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DE102007048362A8 - System und Verfahren zum Untersuchen eines Objekts - Google Patents

System und Verfahren zum Untersuchen eines Objekts Download PDF

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Publication number
DE102007048362A8
DE102007048362A8 DE102007048362A DE102007048362A DE102007048362A8 DE 102007048362 A8 DE102007048362 A8 DE 102007048362A8 DE 102007048362 A DE102007048362 A DE 102007048362A DE 102007048362 A DE102007048362 A DE 102007048362A DE 102007048362 A8 DE102007048362 A8 DE 102007048362A8
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DE
Germany
Prior art keywords
examining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE102007048362A
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English (en)
Other versions
DE102007048362B9 (de
DE102007048362B4 (de
DE102007048362A1 (de
Inventor
Christoph Dr. Hauger
Werner Dr. Nahm
Theo Prof. Lasser
Marcel Dr. Leutenegger
Erica Dr. Martin-Williams
Antonio Lopez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ecole Polytechnique Federale de Lausanne EPFL
Carl Zeiss Meditec AG
Original Assignee
ECOLE POLYTECH
Ecole Polytechnique Federale de Lausanne EPFL
Carl Zeiss Surgical GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ECOLE POLYTECH, Ecole Polytechnique Federale de Lausanne EPFL, Carl Zeiss Surgical GmbH filed Critical ECOLE POLYTECH
Priority to DE102007048362.9A priority Critical patent/DE102007048362B9/de
Priority to PCT/EP2008/008547 priority patent/WO2009046985A2/en
Publication of DE102007048362A1 publication Critical patent/DE102007048362A1/de
Publication of DE102007048362A8 publication Critical patent/DE102007048362A8/de
Priority to US12/757,000 priority patent/US8929974B2/en
Application granted granted Critical
Publication of DE102007048362B4 publication Critical patent/DE102007048362B4/de
Publication of DE102007048362B9 publication Critical patent/DE102007048362B9/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A61B5/0261—Measuring blood flow using optical means, e.g. infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00434—Neural system
    • A61B2018/00446—Brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00—Medical imaging apparatus involving image processing or analysis
    • A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • A61B2576/026—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30016—Brain
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physiology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
DE102007048362.9A 2007-10-09 2007-10-09 System und Verfahren zum Untersuchen eines Objekts Active DE102007048362B9 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE102007048362.9A DE102007048362B9 (de) 2007-10-09 2007-10-09 System und Verfahren zum Untersuchen eines Objekts
PCT/EP2008/008547 WO2009046985A2 (en) 2007-10-09 2008-10-09 System and method for examining an object
US12/757,000 US8929974B2 (en) 2007-10-09 2010-04-08 System and method for examining an illuminated object

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102007048362.9A DE102007048362B9 (de) 2007-10-09 2007-10-09 System und Verfahren zum Untersuchen eines Objekts

Publications (4)

Publication Number Publication Date
DE102007048362A1 DE102007048362A1 (de) 2009-04-23
DE102007048362A8 true DE102007048362A8 (de) 2009-08-13
DE102007048362B4 DE102007048362B4 (de) 2017-04-27
DE102007048362B9 DE102007048362B9 (de) 2017-08-17

Family

ID=40151643

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102007048362.9A Active DE102007048362B9 (de) 2007-10-09 2007-10-09 System und Verfahren zum Untersuchen eines Objekts

Country Status (3)

