DD293962A5 - Verfahren zur herstellung einer pharmazeutischen formulierung - Google Patents

Verfahren zur herstellung einer pharmazeutischen formulierung Download PDF

Info

Publication number: DD293962A5
Authority: DD; German Democratic Republic
Prior art keywords: purine; methoxy; compound; arabinofuranosyl; formula
Prior art date: 1987-05-30

Application number

DD88340139A

Other languages

German (de)

English (en)

Inventor

Thomas A Krenitsky

George W Koszalka

Jones Lynda Addington

Devron R Averett

Allan R Moorman

Original Assignee

��@��@��@��k��

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-30

Filing date

1988-05-27

Publication date

1991-09-19

1988-05-27 Application filed by ��@��@��@��k�� filed Critical ��@��@��@��k��

1991-09-19 Publication of DD293962A5 publication Critical patent/DD293962A5/de

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 8
238000004519 manufacturing process Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 claims abstract description 43
-1 methoxy, ethoxy, propoxy Chemical group 0.000 claims abstract description 38
238000000034 method Methods 0.000 claims abstract description 21
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 8
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 8
125000003545 alkoxy group Chemical group 0.000 claims abstract description 7
239000001257 hydrogen Substances 0.000 claims abstract description 7
125000001153 fluoro group Chemical group F* 0.000 claims abstract description 6
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 5
125000003277 amino group Chemical group 0.000 claims abstract description 4
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 4
229910052757 nitrogen Inorganic materials 0.000 claims abstract description 4
229910052736 halogen Inorganic materials 0.000 claims abstract description 3
150000002367 halogens Chemical group 0.000 claims abstract description 3
125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 3
125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims abstract description 3
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims abstract 3
150000001875 compounds Chemical class 0.000 claims description 76
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical group N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims description 16
125000000217 alkyl group Chemical group 0.000 claims description 11
125000000753 cycloalkyl group Chemical group 0.000 claims description 2
125000002346 iodo group Chemical group I* 0.000 claims description 2
239000000546 pharmaceutical excipient Substances 0.000 claims description 2
229940124531 pharmaceutical excipient Drugs 0.000 claims description 2
125000000714 pyrimidinyl group Chemical group 0.000 claims description 2
QVDVENIYNXDSOK-UHFFFAOYSA-N n-methoxy-n-methylmethanamine Chemical compound CON(C)C QVDVENIYNXDSOK-UHFFFAOYSA-N 0.000 claims 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
239000000203 mixture Substances 0.000 abstract description 46
238000009472 formulation Methods 0.000 abstract description 11
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ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract description 2
229910052740 iodine Inorganic materials 0.000 abstract description 2
239000011630 iodine Substances 0.000 abstract 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 193
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WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 90
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 85
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 78
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241000701085 Human alphaherpesvirus 3 Species 0.000 description 18
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150000002148 esters Chemical class 0.000 description 16
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 16
238000007792 addition Methods 0.000 description 15
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VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 8
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
241000701022 Cytomegalovirus Species 0.000 description 8
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 8
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FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 8
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229910052786 argon Inorganic materials 0.000 description 7
239000003995 emulsifying agent Substances 0.000 description 7
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230000002829 reductive effect Effects 0.000 description 7
239000000126 substance Substances 0.000 description 7
DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 7
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
DRTQHJPVMGBUCF-CCXZUQQUSA-N arauridine Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-CCXZUQQUSA-N 0.000 description 6
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XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 4
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239000001226 triphosphate Substances 0.000 description 4
125000001999 4-Methoxybenzoyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C(*)=O 0.000 description 3
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LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
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OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
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RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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DQWPFSLDHJDLRL-UHFFFAOYSA-N triethyl phosphate Chemical compound CCOP(=O)(OCC)OCC DQWPFSLDHJDLRL-UHFFFAOYSA-N 0.000 description 1
UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical class [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines Containing Plant Substances (AREA)

DD88340139A 1987-05-30 1988-05-27 Verfahren zur herstellung einer pharmazeutischen formulierung DD293962A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB878712745A GB8712745D0 (en)	1987-05-30	1987-05-30	Antiviral compounds

Publications (1)

Publication Number	Publication Date
DD293962A5 true DD293962A5 (de)	1991-09-19

Family

ID=10618179

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DD88340139A DD293962A5 (de)	1987-05-30	1988-05-27	Verfahren zur herstellung einer pharmazeutischen formulierung
DD88316143A DD282694A5 (de)	1987-05-30	1988-05-27	Antivirale verbindungen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DD88316143A DD282694A5 (de)	1987-05-30	1988-05-27	Antivirale verbindungen

