DE102004021739B4 - Metal implant with surface coating - Google Patents
Metal implant with surface coating Download PDFInfo
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- DE102004021739B4 DE102004021739B4 DE200410021739 DE102004021739A DE102004021739B4 DE 102004021739 B4 DE102004021739 B4 DE 102004021739B4 DE 200410021739 DE200410021739 DE 200410021739 DE 102004021739 A DE102004021739 A DE 102004021739A DE 102004021739 B4 DE102004021739 B4 DE 102004021739B4
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- metal implant
- selenium
- layer
- metal
- implant according
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- 239000007943 implant Substances 0.000 title claims abstract description 22
- 229910052751 metal Inorganic materials 0.000 title claims abstract description 18
- 239000002184 metal Substances 0.000 title claims abstract description 18
- 239000011248 coating agent Substances 0.000 title 1
- 238000000576 coating method Methods 0.000 title 1
- 239000011669 selenium Substances 0.000 claims abstract description 22
- 229910052711 selenium Inorganic materials 0.000 claims abstract description 21
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000010410 layer Substances 0.000 claims abstract description 13
- 230000003647 oxidation Effects 0.000 claims abstract description 6
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 6
- 239000002344 surface layer Substances 0.000 claims abstract description 5
- 239000003792 electrolyte Substances 0.000 claims description 10
- 239000010936 titanium Substances 0.000 claims description 7
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 claims description 3
- 229940062672 calcium dihydrogen phosphate Drugs 0.000 claims description 3
- 235000019691 monocalcium phosphate Nutrition 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 3
- -1 alkali metal selenates Chemical class 0.000 claims description 2
- 239000000956 alloy Substances 0.000 claims description 2
- 229910045601 alloy Inorganic materials 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- 229960001714 calcium phosphate Drugs 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
- 239000002585 base Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 229940091258 selenium supplement Drugs 0.000 description 15
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 229940065287 selenium compound Drugs 0.000 description 3
- 150000003343 selenium compounds Chemical class 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FDKWRPBBCBCIGA-REOHCLBHSA-N (2r)-2-azaniumyl-3-$l^{1}-selanylpropanoate Chemical compound [Se]C[C@H](N)C(O)=O FDKWRPBBCBCIGA-REOHCLBHSA-N 0.000 description 1
- PMYDPQQPEAYXKD-UHFFFAOYSA-N 3-hydroxy-n-naphthalen-2-ylnaphthalene-2-carboxamide Chemical compound C1=CC=CC2=CC(NC(=O)C3=CC4=CC=CC=C4C=C3O)=CC=C21 PMYDPQQPEAYXKD-UHFFFAOYSA-N 0.000 description 1
- FDKWRPBBCBCIGA-UWTATZPHSA-N D-Selenocysteine Natural products [Se]C[C@@H](N)C(O)=O FDKWRPBBCBCIGA-UWTATZPHSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000006587 Glutathione peroxidase Human genes 0.000 description 1
- 108700016172 Glutathione peroxidases Proteins 0.000 description 1
- PEAWWLOMUTVTBZ-UHFFFAOYSA-N O=[Se].[O-2].[O-2].O.[Na+].[K+].[Zn+2] Chemical compound O=[Se].[O-2].[O-2].O.[Na+].[K+].[Zn+2] PEAWWLOMUTVTBZ-UHFFFAOYSA-N 0.000 description 1
- 239000002519 antifouling agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000004053 dental implant Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000003641 microbiacidal effect Effects 0.000 description 1
- 229940124561 microbicide Drugs 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 230000009979 protective mechanism Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- ZKZBPNGNEQAJSX-UHFFFAOYSA-N selenocysteine Natural products [SeH]CC(N)C(O)=O ZKZBPNGNEQAJSX-UHFFFAOYSA-N 0.000 description 1
- 229940055619 selenocysteine Drugs 0.000 description 1
- 235000016491 selenocysteine Nutrition 0.000 description 1
- 229960001881 sodium selenate Drugs 0.000 description 1
- 235000018716 sodium selenate Nutrition 0.000 description 1
- 239000011655 sodium selenate Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
- A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Medizinisches Metallimplantat mit biokompatibler, poröser Oberflächenschicht, dadurch gekennzeichnet, dass die Schicht durch elektrochemisch-plasmachemische anodische Oxidation erhalten wird und Selen enthält.medical Metal implant with biocompatible, porous surface layer, characterized that the layer by electrochemical-plasmachemic anodic Oxidation is obtained and contains selenium.
