DE10134603A1 - Cosmetic or dermatological preparations with a long-lasting cooling effect - Google Patents

Abstract

Cooling cosmetic or medicinal topical preparations are characterized by having a content of methyl palmitate.

Description

The present invention relates to cosmetic and dermatological preparations long-lasting cooling effect, in particular cosmetic and cosmetic skin care dermatological preparations.

The skin is the largest organ in humans. Among its many functions (for example for heat regulation and as a sensory organ) is the barrier function that Dehydration of the skin (and ultimately the entire organism) prevents that important. At the same time, the skin acts as a protective device against penetration and the absorption of substances coming from outside. This barrier function is brought about by the epidermis, which as the outermost layer is the actual protective cover against the Environment forms. At around a tenth of the total thickness, it is also the thinnest Layer of skin.

The outermost layer of the epidermis, the stratum corneum (horny layer), is important Barrier layer of particular importance u. a. for protection against environmental influences and Dehydration. The horny layer is constantly worn out and in contact with the environment must therefore be renewed continuously.

The stratum corneum is a skin model that is widely used in the professional world today Two-component system, similar to a brick wall (brick-mortar model), on. In this model, the corneocytes (horn cells) correspond to the bricks that complex lipid membrane in the intercellular spaces corresponds to this Mortar.

In addition to their barrier effect against external chemical and physical influences the epidermal lipids also contribute to the cohesion of the horny layer and have an influence on the smoothness of the skin. In contrast to the sebum lipids, which are not closed Forming film on the skin are the epidermal lipids over the entire horny layer distributed.

The extremely complex interaction of the moisture-binding substances and the Lipids from the upper layers of the skin are very important for the regulation of skin moisture. Therefore, cosmetics usually contain, in addition to balanced lipid blends and Water, water-binding substances.

In addition to the chemical composition, there is also the physical behavior of these substances matter. Therefore, the development is very good biocompatible emulsifiers or surfactants with liquid crystalline properties are desirable. Products formulated in this way support the liquid crystalline organization of Intercellular lipids of the stratum corneum and thus improve the barrier properties of the Stratum corneum. It is particularly advantageous if their molecular constituents consist of substances that occur naturally in the epidermis.

Cosmetic skin care means primarily that the natural Function of the skin as a barrier against environmental influences (e.g. dirt, chemicals, Microorganisms) and against the loss of the body's own substances (e.g. water, natural fats, Electrolytes) is strengthened or restored.

If this function is disturbed, the absorption of toxic or allergenic substances may increase Substances or for infestation of microorganisms and as a result too toxic or allergic skin reactions are coming.

The aim of skin care is also to reduce the fat and fat caused by daily washing Compensate for skin water loss. This is especially important when the natural Regeneration capacity is not sufficient. In addition, skin care products are said to exist Protect environmental influences, especially from the sun and wind, and skin aging delay.

Medical topical compositions typically contain one or more Medications in effective concentration. For the sake of simplicity, it becomes clean Differentiation between cosmetic and medical application and corresponding Products on the legal provisions of the Federal Republic of Germany referenced (e.g. cosmetics regulation, food and drug law).

Common cosmetic dosage forms are emulsions, i.e. metastable two or Multi-phase systems in which the individual phases are in the liquid state. The most common emulsions are O / W and W / O emulsions. rarer Dosage forms are multiple emulsions, i.e. those which are dispersed in the droplets (or discontinuous) phase in turn droplets of another dispersed phase included, e.g. B. W / O / W emulsions and O / W / O emulsions.

In order to be able to guarantee the metastability of emulsions, as a rule Surface-active substances, i.e. emulsifiers, are necessary.

It is possible to produce emulsifier-free preparations, which are used, for example, in a aqueous phase dispersed oil droplets, similar to an O / W emulsion. A prerequisite for this can be that the continuous aqueous phase is the dispersed Phase stabilizing gel structure and other circumstances more. Such systems are sometimes called hydrodispersions or oleodispersions, depending on which is the disperse and which is the continuous phase.

Usual, and more and more widespread cosmetic and dermatological forms of preparation are gels.

In the technical sense, gels are understood to mean: Relatively stable, light deformable disperse systems from at least two components, which usually consist of a - mostly solid - colloidally divided substance from long-chain molecular groups (e.g. Gelatin, silica, polysaccharides) as a scaffold and a liquid Dispersing agents (e.g. water) exist. The colloidally divided substance is often called a thickening or gelling agent. It forms a spatial network in the dispersant, where individual colloidal particles are present via electrostatic interaction can be more or less firmly linked. The dispersant, which surrounding the network is characterized by electrostatic affinity for the gelling agent, d. that is, a predominantly polar (in particular: hydrophilic) gelling agent gels preferably a polar dispersing agent (especially: water), whereas a predominantly non-polar gelling agent preferably non-polar gelling agent gelled.

Strong electrostatic interactions, for example in Hydrogen bonds between gelling agent and dispersing agent, but also between Dispersant molecules are realized with each other, can lead to strong crosslinking also lead the dispersant. Hydrogels can be almost 100% water exist (in addition, for example, about 0.2-1.0% of a gelling agent) and thereby quite solid Have consistency. The water content is in ice-like structural elements, so that gele therefore originates from its name (from lat. "gelatum" = "frozen" about the alchemical expression "gelatina" (16th century) for nhdt. "Gelatin"] is fair become.

In cosmetic and pharmaceutical galenics there are also lipogels and Oleogels (from waxes, fats and fatty oils) and carbogels (from paraffin or Petrolatum) common. In practice, a distinction is made between oleogels, which are practically water-free are present, hydrogels which are practically fat-free. Most of the time, gels are transparent. In In cosmetic or pharmaceutical galenics, gels are usually distinguished due to semi-solid, often flowable consistency.

So-called surfactant gels are also common preparations of the prior art Technology. This means systems that, in addition to water, have a high concentration Emulsifiers typically have more than about 25% by weight, based on the Total composition. Solubilized in these surfactant gels, also "surfactant" called "gels", oil components, microemulsion gels are obtained, which are also called "ringing gels" are referred to. By adding nonionic emulsifiers, For example, alkyl polyglycosides, cosmetically elegant microemulsion gels receive.

So far, the cooling effect of cosmetic preparations has been based on two basic principles:
Use of components which, after topical application, evaporate in gaseous form and remove the required amount of energy, the so-called enthalpy of vaporization, for the most part from the skin surface. Suitable liquid components are therefore used in corresponding non-occlusive cosmetics. Ethanol has proven to be particularly suitable here, and formulations with a high water content also have a clear cooling effect.

Use of so-called cooling agents that work with the skin's heat receptors Interact and thus trigger a feeling of cold without a measurable to generate physical cooling. Menthol and various come in particular for this Menthol derivatives (Frescolate, Physcool, Questice L, etc.) are used. In particular high ethanol levels as well as menthol and its derivatives are, besides the irritating Potential. in particular due to its distinct smell for numerous purposes not suitable from an olfactory point of view. Such effects often enough In addition, substances also increase blood circulation, on the contrary Causes a feeling of warmth.

In the literature, for example, ionic compounds, in particular Ammonium salts, described as cooling agents. Also used as cooling preparations Widely used isopropanolic gels with camphor and menthol additives.