Country Status (31)

Country	Link
US (2)	US5424295A (zh)
EP (1)	EP0294114B1 (zh)
JP (1)	JP2667873B2 (zh)
KR (1)	KR970009474B1 (zh)
CN (1)	CN1020107C (zh)
AT (1)	ATE142636T1 (zh)
AU (1)	AU622403B2 (zh)
CA (1)	CA1330990C (zh)
CS (1)	CS277006B6 (zh)
CY (2)	CY2001A (zh)
DD (2)	DD293962A5 (zh)
DE (2)	DE3855522T2 (zh)
DK (1)	DK171670B1 (zh)
ES (1)	ES2091750T3 (zh)
FI (1)	FI89805C (zh)
GB (1)	GB8712745D0 (zh)
GR (1)	GR3021257T3 (zh)
HK (1)	HK78497A (zh)
HU (2)	HU199870B (zh)
IL (1)	IL86531A (zh)
LU (1)	LU91370I2 (zh)
MC (1)	MC1935A1 (zh)
MY (1)	MY103567A (zh)
NL (1)	NL300302I2 (zh)
NO (2)	NO172543C (zh)
NZ (1)	NZ224813A (zh)
PH (1)	PH27292A (zh)
PL (1)	PL157684B1 (zh)
PT (1)	PT87592B (zh)
SA (1)	SA99200688A (zh)
ZA (2)	ZA883829B (zh)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8712745D0 (en) *	1987-05-30	1987-07-01	Wellcome Found	Antiviral compounds
US6060459A (en) *	1987-10-28	2000-05-09	Pro-Neuron, Inc.	Enhancing blood cell count with oxypurine nucleosides
DD293498A5 (de) *	1989-07-20	1991-09-05	Zi Fuer Molekularbiologie Der Adw,De	Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
GB8919607D0 (en) *	1989-08-30	1989-10-11	Wellcome Found	Novel entities for cancer therapy
US6337209B1 (en)	1992-02-26	2002-01-08	Glaxo Wellcome Inc.	Molecular constructs containing a carcinoembryonic antigen regulatory sequence
KR910007655A (ko) *	1989-10-03	1991-05-30	엠. 피. 잭슨	치료용 뉴클레오시드
US5206351A (en) *	1990-06-15	1993-04-27	Ash Stevens, Inc.	Process for the preparation of 2-amino (2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl)adenine
GB9015914D0 (en) *	1990-07-19	1990-09-05	Wellcome Found	Heterocyclic compounds
US5283331A (en) *	1990-12-20	1994-02-01	Nippon Kayaku Kabushiki Kaisha	2-halogeno-oxetanocin A and phosphoric ester thereof
GB9104165D0 (en) *	1991-02-27	1991-04-17	Wellcome Found	Novel entities for hiv therapy
US5961987A (en) *	1996-10-31	1999-10-05	University Of Iowa Research Foundation	Ocular protein stimulants
JP3619017B2 (ja)	1998-06-24	2005-02-09	日本臓器製薬株式会社	新規アラビノシルアデニン誘導体
US6653318B1 (en)	1999-07-21	2003-11-25	Yale University	5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
EP1261350B1 (en) *	2000-02-18	2006-07-12	Southern Research Institute	Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amine
US6753322B2 (en) *	2000-06-06	2004-06-22	Pfizer Inc	2-aminocarbonyl-9H-purine derivatives
JP3421330B2 (ja) *	2000-11-02	2003-06-30	持田製薬株式会社	ビダラビン注射用乾燥製剤
US7321033B2 (en) *	2001-11-27	2008-01-22	Anadys Pharmaceuticals, Inc.	3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
YU45204A (sh)	2001-11-27	2006-08-17	Anadys Pharmaceuticals Inc.	3-BETA-D-RIBOFURANOZILTIAZOLO/4,5-d/ PIRIMIDINSKI NUKLEOZIDII NJIHOVA UPOTREBA
WO2004028481A2 (en) *	2002-09-30	2004-04-08	Genelabs Technologies, Inc.	Nucleoside derivatives for treating hepatitis c virus infection
