DE102006029500A1 - Use of an antimicrobial hardening alginate composition for the topical treatment of wounds and inflammations in human, dental and veterinary medicine - Google Patents

Abstract

Use of a multicomponent agent that cures at the point of use to a dimensionally stable alginate mass, which is similar to known alginate impression materials, but a first addition increasing the absorption of aqueous liquids and their diffusion into and out of the cured composition and a second additive in the form at least an antimicrobial agent, as an agent for the treatment of external wounds and inflammation in human, dental and veterinary medicine and for local infection and inflammation prevention.

Description

The The present invention relates to the use of a curing Alginate composition with an addition of an antimicrobial agent (Antiseptic or chemotherapeutic agent) and a means to increase the Moisture absorption and diffusion for the treatment of wounds and inflammation in human, dental and veterinary medicine, especially for topical or local use in wounds and inflammation of the mouth area and in acute and chronic wounds in dermatology.

Of the Term "treatment" is used in the this application understood as a generic preamble, the besides the direct treatment of an acute wound and / or inflammation as well prophylaxis, e.g. of inflammatory Skin or mucous membrane sections, and / or the treatment of wounds and inflammations includes.

The patent EP 1 244 434 B1 (Schulz / Schlimbach) describes the topical application of a certain class of chemotherapeutic agents or antibiotics, namely so-called gyrase inhibitors in the form of quinolinecarboxylic or oxoquinolizines, in wound healing and inflammation in the mouth, wherein the active ingredient in particular as an aqueous solution, which can be thickened with thickening agents such as polysaccharides, optionally in combination with a medicament carrier, is applied. As a drug carrier, for example, a silicone impression material is recommended for applications in human and veterinary medicine.

The However, silicone compound is incompatible with the applied aqueous solutions of active ingredients, so that can be expected with a drainage of the active ingredient-containing aqueous phase must, where these in unwanted Way, e.g. by ingestion, in the body or not to be treated Skin or mucous membrane sections can get. Furthermore, a temporary removal and re-application of the precisely fitting medicament carrier excluded, because it contains no antimicrobial additive in its mass and therefore can not be kept germ-free in a simple way. Also would have the drug solution in a repeated application each time new applied to the drug carrier become. The thickened solutions of the active ingredient alone do not form a mechanically stable gel, so that the e.g. solutions thickened with hydroxyethylcellulose Mouth area not removed as a gel-like hardened solid can be and, after refreshing the active ingredient, possibly also used again can be.

In the DE 100 61 195 B4 (3M / ESPE AG) proposes to enrich a dental impression material with diagnostic additives that provide in contact with an infected tissue an identifiable, eg visually recognizable signal that allows to detect infected tissue areas and allows in a subsequent step their targeted treatment. The proposed procedure seems very complex and not very practical.

It There is still a need for a drug for topical Treatment of wounds and inflammation in human, dental and veterinary medicine, with which also a wound or inflammation with a complicated surface shape without loss of active substance form-fitting can be treated and at the same time, at least for the usual Treatment times, both for a wound treatment desirable binding capacity for wound secretions or - in dentistry - pocket secretions in periodontal diseases as well as the germicidal antimicrobial Features.

Further It may be seen as a further object to provide an in situ producible, as a whole removable, precisely fitting shaped body of the required mechanical stability to disposal to ask for the time of treatment at the same time the function of a drug carrier, drug depots and a protective one Apply wound cover can.

This object is achieved according to claim 1 by the use of a multicomponent agent which cures at the point of use to form a dimensionally stable alginate mass which contains an additive which increases the absorption and diffusion of aqueous liquids into and out of the hardened mass and an addition of at least one antimicrobial active substance , as a treatment for external wounds and inflammation in human, dental and veterinary medicine and local infection and inflammation prevention. The mass generated in situ at the treatment site constitutes a drug moiety for topical or local topical treatment of skin and mucous membrane wounds and inflammations in human, dental and veterinary medicine on the basis of a hardening alginate mass known per se for molding purposes, the composition thereof modified and adapted for the new purpose of use, that it has a first additive that enables it to absorb moisture in the form of bag secretions, and the Improved diffusion of moisture in the mass, and has a further additive in the form of an antimicrobial agent, which diffuses out of the cured composition over long periods of time and makes the treatment site germ-free or germ-free.

