DE102004041573A1 - New agent for the treatment of keratinic fibers - Google Patents

Abstract

The present invention relates to an agent for the treatment of keratinic fibers which contains at least one protease and at least one further component which is selected from protein hydrolysates as well as vitamins, provitamins and vitamin precursors as well as their derivatives. Furthermore, the invention relates to corresponding uses and methods for the treatment of keratinic fibers.

Description

The The present invention relates to an agent for the treatment of keratinous Fibers, the at least one protease and at least one other Component contains the selected is among protein hydrolysates as well as vitamins, provitamins and Vitamin precursors and their derivatives. Furthermore, the invention relates corresponding uses as well as methods of treatment of keratinic Fibers.

Human Hair is becoming more diverse today Treated with hair cosmetic preparations. These include about Cleaning hair with shampoos, care and regeneration with rinses and cures, as well as bleaching, dyeing and deforming the hair with colorants, Tints, Wells and styling preparations. There are funds for change or nuancing the color of the head hair a prominent role. This behavior leads to make hair more diverse Exposed to straining influences are those that have a negative effect on the surface structure.

investigations have shown that 70 percent of women are several times a week Wash your hair, 8% of it daily. This care behavior leads to, that the so-called "all-purpose shampoos" by diverse, needs-based and replaced more gentle recipes become. Parallel to this grows also the need for supplementary Care products, because mechanical loads such as combing, blow drying or Rubbing on the clothes strain the hair. Furthermore act chemical treatments such. B. perms or color changes additionally onerous. A hair becomes, until it reaches a length of 20 cm, an average of 400 times washed, blown and brushed. Under the microscope is undamaged Hair comparable to a pinecone. It is from a closed Surrounding scaly layer. When attacked hair is this layer not closed anymore. The scales stop and break partially out. The incident light is no longer reflected, the Hair looks dull and dull. Hair remedies mitigate worse Problems, but often make the hair "heavy" and act in many cases only on the surface hair, so they do not completely regenerate can.

It has therefore not lacked efforts to damage the To counteract hair structure by using care ingredients or prevent. Various care components have been developed which are specifically used as aftertreatment agent for damaged hair. Furthermore, the hair treatment agents themselves, such as, for example, the fixatives in the context of a permanent wave treatment or the colorants, with additional Care substances offset. For example, in DE-A1-196 17 569 proposed to use special amino acids as care substances.

The DE-C-197 09 334 discloses the use of proteolytically active enzymes for enzymatic dissolution or replacement the one unwanted Roughness of the hair surface causing splayed cuticle edges of the hair.

It was now surprisingly found that the combined use of proteolytically active enzymes and protein hydrolysates and / or vitamins, provitamins and vitamin precursors and their derivatives in keratinic fibers, in particular in Hair, a considerable Repair effect causes. As a result, the condition of the hair during the Improved hair treatment from the inside by the used care substances penetrate into the hair to be treated. This leads to a regeneration or structural stabilization of the hair, which is not exclusive to the hair surface limited remains.

object The present invention is therefore an agent for treatment keratinic fibers containing at least one protease and at least contains another component, the selected is among protein hydrolysates as well as vitamins, provitamins and Vitamin precursors and their derivatives.

The explained above Combination treatment of the keratinic fibers with the agent according to the invention leads advantageously to improve the injured Structure of the fibers.

The inventive agent For the treatment of keratinic fibers, one or more protease may be used Contain different proteases.

Proteases cleave peptide bonds within an amino acid chain. This may cause the Abschup pore can be increased and amino acid side chains can be exposed. Thus, the penetration of the repair agents into the hair can be improved.

It can according to the invention pro- and / or eukaryotic proteases are used. They differ among other things by their gap specificity (targeted after certain amino acids in a chain or at random). For example, trypsin cleaves peptide bonds after the amino acids arginine and lysine. This results in free amino groups on the protein side chains, with which appropriate reactions are possible. The keratin structure is attacked less heavily than when using unspecific cleaving proteases such as e.g. bacterial subtilisins.

In principle, all proteases can be used in the agent according to the invention, in particular the enzymes classified under EC 3.4 - Acting on peptide bonds (peptidases), which are available for example on the Internet under the URL
http://www.chem.gmul.ac.uk/iubmb/enzyme/EC3/4/
are listed.

preferred Proteases according to the invention are the serine Endopeptidases (E.C.3.4.21) and the cysteine endopeptidases (E.C.3.4.22).

Particularly according to the invention preferred proteases are selected under subtilisin (EC 3.4.21.62), papain (EC 3.4.22.2) and bromelain (EC 3.4.22.32).

The Enzymes are in the agent according to the invention preferably in amounts of 0.005 to 10 wt .-%, based on the total Preparation, included. Amounts of 0.01 to 5 wt .-% are special prefers.

The at least one further component is in the agent according to the invention preferably in amounts of 0.005 to 10 wt .-%, based on the total Preparation, included. Amounts of 0.01 to 2 wt .-% are special prefers.