The application of these substances, especially on irritated skin, is in any case problematic. In addition, many of these compounds are poorly water-soluble. Your Use is therefore limited to a few cosmetics and dermatics.

The object of the present invention was therefore to care and cosmetic to provide medical preparations that do not have the disadvantages of the prior art Have technology, especially those that are on the skin or mucous membranes applied, moisturizing and / or cooling.

DE 43 12 656 describes the use cosmetically or pharmaceutically harmless substances with positive enthalpy of solution in cosmetic or medicinal topical preparations, characterized in that the substance or Substances are present in the preparations in a largely anhydrous medium and / or shielded from a water-containing medium by a material barrier become.

Although this procedure is basically a cosmetically satisfactory preparation can lead, but these are extremely difficult to produce galenically.

It was therefore the object of the present invention, the shortcomings of the prior art Remedy technology and cooling cosmetic or dermatological preparations To provide, which are easy to manufacture, no irritation to skin or Exercise mucous membranes and pleasant when used as directed Donate cooling.

However, it was astounding and unpredictable for those skilled in the art that cooling cosmetic or medical topical preparations, characterized by a content of methyl palmitate, eliminate the disadvantages of the prior art.

According to the invention, the use of methyl palmitate for the production is also cooling active cosmetic or medical topical preparations.

These preparations according to the invention develop their cooling effect within a wide range of use concentrations of methyl palmitate, for example 0.5-50 % By weight, advantageously 1-20% by weight, based on the total weight of the preparations. They are easy to formulate and make no great demands Manufacturing operations.

The preparations according to the invention may also be used if necessary other cooling agents, for example menthol or menthol derivatives sensory modification or to enhance the cooling effect.

According to the invention, preparations containing the inventive Contain active ingredient combinations, usual antioxidants are used.

The antioxidants are advantageously selected from the group consisting of amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D, L-carnosine, D- Carnosine, L-carnosine and their derivatives (e.g. anserine), carotenoids, carotenes (e.g. α-carotene, β-carotene, lycopene) and their derivatives, lipoic acid and their derivatives (e.g. dihydroliponic acid), Aurothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl) , Oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (e.g. buthioninsulfoximines Homocysteine sulfoximine, buthionine sulfones, penta-, hexa-, heptathionine sulfone oximin) in very low tolerable doses (e.g. B. pmol to µmol / kg), furthermore (metal) chelators (e.g. α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, bile acid, Bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g. γ-linolenic acid, linoleic acid, oleic acid), folic acid and their derivatives, alanine diacetic acid, flavonoids, polyphenols, catechins, vitamin C and derivatives ( e.g. ascorbyl palmitate, Mg ascorbyl phosphate, ascorbylacetate), tocopherols and derivatives (e.g. vitamin E acetate), as well as coniferyl benzoate of benzoic resin, rutinic acid and its derivatives, ferulic acid and its derivatives, butylated hydroxytoluene, butylated hydroxyanidic acid, Nordarzydajihihid, nordihydajihihuethane, nordihydajihihu acid , Trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives (e.g. ZnO, ZnSO ₄ ) selenium and its derivatives (e.g. selenomethionine), stilbene and their derivatives (e.g. stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these active substances.

The amount of antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30% by weight, particularly preferably 0.05-20% by weight, in particular 1-10 wt .-%, based on the total weight of the preparation.

Prophylaxis or cosmetic or dermatological treatment with the Active ingredient used according to the invention or with the cosmetic or topical dermatological preparations with an effective content of the invention The active ingredient used is carried out in the usual way, in such a way that the Active ingredient used according to the invention or the cosmetic or topical dermatological preparations with an effective content of used according to the invention Active ingredient is applied to the affected skin.

The active ingredient used according to the invention can advantageously be incorporated into usual cosmetic and dermatological preparations, which come in different forms can be present. So you can z. B. a solution, an emulsion of the water-in-oil type (W / O) or of the oil-in-water (O / W) type, or a multiple emulsions, for example of the type water-in-oil-in-water (W / O / W) or oil-in-water-in-oil (O / W / O), one Hydrodispersion or lipodispersion, a gel, a solid stick or an aerosol represent.

Emulsions according to the invention in the sense of the present invention, for. B. in the form of a Cream, a lotion, a cosmetic milk are advantageous and contain z. B. fats, Oils, waxes and / or other fat bodies, as well as water and one or more Emulsifiers commonly used for such a type of formulation become.

It is also possible and advantageous in the sense of the present invention that Active ingredient used according to the invention in aqueous systems or surfactant preparations for Insert cleaning of the skin and hair.

It is of course known to the person skilled in the art that sophisticated cosmetic Compositions are usually not conceivable without the usual auxiliaries and additives. among them include, for example, consistency agents, fillers, perfume, dyes, emulsifiers, additional active ingredients such as vitamins or proteins, light stabilizers, stabilizers, Insect repellents, alcohol, water, salts, antimicrobial, proteolytic or keratolytic effective substances etc.

Mutatis mutandis, corresponding formulation requirements apply medical preparations.

Medical topical compositions in the sense of the present invention usually contain one or more drugs in effective concentration. The For the sake of simplicity, it becomes a clear distinction between cosmetic and medical application and corresponding products to the statutory provisions the Federal Republic of Germany (e.g. cosmetics regulation, food and Drugs Act).

It is also advantageous to use the active ingredient used according to the invention as Add an additive to preparations that already have other active ingredients for other purposes contain.

Cosmetic or topical dermatological compositions can accordingly used in the sense of the present invention, depending on its structure, for example are used as skin protection cream, cleansing milk, sun protection lotion, nutrient cream, daily or night cream, etc. It may be possible and advantageous that compositions according to the invention as the basis for pharmaceutical formulations use.

If appropriate, such cosmetic and dermatological ones are also favorable Preparations in the form of a sunscreen. Preferably included In addition to the active ingredient used according to the invention, these additionally contain at least one UVA filter substance and / or at least one UVB filter substance and / or at least an inorganic pigment.

However, it is also advantageous in the sense of the present invention to use such cosmetic and to create dermatological preparations, the main purpose of which is not the Protection against sunlight is, but which nevertheless contains UV protection substances contain. For example, day creams are usually UV-A or UV-B Filter substances incorporated.

Preparations according to the invention can advantageously contain substances which have UV Absorb radiation in the UVB range, taking the total amount of filter substances z. B. 0.1% by weight to 30% by weight, preferably 0.5 to 10% by weight, in particular 1 to 6 % By weight, based on the total weight of the preparations.

• - 3-Benzylidencampher und dessen Derivate, z. B. 3-(4-Methylbenzyliden)campher,
• - 4-Aminobenzoësäure-Derivate, vorzugsweise 4-(Dimethylamino)-benzoësäure(2- ethylhexyl)ester, 4-(Dimethylamino)benzoësäureamylester;
• - Ester der Zimtsäure, vorzugsweise 4-Methoxyzimtsäure(2-ethylhexyl)ester, 4-Methoxyzimtsäureisopentylester;
• - Ester der Salicylsäure, vorzugsweise Salicylsäure(2-ethylhexyl)ester, Salicylsäure- (4-isopropylbenzyl)ester, Salicylsäurehomomenthylester;
• - Derivate des Benzophenons, vorzugsweise 2-Hydroxy-4-methoxybenzophenon, 2- Hydroxy-4-methoxy-4'-methylbenzophenon, 2,2'-Dihydroxy-4-methoxybenzophenon;
• - Ester der Benzalmalonsäure, vorzugsweise 4-Methoxybenzalmalonsäuredi(2-ethylhexyl)ester;
• - 2,4,6-Trianilino-(p-carbo-2'-ethyl-1'-hexyloxy)-1,3,5-triazin.