The to be used according to the invention curing Alginate pulp and its preferred uses are provided by Features and feature combinations and preferred embodiments according to claims 2 to 12 closer characterized.

It is already known to use alginate-based materials also in wound healing and granulation agents, particularly in the form of absorbent spun alginate fiber pads for tamponing and in the form of non-hardening gels combined with a cover dressing. It has also been proposed to use, as a wound dressing, also foamed alginate compositions which are produced from two aqueous components which contain the typical components of a effervescent mixture (acidic and acid-sensitive basic carbonate salt) ( US 4,948,575 ). It is also known to produce wound dressings in the form of cast dried alginate sheets which are suitable as wound dressing (US Pat. US 6,706,279 ).

In curing Formal alginates have long been used in dentistry in impression materials used. When the term "hardening alginates" is used in the present application, below is an alginate-containing curing base composition understood in a conventional manner, previously provided only as impression material was. Such a mass contains as basic components soluble Alginates, in particular sodium, potassium and / or ammonium or Amine salt alginates (e.g., triethanolamine alginate), poorly soluble and / or soluble calcium salts, in particular calcium sulfate in the form of its hydrates and calcium silicate and optionally calcium chloride, and also retarders alkali metal and ammonium phosphates, in particular trisodium phosphate, the predominant with the calcium sulfate with the formation of almost insoluble Calcium phosphate reacts and only then in the curing reaction enters with the alkali alginate, and optionally fillers, in particular diatomaceous earth or silicic acids. The proportions of said ingredients are adjusted that the curing reaction under the conditions of use in the desired time expires and a hardened Product with the desired mechanical strength and dimensional accuracy and resistance is obtained.

Examples of curing dental impression materials can be found, for example, in US Pat DE 35 11 721 A1 or the EP 0 359 189 A2 or in the earlier publications mentioned therein in the introduction. It is also to be mentioned that it has already been proposed to dispense such hardening alginate impression materials with disinfectants in order to keep the cured impression sterile after removal from the mouth and thus to interrupt the chain of infection in the further processing of the impression in the dental laboratory, cf. DE 37 24 243 A1 (BAYER AG) or Denis A. Flanagan et al.: Dental Materials (1999), Volume Date 1998, 14 (6), 399-404 (ISSN 0109-5641) ,

Alginate impression materials which have been modified to improve the processability or mixability are, for example, dust-free alginate compositions according to EP 0 217 270 B1 (BAYER AG) or from two pasty components mixable alginate impression materials according to DE 31 35 567 A1 . EP 0 126 824 A2 or according to EP 0 534 264 B1 (BAYER AG).

As a preferred embodiment of the present invention on the two-component formulation according to EP 0 534 264 B1 is to supplement the disclosure of the present application expressly to the entire description of EP 0 534 264 B1 directed. In addition, reference is additionally made to the prior art discussed in the introduction to all the aforementioned patent applications and patents.

In dental dealers curing Alginate Impression are reasonably available, for example, products available in the form of ^® under the brands Palgat Plus or Palgat ^® Plus Quick Fa. 3M / ESPE AG. In the context of the present invention, such products or their precursors described in the above prior art or commercially available as molding compositions may be used, among others, as base formulations, which are transformed according to the invention by the absorption-promoting and antimicrobial additives into wound and inflammatory treatment agents.

One on the teaching of the patent EP 0 534 264 B1 based commercial product for the production of dental impression materials could not be determined. While the high level of hydrophilic or even hygroscopic ingredients used as "paste formers" for a first anhydrous mass, as taught by the teaching of the cited patent, may have hindered practical use as a product for impression materials, it has been found that the base formulation according to patent EP 0 534 264 B1 yourself is particularly well suited to be modified for the purposes of the present invention, in particular by introducing into the first paste as an additional constituent a cellulose derivative (carboxymethylcellulose, CMC) (according to US Pat EP 0 534 264 B1 CMC is only used as an alternative to the preferred sodium acrylic acid-acrylamide copolymer thickener or the gelling agent for the aqueous component B in amounts, based on the component B, in the range from 0.3 wt .-% to 1 wt. % mentioned).