The agent according to the invention may comprise protein hydrolysates, preferably cationized protein hydrolysates, wherein the protein hydrolyzate on which the animal is based, for example from collagen, milk or keratin, from the plant, for example from wheat, maize, rice, potatoes, soya or almonds, from marine life forms, for example from fish collagen or algae, or biotechnologically derived protein hydrolysates. The protein hydrolyzates on which the cationic derivatives according to the invention are based can be obtained from the corresponding proteins by chemical, in particular alkaline or acid hydrolysis, by enzymatic hydrolysis and / or a combination of both types of hydrolysis. The hydrolysis of proteins usually results in a protein hydrolyzate having a molecular weight distribution of about 100 daltons up to several thousand daltons. Preference is given to those cationic protein hydrolyzates whose underlying protein content has a molecular weight of 100 to 25,000 daltons, preferably 250 to 5000 daltons. Furthermore, cationic protein hydrolyzates are to be understood as meaning quaternized amino acids and mixtures thereof. The quaternization of the protein hydrolyzates or amino acids is often carried out using quaternary ammonium salts such as N, N-dimethyl-N- (n-alkyl) -N- (2-hydroxy-3-chloro-n-propyl) ammonium halides. Furthermore, the cationic protein hydrolysates may also be further derivatized. As typical examples of the cationic protein hydrolyzates and derivatives according to the invention, those mentioned under the INCI names in the "International Cosmetic Ingredient Dictionary and Handbook", (seventh edition 1997, The Cosmetic, Toiletry, and Fragrance Association 1101 17 ^th Street, NW, Suite 300 Cocodimium Hydroxypropyl Hydrolyzed Collagen, Cocodimopnium Hydroxypropyl Hydrolyzed Casein, Cocodimonium Hydroxypropyl Hydrolyzed Collagen, Cocodimonium Hydroxypropyl Hydrolyzed Hair Keratin, Cocodimonium Hydroxypropyl Hydrolyzed Keratin, Cocodimonium Hydroxypropyl Hydrolyzed Rice Protein, Cocodimonium Hydroxypropyl Hydrolyzed Silk, Cocodimonium Hydroxypropyl Hydrolyzed Soy Protein, Cocodimonium Hydroxypropyl Hydrolyzed Wheat Protein, Cocodimonium Hydroxypropyl Silk Amino Acids, Hydroxypropyl Arginine Lauryl / Myristyl Ether HCl, Hydroxypropyltrimonium Gelatin, Hydroxypropyltrimonium Hydrolyzed Casein, Hydroxypropyltrimonium Hydrolyzed Collagen, Hydroxypropyltrimonium Hydrolyzed Conchiolin Protein, Hydroxypropyltrimonium Hydrolyzed Keratin, Hydroxypropyltrimonium Hydrolyzed Rice Bran Protein, Hydroxypropyltrinium Hydrolyzed Silk, Hydroxypropyltrimonium Hydrolyzed Soy Protein, Hydroxypropyl Hydrolyzed Vegetable Protein, Hydroxypropyltrimonium Hydrolyzed Wheat Protein, Hydroxypropyltrimonium Hydrolyzed Wheat Protein / Siloxysilicate, Laurdimonium Hydroxypropyl Hydrolyzed Soy Protein, Lauridimonium Hydroxypropyl Hydrolyzed Wheat Protein, Lauridimonium Hydroxypropyl Hydrolyzed Wheat Protein / Siloxic Acid, Lauryldimonium Hydroxypropyl Hydrolyzed Casein, Lauryldimonium Hydroxypropyl Hydrolyzed Collagen, Lauryldimony Hydroxypropyl Hydrolyzed Keratin, Lauryldimonium Hydroxypropyl Hydrolyzed Silk, Lauryldimonium Hydroxypropyl Hydrolyzed Soy Protein, Steardimonium Hydroxypropyl Hydrolyzed Casein, Steardimonium Hydroxypropyl Hydrolyzed Collagen, Steardimonium Hydroxypropyl Hydrolyzed Keratin, Steardimonium Hydroxypropyl Hydrolyzed Rice Protein, Steardimonium Hydroxypropyl Hydro lyzed Silk, Steardimonium Hydroxypropyl Hydrolyzed Soy Protein, Steardimonium Hydroxypropyl Hydrolyzed Vegetable Protein, Steardimonium Hydroxypropyl Hydrolyzed Wheat Protein, Steartrimonium Hydroxyethyl Hydrolyzed Collagen, Quaternium-76 Hydrolyzed Collagen, Quaternium-79 Hydrolyzed Collagen, Quaternium-79 Hydrolyzed Keratin, Quaternium-79 Hydrolyzed Milk Protein, Quaternium-79 Hydrolyzed Silk, Quaternium-79 Hydrolyzed Soy Protein, Quaternium-79 Hydrolyzed Wheat Protein. Very particular preference is given to wheat-based protein hydrolysates available under the trade names Gluadin WQ and Gluadin WLM.

It has invented as preferred proven when the agent at least one cationic protein hydrolyzate contains. In this case, the effect of the invention be further increased if the funds of the present Invention at least one cationic and at least one nonionic Contain protein hydrolyzate.

Farther it has according to the invention as preferred proven when the means at least one wheat protein hydrolyzate contain.

Farther can the agent of the invention Vitamins, Provitamine and vitamin precursor and their derivatives contain.

there are such according to the invention Vitamins, pro-vitamins and vitamin precursors are preferred, usually the groups A, B. C, E, F and H are assigned.

The group of substances called vitamin A includes retinol (vitamin A ₁ ) and 3,4-didehydroretinol (vitamin A ₂ ). The β-carotene is the provitamin of retinol. As vitamin A component according to the invention, for example, vitamin A acid and its esters, vitamin A aldehyde and vitamin A alcohol and its esters such as the palmitate and the acetate into consideration. The preparations used according to the invention preferably contain the vitamin A component in amounts of 0.05-1% by weight, based on the total preparation.

• – itamin B₁ (Thiamin)
• – Vitamin B₂ (Riboflavin)
• – Vitamin B₃. Unter dieser Bezeichnung werden häufig die Verbindungen Nicotinsäure und Nicotinsäureamid (Niacinamid) geführt. Erfindungsgemäß bevorzugt ist das Nicotinsäureamid, das in den erfindungsgemäß verwendetenen Mitteln bevorzugt in Mengen von 0,05 bis 1 Gew.-%, bezogen auf das gesamte Mittel, enthalten ist.
• – Vitamin B₅ (Pantothensäure, Panthenol und Pantolacton). im Rahmen dieser Gruppe wird bevorzugt das Panthenol und/oder Pantolacton eingesetzt. Erfindungsgemäß einsetzbare Derivate des Panthenols sind insbesondere die Ester und Ether des Panthenols sowie kationisch derivatisierte Panthenole. Einzelne Vertreter sind beispielsweise das Panthenoltriacetat, der Panthenolmonoethylether und dessen Monoacetat sowie die in der WO 92/13829 offenbarten kationischen Panthenolderivate. Die genannten Verbindungen des Vitamin B₅-Typs sind in den erfindungsgemäß verwendeten Miteln bevorzugt in Mengen von 0,05 – 10 Gew.-%, bezogen auf das gesamte Mittel, enthalten. Mengen von 0,1 – 5 Gew.-% sind besonders bevorzugt.
• – Vitamin B₆ (Pyridoxin sowie Pyridoxamin und Pyridoxal).

The vitamin B group or the vitamin B complex include, among others

• - itamin B ₁ (thiamine)
• - Vitamin B ₂ (riboflavin)
• - Vitamin B ₃ . Under this name, the compounds nicotinic acid and nicotinamide (niacinamide) are often performed. Preferred according to the invention is the nicotinic acid amide, which is preferably contained in the agents according to the invention in amounts of from 0.05 to 1% by weight, based on the total agent.
• - Vitamin B ₅ (pantothenic acid, panthenol and pantolactone). Panthenol and / or pantolactone are preferably used in the context of this group. Derivatives of panthenol which can be used according to the invention are, in particular, the esters and ethers of panthenol and also cationically derivatized panthenols. Individual representatives are, for example, the panthenol triacetate, the panthenol monoethyl ether and its monoacetate and also the cationic panthenol derivatives disclosed in WO 92/13829. The said compounds of the vitamin B ₅ type are preferably contained in the agents used according to the invention in amounts of 0.05-10% by weight, based on the total agent. Amounts of 0.1-5 wt .-% are particularly preferred.
• - Vitamin B ₆ (pyridoxine and pyridoxamine and pyridoxal).

vitamin C (ascorbic acid). Vitamin C is preferred in the compositions used in the invention used in amounts of 0.1 to 3 wt .-%, based on the total agent. The use in the form of palmitic acid ester, glucosides or Phosphates may be preferred. The use in combination with Tocopherols may also be preferred.

vitamin E (tocopherols, especially α-tocopherol). Tocopherol and its derivatives, including in particular the esters such as the acetate, the nicotinate, the phosphate and the succinate fall, are used in the invention Means preferably in amounts of 0.05-1 wt .-%, based on the entire medium, included.