Description
Die Erfindung betrifft oberflächenbeschichtete medizinische Metallimplantate, besonders aus Titan oder Titanbasislegierungen, geeignet für die Implantation in Knochen, sowie die Herstellung der beschichteten Metallimplantate.The The invention relates to surface-coated medical metal implants, in particular of titanium or titanium-based alloys, suitable for the implantation in bone, as well as the production of the coated ones Metal implants.
Selen besitzt im menschlichen Organismus eine essentielle Rolle für das Immunsystem. Es liegt dabei in einer Vielzahl von Proteinen vor. Das Spurenelement ist unter anderem Bestandteil des antioxidativ wirkenden Enzyms Glutathionperoxidase, welches den Schutzmechanismus gegen freie Radikale durch das Selen aktiviert. Auch die Aktivität eines Schilddrüsenhormones ist durch gezielte Selenaufnahme beeinflussbar. Das Element ist hierbei im Selenocystein gebunden.selenium has an essential role for the immune system in the human organism. It is present in a variety of proteins. The trace element is part of the antioxidant enzyme Glutathione peroxidase, which is the protective mechanism against free Radicals activated by the selenium. Also the activity of a thyroid Hormones is influenced by specific selenium intake. The element is bound in selenocysteine.
Neben der Stärkung des Immunsystems besitzt Selen eine entzündungshemmende Wirkung. Entsprechende Anwendungen werden in der Krebstherapie beschrieben und zur Heilung genutzt. Die tägliche Selenaufnahmedosis sollte zwischen 70 und 400 μg/Tag liegen, da sonst Mangelerscheinungen oder Selenosen folgen.Next the strengthening In the immune system selenium has an anti-inflammatory effect. Appropriate Applications are described in cancer therapy and for healing used. The daily Selenaufnahmedosis should be between 70 and 400 micrograms / day, otherwise deficiency symptoms or Selenoses follow.
Die
antiseptische bzw. entzündungshemmende
Wirkung von Selenverbindungen wird als „anti-fouling agent" in WO 00/016624 A1 bei medizinischen
Implantanten beschrieben. Dabei wird die Selenverbindung aber erst
kurz vor der Anwendung durch Tränken
aufgebracht. Ein weiterer Einsatz selenhaltiger Implantatmaterialien
für subkutane
Implantate auf der Basis von Gläsern
geschmolzener Natriumoxid-Kaliumoxid-Zinkoxid-Selenoxid-Mischungen
findet sich in
Nach WO 02/078759 A1 können poröse Oberflächenschichten auf Ti-Implantaten mittels Ethylendiamintetraessigsäure-haltigen Elektrolyten erhalten werden.To WO 02/078759 A1 can porous surface layers on Ti implants using ethylenediaminetetraacetic acid-containing Electrolytes are obtained.
In WO 00/72776 A1 werden poröse Oxidschichtstrukturen auf Ti-Implantaten diskutiert, die keine Selen-Komponenten enthalten, aber auch keine die Biokompatibilität steigernden Verbindungen wie beispielsweise Ca-Phosphate aufweisen, wie sie in US-Patent 6,596,338 B2 aufgeführt werden.In WO 00/72776 A1 become porous Oxide layer structures discussed on Ti implants that do not contain selenium components but also biocompatibility-enhancing compounds such as For example, have Ca phosphates, as described in US Patent 6,596,338 B2 listed become.
Der vorliegenden Erfindung lag die Aufgabe zugrunde, Oberflächen von Metallimplantaten derart zu beschichten bzw. zu modifizieren, dass biokompatible poröse Oberflächen mit biologisch wirksamen Selenkomponenten entstehen und eine Verbesserung der antiseptischen bzw. entzündungshemmenden Wirkung der Metallimplantate erreicht wird.Of the Present invention was based on the object surfaces of To coat or modify metal implants such that biocompatible porous surfaces with biologically active selenium components and an improvement the antiseptic or anti-inflammatory Effect of metal implants is achieved.