It has not yet been proposed, the type of products known impression compounds based on hardening alginates as topically to use acting drug, and in known impression materials Any existing disinfecting additives do not serve the wound disinfection and wound sterilization when applied to a patient, but the preservation.

Of the The present invention is based on the finding that a curing Alginate impression mass, which is in the o.g. Was modified as advantageous Medicines for the treatment and / or aftercare and / or prophylaxis of wounds and infections in the mouth, preferably for teeth and the periodontium, and for the treatment of dermatological wounds, especially bad healing chronic wounds, can be used, the from the basic compositions formed with positive impressions a content of antimicrobial agents as a drug carrier and Serve drug depot and possibly also for repeated treatment can be used.

For their use, the compositions according to the invention, as well as most customary alginate impression materials, are usually provided as multicomponent kit comprising the individual components as powders or granules to be processed with water to form a paste which can be applied and cured at the place of application, or in semi-finished paste form contains, in particular in the form of two pastes, the according to suitably modified basic recipes according to EP 0 534 264 B1 based.

ever according to the preferred field of application, the kits may also be further Containing adjuvants, e.g. so-called impression tray for applications in the mouth area, e.g. such as they are for the preparation of alginate impressions usually used, or patches, on the skin or mucous membrane adhere and the alginate mass until it hardens and then the Self-supporting cured Mass during Keep the wound treatment on the application site.

at the known, used as dental impression compounds curing Alginates are first and foremost based on high imaging accuracy and dimensional stability at. They therefore have no absorbency for aqueous liquids, e.g. Water or Wound secretion or pocket secretion on, but form a smooth, hermetic Cover. In this form they are not for a wound treatment suitable as materials for the wound treatment, depending on the intended use, at least a certain absorption capacity for wound secretions Should have and / or Taschensekrete and a diffusion of aqueous Flüssigkeitn and dissolved in it Active ingredients in the cured Allow mass and out of this should.

To For this purpose, according to the present Invention in the formulations of the known dental alginate impression materials as additional Components absorption and diffusion improving ingredients incorporated. These are, for example, hydrophilic substances with a sufficient water binding capacity, in pure form a solid, waxy or semi-liquid or liquid Have consistency and are miscible with Alginatabformmassen, do not emigrate from these and in the quantities applied curing not undesirable influence. Preference is given to cellulose derivatives, in particular carboxymethylcellulose (Sodium carboxymethylcellulose, also as cellulose glycolate, cellulose gum; CMC) or the like Cellulose derivatives, or microbial synthetic hydrocolloids such as especially xanthan gum. Other ingredients with absorption or diffusion-improving properties, in particular in combination with cellulose derivatives such as CMC are water-soluble or water-dispersible polyalkylene derivatives (In particular, polyethylene glycols (PEG) with average molecular weights from 300 to 4000 g / mol, e.g. PEG 400). Furthermore, the desired Properties also by hydrocolloids that are not alginates belong, e.g. Plant exudates, seed mucilages or microbial biosynthetic or synthetic hydrocolloids, or by increased levels of added hydrophilic or soluble Alginate derivatives, e.g. of sodium alginate, obtained or beneficial to be influenced. Of the numerous substances studied So far, CMC and, to a lesser extent, xanthan gum than am best suited. CMS is in trade in many qualities under Trade designations such as Cellugel available.