Vitamin F. Under the term "vitamin F" are usually essential fatty acids, in particular Linoleic acid, linolenic acid and arachidonic acid, understood.

vitamin H. The vitamin H is the compound (3aS, 4S, 6aR) -2-oxohexahydrothienol [3,4-d] imidazole-4-valeric acid, for the But in the meantime, the trivial name Biotin has prevailed. biotin is used in the invention Agents preferably in amounts of 0.0001 to 1.0 wt .-%, in particular in Amounts of 0.001 to 0.01 wt .-% included.

Prefers contain the inventively used Means vitamins, provitamins and vitamin precursors from the groups A, B, E and H.

Panihenol, Pantolactone, pyridoxine and its derivatives as well as nicotinic acid amide and biotin are particularly preferred. Panthenol, pantolactone as well nicotinamide are very particularly preferred. As especially suitable According to the invention, pantolactone proved.

in the Frame of a particularly preferred embodiment of the present invention Invention contains the agent of the invention at least one protein hydrolyzate and at least one vitamin, provitamin or a vitamin precursor and one of their derivatives.

Very particularly preferred for the purposes of the present invention is an active ingredient combination of pantolactone, at least one cationic and at least one nonionic wheat protein hydrolyzate. This is achieved for example by the use of pantolactone in combination with the commercial products Gluadin ^® WQ and Gluadin ^® WLM.

Regarding the timing is subject to the use of the agent according to the invention no restrictions. It is possible in principle two separate preparations containing (a) the protease and (b) the at least one further component in succession in any Order on the fibers. This should, however between steps (a) and (b) not too long in time Distance, so that the fibers between the steps are not dry.

Even though the agent of the invention in principle can remain on the hair, the agent is preferred rinsed after an exposure time of 1 minute to 60 hours. This rinse can be done with pure water or a regular shampoo. Exposure times from 5 to 15 minutes have proven sufficient in most cases.

Independent of the exact course of the pretreatment, it has been advantageous proven, the agent of the invention at a temperature of 20 to 55 ° C, in particular from 35 to 40 ° C, apply.

Regarding the type, according to the agent of the invention on the keratinic fiber, especially human hair, applied there are no fundamental restrictions. As packaging this is the agent of the invention containing preparations are, for example, creams, lotions, Solutions, waters, Emulsions such as W / O, O / W, PIT emulsions (emulsions according to the teaching phase inversion, called PIT), microemulsions and multiple Emulsions, gels, sprays, aerosols and foam aerosols suitable. These are usually watery or aqueous-alcoholic Basis formulated. The alcoholic component is lower Alkanols and polyols such as propylene glycol and glycerol are used. ethanol and isopropanol are preferred alcohols. Water and alcohol can in the aqueous alcoholic base in a weight ratio from 1:10 to 10: 1. Water and aqueous-alcoholic mixtures, which up to 50 wt .-%, in particular up to 25 wt .-%, based on alcohol to the mixture alcohol / water, th contained, can according to the invention preferred Be fundamentals. The pH of these preparations can in principle at values of 2-11 lie. It is preferably between 2 and 7, with values of 3 to 7 5 are particularly preferred. To adjust this pH can virtually every one for cosmetic use acid or base can be used. Usually be called acids Consumed acids. Under Be enjoyment acids such acids understood that under the usual Food intake and positive effects to have the human organism. Acetic acids are, for example, acetic acid, lactic acid, tartaric acid, citric acid, malic acid, ascorbic acid and Gluconic. In the context of the invention is the use of citric acid and lactic acid particularly preferred. Preferred bases are ammonia, alkali hydroxides, Triethanolamine and N, N, N ', N'-tetrakis (2-hydroxypropyl) ethylenediamine.

The agent can be made up as a single-chamber system or as a two-chamber system. In a bicameral system, typically the enzyme component (protease) and the repair material component (Protein hydrolysates, pantolactone, panthenol or niacinamide) spatially separated.

• a) die Enzymkomponente (Protease) und
• b) die Repairstoffkomponente (Proteinhydrolisate, Pantolacton, Panthenol oder Niacinamid)

umfasst.Another object of the present invention is a two-part kit for the treatment of keratinic fibers, which is characterized in that it

• a) the enzyme component (protease) and
• b) the repair substance component (protein hydrolysates, pantolactone, panthenol or niacinamide)

includes.

Next the invention mandatory required enzyme and the at least one other above Component, the agent can in principle all other, the expert for such cosmetic agent known components.

• – anionische Tenside, insbesondere Alkylsulfate, Alkylpolyglykolethersulfate und Ethercarbonsäuren mit 10 bis 18 C-Atomen in der Alkylgruppe und bis zu 12 Glykolethergruppen im Molekül, Seifen sowie Sulfobernsteinsäuremono- und -dialkylester mit 8 bis 18 C-Atomen in der Alkylgruppe und Sulfobernsteinsäuremono-alkylpolyoxyethyl-ester mit 8 bis 18 C-Atomen in der Alkylgruppe und 1 bis 6 Oxyethylgruppen,
• – ampholytische Tenside wie beispielsweise N-Alkylglycine, N-Alkylpropionsäuren, N-Alkylaminobuttersäuren, N-Alkyliminodipropionsäuren, N-Hydroxyethyl-N-alkylamidopropylglycine, N-Alkyltaurine, N-Alkylsarcosine, 2-Alkylaminopropionsäuren und Alkyl-aminoessigsäuren mit jeweils etwa 8 bis 18 C-Atomen in der Alkylgruppe,
• – nichtionische Polymere wie beispielsweise Vinylpyrrolidon/Vinylacrylat-Copolymere, Polyvinylpyrrolidon und Vinylpyrrolidon/Vinylacetat-Copolymere und Polysiloxane,
• – Verdickungsmittel wie Agar-Agar, Guar-Gum, Alginate, Xanthan-Gum, Gummi arabicum, Karaya-Gummi, Johannisbrotkernmehl, Leinsamengummen, Dextrane, Cellulose-Derivate, z. B. Methylcellulose, Hydroxyalkylcellulose und Carboxymethylcellulose, Stärke-Fraktionen und Derivate wie Amylose, Amylopektin und Dextrine, Tone wie z. B. Bentonit oder vollsynthetische Hydrokolloide wie z. B. Polyvinylalkohol,
• – Strukturanten wie Maleinsäure und Milchsäure,
• ,haarkonditionierende Verbindungen wie Phospholipide, beispielsweise Sojalecithin, Ei-Lecitin und Kephaline, sowie Silikonöle,
• – Parfümöle, Dimethylisosorbid und Cyclodextrine,
• – Lösungsmittel und -vermittler wie Ethanol, Isopropanol, Ethylenglykol, Propylenglykol, Glycerin und Diethylenglykol,
• – symmetrische und unsymmetrische, lineare und verzweigte Dialkylether mit insgesamt zwischen 12 bis 36 C-Atomen, insbesondere 12 bis 24 C-Atomen, wie beispielsweise Di-n-octylether, Di-n-decylether, Di-n-nonylether, Di-n-undecylether und Di-n-dodecylether, n-Hexyl-n-octylether, n-Octyl-n-decylether, n-Decyl-n-undecylether, n-Undecyl-n-dodecylether und n-Hexyl-n-Undecylether sowie Di-tert-butylether, Di-iso-pentylether, Di-3- ethyldecylether, tert.-Butyl-n-octylether, iso-Pentyl-n-octylether und 2-Methyl-pentyl-n-octylether,
• – Fettalkohole, insbesondere lineare und/oder gesättigte Fettalkohole mit 8 bis 30 C-Atomen, und Monoester der Fettsäuren mit Alkoholen mit 6 bis 24 C-Atomen,
• – faserstrukturverbessernde Wirkstoffe, insbesondere Mono-, Di- und Oligosaccharide, wie beispielsweise Glucose, Galactose, Fructose, Fruchtzucker und Lactose,
• – konditionierende Wirkstoffe wie Paraffinöle, pflanzliche Öle, z. B. Sonnenblumenöl, Orangenöl, Mandelöl, Weizenkeimöl und Pfirsichkernöl sowie Phospholipide, beispielsweise Sojalecithin, Ei-Lecithin und Kephaline,
• – quaternierte Amine wie Methyl-1-alkylamidoethyl-2-alkylimidazolinium-methosulfat,
• – Entschäumer wie Silikone,
• – Farbstoffe zum Anfärben des Mittels,
• – Antischuppenwirkstoffe wie Piroctone Olamine, Zink Omadine und Climbazol,
• – Lichtschutzmittel, insbesondere derivatisierte Benzophenone, Zimtsäure-Derivate und Triazine,
• – weitere Substanzen zur Einstellung des pH-Wertes, wie beispielsweise α- und β-Hydroxycarbonsäuren
• – Wirkstoffe wie Allantoin und Bisabolol,
• – Cholesterin,
• – Konsistenzgeber wie Zuckerester, Polyolester oder Polyolalkylether,
• – Fette und Wachse wie Walrat, Bienenwachs, Montanwachs und Paraffine,
• – Fettsäurealkanolamide,
• – Komplexbildner wie EDTA, NTA, β-Alanindiessigsäure und Phosphonsäuren,
• – Quell- und Penetrationsstoffe wie Glycerin, Propylenglykolmonoethylether, Carbonate, Hydrogencarbonate, Guanidine, Harnstoffe sowie primäre, sekundäre und tertiäre Phosphate,
• – Trübungsmittel wie Latex, Styrol/PVP- und Styrol/Acrylamid-Copolymere
• – Perlglanzmittel wie Ethylenglykolmono- und -distearat sowie PEG-3-distearat,
• – Pigmente,
• – Reduktionsmittel wie z. B. Thioglykolsäure und deren Derivate, Thiomilchsäure, Cysteamin, Thioäpfelsäure und α-Mercaptoethansulfonsäure,
• – Treibmittel wie Propan-Butan-Gemische, N₂O, Dimethylether, CO₂ und Luft,
• – Antioxidantien.