The UVB filters can be oil-soluble or water-soluble. As oil-soluble substances such. B. To name:

• - 3-Benzylidene camphor and its derivatives, e.g. B. 3- (4-methylbenzylidene) camphor,
• - 4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;
• - Esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester;
• - Esters of salicylic acid, preferably salicylic acid (2-ethylhexyl) ester, salicylic acid (4-isopropylbenzyl) ester, salicylic acid homomethyl ester;
• - Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone;
• - Esters of benzalmalonic acid, preferably 4-methoxybenzalmalonic acid di (2-ethylhexyl) ester;
• - 2,4,6-trianilino- (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine.

• - 2-Phenylbenzimidazol-5-sulfonsäure und deren Salze, z. B. Natrium-, Kalium- oder Triethanolammonium-Salze,
• - Sulfonsäure-Derivate von Benzophenonen, vorzugsweise 2-Hydroxy-4-methoxybenzophenon-5-sulfonsäure und ihre Salze;
• - Sulfonsäure-Derivate des 3-Benzylidencamphers, wie z. B. 4-(2-Oxo-3-bornylidenmethyl)benzolsulfonsäure, 2-Methyl-5-(2-oxo-3-bornylidenmethyl)sulfonsäure und ihre Salze.

The following are advantageous as water-soluble substances:

• - 2-Phenylbenzimidazole-5-sulfonic acid and its salts, e.g. B. sodium, potassium or triethanolammonium salts,
• - Sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts;
• - Sulfonic acid derivatives of 3-benzylidene camphor, such as. B. 4- (2-oxo-3-bornylidene methyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bornylidene methyl) sulfonic acid and their salts.

The list of the UVB filters mentioned, which can be used according to the invention, should of course not be limiting.

The invention also relates to the combination of an inventive UVA filter with a UVB filter or an inventive cosmetic or dermatological preparation, which also contains a UVB filter.

It can also be advantageous to use UVA filters in preparations according to the invention to be used, usually in cosmetic and / or dermatological preparations are included. Such filter substances are preferably derivatives of dibenzoylmethane, especially 1- (4'-tert-butylphenyl) -3- (4'-methoxyphenyl) - propane-1,3-dione and 1-phenyl-3- (4'-isopropylphenyl) propane-1,3-dione. Also Preparations containing these combinations are the subject of the invention. It the same amounts of UVA filter substances can be used as for UVB Filter substances were called.

Cosmetic and / or dermatological preparations in the sense of the present Invention can also contain inorganic pigments, which are usually used in the Cosmetics can be used to protect the skin from UV rays. It is about for oxides of titanium, zinc, iron, zirconium, silicon, manganese, aluminum, cerium and mixtures thereof, as well as modifications in which the oxides are the active agents are. Pigments based on titanium dioxide are particularly preferred. The amounts mentioned for the above combinations can be used become.

The cosmetic preparations according to the invention can be cosmetic auxiliaries contain, as they are usually used in such preparations, for. B. Preservatives, bactericides, deodorising substances, antiperspirants, Insect repellents, vitamins, anti-foaming agents, dyes, Pigments with coloring effect, thickeners, softening substances, moisturizing and / or moisturizing substances, fats, oils, waxes or other usual Components of a cosmetic formulation such as alcohols, polyols, polymers, Foam stabilizers, electrolytes, organic solvents or silicone derivatives.

Preparations according to the invention can also advantageously contain substances absorb the UV radiation in the UVB range, the total amount of Filter substances e.g. B. 0.1% by weight to 30% by weight, preferably 0.5 to 10% by weight, is in particular 1.0 to 6.0% by weight, based on the total weight of the preparations, to provide cosmetic preparations that protect the hair or skin protect the entire range of ultraviolet radiation. You can also use it as a Use sunscreen for your hair.

• - 3-Benzylidencampher-Derivate, vorzugsweise 3-(4-Methylbenzyliden)campher, 3- Benzylidencampher;
• - 4-Aminobenzoësäure-Derivate, vorzugsweise 4-(Dimethylamino)-benzoësäure(2- ethylhexyl)ester, 4-(Dimethylamino)benzoësäureamylester;
• - Ester der Zimtsäure, vorzugsweise 4-Methoxyzimtsäure(2-ethylhexyl)ester, 4-Methoxyzimtsäureisopentylester;
• - Ester der Salicylsäure, vorzugsweise Salicylsäure(2-ethylhexyl)ester, Salicylsäure(4-isopropylbenzyl)ester, Salicylsäurehomomenthylester,
• - Derivate des Benzophenons, vorzugsweise 2-Hydroxy-4-methoxybenzophenon, 2- Hydroxy-4-methoxy-4'-methylbenzophenon, 2,2'-Dihydroxy-4-methoxybenzophenon;
• - Ester der Benzalmalonsäure, vorzugsweise 4-Methoxybenzalmalonsäuredi(2-ethylhexyl)ester,
• - 2,4,6-Trianilino-(p-carbo-2'-ethyl-1'-hexyloxy)-1,3,5-triazin.

If the preparations according to the invention contain UVB filter substances, they can be oil-soluble or water-soluble. Oil-soluble UVB filters advantageous according to the invention are e.g. B .:

• - 3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;
• - 4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;
• - Esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester;
• Esters of salicylic acid, preferably salicylic acid (2-ethylhexyl) ester, salicylic acid (4-isopropylbenzyl) ester, salicylic acid homomethyl ester,
• - Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone;
• Esters of benzalmalonic acid, preferably 4-methoxybenzalmalonic acid di (2-ethylhexyl) ester,
• - 2,4,6-trianilino- (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine.

• - Salze der 2-Phenylbenzimidazol-5-sulfonsäure wie ihr Natrium-, Kalium- oder ihr Triethanolammonium-Salz, sowie die Sulfonsäure selbst;
• - Sulfonsäure-Derivate von Benzophenonen, vorzugsweise 2-Hydroxy-4-methoxybenzophenon-5-sulfonsäure und ihre Salze;
• - Sulfonsäure-Derivate des 3-Benzylidencamphers, wie z. B. 4-(2-Oxo-3-bornylidenmethyl)benzolsulfonsäure, 2-Methyl-5-(2-oxo-3-bornylidenmethyl)sulfonsäure und ihre Salze sowie das 1,4-di(2-oxo-10-Sulfo-3-bornylidenmethyl)-Benzol und dessen Salze (die entprehenden 10-Sulfato-verbindungen, beispielsweise das entsprechende Natrium-, Kalium- oder Triethanolammonium-Salz), auch als Benzol-1,4- di(2-oxo-3-bornylidenmethyl-10-Sulfonsäure bezeichnet

Advantageous water-soluble UVB filters are e.g. B .:

• - Salts of 2-phenylbenzimidazole-5-sulfonic acid such as its sodium, potassium or triethanolammonium salt, and the sulfonic acid itself;
• - Sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts;
• - Sulfonic acid derivatives of 3-benzylidene camphor, such as. B. 4- (2-oxo-3-bornylidenemethyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bornylidenemethyl) sulfonic acid and its salts and 1,4-di (2-oxo-10-sulfo- 3-bornylidene methyl) -benzene and its salts (the corresponding 10-sulfato compounds, e.g. the corresponding sodium, potassium or triethanolammonium salt), also as benzene-1,4-di (2-oxo-3-bornylidene methyl) Designated 10-sulfonic acid

The list of UVB filters mentioned in combination with the invention Active ingredient combinations can of course not be used be limiting.

