium benzoate and/or mandarin extract |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE10217808A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE202015100233U1 (en) | 2014-01-23 | 2015-02-12 | Contipro Biotech S.R.O. | Nutritional composition based on hyaluronan for use as an articular diet |
| EP3053458A1 (en) * | 2015-01-28 | 2016-08-10 | Paninkret Chemisch-Pharmazeutisches Werk GmbH | Spray-Dried Composition Comprising an Acerola Fruit Extract and Hydrolyzed Collagen |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68911127T2 (en) * | 1988-10-14 | 1994-06-09 | Basf Corp | METHOD FOR PRODUCING A FREE-FLOWING SPRAY-DRIED EDIBLE POWDER THAT CONTAINS OIL. |
| DE4327147C2 (en) * | 1993-08-12 | 1996-12-19 | Klinge Co Chem Pharm Fab | A pharmaceutical composition which contains a mixture of gelatin of different solubility in addition to the active ingredient |
| DE69519327T2 (en) * | 1994-05-17 | 2001-03-15 | Dielen Laboratories, Valognes | Protein hydrolyzate from marine animals, method of manufacture and use |
-
2002
- 2002-04-22 DE DE10217808A patent/DE10217808A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE68911127T2 (en) * | 1988-10-14 | 1994-06-09 | Basf Corp | METHOD FOR PRODUCING A FREE-FLOWING SPRAY-DRIED EDIBLE POWDER THAT CONTAINS OIL. |
| DE4327147C2 (en) * | 1993-08-12 | 1996-12-19 | Klinge Co Chem Pharm Fab | A pharmaceutical composition which contains a mixture of gelatin of different solubility in addition to the active ingredient |
| DE69519327T2 (en) * | 1994-05-17 | 2001-03-15 | Dielen Laboratories, Valognes | Protein hydrolyzate from marine animals, method of manufacture and use |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE202015100233U1 (en) | 2014-01-23 | 2015-02-12 | Contipro Biotech S.R.O. | Nutritional composition based on hyaluronan for use as an articular diet |
| EP3053458A1 (en) * | 2015-01-28 | 2016-08-10 | Paninkret Chemisch-Pharmazeutisches Werk GmbH | Spray-Dried Composition Comprising an Acerola Fruit Extract and Hydrolyzed Collagen |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OP8 | Request for examination as to paragraph 44 patent law | ||
| 8131 | Rejection |