DE102010013272A1 - Microbiologically stable application-friendly preparation with thickeners - Google Patents

Abstract

Cosmetic or dermatological preparations with one or more substances that have a thickening effect, through the addition of benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate, show improved sensor technology and sufficient microbiological stability.

Description

The invention encompasses cosmetic or dermatological preparations with benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate and one or more thickening substances.

Multi-component systems such as solutions, emulsions or suspensions are frequently adjusted or thickened to higher viscosities for reasons of economy or performance or for reasons of stability. So z. B. can be achieved by increasing the viscosity of the external or internal phase of emulsions or suspensions that the time to demixing of the components of such a system can be significantly extended, which manifests itself in an extension of the storage time. By increasing the viscosity of many products their uniform distribution is improved, especially on uneven surfaces. This applies in particular to skincare and pharmaceutical ointments on the skin.

The temperature behavior of the polymers is an important property. In general, polymers exhibit high viscosity at low temperatures and low viscosity at high temperatures. However, such polymers are often desirable which thicken above certain temperatures, but remain pumpable and processable at low temperatures in solution, i. H. are also easy to use.

Examples of such thickeners are cellulose ethers and other cellulose derivatives (for example carboxymethylcellulose, hydroxyethylcellulose), gelatin, starch and starch derivatives, sodium alginates, fatty acid polyethylene glycol esters, agar-agar, tragacanth or dextrins.

However, the thickeners mentioned show a variety of disadvantages in the application. So z. As the cellulose derivatives or generally based on natural raw materials and the resulting formulations very susceptible to bacteria. Ie. the addition of thickeners in cosmetic preparations often increases the requirements with regard to their microbiological stability.

Another problem arises due to the applications and manipulations of such thickened preparations.

For example, fatty acid polyethylene glycol ester tends to hydrolyze in the presence of water, the resulting insoluble fatty acids cause undesirable turbidity. Depending on their origin, thickening agents of natural origin (eg agar-agar or tragacanth) have widely varying composition, so that it is difficult to provide consistency in terms of production technology.

In terms of application, these preparations are also due to the formation of unpleasant, "thread-pulling" gels.

A particular problem with the thickening of cosmetic preparations is that the preparations become sticky due to the addition of the polymeric thickener and tend to "pull threads". The increasing stickiness makes the products sensory unattractive. Tackiness and the tendency to "pull threads" also makes it difficult to remove them from the storage container. These phenomena are particularly unpleasant for gelatinous preparations and for preparations which contain water-soluble and / or water-dispersible thickeners or stabilizers.

Cosmetic or dermatological preparations can be easily characterized with regard to these sensor criteria.

0.4 g of a formulation stored at 25 ° C is applied between thumb and forefinger. The formulation is gently squeezed and the fingers apart. The process is performed 3 times at a speed of 2 movements per second. The length of the tip or the length of the product thread formed is evaluated.

The division depending on the forming thread is then:
Length of lace / product thread> 2 cm 4 → pulling strong threads
Length of lace / product thread 1-2 cm 4 → Pulling threads
Length of lace / product thread <1 cm 4 → pulling low threads
Tip length / product thread <0.5 cm → Do not pull threads

Ie. Preparations with a thread formation of less than 0.5 cm are considered "non-stringy" and thus cosmetically user-friendly or sensory-acceptable.

Another problem in the production of cosmetic preparations is evident in the combination with thickening substances. These lead to the clogging of the spray devices, in particular in the spray application.

In addition to these performance and sensory properties, cosmetic preparations must also be formulated for long-term stability against microbial contamination.

The microbial stability has so far been solved by the addition of preservatives.

Known preservatives are the compounds known as parabens, in particular 4-hydroxybenzoic acid and its esters, methylparaben, ethylparaben, propylparaben, isopropylparaben, butylparaben, isobutylparaben, phenylparaben.

Furthermore, phenoxyethanol, ethylene glycol monophenyl ether, Phenyl, phenoxetol ^®, for the preservation of cosmetic products is known.

Providing preparations without preservatives, however, is a desire of consumers.

Other known auxiliaries for microbial stabilization are benzethonium chloride, lauroylethylarginate, octopirox and methylisothiazolinone.