Other active ingredients, auxiliaries and additives are, for example

• Anionic surfactants, in particular alkyl sulfates, alkyl polyglycol ether sulfates and ether carboxylic acids having 10 to 18 carbon atoms in the alkyl group and up to 12 glycol ether groups in the molecule, soaps and sulfosuccinic acid mono- and dialkyl esters having 8 to 18 carbon atoms in the alkyl group and sulfosuccinic acid mono-alkylpolyoxyethyl- esters having 8 to 18 C atoms in the alkyl group and 1 to 6 oxyethyl groups,
• Ampholytic surfactants such as N-alkylglycines, N-alkylpropionic acids, N-alkylaminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropylglycines, N-alkyltaurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids each having about 8 to 18 C atoms in the alkyl group,
• Nonionic polymers such as vinyl pyrrolidone / vinyl acrylate copolymers, polyvinyl pyrrolidone and vinyl pyrrolidone / vinyl acetate copolymers and polysiloxanes,
• Thickeners such as agar-agar, guar gum, alginates, xanthan gum, gum arabic, karaya gum, locust bean gum, linseed gums, dextrans, cellulose derivatives, e.g. For example, methylcellulose, hydroxyalkylcellulose and carboxymethylcellulose, starch fractions and derivatives such as amylose, amylopectin and dextrins, clays such. As bentonite or fully synthetic hydrocolloids such. For example, polyvinyl alcohol,
• - structurants such as maleic acid and lactic acid,
• hair-conditioning compounds such as phospholipids, for example soya lecithin, egg lecithin and cephalins, and silicone oils,
• Perfume oils, dimethylisosorbide and cyclodextrins,
• Solvents and mediators such as ethanol, isopropanol, ethylene glycol, propylene glycol, glycerol and diethylene glycol,
• - symmetrical and unsymmetrical, linear and branched dialkyl ethers having a total of from 12 to 36 carbon atoms, in particular 12 to 24 carbon atoms, such as di-n-octyl ether, di-n-decyl ether, di-n-nonyl ether, di-n -undecyl ether and di-n-dodecyl ether, n-hexyl n-octyl ether, n-octyl n-decyl ether, n-decyl n-undecyl ether, n-undecyl n-dodecyl ether and n-hexyl n-undecyl ether and di tert-butyl ether, di-iso-pentyl ether, di-3-ethyl decyl ether, tert-butyl n-octyl ether, iso-pentyl n-octyl ether and 2-methyl pentyl n-octyl ether,
• Fatty alcohols, in particular linear and / or saturated fatty alcohols containing 8 to 30 carbon atoms, and monoesters of the fatty acids with alcohols having 6 to 24 carbon atoms,
• Fiber-structure-improving active substances, in particular mono-, di- and oligosaccharides, such as, for example, glucose, galactose, fructose, fructose and lactose,
• - Conditioning agents such as paraffin oils, vegetable oils, eg. Sunflower oil, orange oil, almond oil, wheat germ oil and peach kernel oil as well as phospholipids, for example soya lecithin, egg lecithin and cephalins,
• Quaternized amines such as methyl-1-alkylamidoethyl-2-alkylimidazolinium methosulfate,
• Defoamers like silicones,
• Dyes for staining the agent,
• Anti-dandruff agents such as Piroctone Olamine, Zinc Omadine and Climbazole,
• - light stabilizers, in particular derivatized benzophenones, cinnamic acid derivatives and triazines,
• - Other substances for adjusting the pH, such as α- and β-hydroxycarboxylic acids
• - active substances such as allantoin and bisabolol,
• - cholesterol,
• Bodying agents such as sugar esters, polyol esters or polyol alkyl ethers,
• - fats and waxes such as spermaceti, beeswax, montan wax and paraffins,
• Fatty acid alkanolamides,
• Complexing agents such as EDTA, NTA, β-alaninediacetic acid and phosphonic acids,
• - Swelling and penetration substances such as glycerol, propylene glycol monoethyl ether, carbonates, hydrogencarbo nate, guanidines, ureas and primary, secondary and tertiary phosphates,
• Opacifiers such as latex, styrene / PVP and styrene / acrylamide copolymers
• Pearlescing agents such as ethylene glycol mono- and distearate and PEG-3-distearate,
• - pigments,
• - Reducing agents such. B. thioglycolic acid and its derivatives, thiolactic acid, cysteamine, thiomalic acid and α-mercaptoethanesulfonic acid,
• Propellants such as propane-butane mixtures, N ₂ O, dimethyl ether, CO ₂ and air,
• - antioxidants.