It can also be advantageous to use UVA filters, which are usually used in cosmetics Preparations are included. These substances are preferably Derivatives of dibenzoylmethane, especially around 1- (4'-tert-Butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione and 1-phenyl-3- (4'-isopropylphenyl) propane-1,3-dione. It the quantities used for the UVB combination can be used.

Cosmetic and dermatological preparations according to the invention advantageously also contain inorganic pigments based on metal oxides and / or other metal compounds which are sparingly soluble or insoluble in water, in particular the oxides of titanium (TiO ₂ ), zinc (ZnO), iron (e.g. Fe ₂ O ₃ ), Zirconium (ZrO ₂ ), silicon (SiO ₂ ), manganese (e.g. MnO), aluminum (Al ₂ O ₃ ), cerium (e.g. Ce ₂ O ₃ ), mixed oxides of the corresponding metals and mixtures such oxides. Pigments based on TiO _{2 are} particularly preferred.

It is particularly advantageous for the purposes of the present invention, although not mandatory if the inorganic pigments are in hydrophobic form, i. that is are treated to be water-repellent on the surface. This surface treatment can be in it exist that the pigments according to known methods with a thin hydrophobic layer.

One such method consists, for example, in that the hydrophobic surface layer after a rectification

nTiO ₂ + m (RO) ₃ Si-R '→ nTiO ₂ (surface)

is produced. n and m are stoichiometric parameters to be used at will, R and R 'are the desired organic radicals. For example, hydrophobized pigments shown in analogy to DE-OS 33 14 742 are advantageous.

Advantageous TiO ₂ pigments are available, for example, under the trade names MT 100 T from TAYCA, M 160 from Kemira and T 805 from Degussa.

Preparations according to the invention can, especially if crystalline or microcrystalline Solids, for example inorganic micropigments in the inventive Preparations are to be incorporated, including anionic, nonionic and / or contain amphoteric surfactants. Surfactants are amphiphilic substances that are organic, non-polar Can dissolve substances in water.

• - anionische Tenside,
• - kationische Tenside,
• - amphotere Tenside und
• - nichtionische Tenside.

The hydrophilic parts of a surfactant molecule are mostly polar functional groups, for example -COO ^- , -OSO ₃ ^2- , -SO ₃ ^- , while the hydrophobic parts generally represent non-polar hydrocarbon radicals. Surfactants are generally classified according to the type and charge of the hydrophilic part of the molecule. There are four groups:

• - anionic surfactants,
• - cationic surfactants,
• - amphoteric surfactants and
• - nonionic surfactants.

Anionic surfactants generally have carboxylate, sulfate or sulfonate groups as functional groups. In an aqueous solution they form negatively charged organic ions in an acidic or neutral environment. Cationic surfactants are characterized almost exclusively by the presence of a quaternary ammonium group. In aqueous solution they form positively charged organic ions in an acidic or neutral environment. Amphoteric surfactants contain both anionic and cationic groups and therefore behave like anionic or cationic surfactants in aqueous solution depending on the pH. They have a positive charge in a strongly acidic environment and a negative charge in an alkaline environment. In the neutral pH range, however, they are zwitterionic, as the following example should illustrate:

RNH ₂ ⁺ CH ₂ CH ₂ COOH X ^- (at pH = 2) X ^- = any anion, e.g. B. Cl ^-

RNH ₂ ⁺ CH ₂ CH ₂ COO ^- (at pH = 7)

RNHCH ₂ CH ₂ COO ^- B ⁺ (at pH = 12) B ⁺ = any cation, e.g. B. Na ⁺

Polyether chains are typical of non-ionic surfactants. Non-ionic surfactants form in aqueous medium no ions.

A. Anionic surfactants

• 1. Acylglutamate, beispielsweise Natriumacylglutamat, Di-TEA-palmitoylaspartat und Natrium Caprylic/Capric Glutamat,
• 2. Acylpeptide, beispielsweise Palmitoyl-hydrolysiertes Milchprotein, Natrium Cocoylhydrolysiertes Soja Protein und Natrium-/Kalium Cocoyl-hydrolysiertes Kollagen,
• 3. Sarcosinate, beispielsweise Myristoyl Sarcosin, TEA-lauroyl Sarcosinat, Natriumlauroylsarcosinat und Natriumcocoylsarkosinat,
• 4. Taurate, beispielsweise Natriumlauroyltaurat und Natriummethylcocoyltaurat,
• 5. AcylLactylate, lauroyllactylat, Caproyllactylat
• 6. Alaninate

Anionic surfactants to be used advantageously are acylamino acids (and their salts), such as

• 1. acylglutamates, for example sodium acylglutamate, di-TEA-palmitoylaspartate and sodium caprylic / capric glutamate,
• 2. acyl peptides, for example palmitoyl-hydrolyzed milk protein, sodium cocoyl-hydrolyzed soy protein and sodium / potassium cocoyl-hydrolyzed collagen,
• 3. sarcosinates, for example myristoyl sarcosin, TEA lauroyl sarcosinate, sodium lauroyl sarcosinate and sodium cocoyl sarcosinate,
• 4. taurates, for example sodium lauroyl taurate and sodium methyl cocoyl taurate,
• 5. Acyl lactylates, lauroyl lactylate, caproyl lactylate
• 6. Alaninate

• 1. Carbonsäuren, beispielsweise Laurinsäure, Aluminiumstearat, Magnesiumalkanolat und Zinkundecylenat,
• 2. Ester-Carbonsäuren, beispielsweise Calciumstearoyllactylat, Laureth-6 Citrat und Natrium PEG-4 Lauramidcarboxylat,
• 3. Ether-Carbonsäuren, beispielsweise Natriumlaureth-13 Carboxylat und Natrium PEG-6 Cocamide Carboxylat,

Carboxylic acids and derivatives, such as

• 1. carboxylic acids, for example lauric acid, aluminum stearate, magnesium alkanolate and zinc undecylenate,
• 2. ester carboxylic acids, for example calcium stearoyl lactylate, laureth-6 citrate and sodium PEG-4 lauramide carboxylate,
• 3. ether carboxylic acids, for example sodium laureth-13 carboxylate and sodium PEG-6 cocamide carboxylate,

• 1. Acyl-isethionate, z. B. Natrium-/Ammoniumcocoyl-isethionat,
• 2. Alkylarylsulfonate,
• 3. Alkylsulfonate, beispielsweise Natriumcocosmonoglyceridsulfat, Natrium C_12-14 Olefin-sulfonat, Natriumlaurylsulfoacetat und Magnesium PEG-3 Cocamidsulfat,
• 4. Sulfosuccinate, beispielsweise Dioctylnatriumsulfosuccinat, Dinatriumlaurethsulfosuccinat, Dinatriumlaurylsulfosuccinat und Dinatriumundecylenamido MEA-Sulfosuccinat

sowie
Schwefelsäureester, wie

• 1. Alkylethersulfat, beispielsweise Natrium-, Ammonium-, Magnesium-, MIPA-, TIPA- Laurethsulfat, Natriummyrethsulfat und Natrium C_12-13 Parethsulfat,
• 2. Alkylsulfate, beispielsweise Natrium-, Ammonium- und TEA-Laurylsulfat.