Benzethonium chloride, benzyl-dimethyl- (4- {2- [4- (1,1,3,3-tetramethylbutyl) -phenoxy] -ethoxy} -ethyl) -ammonium chloride,

Benzethonium chloride shows how many quaternary ammonium compounds biocidal properties.

As a disinfectant it is used in cleaning agents but also in medicines (spermicides, lozenges against angina). Grapefruit seed extracts may contain benzethonium chloride in concentrations of 7-11%.

In cosmetics, the use of benzethonium chloride is known, such as in WO 2007015243 . WO 2004034964 . EP 1310234 . WO 2002008377 described.

Laurylethylarginat, Lauroylethylarginat or also ethyl lauroyl arginate HCl, for example as Aminat G from Vedeqsa, Inc. available, is used as a preservative in cosmetic preparations.

Aminate-G (INCI: Glycerol and ethyl lauroyl arginate HCl) shows a large antimicrobial spectrum and is FDA-approved as an additive in foods (see eg WO 2008133724 ).

Piroctone Olamine, 1-hydroxy-4-methyl-6- (2,4,4-trimethylpentyl) -2 (1H) -pyridone, also referred to as octopirox, is an antimicrobial used as a preservative and has e.g. B. is used in shampoos as anti-dandruff. Octopirox is well tolerated by the skin and physiologically indifferent.

Octopirox has the structure

Methylisothiazolinone (2-methyl-2H-isothiazol-3-one (MIT)) is a class of compounds with high microbicidal activity, which is mainly used for the preservation of technical products and now less of cosmetic products.

In cosmetic preparations, methyl isothiazolinone, for example in US 6511673 or EP 1488699 , described in combination with parabens or phenoxyethanol.

Other uses of methylisothiazolinone are in EP 1525797 . EP 1527684 . EP 1527685 . EP 1621076 disclosed.

With regard to increasing health impairments and allergies and the urge of consumers for more ecologically compatible cosmetics, there is the problem that these preparations must still have sufficient stability and above all skin compatibility and sufficiently acceptable sensors.

Furthermore, a simple replacement or avoidance of parabens and / or phenoxyethanol is not readily possible without sacrificing stability and performance.

It is therefore an object to provide cosmetic or dermatological preparations which enable the use of thickening substances without sacrificing sensory acceptance and ease of use, in particular without any loss of applicability by means of spraying devices. At the same time it is the task that these preparations then also have sufficient microbiological stability and preferably do not comprise parabens or phenoxyethanols.

An additional object is that these preparations are microbially stable, skin-friendly and user-friendly.

The invention encompasses cosmetic or dermatological preparations comprising benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate in combination with one or more thickening substances.

The proportion of benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate is preferably in the range of 0.01 to 5 wt .-%, in particular in the range of 0.1 to 2 wt .-%, based on the total mass of the preparation to choose ,

In the preparation can advantageously several, d. H. two, three or all of the substances benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate.

Thickening substances, also called thickeners, are substances or compounds which cause a change in the viscosity of the preparations containing them compared with the same preparation without the verifier.

Preferred thickeners are selected from the group of fatty alcohols or hydroxy fatty alcohols having 12 to 22 and preferably 16 to 18 carbon atoms and partial glycerides, fatty acids or hydroxyfatty acids. Preference is given to a combination of these substances with alkyl oligoglucosides and / or fatty acid N-methylglucamides of the same chain length and / or polyglycerol poly-12-hydroxystearates. Suitable thickeners are, for example, Aerosil types (hydrophilic silicic acids), polysaccharides, in particular xanthan gum, guar guar, agar agar, carageenan, alginates and tyloses, carboxymethyl cellulose and hydroxyethyl cellulose, and also higher molecular weight polyethylene glycol mono- and diesters of fatty acids, ammonium acryloyl dimethyl taurate / VP copolymer, polyacrylates, (e.g., Carbopole ™ and Pemulen types from Goodrich; Synthalene ™ from Sigma; Keltrol grades from Kelco; Sea urchin types from Seppic; Salcare types of Allied Colloids), polyacrylamides, polymers, polyvinyl alcohol and polyvinylpyrrolidone.

As thickeners for W / O emulsions metal salts of fatty acids, such as. For example, magnesium, aluminum and / or zinc stearate or ricinoleate are preferably used.