PL1824482T3 (pl)	2004-12-17	2014-07-31	Anadys Pharmaceuticals Inc	3,5-Dipodstawione oraz 3,5,7-tripodstawione związki 3H-oksazolo- oraz 3H-tiazolo[4,5-d]pirymidyn-2-onowe i ich proleki
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1987
- 1987-05-30 GB GB878712745A patent/GB8712745D0/en active Pending
1988
- 1988-05-27 DD DD88340139A patent/DD293962A5/de not_active IP Right Cessation
- 1988-05-27 ZA ZA883829A patent/ZA883829B/xx unknown
- 1988-05-27 DE DE3855522T patent/DE3855522T2/de not_active Expired - Lifetime
- 1988-05-27 PL PL1988272729A patent/PL157684B1/pl unknown
- 1988-05-27 ES ES88304813T patent/ES2091750T3/es not_active Expired - Lifetime
- 1988-05-27 HU HU882706A patent/HU199870B/hu active Protection Beyond IP Right Term
- 1988-05-27 PT PT87592A patent/PT87592B/pt not_active IP Right Cessation
- 1988-05-27 HU HU895829A patent/HU205001B/hu unknown
- 1988-05-27 DE DE122008000003C patent/DE122008000003I2/de active Active
- 1988-05-27 MC MC881981A patent/MC1935A1/xx unknown
- 1988-05-27 FI FI882511A patent/FI89805C/fi not_active IP Right Cessation
- 1988-05-27 CA CA000567966A patent/CA1330990C/en not_active Expired - Lifetime
- 1988-05-27 KR KR1019880006295A patent/KR970009474B1/ko not_active IP Right Cessation
- 1988-05-27 DK DK289788A patent/DK171670B1/da not_active IP Right Cessation
- 1988-05-27 CN CN88103820A patent/CN1020107C/zh not_active Expired - Lifetime
- 1988-05-27 NZ NZ224813A patent/NZ224813A/en unknown
- 1988-05-27 AU AU16718/88A patent/AU622403B2/en not_active Expired
- 1988-05-27 CS CS883635A patent/CS277006B6/cs not_active IP Right Cessation
- 1988-05-27 EP EP88304813A patent/EP0294114B1/en not_active Expired - Lifetime
- 1988-05-27 AT AT88304813T patent/ATE142636T1/de active
- 1988-05-27 IL IL86531A patent/IL86531A/xx active Protection Beyond IP Right Term
- 1988-05-27 JP JP63128562A patent/JP2667873B2/ja not_active Expired - Lifetime
- 1988-05-27 MY MYPI88000569A patent/MY103567A/en unknown
- 1988-05-27 DD DD88316143A patent/DD282694A5/de not_active IP Right Cessation
- 1988-05-27 NO NO882357A patent/NO172543C/no not_active IP Right Cessation
1989
- 1989-09-01 PH PH39191A patent/PH27292A/en unknown
- 1989-10-05 ZA ZA897598A patent/ZA897598B/xx unknown
1993
- 1993-08-23 US US08/110,487 patent/US5424295A/en not_active Expired - Lifetime
1995
- 1995-03-14 US US08/403,363 patent/US5539098A/en not_active Expired - Lifetime
1996
- 1996-10-03 GR GR960402608T patent/GR3021257T3/el unknown
1997
- 1997-06-12 HK HK78497A patent/HK78497A/xx not_active IP Right Cessation
- 1997-12-05 CY CY200197A patent/CY2001A/xx unknown
1999
- 1999-10-18 SA SA99200688A patent/SA99200688A/ar unknown
2007
- 2007-10-10 LU LU91370C patent/LU91370I2/fr unknown
- 2007-11-02 NL NL300302C patent/NL300302I2/nl unknown
- 2007-12-21 NO NO2007016C patent/NO2007016I2/no unknown
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- 2008-01-25 CY CY200800001C patent/CY2008001I1/el unknown