The inventive agent can also Containing surfactants. These can be both anionic, ampholytic, zwitterionic or nonionic surfactants as well to act cationic surfactants. The expert can do a possible Influence of different surfactants on the activity of the protease optionally check by simple preliminary tests.

In a preferred embodiment The present invention is a combination of anionic and nonionic surfactants or a combination of anionic and amphoteric surfactants used.

It but has in individual cases proved to be advantageous, the surfactants of amphoteric or nonionic Select surfactants.

When Anionic surfactants are all suitable for use in compositions according to the invention on the human body suitable anionic surface-active Substances. These are characterized by a water-solubilizing, anionic group such as. As a carboxylate, sulfate, sulfonate or phosphate group and a lipophilic alkyl group of about 10 up to 22 C atoms. additionally can in the molecule Glycol or polyglycol ether groups, ester, ether and amide groups and hydroxyl groups.

• – Anlagerungsprodukte von 2 bis 30 Mol Ethylenoxid und/oder 0 bis 5 Mol Propylenoxid an lineare Fettalkohole mit 8 bis 22 C-Atomen, an Fettsäuren mit 12 bis 22 C-Atomen und an Alkylphenole mit 8 bis 15 C-Atomen in der Alkylgruppe,
• – C₁₂-C₂₂-Fettsäuremono- und -diester von Anlagerungsprodukten von 1 bis 30 Mol Ethylenoxid an Glycerin,
• – C₈-C₂₂-Alkylmono- und -oligoglycoside und deren ethoxylierte Analoga sowie
• – Anlagerungsprodukte von 5 bis 60 Mol Ethylenoxid an Rizinusöl und gehärtetes Rizinusöl.

Nonionic surfactants contain as hydrophilic group z. A polyol group, a polyalkylene glycol ether group or a combination of polyol and polyglycol ether groups. Such compounds are, for example

• Addition products of 2 to 30 moles of ethylene oxide and / or 0 to 5 moles of propylene oxide onto linear fatty alcohols having 8 to 22 carbon atoms, to fatty acids containing 12 to 22 carbon atoms and to alkylphenols having 8 to 15 carbon atoms in the alkyl group,
• C ₁₂ -C ₂₂ -fatty acid mono- and diesters of addition products of 1 to 30 mol of ethylene oxide with glycerol,
• C ₈ -C ₂₂ alkyl mono- and oligoglycosides and their ethoxylated analogs, and
• - Addition products of 5 to 60 moles of ethylene oxide with castor oil and hydrogenated castor oil.

Preferred nonionic surfactants are alkyl polyglycosides of the general formula R ¹ O- (Z) _x . These connections are identified by the following parameters.

The alkyl radical R ¹ contains 6 to 22 carbon atoms and may be both linear and branched. Preference is given to primary linear and methyl-branched in the 2-position aliphatic radicals. Such alkyl radicals are, for example, 1-octyl, 1-decyl, 1-lauryl, 1-myristyl, 1-cetyl and 1-stearyl. Particularly preferred are 1-octyl, 1-decyl, 1-lauryl, 1-myristyl. When using so-called "oxo-alcohols" as starting materials, compounds with an odd number of carbon atoms in the alkyl chain predominate.

The alkyl polyglycosides which can be used according to the invention can contain, for example, only one particular alkyl radical R ¹ . Usually, however, these compounds are prepared starting from natural fats and oils or mineral oils. In this case, the alkyl radicals R are mixtures corresponding to the starting compounds or corresponding to the particular work-up of these compounds.

• – im wesentlichen aus C₈- und C₁₀-Alkylgruppen,
• – im wesentlichen aus C₁₂- und C₁₄-Alkyigruppen,
• – im wesentlichen aus C₈- bis C₁₆-Alkylgruppen oder
• – im wesentlichen aus C₁₂- bis C₁₆-Alkylgruppen besteht.

Particular preference is given to those alkylpolyglycosides in which R ¹

• Consisting essentially of C ₈ and C ₁₀ -alkyl groups,
• Essentially C ₁₂ and C ₁₄ -alkyl groups,
• - Essentially from C ₈ - to C ₁₆ alkyl groups or
• - Consists essentially of C ₁₂ - to C ₁₆ -alkyl groups.

As sugar building block Z it is possible to use any desired mono- or oligosaccharides. Usually, sugars with 5 or 6 carbon atoms and the corresponding oligosaccharides are used. Such sugars are, for example, glucose, fructose, galactose, arabinose, ribose, xylose, lyxose, allose, altrose, Mannose, gulose, idose, talose and sucrose. Preferred sugar building blocks are glucose, fructose, galactose, arabinose and sucrose; Glucose is particularly preferred.

The usable according to the invention Alkyl polyglycosides contain on average from 1.1 to 5 sugar units. Alkyl polyglycosides having x values of 1.1 to 1.6 are preferred. Very particular preference is given to alkyl glycosides in which x 1.1 to 1.4.

The Alkyl glycosides can in addition to their surfactant effect also serve the fixation of fragrance components to improve on the hair. The person skilled in the art will therefore be that one over the effect of the perfume oil beyond the duration of the hair treatment the hair desired is, preferably to this class of substance as a further ingredient the preparations according to the invention To fall back on.

Also The alkoxylated homologs of said alkyl polyglycosides can be used according to the invention become. These homologs can an average of up to 10 ethylene oxide and / or propylene oxide units per alkyl glycoside unit.

Furthermore, zwitterionic surfactants can be used, in particular as cosurfactants. Zwitterionic surfactants are surface-active compounds which carry at least one quaternary ammonium group and at least one -COO ^(-) or -SO ₃ ^(-) group in the molecule. Particularly suitable zwitterionic surfactants are the so-called betaines, such as the N-alkyl-N, N-dimethylammonium glycinates, for example cocoalkyldimethylammonium glycinate, N-acylaminopropyl-N, N-dimethylammonium-gyccinates, for example cocoacylaminopropyl-dimethylammonium glycinate, and Alkyl-3-carboxylmethyl-3-hydroxyethyl-imidazolines each having 8 to 18 carbon atoms in the alkyl or acyl group and the Kokosacylaminoethylhydroxyethylcarboxymethylglycinat. A preferred zwitterionic surfactant is the fatty acid amide derivative known by the INCI name Cocamidopropyl Betaine.

Also particularly suitable as co-surfactants are ampholytic surfactants. Ampholytic surfactants are understood as meaning those surface-active compounds which, apart from a C ₈ -C ₁₈ -alkyl or acyl group in the molecule, contain at least one free amino group and at least one -COOH or -SO ₃ H group and are capable of forming internal salts. Examples of suitable ampholytic surfactants are N-alkylglycines, N-alkylpropionic acids, N-alkylaminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropylglycines, N-alkyltaurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids each having about 8 to 18 C Atoms in the alkyl group. Particularly preferred ampholytic surfactants are N-cocoalkylaminopropionate, cocoacylaminoethylaminopropionate and C _12-18 acylsarcosine.