Phosphoric acid esters and salts, such as DEA-oleth-10-phosphate and dilaureth-4-phosphate,
Sulfonic acids and salts such as

• 1. acyl isethionates, e.g. B. sodium / ammonium cocoyl isethionate,
• 2. alkylarylsulfonates,
• 3. alkyl sulfonates, for example sodium cocosmonoglyceride sulfate, sodium C _12-14 olefin sulfonate, sodium lauryl sulfoacetate and magnesium PEG-3 cocamide sulfate,
• 4. Sulfosuccinates, for example dioctyl sodium sulfosuccinate, disodium laureth sulfosuccinate, disodium lauryl sulfosuccinate and disodium undecylenamido MEA sulfosuccinate

such as
Sulfuric acid esters, such as

• 1. alkyl ether sulfate, for example sodium, ammonium, magnesium, MIPA, TIPA laureth sulfate, sodium myreth sulfate and sodium C _12-13 pareth sulfate,
• 2. Alkyl sulfates, for example sodium, ammonium and TEA lauryl sulfate.

B. Cationic surfactants

• 1. Alkylamine,
• 2. Alkylimidazole,
• 3. Ethoxylierte Amine und
• 4. Quaternäre Tenside.
• 5. Esterquats

Cationic surfactants to be used advantageously

• 1. alkylamines,
• 2. alkylimidazoles,
• 3. Ethoxylated amines and
• 4. Quaternary surfactants.
• 5. Esterquats

Quaternary surfactants contain at least one N atom that has 4 alkyl or aryl groups is covalently linked. Regardless of the pH value, this leads to a positive charge. Alkyl betaine, alkyl amidopropyl betaine and alkyl amidopropyl hydroxysulfain are advantageous. The cationic surfactants used according to the invention can also be preferred are selected from the group of quaternary ammonium compounds, in particular Benzyltrialkylammoniumchloride or bromide, such as Benzyldimethylstearylammonium chloride, furthermore alkyltrialkylammonium salts, for example for example Cetyltrimethylammonium chloride or bromide, Alkyldimethylhydroxyethylammonium chlorides or bromides, dialkyldimethylammonium chlorides or bromides, Alkylamidethyltrimethylammonium ether sulfates, alkylpyridinium salts, for example lauryl or Cetylpyrimidinium chloride, imidazoline derivatives and compounds with cationic Character such as amine oxides, for example alkyldimethylamine oxides or Alkylaminoethyldimethylamine. Cetyltrimethylammonium salts are particularly advantageous use.

C. Amphoteric surfactants

• 1. Acyl-/dialkylethylendiamin, beispielsweise Natriumacylamphoacetat, Dinatriumacylamphodipropionat, Dinatriumalkylamphodiacetat, Natriumacylamphohydroxypropylsulfonat, Dinatriumacylamphodiacetat und Natriumacylamphopropionat,
• 2. N-Alkylaminosäuren, beispielsweise Aminopropylalkylglutamid, Alkylaminopropionsäure, Natriumalkylimidodipropionat und Lauroamphocarboxyglycinat.

Amphoteric surfactants to be used advantageously

• 1. acyl- / dialkylethylenediamine, for example sodium acylamphoacetate, disodium acylamphodipropionate, disodium alkylamphodiacetate, sodium acylamphohydroxypropylsulfonate, disodium acylamphodiacetate and sodium acylamphopropionate,
• 2. N-alkylamino acids, for example aminopropylalkylglutamide, alkylaminopropionic acid, sodium alkylimidodipropionate and lauroamphocarboxyglycinate.

D. Non-ionic surfactants

• 1. Alkohole,
• 2. Alkanolamide, wie Cocamide MEA/DEA/MIPA,
• 3. Aminoxide, wie Cocoamidopropylaminoxid,
• 4. Ester, die durch Veresterung von Carbonsäuren mit Ethylenoxid, Glycerin, Sorbitan oder anderen Alkoholen entstehen,
• 5. Ether, beispielsweise ethoxylierte/propoxylierte Alkohole, ethoxylierte/propoxylierte Ester, ethoxylierte/propoxylierte Glycerinester, ethoxylierte/propoxylierte Cholesterine, ethoxylierte/propoxylierte Triglyceridester, ethoxyliertes propoxyliertes Lanolin, ethoxylierte/propoxylierte Polysiloxane, propoxylierte POE-Ether und Alkylpolyglycoside wie Laurylglucosid, Decylglycosid und Cocoglycosid.
• 6. Sucroseester, -Ether
• 7. Polyglycerinester, Diglycerinester, Monoglycerinester
• 8. Methylglucosester, Ester von Hydroxysäuren

Non-ionic surfactants to be used advantageously

• 1. alcohols,
• 2. alkanolamides, such as cocamides MEA / DEA / MIPA,
• 3. amine oxides, such as cocoamidopropylamine oxide,
• 4. esters which are formed by esterification of carboxylic acids with ethylene oxide, glycerol, sorbitan or other alcohols,
• 5. ethers, for example ethoxylated / propoxylated alcohols, ethoxylated / propoxylated esters, ethoxylated / propoxylated glycerol esters, ethoxylated / propoxylated cholesterols, ethoxylated / propoxylated triglyceride esters, ethoxylated propoxylated lanolin, ethoxylated / propoxylated polysiloxanes, propoxylated POE ethers and alkylpolyglycosides such as lauryl polyglycosides cocoglycoside.
• 6. sucrose esters, ether
• 7. Polyglycerol esters, diglycerol esters, monoglycerol esters
• 8. Methyl glucose esters, esters of hydroxy acids

It is also advantageous to use a combination of anionic and / or amphoteric surfactants with one or more non-ionic surfactants.

The surface-active substance can be in a concentration between 1 and 95 wt. are present in the preparations according to the invention, based on the total weight of the preparations.

• - Mineralöle, Mineralwachse
• - Öle, wie Triglyceride der Caprin- oder der Caprylsäure, ferner natürliche Öle wie z. B. Rizinusöl;
• - Fette, Wachse und andere natürliche und synthetische Fettkörper, vorzugsweise Ester von Fettsäuren mit Alkoholen niedriger C-Zahl, z. B. mit Isopropanol, Propylenglykol oder Glycerin, oder Ester von Fettalkoholen mit Alkansäuren niedriger C- Zahl oder mit Fettsäuren;
• - Alkylbenzoate;
• - Silikonöle wie Dimethylpolysiloxane, Diethylpolysiloxane, Diphenylpolysiloxane sowie Mischformen daraus.