Country Link
US (1) US8929974B2 (de)
DE (1) DE102007048362B9 (de)
WO (1) WO2009046985A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
US8224021B2 (en) * 2008-03-14 2012-07-17 Millivision Technologies, Inc. Method and system for automatic detection of a class of objects
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
EP2687235A3 (de) 2008-05-02 2014-11-05 Novadaq Technologies Inc. Verfahren zur Herstellung und Verwendung substanzbeladener Erythrozyten (S-LES) zur Beobachtung und Behandlung von mikrovaskulärer Hämodynamik
EP2309919B1 (de) 2008-07-10 2019-03-06 Ecole Polytechnique Federale De Lausanne (EPFL) EPFL-TTO Funktionale optische kohärenzdarstellung
DE102008040802B4 (de) * 2008-07-28 2014-09-18 Carl Zeiss Meditec Ag Verfahren zur quantitativen Darstellung des Blutflusses sowie Operationsmikroskop und Analysesystem
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
DE102011003606A1 (de) * 2011-02-03 2012-08-09 Siemens Aktiengesellschaft Verfahren zum Entfernen unerwünschter perfusionsbedingter Signale aus MR-Bildern, Magnetresonanzanlage, Computerprogrammprodukt und elektronisch lesbarer Datenträger
FR2985023B1 (fr) 2011-12-23 2016-05-06 Commissariat Energie Atomique Systeme de reconstruction de proprietes optiques d'un milieu diffusant, comprenant une source de rayonnement pulsee et au moins deux detecteurs de deux types differents, et procede de reconstruction associe
EP2840957B1 (de) * 2012-04-27 2024-01-03 Stryker European Operations Limited Medizinische vorrichtung mit kohärenter optischer bildgebung und verfahren
WO2013190391A2 (en) 2012-06-21 2013-12-27 Novadaq Technologies Inc. Quantification and analysis of angiography and perfusion
US10101571B2 (en) * 2012-07-10 2018-10-16 Novadaq Technologies ULC Perfusion assessment multi-modality optical medical device
DE102012019469A1 (de) * 2012-09-28 2014-04-03 Carl Zeiss Meditec Ag Verfahren zur Realisierung von OCT- und sonstigen Bildaufnahmen eines Auges
DE102014103044A1 (de) * 2014-03-07 2015-09-10 Carl Zeiss Meditec Ag Chirurgisches Assistenzsystem
CA2963987A1 (en) 2014-09-29 2016-04-07 Novadaq Technologies Inc. Imaging a target fluorophore in a biological material in the presence of autofluorescence
EP3915467A1 (de) 2014-10-09 2021-12-01 Novadaq Technologies ULC Quantifizierung der absoluten blutströmung in gewebe mittels fluoreszenzvermittelter photoplethysmographie
WO2016176781A1 (en) 2015-05-07 2016-11-10 Novadaq Technologies Inc. Methods and systems for laser speckle imaging of tissue using a color image sensor
CA3049922A1 (en) 2017-02-10 2018-08-16 Novadaq Technologies ULC Open-field handheld fluorescence imaging systems and methods
CA3102138A1 (en) * 2018-06-08 2019-12-12 East Carolina University Determining peripheral oxygen saturation (spo2) and hemoglobin concentration using multi-spectral laser imaging (msli) methods and systems
WO2020081159A2 (en) * 2018-09-05 2020-04-23 East Carolina University Systems for detecting vascular and arterial disease in asymptomatic patients and related methods
CA3134066A1 (en) 2019-03-26 2020-10-01 East Carolina University Near-infrared fluorescence imaging for blood flow and perfusion visualization and related systems and computer program products
US10878568B1 (en) * 2019-08-08 2020-12-29 Neuroptica, Llc Systems and methods for imaging disease biomarkers
US20240000293A1 (en) * 2020-11-09 2024-01-04 Ariel Scientific Innovations Ltd. Medical imaging method and device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4109647A (en) 1977-03-16 1978-08-29 The United States Of America As Represented By The Secretary Of The Department Of Health, Education And Welfare Method of and apparatus for measurement of blood flow using coherent light
US5361769A (en) 1991-08-22 1994-11-08 Gert Nilsson Method and a system for measuring fluid flow movements by a laser-doppler technique
AT409451B (de) 1999-12-14 2002-08-26 Hoffmann La Roche Vorrichtung zur bestimmung der örtlichen verteilung einer messgrösse
DE69727220T2 (de) 1996-05-22 2004-12-30 Moor Instruments Ltd., Axminster Vorrichtung zur darstellung der blutströmung in haargefässen
US20050187477A1 (en) 2002-02-01 2005-08-25 Serov Alexander N. Laser doppler perfusion imaging with a plurality of beams