According to the invention as cationic surfactants, especially those of the quaternary ammonium type, the esterquats and amidoamines used.

preferred quaternary Ammonium compounds are ammonium halides, especially chlorides and Bromides such as alkyltrimethylammonium chlorides, dialkyldimethylammonium chlorides and trialkylmethylammonium chlorides, e.g. Cetyltrimethylammonium chloride, Stearyltrimethylammonium chloride, distearyldimethylammonium chloride, Lauryldimethylammonium chloride, Lauryldimethylbenzylammoniumchlorid and tricetylmethylammonium chloride, as well as those under the INCI names Quaternium-27 and Quaterniuni-83 known imidazolium compounds. The long alkyl chains of the above surfactants are preferred 10 to 18 carbon atoms.

Esterquats are known substances which contain both at least one ester function and at least one quaternary ammonium group as a structural element. Preferred ester quats are quaternized ester salts of fatty acids with triethanolamine, quaternized ester salts of fatty acids with diethanolalkylamines and quaternized ester salts of fatty acids with 1,2-dihydroxypropyldialkylamines. Such products are marketed under the trade names Stepantex® ^{®, ®} and Dehyquart® Armocare® ^®. The products Armocare ^® VGH-70, a N, N-bis (2-palmitoyloxyethyl) dimethylammonium chloride, as well as Dehyquart ^® F-75 and Dehyquart ^® AU-35 are examples of such esterquats.

The alkylamidoamines are usually prepared by amidation of natural or synthetic fatty acids and fatty acid cuts with dialkylaminoamines. An inventively particularly suitable compound from this group is that available under the name Tegoamid ^® S 18 commercially stearamidopropyl dimethylamine.

at it may be the compounds with alkyl groups used as surfactant each are uniform substances. It is, however, in usually preferred in the preparation of these substances by native to go out with vegetable or animal raw materials, so that one Substance mixtures with different, from the respective raw material dependent alkyl chain lengths receives.

at the surfactants, the adducts of ethylene and / or propylene oxide represent fatty alcohols or derivatives of these addition products, can both products with a "normal" homolog distribution as well as those with a narrow homolog distribution become. Under "normal" homolog distribution are understood to mean mixtures of homologs which are used in the Reaction of fatty alcohol and alkylene oxide. under the use of Alkali metals, alkali metal hydroxides or alkali metal alcoholates as catalysts. Narrowed homolog distributions are obtained when, for example Hydrotalcites, alkaline earth metal salts of ether carboxylic acids, alkaline earth metal oxides, hydroxides or alcoholates are used as catalysts. The use of products with narrow homolog distribution may be preferred.

Regarding further optional components as well as the amounts of these components used expressly on the specialist manuals known to those skilled in the art, eg. B. Kh. Schrader, Basics and formulations of cosmetics, 2nd edition, Hüthig Buch Verlag, Heidelberg, 1989, referenced.

One Another object of the present invention is the use at least one protease and at least one further component, the selected is among protein hydrolysates as well as vitamins, provitamins and Vitamin precursors and their derivatives to improve the structure keratinic fibers.

One Another object of the present invention is a method for improving the structure of keratinic fibers, characterized that is an agent according to the invention on the keratin fibers.

EXAMPLES

The following examples illustrate the invention without, however, limiting it to: Example 1: Hair conditioner Eumulgin ^® B2 0.3 Cetyl / stearyl 3.3 isopropyl 0.5 Paraffin oil perliquidum 15 cSt. DAB 9 0.3 Dehyquart® ^® A-CA 2.0 Gluadin® ^® WQ 0.2 Gluadin® ^® WLM 0.5 pantolactone 0.5 Subtilisin or papain 0.5 Phenonip ^® 0.8 water ad 100 pH = 7.0 Example 2: Hair rinse Eumulgin ^® B2 0.3 CetyllStearylalkohol 3.3 isopropyl 0.5 Paraffin oil perliquidum 15 cSt. DAB 9 0.3 Dehyquart ^® L 80 2.0 Gluadin® ^® WQ 0.5 Gluadin® ^® WLM 0.2 pantolactone 1.0 Subtilisin or papain 1.0 citric acid 0.4 Phenonip ^® 0.8 water ad 100 pH 7.0 Example 3: Hair Conditioner (rinse off) Dehyquart® ^® F75 4.0 CetyllStearylalkohol 4.0 Paraffin oil perliquidum 15 cSt. DAB 9 1.5 Dehyquart® ^® A-CA 4.0 Salcare ^® SC 96 0.5 Gluadin® ^® WQ 1.0 Gluadin® ^® WLM 1.0 pantolactone 0.5 Subtilisin or papain 0.2 citric acid 0.15 Phenonip ^® 0.8 water ad 100 pH = 7.0 Example 4: Hair Conditioner (rinse off) Dehyquart® ^® L80 4.0 Cetyl / stearyl 6.0 Paraffin oil perliquidum 15 cSt. DAB 9 2.0 Rewoquat ^® W 75 2.0 Sepigel ^® 305 0.5 Gluadin® ^® WQ 0.2 Gluadin® ^® WLM 0.5 pantolactone 0.5 Subtilisin or papain 0.5 citric acid 0.15 Phenonip ^® 0.8 water ad 100 pH = 7.0 Example 5: Conditioner (remaining on the hair) Dehyquart® ^® F75 0.3 Salcare ^® SC 96 5.0 Dow ^Corning® 200 Fluid, 5 cSt. 1.5 Gafquat ^® 755N 1.5 Biodocarb ^® 0.8 Gluadin® ^® WQ 0.2 Gluadin® ^® WLM 0.5 pantolactone 0.5 Subtilisin or papain 0.5 perfume oil 0.25 water ad 100 pH = 7.0 Example 6: Conditioner (remaining on the hair) Sepigel ^® 305 5.0 Dow Corning ^® Q2-5220 5 cSt. 1.5 Genamin ^® DSAC 0.3 Phenonip ^® 0.8 Gluadin® ^® WQ 0.5 Gluadin® ^® WLM 0.8 pantolactone 1.0 Subtilisin or papain 0.8 perfume oil 0.25 water ad 100 pH = 7.0 Example 7: Shampoo (in%): Laureth sulfate 25% 40 citric acid 0.1 sodium benzoate 0.5 Disodium Cocoamphodiacetate 6.0 salicylic acid 0.1 Hydrotriticum ^® WQ 1.0 Gluadin® ^® WQ 0.2 Gluadin® ^® WLM 0.5 pantolactone 0.5 Subtilisin or papain 0.2 Cetiol ^® HE 0.5 Perfume 0.4 NaCl 0.5 water Ad 100 Example 8: Shampoo (in%): Laureth sulfate 25% (alkaline dilution) 25.0 Citric Acid Mono Regular 0.3 Timiron ^® 0.5 sodium benzoate 0.5 Panthenol 75 L 0.2 Euperlan ^® PK 3000 8.0 Plantacare® ^® 818 UP 2.0 Uvinul ^® MS40 1.0 salicylic acid 0.2 Ajidew ^® NI-50 2.0 Cutina ^® HR Ground 0.5 Cetiol ^® HE 1.0 citric acid 0.03 ^Jaguar® Excel 0.3 Gluadin® ^® WQ 0.2 Gluadin® ^® WLM 0.5 pantolactone 0.5 Subtilisin or papain 0.5 sodium chloride 0.3 water Ad 100. Example 9: Shampoo (in%): Laureth sulfate 25% (alkaline dilution) 50 citric acid 0.4 Arlypon ^® F 0.5 Antil 171 ^® 0.3 Wheat protein hydrolyzate Cationized 1.5 sodium benzoate 0.5 Euperlan ^® PK 3000 6.0 Cocamidopropyl Betaine 45% 5.0 salicylic acid 0.2 Silsoft ^® A-858 0.3 Gluadin® ^® WQ 1.0 Gluadin® ^® WLM 1.0 pantolactone 0.5 Subtilisin or papain 0.2 Cutina ^® HR 0.2 Cetiol ^® HE 1.0 water Ad 100 Example 10: Hair styling gel: Desalinated water ad 100 Synthalen ^® K 0.6 Neutrol ^® TE 0.5 glycerin 8.00 Ethyl alcohol denatured 96 vol% Fls 30.00 Gluadin® ^® WQ 0.5 Gluadin® ^® WLM 0.5 pantolactone 1.0 Subtilisin or papain 0.2 Polyethyienglykol 2.00 PVP / VA W-635 6.50 Cremophor ^® RH 40 1.00 Perfume 0.50 pH = 7.0 Example 11: Hairspray: Amphomer.RTM ^® 3.00 Luviskol ^® VA 37 16.00 Amino-methyl-propanol 100 0.60 isopropyl 0.12 Gluadin® ^® WQ 0.5 Gluadin® ^® WLM 0.5 pantolactone 0.2 Subtilisin or papain 1.0 Perfume 0.20 Desalinated water ad 100 ethyl alcohol 67,50 pH = 7.0 Example 12: Hair Tonic: Desalinated water ad 100 Panthenol 75 0.1 Gluadin® ^® WQ 0.2 Gluadin® ^® WLM 0.5 pantolactone 0.5 Subtilisin or papain 0.5 Carbopol ^® 0.1 Neutrol ^® TE 0.10 ethyl alcohol 30.0 pH = 7.0 Example 13: Hair rinse as in Ex. 1, as a 2-component System 1. Chamber: Eumulgin ^® B2 0.3 Cetyl / stearyl 3.3 isopropyl 0.5 Paraffin oil perliquidum 15 cSt. DAB 9 0.3 Dehyquart® ^® A-CA 2.0 Gluadin® ^® WQ 0.2 Gluadin® ^® WLM 0.5 pantolactone 0.5 Phenonip ^® 0.8 water ad 100 pH = 4.0 2nd chamber Subtilisin or papain 0.5 (or papaya extract 1.0) water ad 100 Example 14: Conditioner analogous Ex 6, but in two application steps: pretreatment with enzyme Subtilisin or papain 0.5 (or papaya extract 1.0) water ad 100 Aftercare with care / repair product: Sepigel ^® 305 5.0 Dow Corning ^® Q2-5220 5 cSt. 1.5 Genamin ^® DSAC 0.3 Phenonip ^® 0.8 Gluadin® ^® WQ 0.5 Gluadin® ^® WLM 0.8 pantolactone 1.0 perfume oil 0.25 water ad 100 Example 15: Test Pattern