The lipid phase of the cosmetic or dermatological emulsions according to the invention can advantageously be selected from the following group of substances:

• - mineral oils, mineral waxes
• - Oils, such as triglycerides of capric or caprylic acid, as well as natural oils such. B. castor oil;
• - Fats, waxes and other natural and synthetic fat bodies, preferably esters of fatty acids with alcohols of low C number, e.g. B. with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with low C number alkanoic acids or with fatty acids;
• - alkyl benzoates;
• - Silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixed forms thereof.

The oil phase of the emulsions of the present invention is advantageously selected from the Group of esters from saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols Chain length of 3 to 30 carbon atoms, from the group of esters from aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols a chain length of 3 to 30 carbon atoms. Such ester oils can then be advantageous are selected from the group of isopropyl myristate, isopropyl palmitate, isopropyl stearate, Isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, Isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyldodecyl palmitate, oleyl oleate, olerlerucate, erucyl oleate, erucylerucate and synthetic, semi-synthetic and natural mixtures of such esters, e.g. B. Jojoba oil.

Furthermore, the oil phase can advantageously be selected from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the Group of saturated or unsaturated, branched or unbranched alcohols, as well as the fatty acid triglycerides, especially the saturated and / or triglycerol esters unsaturated, branched and / or unbranched alkane carboxylic acids of a chain length from 8 to 24, especially 12-18 C atoms. The fatty acid triglycerides can for example advantageously selected from the group of synthetic, semi-synthetic and natural oils, e.g. B. olive oil, sunflower oil, soybean oil, peanut oil, Rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.

Any mixtures of such oil and wax components are also advantageous in To use the sense of the present invention. It can also be advantageous if necessary be waxes, for example cetyl palmitate, as the sole lipid component of the oil phase use.

The oil phase is advantageously selected from the group 2-ethylhexyl isostearate, octyldodecanol, isotridecylisononanoate, isoeicosane, 2-ethylhexyl cocoate, C _12-15 alkyl benzoate, caprylic capric acid triglyceride, dicaprylyl ether.

Mixtures of C _12-15 alkyl benzoate and 2-ethylhexyl isostearate, mixtures of C _12-15 alkyl benzoate and isotridecyl isononanoate and mixtures of C _12-15 alkyl benzoate, 2-ethyl hexyl isostearate and isotridecyl isononanoate are particularly advantageous.

Of the hydrocarbons, paraffin oil, squalane and squalene are advantageous in the sense to use the present invention.

The oil phase can advantageously also have a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or the silicone oils. Such silicones or silicone oils can be present as monomers, which are generally characterized by structural elements, as follows:

Linear silicones with a plurality of siloxy units which can advantageously be used according to the invention are generally characterized by structural elements as follows:


wherein the silicon atoms can be substituted with the same or different alkyl radicals and / or aryl radicals, which are generally represented here by the radicals R ₁ -R ₄ (to say that the number of different radicals is not necessarily limited to up to 4). m can assume values of 2-200,000.

Cyclic silicones to be used advantageously according to the invention are generally characterized by structural elements as follows


wherein the silicon atoms can be substituted with the same or different alkyl radicals and / or aryl radicals, which are generally represented here by the radicals R ₁ -R ₄ (to say that the number of different radicals is not necessarily limited to up to 4). n can take values from 3/2 to 20. Broken values for n take into account that there may be odd numbers of siloxyl groups in the cycle.

Cyclomethicone (eg decamethylcyclopentasiloxane) is advantageous as according to the invention silicone oil to be used. But other silicone oils are also advantageous in To use the sense of the present invention, for example Undecamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane), cetyldimethicone, Behenoxydimethicone.

Mixtures of cyclomethicone and isotridecyl isononanoate and are also advantageous those made from cyclomethicone and 2-ethylhexyl isostearate.

However, it is also advantageous to use silicone oils of a constitution similar to that above to select designated compounds whose organic side chains derivatize, for example, are polyethoxylated and / or polypropoxylated. These include, for example Polysiloxane-polyalkyl-polyether copolymers such as the cetyl-dimethicone copolyol, the (cetyl- Dimethicone copolyol (and) polyglyceryl 4-isostearate (and) hexyl laurate).

Mixtures of cyclomethicone and are also particularly advantageous Isotridecyl isononanoate, from cyclomethicone and 2-ethylhexyl isostearate.

The aqueous phase of the preparations according to the invention optionally contains advantageous alcohols, diols or polyols of low C number, and their ethers, preferably Ethanol, isopropanol, propylene glycol, glycerin, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, Diethylene glycol monomethyl or monoethyl ether and analog products, also alcohols low C number, e.g. As ethanol, isopropanol, 1,2-propanediol, glycerin and in particular one or more thickeners, which one or which are advantageously chosen can from the group silicon dioxide, aluminum silicates.

Preparations according to the invention in the form of emulsions contain in particular advantageously one or more hydrocolloids. These hydrocolloids can be beneficial are selected from the group of gums, polysaccharides, cellulose derivatives, Layered silicates, polyacrylates and / or other polymers.

Preparations according to the invention which are present as hydrogels contain one or several hydrocolloids. These hydrocolloids can advantageously be from the aforementioned group to get voted.

Gums include plant or tree sap that harden in the air and Forming resins or extracts from aquatic plants. From this group can be advantageous in Gum arabic, for example Carob flour, tragacanth, karaya, guar gum, pectin, gellan gum, carrageenan, Agar, Algine, Chondrus, Xanthan Gum.

Another advantage is the use of derivatized gums such. B. Hydroxypropyl guar (Jaguar® HP 8).

Among the polysaccharides and derivatives are e.g. B. hyaluronic acid, chitin and Chitosan, chondroitin sulfates, starch and starch derivatives.

Among the cellulose derivatives are e.g. B. methyl cellulose, carboxymethyl cellulose, Hydroxyethyl cellulose, hydroxypropyl methyl cellulose.

Layered silicates include naturally occurring and synthetic ones Clays such as B. montmorillonite, bentonite, hectorite, laponite, magnesium aluminum silicates such as Veegum®. These can be used as such or in a modified form such as z. B. Stearylalkonium Hektorite.

Furthermore, silica gels can also advantageously be used.

Among the polyacrylates are e.g. B. Carbopol types from Goodrich (Carbopol 980, 981, 1382, 5984, 2984, EDT 2001 or Pemulen TR2).

Among the polymers are e.g. B. polyacrylamides (Seppigel 305), Polyvinyl alcohols, PVP, PVP / VA copolymers, polyglycols.

Preparations according to the invention which are present as emulsions contain one or several emulsifiers. These emulsifiers can advantageously be chosen from the Group of nonionic, anionic, cationic or amphoteric emulsifiers.