It has been found in preliminary experiments that, based on the final composition of the hardening alginate, in powder formulations up to 30 wt .-% CMC can be added, however, with addition amounts of not more than about 20 wt .-%, based on the ready mixed curing Mass, for powders give the best results. When used in paste-type formulations, eg based on EP 0 534 264 B1 , CMC levels in the range of 1-5 wt .-%, preferably from 1.5 to 3.5 wt .-%, based on the constituents of the mass without water, have proved most suitable, wherein the CMC of the anhydrous first Component is to add. By the CMC addition, the water absorption ability of a cured alginate increases on the basis of a commercial product such as Palgat ^® from 0 wt .-% to values of about 30 wt .-% (after 30 min) or - in dermatology at idle times of 8 h - to about 85%. Wound secretion, which is to be regarded as a special aqueous liquid, is absorbed in appropriate amounts, has the effect of hardening the alginate mass, and its absorption by the hardened mass has the effect of promoting wound healing.

If in the dermatological area, severe oozing wounds are treated should it be within the range of variation of the present Invention to add constituents to the components of the matrix, the formation of an open-cell foam with an enlarged hydrophilic surface and an elevated one absorbance for wound secretions enable.

When contains additional additive the composition is an antimicrobial agent, also referred to as a "microbicide" can. Antimicrobial agents include i.a. anti bacterial, antiviral and antifungal substances, e.g. of the antiseptic type, already used as therapeutics chemotherapeutic agents and suitable Antibiotics. The antimicrobial agents used must be in the alginate molding compound, or in the alginate molding compound with the absorption-enhancing additive, be dispersible, sufficiently stable in the mass and also in be able to get out of the hardened Alginate mass over longer Periods with one for the desired treatment sufficient speed, quantity and to diffuse out constancy.

Examples which may be mentioned of antimicrobial additives include (i) cationic antiseptics which singly or multiply contain the biguanide structural element -NH-C (NHNH) -NH-C (NHNH) -NH-, for example chlorhexidine, alexidine or polyhexanide (active ingredient of Lavasept ^®), or (ii) antiseptics, whose operating principle is based on the elimination of formaldehyde and containing the structural element Z-CH ₂ -Z, wherein Z represents a heteroatom, preferably nitrogen, is to carry the arbitrary Substitutienten or May be part of a heterocyclic ring, such as taurolidine, or (iii) antiseptics containing a quaternized pyridine ring, which may also be substituted, such as cetylpyridinium bromide or octenidine dihydrochloride or (iv) antiseptics containing a quaternary ammonium ion, such as undecylenamidopropyl Betaine, and / or (v) gyrase inhibitors (especially the cationic chemotherapeutic agents used in the EP 1 244 434 B1 are described under the formulas 1 and 2, preferably moxifloxacin or gatifloxacin, particularly preferably as hydrochloride). Of course, mixtures of mutually compatible antimicrobial agents are useful. Instead of the active substances mentioned or together with them, antimycotics or substances acting as fungicides may, if necessary and appropriate, be used. Presently preferred are antimicrobial agents in the form of antiseptics with biguanide structural elements or quaternized pyridine rings, gyrase inhibitors, antimycotics and mixtures thereof, especially chlorhexidine, octenidine, moxifloxacin, gatifloxacin, clotrimazole and combinations thereof.

Under cationizable substances are understood to be those that are capable of are, with acids Acid addition salts to form the salts with strong acids, such as hydrogen halide acids or sulfonic acids, preferably water-soluble are.

The in the EP 1 244 434 B1 substances described under formula 1 belong to the class of gyrase inhibitors in the form of quinolone or naphthyridonecarboxylic acid derivatives, the substances described under formula 2 to the class of 4H-4-oxoquinolizines. Active compounds of the formula 1 are preferably used in the present invention. Possibly. It is also possible to use, for example, antimycotics and wound-healing-promoting substances (natural products being preferred).

Of the antimicrobial additive causes a sterility of the treatment site. The cured at the treatment site Alginate mass gives a self-supporting, adapted to the wound surface Moldings.

It is within the scope of the inventive use, curing alginate with different antimicrobial agents in succession to act, e.g. first as fast as possible extensive disinfection and killing of germs in the wound, e.g. using a Mass with a gyrase inhibitor, and then a longer post-purification and germ free Wound during their healing using another antimicrobial active substance, e.g. of chlorhexidine.