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7404640B2 (en) * 2002-06-14 2008-07-29 Physical Sciences, Inc. Monitoring blood flow in the retina using a line-scanning laser ophthalmoscope
DE10362401B3 (de) * 2002-08-28 2022-03-10 Carl Zeiss Meditec Ag Mikroskopiesystem und Mikroskopieverfahren
WO2006111909A1 (en) 2005-04-20 2006-10-26 Cvl Cosmetics S.A. Instrument and method for high-speed perfusion imaging
US20130296715A1 (en) * 2005-04-20 2013-11-07 Ecole Polytechnique Federale De Lausanne (Epfl) Instrument and method for high-speed perfusion imaging
US7450243B2 (en) * 2006-07-10 2008-11-11 The Board Of Trustees Of The University Of Illinois Volumetric endoscopic coherence microscopy using a coherent fiber bundle
DE102007018641B8 (de) * 2007-04-19 2009-10-08 Carl Zeiss Surgical Gmbh Navigationssystem für Gehirnoperationen
CN101784227B (zh) * 2007-07-06 2013-12-04 工业研究有限公司 激光散斑成像系统和方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4109647A (en) 1977-03-16 1978-08-29 The United States Of America As Represented By The Secretary Of The Department Of Health, Education And Welfare Method of and apparatus for measurement of blood flow using coherent light
US5361769A (en) 1991-08-22 1994-11-08 Gert Nilsson Method and a system for measuring fluid flow movements by a laser-doppler technique
DE69727220T2 (de) 1996-05-22 2004-12-30 Moor Instruments Ltd., Axminster Vorrichtung zur darstellung der blutströmung in haargefässen
AT409451B (de) 1999-12-14 2002-08-26 Hoffmann La Roche Vorrichtung zur bestimmung der örtlichen verteilung einer messgrösse
US20050187477A1 (en) 2002-02-01 2005-08-25 Serov Alexander N. Laser doppler perfusion imaging with a plurality of beams

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M.D.Stern: In vivo evalution of microcirculation by coherent light scattering, in Nature Vol. 254 March 6, 1975, S.56-58

Also Published As

Publication number Publication date
DE102007048362B9 (de) 2017-08-17
WO2009046985A3 (en) 2009-07-09
WO2009046985A2 (en) 2009-04-16
DE102007048362B4 (de) 2017-04-27
US20110090325A1 (en) 2011-04-21
US8929974B2 (en) 2015-01-06
DE102007048362A1 (de) 2009-04-23

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Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8181 Inventor (new situation)

Inventor name: LEUTENEGGER, MARCEL, DR., SILENEN, CH

Inventor name: MARTIN-WILLIAMS, ERICA, DR., PULLY, CH

Inventor name: NAHM, WERNER, DR., 74426 BUEHLERZELL, DE

Inventor name: LOPEZ, ANTONIO, RENENS, CH

Inventor name: LASSER, THEO, PROF., DENGES, CH

Inventor name: HAUGER, CHRISTOPH, DR., 73431 AALEN, DE

8196 Reprint of faulty title page (publication) german patentblatt: part 1a6
OP8 Request for examination as to paragraph 44 patent law
R081 Change of applicant/patentee

Owner name: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL, CH

Free format text: FORMER OWNERS: CARL ZEISS SURGICAL GMBH, 73447 OBERKOCHEN, DE; ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), LAUSANNE, CH

Owner name: CARL ZEISS MEDITEC AG, DE

Free format text: FORMER OWNERS: CARL ZEISS SURGICAL GMBH, 73447 OBERKOCHEN, DE; ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL), LAUSANNE, CH

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Representative=s name: PATENT- UND RECHTSANWAELTE DIEHL & PARTNER GBR, DE

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R018 Grant decision by examination section/examining division
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