Further thickeners are suitable cationic polymers, such as cationic cellulose derivatives, such as. Quaternized hydroxyethylcellulose available under the name Polymer JR 400 ™ from Amerchol, cationic starch, copolymers of diallylammonium salts and acrylamides, quaternized vinylpyrrolidone / vinyllmidazole polymers, e.g. Luviquat ™ (BASF), condensation products of polyglycols and amines, quaternized collagen polypeptides such as lauryldimonium hydroxypropyl hydrolyzed collagen (eg Lamequat ™ L / Grünau), quaternized wheat polypeptides, polyethylenimine, cationic silicone polymers such as e.g. As amodimethicones, copolymers of adipic acid and Dimethylaminohydroxypropyldiethylentriamin (Cartaretine TM / Sandoz), copolymers of acrylic acid with dimethyl-diallyl ammonium chloride (Merquat TM 550 / Chemviron), Polyaminopolyamide, such as. B. described in the FR 2252840 A and their crosslinked water-soluble polymers, cationic chitin derivatives such as quaternized chitosan, optionally microcrystalline distributed, condensation products of dihaloalkylene, such as. B. dibromobutane with bis-dialkylamines, such as. B. bis-dimethylamino-1,3-propane, cationic guar gum, such as. Jaguar ™ CBS, Jaguar ™ C1 Jaguar ™ C-16 from Celanese, quaternized ammonium salt polymers, e.g. Mirapol ™ A-15, Mirapol ™ AD-1, Mirapol ™ AZ-1 from Miranol. Further thickeners are anionic, zwitterionic, amphoteric and nonionic polymers, such as, for example, vinyl acetate / crotonic acid copolymers, vinylpyrrolidone / vinyl acrylate copolymers, vinyl acetate / butyl maleate / isobornyl acrylate copolymers, methyl vinyl ether / maleic anhydride copolymers and their esters, uncrosslinked polyols crosslinked with polyols, Acrylamidopropyltrimethylammonium chloride / acrylate copolymers, octylacrylamide / methylmethacrylate / tert. Butylaminoethyl methacrylate / 2-hydroxypropyl methacrylate copolymers, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate copolymers, vinylpyrrolidone / dimethylaminoethyl methacrylate / vinylcaprolactam terpolymers and optionally derivatized cellulose ethers; microcrystalline cellulose and silicones.

Other suitable polymers and thickeners are listed in Cosmetic Toiletries 108, 95 (1993).

Especially preferred thickeners include xanthan gum, carageenan, alginates and tyloses, carboxymethyl cellulose, microcrystalline cellulose and hydroxyethyl cellulose, polyacrylates (eg Carbopols ™ and Noveon's Pemulen types).

Surprisingly, the thickeners in combination with the substances according to the invention, benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate, can be used in the preparation without this contributing to prolongedness, ie. H. pull to the strings that leads to formulations.

Also, the discharge of the preparations according to the invention by a dispenser works perfectly over a wide temperature range of + 5 ° C to + 60 ° C, which was not expected in view of the thickening properties and stickiness shown.

This is surprisingly made possible by the inventive agents, benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate. However, agents which are not actually known to have a viscosity or tackiness affect the sliding properties of the entire formulation in such a way that the adhesion of the compositions containing them to surfaces is positively influenced. Thus, it is also to be explained that the adhesion to the surfaces in the dispenser systems is positively influenced, so that a pumpability can be ensured over a wide temperature range.

For comparison, for example, shows a cosmetic preparation with parabens or phenoxyethanol and a thickener, here xanthan gum, an unacceptable stickiness.

If instead of the known preservatives paraben or phenoxyethanol, a substance according to the invention, such as benzethonium chloride, is used in the otherwise identical preparation, the tackiness is surprisingly greatly improved, as the following comparison shows. Raw material (in% by weight) Recipe A Recipe B Ethylhexylzimtsäureester 0.5 0.5 octocrylene 3.0 3.0 Ethylhexylsalicylsäureester 4.0 4.0 Until Ethylhexyloxyphenolmethoxyphenyltriazin 2.5 2.5 hydrogenated coconut oil glycerides 2.0 2.0 phenoxyethanol 0.6 - C12-15 alkyl benzoate 3.0 3.0 C18-36 fatty acid triglycerides 1.0 1.0 Vitamin E acetate 1.0 1.0 Diethylhexylbutamidotriazon 2.0 2.0 linear silicone oil 3.0 3.0 Acrylate / C10-30 Alkyl Acrylate Crosspolymer 0.4 0.4 Xanthan gum 0.9 0.9 citric acid 0.1 0.1 EDTA sodium salt 1.0 1.0 glycerin 4.4 4.4 sodium citrate 0.17 0.17 glucosylrutin 0.25 0.25 ethanol 3.0 3.0 methylparaben 0.4 - benzethonium - 2.0 water ad 100 ad 100 Length of the tip / product thread of recipe A = 1.8 cm
Length of the tip / product thread of recipe B = 0.4 cm

The "threading" is to be classified in the preparation B according to the invention as "not pulling threads".