The Components of the composition according to the invention are usually in the form of individual components to be mixed before, with the individual components the o.g. Additions depending on compatibility or expediency contain. The ready-to-use individual components are either pasty and can are mixed directly or they are with a given amount of water to mix. Active ingredients are usually in a pre-dilution with solid or flowable excipients (Extenders, fillers, Diluents, Components of alginate impression material) used to unwanted concentration fluctuations to minimize in the finished mass.

The Production and use of a first embodiment of a medicament according to the invention for the Application in the mouth area, for example, by dry Mixing from 1 to 30 parts by weight, preferably from 3 to 12 parts by weight, Alginate impression material with the corresponding weight part antimicrobial Active substance, stir one part by weight of the mixture with 1-10 parts by weight of water, Apply the mass to a spoon and introduce the medicine into the oral cavity of the patient, leaving the teeth and the periodontal apparatus are covered by the mass. The crowd however, it may e.g. also be applied by syringe without additional support. To 0.5-5 Minutes binds the mass to a mechanically stable, self-supporting Gel used for wound or inflammatory treatment, e.g. Further 3-30 minutes left in the patient's mouth and then takes, e.g. with tweezers.

When Alginate impression material for Powder products are currently preferred a mixture of 10-79.9 wt .-% Sodium, potassium or Ammonium or amine salt alginate, 10-20 wt .-% calcium sulfate, preferably as dihydrate, 0-15 % By weight of other calcium salts, preferably calcium silicate, 0.1-3% by weight Alkali metal or ammonium phosphates, preferably tetrasodium pyrophosphate or trisodium phosphate, 0-80% by weight fillers, preferably kieselguhr or diatomaceous earth, and 0-10% by weight of other excipients, such as e.g. Pigments, potassium fluorotitanate and fragrances.

In the case of a multicomponent agent in the form of two pastes, which can be kept ready in a multi-chamber bag and mixed by means of a mixing syringe with two syringe plunger only in the application and applied to the treatment site, where they cure to form a rubber-elastic dimensionally stable Förmkörper, are masses on the base of basic recipes according to EP 0 534 264 B1 preferred with the following example 2 removable formulation changes (especially CMC additive in paste A). The basic formulations for the two pastes A and B are according to EP 0 534 264 B1 as follows:

Paste A:

10-25% by weight of calcium sulfate dihydrate, 15-23% by weight of soluble alginate, in particular alkali metal alginate, 3-7% by weight of metal oxide (MgO, ZnO), 0.5-3% by weight of alkali metal phosphate (Na ₄ P ₂ O ₇ , K ₄ P ₂ O ₇ , Na ₃ PO ₄ ), and 50-65 wt .-% hydrophilic paste formers (glycerol, polyalkylene glycols) and optionally color pigments.

Paste B:

75-86% by weight Water (demineralized), 15-25 By weight of diatomaceous or silica, 0.3-1 Wt .-% gelling agent and possibly fragrances.

The Hardening alginate composition according to the invention with the antimicrobial additive may, during the curing phase, in the plastic phase that has passed through, to any desired skin or mucosal surface applied, e.g. with a spatula or an application syringe. The formed coating is germicidal, hemostatic, very well tolerated and hypoallergenic and easily removable.

The Components of the composition can be used together in sterile Bottling. e.g. in two-chamber tubular bags with predetermined breaking point or in shape a mixing and application syringe, are supplied and for the application be mixed.

The preferably provided comparatively high concentrations of antimicrobial agent allow treatment within a short time periods while the stay of a patient in the practice of the dentist.

By The high content of antimicrobial agent is also a microbiological Contamination of the drug when stored properly excluded. Due to the depot effect is always enough antimicrobial agent on the surface provided, also for possible repeated treatments with the same medicine.

The considerable absorbency the cured one Alginate mass leads to a desirable Absorption of wound secretions or pocket secretions and thus supports The Cure.