• a) Partialfettsäureester und Fettsäureester mehrwertiger Alkohole und deren ethoxylierte Derivate (z. B. Glycerylmonostearate, Sorbitanstearate, Glycerylstearylcitrate, Sucrosestearate)
• b) ethoxilierte Fettalkohole und Fettsäuren
• c) ethoxilierte Fettamine, Fettsäureamide, Fettsäurealkanolamide
• d) Alkylphenolpolyglycolether (z. B. Triton X)

Among the nonionic emulsifiers are

• a) Partial fatty acid esters and fatty acid esters of polyhydric alcohols and their ethoxylated derivatives (e.g. glyceryl monostearates, sorbitan stearates, glyceryl stearyl citrates, sucrose stearates)
• b) ethoxylated fatty alcohols and fatty acids
• c) ethoxylated fatty amines, fatty acid amides, fatty acid alkanolamides
• d) alkylphenol polyglycol ether (e.g. Triton X)

• a) Seifen (z. B. Natriumstearat)
• b) Fettalkoholsulfate
• c) Mono-, Di- und Trialkylphosphosäureester und deren Ethoxylate

Among the anionic emulsifiers are

• a) soaps (e.g. sodium stearate)
• b) fatty alcohol sulfates
• c) mono-, di- and trialkylphosphonic acid esters and their ethoxylates

• a) quaternäre Ammoniumverbindungen mit einem langkettigen aliphatischen Rest z. B. Distearyldimonium Chloride

Among the cationic emulsifiers are

• a) quaternary ammonium compounds with a long-chain aliphatic radical z. B. Distearyldimonium Chloride

• a) Alkylamininoalkancarbonsäuren
• b) Betaine, Sulfobetaine
• c) Imidazolinderivate

Among the amphoteric emulsifiers are

• a) Alkylamininoalkane carboxylic acids
• b) betaines, sulfobetaines
• c) Imidazoline derivatives

There are also naturally occurring emulsifiers, including beeswax, Wool wax, lecithin and sterols belong to it.

• - der Fettalkoholethoxylate
• - der ethoxylierten Wollwachsalkohole,
• - der Polyethylenglycolether der allgemeinen Formel R-O-(-CH₂-CH₂-O-)_n-R',
• - der Fettsäureethoxylate der allgemeinen Formel R-COO-(-CH₂-CH₂-O-)_n-H,
• - der veretherten Fettsäureethoxylate der allgemeinen Formel R-COO-(-CH₂-CH₂-O-)_n-R',
• - der veresterten Fettsäureethoxylate der allgemeinen Formel R-COO-(-CH₂-CH₂-O-)_n-C(O)R',
• - der Polyethylenglycolglycerinfettsäureester
• - der ethoxylierten Sorbitanester
• - der Cholesterinethoxylate
• - der ethoxylierten Triglyceride
• - der Alkylethercarbonsäuren der allgemeinen Formel R-O-(-CH₂-CH₂-O-)_n-CH₂-COOH nd n eine Zahl von 5 bis 30 darstellen,
• - der Polyoxyethylensorbitolfettsäureester,
• - der Alkylethersulfate der allgemeinen Formel R-O-(-CH₂-CH₂-O-)_n-SO₃-H
• - der Fettalkoholpropoxylate der allgemeinen Formel R-O-(-CH₂-CH(CH₃)-O-)_n-H,
• - der Polypropylenglycolether der allgemeinen Formel R-O-(-CH₂-CH(CH₃)-O-)_n-R',
• - der propoxylierten Wollwachsalkohole,
• - der veretherten Fettsäurepropoxylate R-COO-(-CH₂-CH(CH₃)-O-)_n-R',
• - der veresterten Fettsäurepropoxylate der allgemeinen Formel R-COO-(-CH₂-CH(CH₃)-O-)_n-C(O)-R',
• - der Fettsäurepropoxylate der allgemeinen Formel R-COO-(-CH₂-CH(CH₃)-O-)_n-H,
• - der Polypropylenglycolglycerinfettsäureester
• - der propoxylierten Sorbitanester
• - der Cholesterinpropoxylate
• - der propoxylierten Triglyceride
• - der Alkylethercarbonsäuren der allgemeinen Formel R-O-(-CH₂-CH(CH₃)O-)_n-CH₂-COOH
• - der Alkylethersulfate bzw. die diesen Sulfaten zugrundeliegenden Säuren der allgemeinen Formel R-O-(-CH₂-CH(CH₃)-O-)_n-SO₃-H
• - der Fettalkoholethoxylate/propoxylate der allgemeinen Formel R-O-X_n-Y_m-H,
• - der Polypropylenglycolether der allgemeinen Formel R-O-X_n-Y_m-R',
• - der veretherten Fettsäurepropoxylate der allgemeinen Formel R-COO-X_n-Y_m-R',
• - der Fettsäureethoxylate/propoxylate der allgemeinen Formel R-COO-X_n-Y_m-H,.

O / W emulsifiers can, for example, advantageously be selected from the group of polyethoxylated or polypropoxylated or polyethoxylated and polypropoxylated products, e.g. B .:

• - The fatty alcohol ethoxylates
• - the ethoxylated wool wax alcohols,
• the polyethylene glycol ether of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -R ',
• the fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -H,
• the etherified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -R ',
• the esterified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -C (O) R ',
• - The polyethylene glycol glycerol fatty acid ester
• - The ethoxylated sorbitan esters
• - the cholesterol ethoxylates
• - The ethoxylated triglycerides
• the alkyl ether carboxylic acids of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -CH ₂ -COOH and n represent a number from 5 to 30,
• - the polyoxyethylene sorbitol fatty acid ester,
• - The alkyl ether sulfates of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -SO ₃ -H
• the fatty alcohol propoxylates of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -H,
• the polypropylene glycol ether of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -R ',
• - the propoxylated wool wax alcohols,
• the etherified fatty acid propoxylates R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -R ',
• the esterified fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -C (O) -R ',
• the fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -H,
• - the polypropylene glycol glycerol fatty acid ester
• - The propoxylated sorbitan esters
• - the cholesterol propoxylates
• - the propoxylated triglycerides
• - The alkyl ether carboxylic acids of the general formula RO - (- CH ₂ -CH (CH ₃ ) O-) _n -CH ₂ -COOH
• - The alkyl ether sulfates or the acids on which these sulfates are based, of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -SO ₃ -H
• the fatty alcohol ethoxylates / propoxylates of the general formula ROX _n -Y _m -H,
• the polypropylene glycol ether of the general formula ROX _n -Y _m -R ',
• the etherified fatty acid propoxylates of the general formula R-COO-X _n -Y _m -R ',
• - The fatty acid ethoxylates / propoxylates of the general formula R-COO-X _n -Y _m -H ,.

According to the invention, the polyethoxylated or polypropoxylated or polyethoxylated and polypropoxylated O / W emulsifiers chosen from the group of substances with HLB values of 11-18, especially advantageous with HLB values of 14.5-15.5, provided the O / W emulsifiers are saturated residues R and R 'have. If the O / W emulsifiers have unsaturated radicals R and / or R ', or if there are isoalkyl derivatives, the preferred HLB value of such emulsifiers can be are also lower or higher.

