DD211566A5 - Verfahren zur herstellung von 6alpha-methylprednisolon-derivaten - Google Patents

Verfahren zur herstellung von 6alpha-methylprednisolon-derivaten Download PDF

Info

Publication number: DD211566A5
Authority: DD; German Democratic Republic
Prior art keywords: methyl; pregnadiene; dione; dihydroxy; hydroxy
Prior art date: 1981-08-18

Application number

DD82242551A

Other languages

German (de)

English (en)

Inventor

Klaus Annen

Karl Petzoldt

Henry Laurent

Rudolf Wiechert

Helmut Hofmeister

Hans Wendt

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-08-18

Filing date

1982-08-16

Publication date

1984-07-18

1982-08-16 Application filed by Schering Ag filed Critical Schering Ag

1984-07-18 Publication of DD211566A5 publication Critical patent/DD211566A5/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
- C12P33/08—Hydroxylating at 11 position

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Genetics & Genomics (AREA)
Pulmonology (AREA)
Biochemistry (AREA)
Dermatology (AREA)
Immunology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Compositions Of Macromolecular Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DD82242551A 1981-08-18 1982-08-16 Verfahren zur herstellung von 6alpha-methylprednisolon-derivaten DD211566A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19813133081 DE3133081A1 (de)	1981-08-18	1981-08-18	Neue 6(alpha)-methylprednisolon-derivate, ihre herstellung und verwendung

Publications (1)

Publication Number	Publication Date
DD211566A5 true DD211566A5 (de)	1984-07-18

Family

ID=6139787

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD82242551A DD211566A5 (de)	1981-08-18	1982-08-16	Verfahren zur herstellung von 6alpha-methylprednisolon-derivaten

Country Status (23)