Accordingly, benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate can advantageously be used in cosmetic or dermatological preparations comprising one or more thickening substances to improve the sensory properties of the preparation.

It is furthermore surprising that the preparations with the substances according to the invention, benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate, instead of parabens and / or phenoyethanol, nevertheless have sufficient microbial stability.

shows this microbial stability impressively.

As part of the biofilm assay, biofilm inhibition at 0 h as well as the biofilm dissolving effect at 24 h are examined by means of a microtiter plate color reaction. The measurement results of the active substances investigated are related to the positive control (PK1). Neither ethylparaben nor methylparaben showed efficacy. In comparison, benzethonium chloride, methylisothiazolinone, piroctone olamine and lauroylethylarginate showed very good biofilm-inhibiting activity. In addition, benzethonium chloride and lauroylethylarginate showed a very good biofilm-dissolving effect. Even with Piroctone Olamine, Methylisothiazolinone a slight biofilm dissolution could be achieved.

In the conventional antibacterial agents distinguishes the bacteriostatic and the bactericidal effect. In the latter, the bacteria are killed by the drug. The bacteriostatic effect, however, prevents the proliferation of bacteria. The preservatives used in cosmetic formulations to prevent bacterial contamination are usually among the bactericidal agents. The use of classic antimicrobial agents, however, on the one hand affects the skin flora and, on the other hand, resistance developments are increasingly being observed in recent years. In contrast to conventional antimicrobial agents, the anti-biofilm agents do not directly interfere with the bacterial metabolism, but merely prevent or dissolve the formation of the bacteria-protecting biofilm. Resistance development is therefore excluded.

The in The test was carried out with Staphylococcus epidermidis, a germ that is not very dangerous for people with normal immunological defense. Staphylococcus epidermidis (syn., Staphylococcus albus, Micrococcus epidermidis, Staphylococcus saprophyticus) is a gram-positive, plasma-coagulase-negative, saprophagic bacterium that colonizes human skin and mucous membranes. Furthermore, it can be found on food and also settles on polymeric surfaces (eg packaging). But in the hospital, in people who are weak in the immune system, if they are unclean, they can be the cause of serious illnesses.

S. epidermidis has a wide spectrum of antibiotic resistance. This is especially true against penicillin and methicillin. The proportion of resistant strains is now 70%.

Therefore, it is the ideal bacterium to show the beneficial effect of the cosmetic preparations according to the invention.

The preparations according to the invention are therefore preferably paraben- and / or phenoxyethanol-free and nevertheless have sufficient microbial stability.

Paraben-free or phenoxyethanol-free means that the proportion of parabens and / or phenoxyethanol below 1 wt .-% leigt, based on the total mass of the preparation. The proportion of parabens and phenoxyethanol 0 wt .-% is advantageous.