Examples

example 1

1a. Preparation of a curing Alginate mass (powder for a batter with water)

It became a hardening Alginate mass based on a commercially available alginate impression material of 55% by weight of diatomaceous earth, 9% by weight of calcium silicate, 15.76% by weight of calcium sulfate dihydrate, 14% by weight of potassium alginate, 1.2% by weight of tetrasodium pyrophosphate, 3 % By weight potassium fluorotitanate, 0.4% by weight Dentomint and 2% by weight Bayferrox yellow 9220, which in addition, based on 100 wt .-% of said ingredients, 20 wt .-% carboxymethylcellulose (CMC Sodium Low Viscosity, Product Number C5678; Viscosity 500-2,500 Pas; Sigma-Aldrich Chemie GmbH, Seinheim, Germany) as well as antimicrobial agent either moxifloxacin (in amounts of 1% by weight, 2% by weight and 3% by weight, based on the constituents mentioned) or chlorhexidine (in amounts of 2% by weight, 3% by weight, 6% by weight and 12% by weight, based on the constituents mentioned).

This Powder forms after addition of the usual Amount of water a pasty Product which at the point of use to a rubbery, forest-stable Mass hardens.

1b. exam the product features

1b ₁ . Water absorption capacity

For the hardened mass were by weighing After contact with water, the water absorption values determined. they were after 15 minutes to 31 wt .-%, after 30 min to 39 wt .-%, after 60 min to 52% by weight, after 4 hours to 62% by weight and after 8 hours to 85% by weight.

1b ₂ . Local antimicrobial efficacy

It were from 1 g of the o.g. Ingredients after adding 3 ml of distillate Mass produced in semi-liquid state in a top and bottom open glass tube with an inside diameter of 8 mm, where they were allowed to cure. The obtained Cylinder of the cured Alginate mass was removed from the tube pushed and cut into slices of about 1 mm thickness. Depending on Approach, the tested cured mass contained 1 wt .-% moxifloxacin or 2 or 6% by weight of chlorhexidine.

The Slices were on the surface of a nutrient agar II poured into a Petri dish (Merck KGaA Darmstadt / Lot V 130583 804) with an addition of a Bacillus subtilis (BGA) spore suspension hung up. The test plates thus obtained were incubated at 37 ° C for 24 h.

The Antimicrobial activity was assessed on inhibition sites. She proved herself for all tested very high and remained for 24 h.

at further tests, after a similar Experimental scheme using problem germs (Pesudomonas aeruginosa, ATCC strain 27853; Staphylococcus aureus MRSA strain 0134-93), essentially the same results were obtained.

Example 2

2a. Preparation of a pasty two-component product to form a hardening after mixing at the treatment site alginate

• * Protanal^® TA 250 M der Fa. FMC BioPolymer, Brüssel/Belgien

Paste B Wasser 80,0 Kieselgur 20,0 PNC 400* 0,9

• * Natrium-Polyacrylat-Verdickungsmittel

Based on modified formulations according to EP 0 534 264 B1 two pastes are made with the following ingredients: Paste A (amounts in g, based on a batch of 124.5 g) Calcium salt (calcium sulfate hemihydrate) 8.5 Calcium salt (calcium sulfate dihydrate) 8.5 Alginate (triethanolamine salt) * 20.0 sodium pyrophosphate 2.5 magnesia 5.0 CMC 6.0 PEG 400 37.0 glycerin 37.0

• * Protanal ^® TA 250 M of the company. FMC BioPolymer, Brussels / Belgium

Paste B water 80.0 diatomaceous 20.0 PNC 400 * 0.9

• * Sodium polyacrylate thickener

to Preparation of the pastes are all dry powdery starting materials sieved (250 mesh) and weighed individually.

to Preparation of paste A is the liquid phase (glycerol, PEG 400) is added a premix of pulverfömigen ingredients and it is first mixed by hand with a spatula for 5 min. Let's connect Mix for another 2 minutes with an Ultraturrax mixer (Level 1) until a homogeneous paste is obtained, but at least 2 minutes, touched.

In similar For the preparation of paste B, the kieselguhr component is used distributed in the water with the addition of the sodium polyacrylate gelling agent, until a homogeneous paste was obtained.