Erfindungsgemäß wird auf
das Metallimplantatmaterial eine poröse selenhaltige Schicht aus bio-kompatiblem
Material mit Hilfe elektrochemisch-plasmachemische Oxidation aufgebracht.
Die erfindungsgemäße Schicht
enthält
im allgemeinen bis zu 1,1% Se. Das Selen wird in die Schichtmatrix eingelagert.
Bevorzugt werden als biokompatible Schichten poröse, Ca-phosphathaltige Schichten eingesetzt,
d.h.
es werden Ca-phosphathaltige Schichten mittels plasmachemisch-elektrochemischer
anodischer Oxidation von Titanimplantaten in selenhaltigen Elektrolytsystemen
erzeugt. Dabei ist der Konzentrationsbereich der darin enthaltenen
Selenverbindungen so zu wählen,
dass keine verstärkte
Selenabscheidung auf der Kathodenoberfläche auftritt, sondern eine
Einlagerung des Selens in die Schicht erfolgt.According to the invention, a porous selenium-containing layer of bio-compatible material is applied to the metal implant material with the aid of electrochemical-plasmachemical oxidation. The layer of the invention generally contains up to 1.1% Se. The selenium is incorporated in the layer matrix. Preference is given to using porous, calcium phosphate-containing layers as biocompatible layers,
ie Ca-phosphate-containing layers are produced by means of plasma-chemical-electrochemical anodic oxidation of titanium implants in selenium-containing electrolyte systems. In this case, the concentration range of the selenium compounds contained therein should be chosen so that no increased selenium deposition on the cathode surface occurs, but a storage of selenium in the layer takes place.
Die so gebildete selenhaltige Schicht ist porös und zeigt eine stark strukturierte Oberfläche. Die auf dem Ti-Substrat fest haftende Schicht verfügt über ein Porensystem, welches nicht untereinander vernetzt ist, sondern aus isolierten geschlossenen bzw. zur Oberfläche geöffneten Poren mit einem mittlerem Porendurchmesser von 1–2 μm besteht.The thus formed selenium-containing layer is porous and shows a highly structured Surface. The firmly adhering to the Ti substrate layer has a Pore system, which is not networked with each other, but out isolated closed or open to the surface pores with a middle Pore diameter of 1-2 microns.
Neben dem Einsatz von Kalziumdihydrogenphospat-Grundelektrolyten, können auch Schwefel- oder Phosphorsäurelösungen als Grundelektrolyt dienen. Die selenhaltige Verbindung wird im Grundelektrolyten gelöst und das Metallimplantat darin bei hohen Spannungen einer elektrochemisch-plasmachemischen Oxidation unterworfen.Next The use of calcium dihydrogen phosphate base electrolytes may also Sulfuric or phosphoric acid solutions as Serve basic electrolyte. The selenium-containing compound is in the base electrolyte solved and the metal implant therein at high voltages of an electrochemical-plasma-chemical Subjected to oxidation.
Der Selenanteil bewirkt eine langsame Freisetzung des Selens. Die mikrobizide Wirkung macht erfindungsgemäß beschichtete Metallimplantate insbesondere für Risikopatientengruppen geeignet.Of the Selenium causes a slow release of selenium. The microbicides Effect makes coated according to the invention Metal implants in particular for Risk patient groups suitable.
Die Erfindung wird an nachstehendem Ausführungsbeispiel beschrieben.The Invention will be described in the following embodiment.