The following examples show cosmetic formulations with acceptable tackiness, ie an improved sensory property in comparison to preparations without the agents according to the invention. The numbers are parts by weight based on the total mass of the preparation. W / O emulsions, 1 2 3 4 5 Triglycerindiisostearat 1.0 0.5 0.25 2.0 3.0 Diglycerindipolyhydroxystearat 1.0 1.5 1.75 3.0 2.0 paraffin oil 12.5 10.0 8.0 5.0 11.5 vaseline 8.0 6.0 5.0 12.0 2.5 hydrogenated coconut glycerides 2.0 1.0 2.5 5.0 0.25 oleate 0.5 0.75 1.0 2.0 0.25 octyldodecanol 0.5 1.0 0.75 3.0 0.25 aluminum stearate 0.4 0.3 0.6 1.0 0.05 dicaprylyl 0.1 0.05 0.15 0.5 1.0 hydrogenated castor oil 0.5 0.75 1.0 2.5 5.0 magnesium sulfate 0.5 0.6 0.5 0.7 1.0 glycerin 3.0 5.0 10.0 15.0 1.5 citric acid 0.2 0.1 0.2 0.3 1.0 sodium citrate 0.2 0.05 0.4 0.3 2.0 Perfume q, s, q, s, q, s, q, s, q, s, ethanol 2.0 - 5.0 - - Caprylic / capric 2.0 2.5 3.0 5.0 0.5 Methylisothiazolinone - 0.10 - 0.06 - benzethonium 2.0 - - 0.15 - piroctone olamine - - 0.25 0.15 - Lauroylethylarginat - - - 0.15 1.75 water ad 100 ad 100 ad 100 ad 100 ad 100 W / O emulsions, 6 7 8th 9 10 PEG-30 dipolyhydroxystearate - 0.5 0.25 - 3.0 Lanolin Alcohol 1.0 1.5 1.75 3.0 - paraffin oil 12.5 10.0 8.0 5.0 10.5 vaseline 8.0 6.0 5.0 12.0 2.5 hydrogenated coconut glycerides 2.0 1.0 2.5 5.0 0.25 Hydrogenated polyisobutene 0.5 0.75 1.0 2.0 0.25 octyldodecanol 0.5 1.0 0.75 3.0 0.25 zinc stearate 0.4 0.3 0.6 1.0 0.05 dicaprylyl 0.1 0.05 0.15 0.5 1.0 hydrogenated castor oil 0.5 0.75 1.0 2.5 5.0 Microcrystalline cellulose 0.5 1.0 0.75 0.25 0.1 magnesium sulfate 0.5 0.6 0.5 0.7 1.0 glycerin 3.0 5.0 10.0 15.0 1.5 citric acid 0.2 0.1 0.2 0.3 1.0 Perfume q, s, q, s, q, s, q, s, q, s, 1,3 butylene glycol 2.0 - 5.0 - - Caprylic / capric 2.0 2.5 3.0 5.0 0.5 Silicone elastomer gel 5.0 - - 3.0 - Methylisothiazolinone - 0.10 - 0.06 - benzethonium 2.0 - - 0.15 - piroctone olamine - - 0.25 0.15 - Lauroylethylarginat - - - 0.15 1.75 talc - - 0.05 - 0.1 water ad 100 ad 100 ad 100 ad 100 ad 100 W / S-emulsion 11 12 13 14 15 Cetyl PEG / PPG-10/1 dimethicone 1.0 - - 3.0 5.0 Cylomethicone + PEG / PPG-18/18 dimethicone (90:10) 10.0 12.5 25 - - cyclic silicone oil (cyclomethicone) 12.5 15 22.0 20.0 15.5 linear silicone oil (dimethicone) 5.0 13.0 5.0 12.0 15.0 hydrogenated polyisobutene 0.5 0.75 1.0 2.0 0.25 octyldodecanol 0.5 1.0 0.75 3.0 0.25 panthenol 0.5 1.0 0.75 0.25 0.1 sodium chloride 2.0 0.6 2.5 0.7 1.0 glycerin 3.0 5.0 10.0 15.0 1.5 citric acid 0.2 0.1 0.2 0.3 1.0 sodium citrate 1.0 0.1 0.4 0.9 2.5 Perfume q, s, q, s, q, s, q, s, q, s, Microcrystalline cellulose 1.0 0.1 0.5 0.25 0.1 Methylisothiazolinone - 0.10 - 0.06 - benzethonium 2.0 - - 0.15 - piroctone olamine - - 0.25 0.15 - Lauroylethylarginat - - - 0.15 1.75 modified starch - 2.5 - 0.15 - water ad 100 ad 100 ad 100 ad 100 ad 100 W / S emulsions 16 17 18 19 20 Cetyl PEG / PPG-10/1 dimethicone 1.0 - - 3.0 5.0 Cylomethicone + PEG / PPG-18/18 dimethicone (90:10) 10.0 12.5 25 - - cyclic silicone oil (cyclomethicone) 12.5 15 8.0 20.0 17.5 linear silicone oil (dimethicone) 5.0 13.0 5.0 12.0 15.0 hydrogenated polyisobutene 0.5 0.75 1.0 2.0 0.25 octyldodecanol 0.5 1.0 0.75 3.0 0.25 panthenol 0.5 1.0 0.75 0.25 0.1 sodium chloride 2.0 0.6 2.5 0.7 1.0 glycerin 3.0 5.0 10.0 15.0 1.5 lactic acid 0.2 0.1 0.2 - - sodium lactate 0.2 1.0 0.05 - - Perfume q, s, q, s, q, s, q, s, q, s, Microcrystalline cellulose 1.0 0.1 1.5 2.5 0.1 stearyl 0.5 - 0.7 - - Methylisothiazolinone - 0.10 - 0.06 - benzethonium 2.0 - - 0.15 - piroctone olamine - - 0.25 0.15 - Lauroylethylarginat - - - 0.15 1.75 modified starch - 2.5 - 0.15 - water ad 100 ad 100 ad 100 ad 100 ad 100 Silicone in water emulsion 21 22 23 24 25 Bis-PEG / PPG-16/16 PEG / PPG 16/16 dimethicone, caprylic / capric triglyceride 1.0 2.0 8.0 3.0 5.0 cyclic silicone oil (cyclomethicone) 12.5 15 25.0 10.0 7.5 linear silicone oil (dimethicone) 5.0 15.0 5.0 12.0 15.0 octyldodecanol 0.5 1.0 0.75 3.0 0.25 glycerin 5.0 7.5 10.0 3.0 1.0 panthenol 0.5 1.0 0.75 0.25 0.1 Perfume q, s, q, s, q, s, q, s, q, s, magnesium stearate 1.0 0.5 2.5 3.7 5.5 Steatyldimethicon 0.5 - 0.7 - - Methylisothiazolinone - 0.10 - 0.06 - benzethonium 2.0 - - 0.15 - piroctone olamine - - 0.25 0.15 - Lauroylethylarginat - - - 0.15 1.75 modified starch - 2.5 - 0.15 - water ad 100 ad 100 ad 100 ad 100 ad 100 O / W emulsion 26 27 28 29 30 Glycerylsteratcitrat 1.0 1.5 1.5 0.5 0.25 Cetylstearylalkohol 2.5 5 0.5 2.0 1.5 ethylhexylmethoxycinnamate 5.0 3.0 2.0 2.0 5.0 Ethylhexylglycerin 1 - 0.5 1 - aluminum chlorohydrate - 1 0.02 1 - ethanol - - 3.0 1 - Ammonium acryloyldimethyltaurate / VP copolymer 0.5 0.75 0.5 2.0 0.25 Blue, water-soluble dye (Blue No. 1) 0.5 1.0 0.4 3.0 0.25 Carbomer - - 0.2 - 0.1 Phosphated starch 1.0 - 4.0 - 0.5 8-hexadecene-1,16-dicarboxylic acid 0.5 0.75 1.0 1.5 2.5 octyldodecanol 0.5 - 1.0 - 2.0 Caprylic / Capric triglyceride - - 1.0 - 0.5 myristate - 1.5 1.0 2.5 - Perfume q, s, q, s, q, s, q, s, q, s, sea salt - - 0.01 0.5 - Methylisothiazolinone - 0.10 - 0.06 - benzethonium 2.0 - - 0.15 - piroctone olamine - - 0.25 0.15 - Lauroylethylarginat - - - 0.15 1.75 glycerin 5 10 7.5 15 7.5 tocopherol 0.5 0.25 0.5 0.1 - Titanium dioxide - 2.5 1.2 0.15 - water ad 100 ad 100 ad 100 ad 100 ad 100 O / W emulsion 31 32 33 34 35 Polyethylene glycol (21) stearyl ether 1 - 2.5 2 1.5 Polyethylene glycol (2) stearyl ether 1 - 5.5 3 7.5 cetearylglucoside - 8th - - - cyclomethicone 12.5 15 28.0 25.0 17.5 dimethicone 5.0 13.0 5.0 12.0 15.0 behenyl 3 2 - 1 - stearyl 3 2 - 2 - Cetylstearylalkohol 3 4 - - 2 hydrogenated polyisobutene 0.5 0.75 1.0 2.0 0.25 octyldodecanol 0.5 1.0 0.75 3.0 0.25 Xanthan gum 0.35 0.5 1.0 0.75 0.15 glycerin 5 10 15 3 7.5 Methylisothiazolinone - 0.10 - 0.06 - benzethonium 2.0 - - 0.15 - piroctone olamine - - 0.25 0.15 - Lauroylethylarginat - - - 0.15 1.75 panthenol 0.5 1.0 0.75 0.25 0.1 Perfume