Both Pastes are then sifted and placed in the chambers of a two-chamber syringe filled.

The relationship from paste A to paste B is in the range from 1: (4 to 5).

Of the respective active ingredient in amounts, as used in Example 1 chlorhexidine and octinidine, respectively, were found to be 6.8 g; moxifloxazine 0.13 g), both paste A and / or paste B can be added, and usually before the preparation of the homogeneous mixtures.

There Water absorption capacity, the gelation and the antimicrobial properties corresponded as far as possible those of the product of Example 1. The preparation of the curing Paste by mixing the two paste-like components as well as the Apply to a wound or infection-prone area in the mouth area (Periodontal disease, peri-implantitis), however, were much more comfortable and product quality more reproducible.

Claims (12)

Use of a multi-component agent, the after mixing the individual components at the place of use to a rigid alginate mass cures, the one the absorption of aqueous liquids and their diffusion into and out of the hardened mass increasing first Additive and a second additive in the form of at least one antimicrobial Contains active substance, as a treatment for external wounds and inflammations in human, dental and veterinary medicine and local infection and inflammation prevention. Use of a composition according to claim 1, wherein the composition comprises at least one first pasty component which is substantially anhydrous and contains the essential ingredients reacting to a hardened alginate mass in a hydrophilic paste former and the first additive and at least one second component comprising substantially water and one or more inert filler (s) and, optionally, a viscosifying gel former, and wherein the second additive is in the form of at least one antimicrobial agent in the first paste, in the second paste or in the first paste both is present. Use according to claim 2, wherein the first pasty component as reactive components soluble Alkali alginates selected are from sodium, potassium and / or ammonium or amine salt alginate, calcium salts, the selected are calcium sulfate, calcium silicate and / or calcium chloride, Alkali metal and ammonium phosphates or pyrophosphates, in particular Trisodium phosphate or sodium pyrophosphate, as well as at least a part of the absorption and diffusion of aqueous liquids increasing contains first additive, the selected is from one or more cellulose derivative (s), in particular carboxymethylcellulose (Sodium carboxymethylcellulose, CMC), and / or xanthan gum. Use according to claim 2, wherein the first pasty component as hydrophilic paste former a polyhydric alcohol and / or a liquid Contains polyalkylene glycol. Use according to claim 4, wherein the polyvalent Alcohol Glycerine or a glycol and the liquid polyalkylene glycol Polyethylene glycol (PEG) having an average molecular weight of 25,000 g / mol or less, in particular from 300 to 4000 g / mol, is. Use according to any one of claims 1 to 5, wherein the antimicrobial Active ingredient selected from a group containing antiseptics Biguanide structural elements, antiseptics with structural elements in Form of quaternized pyridine rings, gyrase inhibitors, antimycotics and Mixtures thereof. Use according to claim 6, wherein the antimicrobial Active ingredient selected from the group chlorhexidine, octenidine, moxifloxacin, gatifloxacin, Clotrimazole and their combinations. Use according to any one of claims 1 to 7, wherein the absorption and diffusion-promoting Addition carboxymethyl cellulose is and, based on the ingredients the hardening Alginate composition other than water, in amounts from 1 to 30 wt .-%, in particular 1-5 Wt .-%, preferably 1.5-3.5 Wt .-%, is present. Use according to any one of claims 1 to 8, wherein the antimicrobial Active ingredient, based on the constituents of the hardening alginate composition, which are not water, in amounts of 0.001 to 5.0 wt .-% present is. Use according to any one of claims 1 to 8, wherein the antimicrobial Active substance Moxifloxazin and / or Gatifloxazin is and, based on the constituents of the hardening Alginate composition which is not water in amounts of 0.001 to 3.0 wt .-% is present. Use according to any one of claims 1 to 8, wherein the antimicrobial Active ingredient is chlorhexidine and, based on the constituents of curing Alginate composition which is not water, in amounts of 0.1 to 12.0 wt .-% is present. Use of a hardening alginate mass after one the claims 1 to 9 for topical use in wounds and inflammations of the mouth area and in chronic and acute wounds in dermatology.