It is advantageous to choose the fatty alcohol ethoxylates from the group of the ethoxylated stearyl alcohols, cetyl alcohols, cetylstearyl alcohols (cetearyl alcohols). The following are particularly preferred:
Polyethylene glycol (13) stearyl ether (steareth-13), polyethylene glycol (14) stearyl ether (steareth-14), polyethylene glycol (15) stearyl ether (steareth-15), polyethylene glycol (16) stearyl ether (steareth-16), polyethylene glycol (17) stearyl ether ( Steareth-17), polyethylene glycol (18) stearyl ether (Steareth-18), polyethylene glycol (19) stearyl ether (Steareth-19), polyethylene glycol (20) stearyl ether (Steareth-20),
Polyethylene glycol (12) isostearyl ether (isosteareth-12), polyethylene glycol (13) isostearyl ether (isosteareth-13), polyethylene glycol (14) isostearyl ether (isosteareth-14), polyethylene glycol (15) isostearyl ether (isosteareth-15), polyethylene glycol (16) isostearyl ether ( Isosteareth-16), polyethylene glycol (17) isostearyl ether (isosteareth-17), polyethylene glycol (18) isostearyl ether (isosteareth-18), polyethylene glycol (19) isostearyl ether (isosteareth-19), polyethylene glycol (20) isostearyl ether (isosteareth-20),
Polyethylene glycol (13) cetyl ether (geteth-13), polyethylene glycol (14) cetyl ether (ceteth-14), polyethylene glycol (15) cetyl ether (ceteth-15), polyethylene glycol (16) cetyl ether (ceteth-16), polyethylene glycol (17) cetyl ether ( Ceteth-17), polyethylene glycol (18) cetyl ether (ceteth-18), polyethylene glycol (19) cetyl ether (ceteth-19), polyethylene glycol (20) cetyl ether (ceteth-20),
Polyethylene glycol (13) isocetyl ether (isoceteth-13), polyethylene glycol (14) isocetyl ether (isoceteth-14), polyethylene glycol (15) isocetyl ether (isoceteth-15), polyethylene glycol (16) isocetyl ether (isoceteth-16), polyethylene glycol (17) isocetyl ether ( Isoceteth-17), polyethylene glycol (18) isocetyl ether (isoceteth-18), polyethylene glycol (19) isocetyl ether (isoceteth-19), polyethylene glycol (20) isocetyl ether (isoceteth-20),
Polyethylene glycol (12) oleyl ether (oleth-12), polyethylene glycol (13) oleyl ether (oleth-13), polyethylene glycol (14) oleyl ether (oleth-14), polyethylene glycol (15) oleyl ether (oleth-15),
Polyethylene glycol (12) lauryl ether (Laureth-12), polyethylene glycol (12) isolauryl ether (Isolaureth-12).

Polyethylene glycol (13) cetyl stearyl ether (ceteareth-13), Polyethylene glycol (14) cetyl stearyl ether (ceteareth-14), polyethylene glycol (15) cetyl stearyl ether (ceteareth-15), Polyethylene glycol (16) cetyl stearyl ether (ceteareth-16), polyethylene glycol (17) cetyl stearyl ether (Ceteareth-17), polyethylene glycol (18) cetylstearyl ether (Ceteareth-18), Polyethylene glycol (19) cetyl stearyl ether (ceteareth-19), polyethylene glycol (20) cetyl stearyl ether (ceteareth-20).

It is also advantageous to choose the fatty acid ethoxylates from the following group:
Polyethylene glycol (20) stearate, polyethylene glycol (21) stearate, polyethylene glycol (22) stearate, polyethylene glycol (23) stearate, polyethylene glycol (24) stearate, polyethylene glycol (25) stearate,
Polyethylene glycol (12) isostearate, polyethylene glycol (13) isostearate, polyethylene glycol (14) isostearate, polyethylene glycol (15) isostearate, polyethylene glycol (16) isostearate, polyethylene glycol (17) isostearate, polyethylene glycol (18) isostearate, polyethylene glycol (19) isostearate, 20) isostearate, polyethylene glycol (21) isostearate, polyethylene glycol (22) isostearate, polyethylene glycol (23) isostearate, polyethylene glycol (24) isostearate, polyethylene glycol (25) isostearate,
Polyethylene glycol (12) oleate, Polyethylene glycol (13) oleate, Polyethylene glycol (14) oleate, Polyethylene glycol (15) oleate, Polyethylene glycol (16) oleate, Polyethylene glycol (17) oleate, Polyethylene glycol (18) oleate, Polyethylene glycol (19) oleate, Polyethylene glycol ( 20) oleate

As an ethoxylated alkyl ether carboxylic acid or its salt, this can be advantageous Sodium laureth-11 carboxylate can be used.

Sodium laureth 1-4 sulfate can advantageously be used as alkyl ether sulfate.

As an ethoxylated cholesterol derivative can be advantageous Polyethylene glycol (30) cholesteryl ether can be used. Polyethylene glycol (25) soyasterol has also proven itself.

Polyethylene glycol (60) evening can advantageously be used as ethoxylated triglycerides Primrose Glycerides can be used (Evening Primrose = evening primrose)

Another advantage is the polyethylene glycol glycerol fatty acid ester from the group Polyethylene glycol (20) glyceryl laurate, polyethylene glycol (21) glyceryl laurate, Polyethylene glycol (22) glyceryl laurate, polyethylene glycol (23) glyceryl laurate, Polyethylene glycol (6) glyceryl caprate / caprinate, polyethylene glycol (20) glyceryl oleate, Polyethylene glycol (20) glyceryl isostearate, polyethylene glycol (18) glyceryl oleate / cocoat to choose.

It is also cheap to use the sorbitan esters from the group Polyethylene glycol (20) sorbitan monolaurate, polyethylene glycol (20) sorbitan monostearate, Polyethylene glycol (20) sorbitan monoisostearate, polyethylene glycol (20) sorbitan monopalmitate, Polyethylene glycol (20) sorbitan monooleate to choose.

Advantageous W / O emulsifiers that can be used are: fatty alcohols with 8 to 30 Carbon atoms, monoglycerol esters saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 8 to 24, in particular 12-18 C atoms, diglycerol esters saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 8 to 24, in particular 12-18 C atoms, monoglycerol ethers of saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 8 to 24, in particular 12-18 carbon atoms, diglycerol ethers saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 8 to 24, in particular 12-18, carbon atoms, Propylene glycol esters saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 8 to 24, in particular 12-18 C- Atoms and sorbitan esters of saturated and / or unsaturated, branched and / or unbranched alkane carboxylic acids with a chain length of 8 to 24, in particular 12-18 C-atoms.

Particularly advantageous W / O emulsifiers are glyceryl monostearate, Glyceryl monoisostearate, glyceryl monomyristate, glyceryl monooleate, diglyceryl monostearate, Diglyceryl monoisostearate, propylene glycol monostearate, propylene glycol monoisostearate, Propylene glycol monocaprylate, propylene glycol monolaurate, sorbitan monoisostearate, Sorbitan monolaurate, sorbitan monocaprylate, sorbitan monoisooleate, sucrose distearate, Cetyl alcohol, stearyl alcohol, arachidyl alcohol, behenyl alcohol, isobehenyl alcohol, Selachyl alcohol, chimyl alcohol, polyethylene glycol (2) stearyl ether (Steareth-2), Glyceryl monolaurate, glyceryl monocaprinate, glyceryl monocaprylate.

The following examples are intended to illustrate, but not limit, the invention. The Numbers relate to% by weight, unless stated otherwise.

The following examples are intended to illustrate the present invention. O / W emulsions

Claims (3)

1. Cooling cosmetic or medical topical preparations, characterized by a content of methyl palmitate. 2. Use of methyl palmitate for the production of cooling cosmetic or medical topical preparations. 3. Preparations according to claim 1 or use according to claim 2, characterized characterized in that the methyl palmitate is present in concentrations of 0.5-50% by weight, advantageously 1-20% by weight, based on the total weight of the preparations.