q, s, q, s, q, s, q, s, q, s, modified starch 0.5 - - 0.15 - water ad 100 ad 100 ad 100 ad 100 ad 100 O / W emulsion 36 37 38 39 40 Glycerylsteratcitrat 1.0 0.5 0.1 0.5 0.3 Polyethylene glycol (20) cetearylether 10.0 1.0 5 - - Triglycerinmethyiglucosedistearat - - - - 2.5 Cyciomethicon - - - 1 - dimethicone 0.5 3.0 0.75 1.5 0.2 behenyl 1 - 2 1 0.2 dicaprylyl 3 5 10 15 5 stearyl - - - 1 0.2 Cetylstearylalkohol - - 1 1 0.2 tocopherol 0.5 0.5 0.75 0.25 0.1 octyldodecanol 0.5 - 0.75 3.0 0.25 panthenol 0.5 - 0.75 0.25 0.1 Carbomer 0.05 0.35 0.15 0.1 0.75 Perfume q, s, q, s, q, s, q, s, q, s, Methylisothiazolinone - 0.10 - 0.06 - benzethonium 2.0 - - 0.15 - piroctone olamine - - 0.25 0.15 - Lauroylethylarginat - - - 0.15 1.75 sorbitol 10 - - 5 - butylene - - - 5 10 propylene glycol - - 10 5 - glycerin - 7.5 - - - water ad 100 ad 100 ad 100 ad 100 ad 100 O / W emulsion 41 42 43 44 45 Glycerylsteratcitrat 1.0 0.75 0.1 0.5 0.3 Polyethylene glycol (20) cetearylether 1.0 - 2 1.5 - Triglycerinmethylglucosedistearat - 5.5 - - 2.5 ethyl butylacetylaminopropionate 5 10 15 20 7.5 cyclomethicone 2 4 6 1 3 dimethicone - 0.5 0.75 - - behenyl 1 - 2 1 0.2 stearyl - 1 - 1 0.2 Cetylstearylalkohol - - 1 1 0.2 medicinal white oil 0.5 0.75 1.0 2.0 0.25 octyldodecanol 0.5 1.0 0.75 3.0 0.25 panthenol 0.5 1.0 0.75 0.25 0.1 Carbomer 0.05 0.1 0.15 0.1 0.44 Perfume q, s, q, s, q, s, q, s, q, s, dicaprylyl 3 5 10 15 5 Methylisothiazolinone - 0.10 - 0.06 - benzethonium 2.0 - - 0.15 - piroctone olamine - - 0.25 0.15 - Lauroylethylarginat - - - 0.15 1.75 tocopherol 0.5 1.0 0.75 0.25 0.1 Caprylic / Capric triglyceride 1 2 3 5 10 modified starch - 2.5 - 0.15 - glycerin 3 5 8th 12 10 water ad 100 ad 100 ad 100 ad 100 ad 100

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Cited patent literature

• WO 2007015243 [0024]
• WO 2004034964 [0024]
• EP 1310234 [0024]
• WO 2002008377 [0024]
• WO 2008133724 [0026]
• US 6511673 [0030]
• EP 1488699 [0030]
• EP 1525797 [0031]
• EP 1527684 [0031]
• EP 1527685 [0031]
• EP 1621076 [0031]
• FR 2252840 A [0042]

Claims (4)

Cosmetic or dermatological, paraben and / or phenoxyethanolfreie preparation comprising benzethonium chloride, methylisothiazolinone, Piroctone olamine and / or lauroylethylarginate in combination with one or more thickening substances. Preparation according to claim 1, characterized in that xanthan gum, carageenan, alginates, tyloses, carboxymethylcellulose, microcrystalline cellulose, hydroxyethylcellulose and / or polyacrylates are selected as thickening substances. Use of benzethonium chloride, methylisothiazolinone, piroctone olamine and / or lauroylethylarginate in cosmetic or dermatological preparations comprising one or more thickening substances for improving the sensory properties of the preparation. Use according to claim 3, characterized in that the preparation is paraben-free and / or phenoxyethanolfrei.

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