Execution:

Pretreatment of the hair strands

The hair (Alkinco 6634) were before the zero measurement with a Texapon.RTM ^® NSO - pre-purified solution (10% AS) and then permed standard. That is, 2 g of permanent wave gel (Poly-Lock 1) were distributed over 1 g of hair strand. Subsequently, after 40 minutes of exposure to the gel under standard conditions, it was rinsed with cold tap water for 60 seconds. This was followed by fixing with 2 g of Poly-Lock 2 per 1 g of hair strand over a period of 10 minutes.

product application

A strand of hair was with an aqueous solution treated by the respective active ingredient mixture. The immersion time was 15 minutes at room temperature. Subsequently, the hair was 30 seconds under cold, flowing Rinsed tap water and air-dried.

DSC measurements

to Verifying the repair effect, DSC measurements were performed. The strands were in small pieces Cut (~ 1 mm) and then 5 aliquots of each strand of hair in the DSC measuring vessels transferred. To Addition of aqua deion. the measurements were made in a temperature range from 110-170 ° C, at 10 ° C / min. determined were the melting point (peak maximum in [° C]) and the Denaturierungsenthalpie (Area below the peak in [J / g]).

The following measured values (significance level> 99%) have resulted: 1st series of measurements (leave-on) zero measurement 152.6 ° C Gluadin® ^® WLM, pantolactone, Exfocellia ^® 153.8 ° C 2nd series of measurements (rinse-off) zero measurement 151.9 ° C Gluadin® ^® WLM and Exfocellia ^® 153.7 ° C Gluadin® ^® WLM, Pantolaeton, Exfocellia ^® 154.2 ° C Exfocellia ^® (Comparative Experiment) 152.7 ° C (no significant improvement) 3rd measurement series (leave-on) zero measurement 151.9 ° C Gluadin® ^® WQ, Gluadin® ^® WLM, Papaya Fruit HPG ^® 153.0 ° C Gluadin® ^® WLM, Papaya Fruit HPG ^® 153.3 ° C Gluadin® ^® WLM, pantolactone, Papaya Fruit HPG ^® 153.9 ° C 4th measurement series (leave-on) zero measurement 152.9 ° C Gluadin ^® WQ (comparative experiment) 153.3 ° C (no significant improvement) Gluadin ^® WLM (comparative experiment) 153.7 ° C (no significant improvement) 5th series of measurements (rinse-off) zero measurement 152.9 ° C Gluadin® ^® WLM, Papaya Fruit HPG ^®, pantolactone 154.4 ° C 6th series of measurements (rinse-off) zero measurement 153.9 ° C Gluadin ^® WQ (comparative experiment) 153.6 ° C (no significant improvement) Gluadin ^® WLM (comparative experiment) 154.6 ° C (no significant improvement)

directory the commercial products used

The commercial products used in the examples are as follows Are defined:

Ajidew ^® NL50 sodium salt the pyrrolidonecarboxylic acid (about 48-52% active ingredient content; INCI name: Sodium PCA) (Ajinomoto) Amphomer.RTM ^® INCI name: Otylacrylamide / Acrylates / Butylaminoethyl Methacrylate Copolymer (National Starci) Antil 171 ^® Polyol fatty acid esters (INCI name: PEG-18 Glyceryl Oleate / Cocoate) (Goldschmidt) Arlypon ^® F C12-14 fatty alcohol with approx. 2.5 EO units (INCI name: Laureth-2) (Cognis) Biodocarb ^® 3-iodo-2-n-butylcarbamate proinyl- (INCI name: iodopropynyl butylcarbamate) (Milker & Grüning) Carbopol ^® Polyarcylic acid (INCI name: Carbomer) (Noveon) Cetiol ^® HE Kokosmonglycerid with approx. 7.3 EO units (INCI name: PEG-7 glyceryl cocoate) (Cognis) Cremophor ^® RH40 hydrogenated castor oil with about 40-45 EO units (INCI name: PEG-40 Hydrogenated Castor Oil) (BASF) Cutina ^® HR hardened castor oil (INCI name: Hydrogenated Castor Oil) (Cognis)