Also Published As

Publication number	Publication date
HU199870B (en)	1990-03-28
DK171670B1 (da)	1997-03-10
IL86531A (en)	1993-07-08
DE122008000003I1 (de)	2008-04-17
AU1671888A (en)	1988-12-01
ZA883829B (en)	1990-01-31
MC1935A1 (fr)	1989-05-19
NO2007016I2 (no)	2008-06-23
PT87592A (pt)	1989-05-31
NZ224813A (en)	1991-04-26
NO172543B (no)	1993-04-26
NO172543C (no)	1993-08-04
JP2667873B2 (ja)	1997-10-27
US5539098A (en)	1996-07-23
GB8712745D0 (en)	1987-07-01
MY103567A (en)	1993-08-28
ES2091750T3 (es)	1996-11-16
FI882511A0 (fi)	1988-05-27
IL86531A0 (en)	1988-11-15
GR3021257T3 (en)	1997-01-31
PL157684B1 (pl)	1992-06-30
KR880013967A (ko)	1988-12-22
JPS63310831A (ja)	1988-12-19
CS8803635A2 (en)	1990-09-12
AU622403B2 (en)	1992-04-09
NL300302I2 (nl)	2008-05-01
SA99200688A (ar)	2005-12-03
EP0294114A2 (en)	1988-12-07
PH27292A (en)	1993-05-04
HUT47129A (en)	1989-01-30
DK289788A (da)	1988-12-01
NO2007016I1 (no)	2008-01-14
DK289788D0 (da)	1988-05-27
FI89805B (fi)	1993-08-13
NO882357D0 (no)	1988-05-27
CY2001A (en)	1997-12-05
DE3855522T2 (de)	1997-02-06
KR970009474B1 (ko)	1997-06-13
DE3855522D1 (de)	1996-10-17
ATE142636T1 (de)	1996-09-15
PT87592B (pt)	1992-09-30
CS277006B6 (en)	1992-11-18
DE122008000003I2 (de)	2010-02-04
HK78497A (en)	1997-06-20
FI89805C (fi)	1993-11-25
NO882357L (no)	1988-12-01
DD282694A5 (de)	1990-09-19
US5424295A (en)	1995-06-13
ZA897598B (en)	1990-01-31
CY2008001I2 (el)	2009-11-04
EP0294114B1 (en)	1996-09-11
CA1330990C (en)	1994-07-26
HU895829D0 (en)	1990-01-28
LU91370I2 (fr)	2007-12-10
HU205001B (en)	1992-03-30
FI882511A (fi)	1988-12-01
EP0294114A3 (en)	1990-01-24
CY2008001I1 (el)	2009-11-04
CN1020107C (zh)	1993-03-17
CN1031233A (zh)	1989-02-22
NL300302I1 (nl)	2008-01-02
PL272729A1 (en)	1989-02-06

Publication	Publication Date	Title
DD293962A5 (de)	1991-09-19	Verfahren zur herstellung einer pharmazeutischen formulierung
DE3650130T2 (de)	1995-03-16	Antivirale Nukleoside.
DE69816992T2 (de)	2004-07-22	Benzimidazolderivate
DE602005005240T2 (de)	2009-03-12	4'-C-substituierte 2-Haloadenosinderivate
DE60026861T2 (de)	2006-09-21	Purin-derivate
DE3689976T2 (de)	1995-03-16	Therapeutische Nucleoside und deren Herstellung.
DE69903708T2 (de)	2003-07-03	2-(purin-9-yl)-tetrahydrofuran-3,4-diol-derivate
EP0484333B1 (de)	1995-11-15	Nucleosid-derivate und deren verwendung als arzneimittel
DE3852710T2 (de)	1995-05-24	Therapeutische Nukleoside.
DE69025529T2 (de)	1996-10-17	Weitere antivirale Pyrimidin-Nukleosiden
DD297650A5 (de)	1992-01-16	Verfahren zur herstellung von fluor-substituierten purin-nucleosiden und sie enthaltender pharmazeutischer zubereitungen
EP0257378B1 (de)	1991-07-03	Pyrimidinderivate, ihre Herstellung und Medikamente, die diese Derivate enthalten
DD274766A5 (de)	1990-01-03	Verfahren zur herstellung einer pharmazeutischen formulierung
DD282229A5 (de)	1990-09-05	Verfahren zur herstellung von therapeutischen acyclischen nucleosiden
DE3875769T2 (de)	1993-04-08	Therapeutische nukleoside.
DE3854811T2 (de)	1996-08-01	Anti-HIV Pyrimidin Nucleoside
DE68914750T2 (de)	1994-10-20	Therapeutische Nucleoside.
DE69324244T2 (de)	1999-09-30	Therapeutische nukleoside der 2',3'-dideoxy-3'-fluor -purin reihe
DE69624827T2 (de)	2003-09-04	5'-substitutierte-ribofuranosyl benzimidazolen als antivirale.
DE3872028T2 (de)	1993-01-14	Therapeutische nucleoside.
DD251984A5 (de)	1987-12-02	Verfahren zur herstellung von 3'-azidonucleosiden und pharmazeutisch vertraeglichen derivaten davon
DE68914809T2 (de)	1994-08-11	Antivirale Wirkstoffe.
RU2112765C1 (ru)	1998-06-10	ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ПРОЯВЛЯЮЩАЯ АКТИВНОСТЬ ПРОТИВ ВИРУСНОЙ ИНФЕКЦИИ И β D-АРАБИНОФУРАНОЗИЛ-2-АМИНО-6-МЕТОКСИ-9Н-ПУРИНЫ
DD278940A5 (de)	1990-05-23	Verfahren zur herstellung eines pharmazeutischen praeparats

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