Beispiel:Example:
30 g/l Kalziumdihydrogenphospat und 0,8 g/l Natriumselenat werden in wässriger Lösung aufgelöst. In diesem Elektrolyten wird die elektrochemisch-plasmachemische Oxidation eines Ti-Dental-implantates mit einer Gesamtoberfläche von 2,5 cm2 bei Elektrolyttemperaturen zwischen 18°C–35°C so durchgeführt, dass 130 s an der Metallimplantatoberfläche Plasmaentladungen auftreten. Das Anodenpotential liegt dabei im Bereich von 165 V.30 g / l calcium dihydrogen phosphate and 0.8 g / l sodium selenate are dissolved in aqueous solution. In this electrolyte, the electrochemical-plasmachemic oxidation of a Ti-dental implant with a total surface area of 2.5 cm 2 at electrolyte temperatures between 18 ° C-35 ° C is performed so that 130 s on the metal implant surface plasma discharges occur. The anode potential is in the range of 165 V.
Anschließend erfolgt die Spülung des Metallimplantates in dest. Wasser. Die Abschlußspülung erfolgt in einem Wasser/Propanol Gemisch 1:1.Then done the conditioner of the metal implant in dest. Water. The final rinse takes place in a water / propanol mixture 1: 1.
Claims (7)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE200410021739 DE102004021739B4 (en) | 2004-04-30 | 2004-04-30 | Metal implant with surface coating |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE200410021739 DE102004021739B4 (en) | 2004-04-30 | 2004-04-30 | Metal implant with surface coating |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE102004021739A1 DE102004021739A1 (en) | 2005-11-24 |
| DE102004021739B4 true DE102004021739B4 (en) | 2007-11-22 |
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ID=35219988
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|---|---|---|---|
| DE200410021739 Expired - Fee Related DE102004021739B4 (en) | 2004-04-30 | 2004-04-30 | Metal implant with surface coating |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090220566A1 (en) * | 2006-02-01 | 2009-09-03 | Jake Barralet | Bioimplants for use in tissue growth |
| DE102006025682A1 (en) | 2006-06-01 | 2007-12-06 | Linde Ag | Production of a medical implant for joints comprises coating the implant with a particulate material by cold gas spraying |
| EP2097118B1 (en) * | 2006-12-21 | 2013-09-18 | Thommen Medical Ag | Bioactive implant coating |
| DE102007032686A1 (en) * | 2007-07-13 | 2009-01-15 | Biotronik Vi Patent Ag | Stent with a coating |
| DE102007042451A1 (en) * | 2007-09-06 | 2009-03-12 | Biotronik Vi Patent Ag | Stent with a body made of a biocorrodible alloy |
| DE102009016554A1 (en) | 2009-02-19 | 2010-09-09 | Heraeus Kulzer Gmbh | Medical implant i.e. dental implant, for implanting in human body, has metallic body comprising surface layer which contains calcium and/or phosphorus, where zirconium and/or zirconium dioxide are stored in surface layer |
| ES2399261B1 (en) * | 2011-09-13 | 2013-10-18 | Universidad De Vigo | SYNTHETIC COATING OF BONE IMPLANT. |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0987031A1 (en) * | 1998-09-15 | 2000-03-22 | Isotis B.V. | Method for coating medical implants |
| DE10227935A1 (en) * | 2002-06-21 | 2004-01-15 | Heraeus Kulzer Gmbh & Co. Kg | Antibiotic coating of porous bodies and process for their production and use |
| EP1407764A1 (en) * | 1998-04-17 | 2004-04-14 | PSIMEDICA Limited | Implants for administering substances and methods of producing implants |
-
2004
- 2004-04-30 DE DE200410021739 patent/DE102004021739B4/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1407764A1 (en) * | 1998-04-17 | 2004-04-14 | PSIMEDICA Limited | Implants for administering substances and methods of producing implants |
| EP1071398B1 (en) * | 1998-04-17 | 2004-05-26 | PSIMEDICA Limited | Implants for administering substances and methods of producing implants |
| EP0987031A1 (en) * | 1998-09-15 | 2000-03-22 | Isotis B.V. | Method for coating medical implants |
| DE10227935A1 (en) * | 2002-06-21 | 2004-01-15 | Heraeus Kulzer Gmbh & Co. Kg | Antibiotic coating of porous bodies and process for their production and use |
Also Published As
| Publication number | Publication date |
|---|---|
| DE102004021739A1 (en) | 2005-11-24 |
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