Dehyquart® ^® A-CA trimethylhexadecylammonium (about 24-26 Active substance; INCI name: Aqua (Water), Cetrimonium Chloride) (Cognis) Dehyquart® ^® F75 Fatty alcohol Methyltriethanolammoniummethylsulfat- Dialkyl ester mixture (INCI name: Distearoylethyl Hydroxyethylmonium Methosulfates, cetearyl alcohol) (HENKEL) Dehyquart® ^® L80 Bis (Cocoylethyl) -hydroxyethyl-methyl-methosulfate (about 76% active ingredient in propylene glycol; INCI name: dicocoylethyl Hydroxyethylmonium methosulfate, propylene glycol) (Henkel) Dow ^Corning® 200 Fluid polydimethylsiloxane (INCI name: Dimethicone) (Dow Corning) Dow Corning ^® Q2-5220 Silicone glycol copolymer (INCI name: Dimethicone Copolyol) (Dow Corning) Eumulgin ^® B2 Cetylstearylalkohol with approx. 20 EO units (INCI name: Ceteareth-20) (Cognis) Euperlan ^® PK3000 approximately 60-64% Solid; INCI name: Glycol Distearate, Glycerin, Laureth-4, Cocamidopropyl Betaine) (Cognis) Exfocellia ^® subtilisin extracted from Bacillus licheniformis (INCI name: Water, Subtilisin, Xanthan Gum) Gafquat ^® 755 Dimethylaminoethylmethacrylate-vinylpyrrolidone copolymer, quaternized with diethyl sulfate (about 19% solids in water; INCI name: Polyquaternium-11) (ISP) Genamin ^® DSAC dimethyl (INCI name: Distearyldimonium Chloride) (Clariant) Gluadin® ^® WLM Wheat protein hydrolyzate (about 21-24% Solid; INCI name: Hydrolyzed Wheat Protein) (Cognis)

Gluadin® ^® WQ Wheat protein hydrolyzate (about 31-35% Solid; INCI name: Aqua (Water), Lauridimonium Hydraxypropyl Hydrolyzed Wheat Protein, Ethylparaben, methylparaben) (Cognis) Hydrotriticum ^® WQ approximately 26-30% Solid; INCI name: Aqua (Water), Hydroxypropyltrimonium Hydrolyzed Wheat protein; (Croda) Jaguar ^Excel® Guarhydroxypropyltrimethylammoniumchlorid (about 89% active ingredient content; INCI name: guar hydroxypropyltrimonium Chlorides) (Rhodia) Neutrol ^® TE N, N, N ', N', - tetrakis (2-hydroxypropyl) ethylenediamine (INCI name: Tetrahydroxypropyl ethylene diamine) (BASF) Papaya Fruit HPG ^® (Ca. 5 to 9.9% Carica papaya in propylene glycol and water, preserved. with parabens; INCI name: Carica papaya L.) (Alban Muller Industrie) Phenonip ^® Hydroxybenzoic acid methyl ester hydroxybenzoic acid ethyl ester hydroxybenzoic acid propyl ester hydroxybenzoic acid butyl ester phenoxyethanol mixture (about 28%) Active substance; INCI name: phenoxyethanol, methylparaben, Ethylparaben, propylparaben, butylparaben) (NIPA) Plantacare® ^® 818UP C8-14 polyglucoside (about 51-53% Akticsubstanzgehalt; INCI name: Coco-Glucoside, Aqua (Water)) (Cognis) PVP / VA W-635 vinylpyrrolidone Vinyl acetate copolymer (about 48-52% solids in Water; INCI name: VP / VA Copolymer) (ISP) Rewoquat ^® W75 I-methyl-2-nortalgalkyl-3-talgfettsäureamidoethylimidazolinium methosulfate (about 75% active ingredient in propylene glycol; INCI name: Quaternium-27, Propylene Glycol) (WITCO)

Salcare ^® SC 96 approximately 50% active substance content; INCI name: Polyquaternium-37, Propylene Glycol Dicaprylate / Dicaprate, PPG-1 Trideceth-6 (CIBA) Sepigel ^® 305 approximately 45-49% Solid; INCI name: polyacrylamide, C13-14 isoparafi = fn, laureth-7) (Seppic) Silsoft ^® A 858 INCI name: DEA PG-Propyl PEG / PPG-18/21 Dimethicone) (GE Silicones) Synthalen ^® K Polyacrylic acid (ca. 89% active ingredient content; INCI name: Carbomer) (3V Sigma) Uvinul ^® MS40 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (100% Active substance content; INCI name: Benzophenone4) (BASF)

Claims (14)

Agent for the treatment of keratinic fibers, containing at least one protease and at least one further component, the selected is among protein hydrolysates as well as vitamins, provitamins and Vitamin precursors and their derivatives. Means according to claim 1, characterized in that the protease selected is among serine endopeptidases and cysteine endopeptidases, in particular under subtilisin, papain and bromelain. Agent according to claim 1 or 2, characterized that the enzymes in amounts of 0.005 to 10 wt .-%, based on the whole preparation, especially in. Amounts of 0.01 to 5 wt .-%. Agent according to one of the preceding claims, characterized in that the at least one further component in amounts of 0.005 to 10 wt .-%, based on the total preparation, is contained, preferably in. amounts of 0.01 to 2 wt .-%. Agent according to one of the preceding claims, characterized characterized in that it comprises at least one protein hydrolyzate and at least a vitamin, provitamin or a vitamin precursor and one of them Contains derivatives. Agent according to one of the preceding claims, characterized labeled as a vitamin, provitamin or a vitamin precursor and one of its derivatives containing pantolactone. Agent according to one of the preceding claims, characterized characterized in that it comprises at least one cationic protein hydrolyzate contains. Agent according to one of the preceding claims, characterized characterized in that it contains at least one wheat protein hydrolyzate. Agent according to one of the preceding claims, characterized characterized in that it is at least one cationic and at least contains a nonionic protein hydrolyzate. Agent according to one of the preceding claims, characterized that it is pantolactone, a cationic as well as a contains nonionic wheat protein hydrolyzate. Agent according to one of the preceding claims, characterized characterized in that it as a single chamber system or as a two-chamber system in the case of a two-chamber system, the enzyme component and the repair material component spatially are separated from each other. Use of at least one protease and at least another component selected from protein hydrolysates as well as vitamins, provitamins and vitamin precursors as well as their derivatives to improve the structure of keratinic fibers. Process for improving the structure keratinischer Fibers, characterized in that one means according to the invention on the keratin fibers. Two-part kit for treating keratinous fibers, characterized in that it a) a first region containing the protease and b) a second area containing the one additional component selected is among protein hydrolysates as well as vitamins, provitamins and Vitamin precursors and their derivatives, includes.