Country	Link
US (1)	US4587236A (da)
EP (1)	EP0072547B1 (da)
JP (1)	JPS5874698A (da)
AT (1)	ATE18768T1 (da)
AU (1)	AU560160B2 (da)
CA (1)	CA1251783A (da)
CS (2)	CS244115B2 (da)
DD (1)	DD211566A5 (da)
DE (2)	DE3133081A1 (da)
DK (1)	DK160505C (da)
ES (1)	ES515081A0 (da)
FI (1)	FI72730C (da)
GB (1)	GB2105339A (da)
GR (1)	GR78361B (da)
HU (1)	HU186965B (da)
IE (1)	IE53753B1 (da)
IL (1)	IL66511A (da)
LU (1)	LU88289I2 (da)
MX (1)	MX9203687A (da)
NO (1)	NO156203C (da)
NZ (1)	NZ201544A (da)
PT (1)	PT75294B (da)
ZA (1)	ZA826017B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS58103399A (ja) *	1981-12-11	1983-06-20	Ota Seiyaku Kk	６α−メチルプレドニゾロン１７−エステル化合物
JPS58208299A (ja) *	1982-05-31	1983-12-03	Ota Seiyaku Kk	６α−メチルプレドニゾロン１７，２１−ジエステル化合物
EP0095894A3 (en) *	1982-05-31	1985-01-02	Ohta Seiyaku Kabushiki Kaisha.	6 alpha-methylprednisolone derivatives
JPS59193900A (ja) *	1983-04-15	1984-11-02	Ota Seiyaku Kk	新規６α−メチルプレドニゾロン１７α−エステル誘導体
JPS597200A (ja) *	1982-07-02	1984-01-14	Ota Seiyaku Kk	６α−メチルプレドニゾロン１７α−エステル化合物
DE3344834A1 (de) *	1983-12-08	1985-06-13	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue hydrocortison-und prednisolon-derivate
AR045536A1 (es) *	2003-08-29	2005-11-02	Ranbaxy Lab Ltd	Inhibidores de la fosfodiesterasa tipo -iv
WO2005051931A2 (en) *	2003-11-26	2005-06-09	Ranbaxy Laboratories Limited	Phosphodiesterase inhibitors
WO2007031838A1 (en)	2005-09-16	2007-03-22	Ranbaxy Laboratories Limited	Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
WO2007045980A1 (en) *	2005-10-19	2007-04-26	Ranbaxy Laboratories Limited	Compositions of phosphodiesterase type iv inhibitors
BRPI0617674A2 (pt)	2005-10-19	2011-08-02	Ranbaxy Lab Ltd	composições farmacêuticas e seus usos
EP2066661A2 (en) *	2006-09-22	2009-06-10	Ranbaxy Laboratories Limited	Phosphodiesterase inhibitors
JP2010504323A (ja) *	2006-09-22	2010-02-12	ランバクシーラボラトリーズリミテッド	Ｉｖ型ホスホジエステラーゼの阻害物質
CN100439388C (zh) *	2006-10-11	2008-12-03	汪家振	甲基泼尼松龙醋丙酸酯的合成方法
EP1958947A1 (en)	2007-02-15	2008-08-20	Ranbaxy Laboratories Limited	Inhibitors of phosphodiesterase type 4
EP2124943A1 (en) *	2007-03-14	2009-12-02	Ranbaxy Laboratories Limited	Pyrazolo [3, 4-b]pyridine derivatives as phosphodiesterase inhibitors
MX2009009793A (es)	2007-03-14	2009-10-16	Ranbaxy Lab Ltd	Derivados de pirazolo (3,4-b) piridina como inhibidores de fosfodiesterasa.
EP2111861A1 (en)	2008-04-21	2009-10-28	Ranbaxy Laboratories Limited	Compositions of phosphodiesterase type IV inhibitors
CN102659886A (zh) *	2010-04-20	2012-09-12	天津金耀集团有限公司	一种醋丙甲泼尼龙新晶型与制备方法
WO2011130877A1 (zh) *	2010-04-21	2011-10-27	天津金耀集团有限公司	醋丙甲泼尼龙一水合物晶型及其制备方法
GR1009641B (el)	2018-06-18	2019-11-12	Laboserve Φαρμακευτικη Βιομηχανια Α.Ε.	Ποσιμες συνθεσεις που περιλαμβανουν νατριοηλεκτρικη μεθυλοπρεδνιζολονη
CN111748010B (zh) *	2019-03-29	2023-12-08	天津药业研究院股份有限公司	一种醋丙甲泼尼龙无水晶型及其组合物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2897218A (en) *	1956-11-23	1959-07-28	Upjohn Co	6-methyl-1-dehydro analogues of cortisone, hydrocortisone and 21-esters thereof
US2867632A (en) *	1956-11-23	1959-01-06	Upjohn Co	6-methyl steroid compounds
US3053832A (en) *	1957-04-29	1962-09-11	Schering Corp	Alkylated cortical steroids
US3176032A (en) *	1958-04-18	1965-03-30	Syntex Corp	17alpha, 21-diacyloxy derivatives of 6alpha-methyl-delta1, 4-pregnadien-3, 20-dione and of 6alpha-methyl-delta4-pregnen-3, 20-dione
GB1047518A (en) *	1963-06-11	1966-11-02	Glaxo Lab Ltd	17ª-monoesters of 11,17,21-trihydroxy steroid compounds
NL6612191A (da) *	1965-08-30	1967-03-01
US3422193A (en) *	1966-08-11	1969-01-14	Schering Corp	17-mono esters of corticoids
DE2144405A1 (de) *	1971-09-04	1973-03-08	Merck Patent Gmbh	Verfahren zur herstellung von estern der pregnanreihe
JPS6040439B2 (ja) *	1978-03-29	1985-09-11	大正製薬株式会社	ヒドロコルチゾン誘導体
JPS5686119A (en) *	1979-12-17	1981-07-13	Taiho Yakuhin Kogyo Kk	Steroid anti-inflammatory
DE3169460D1 (en) *	1980-12-23	1985-04-25	Schering Ag	6-alpha-methyl hydrocortisone derivatives, their preparation and their utilization
IL66432A0 (en) *	1981-08-04	1982-12-31	Plurichemie Anstalt	Process for the preparation of steroidal esters
EP0095894A3 (en) *	1982-05-31	1985-01-02	Ohta Seiyaku Kabushiki Kaisha.	6 alpha-methylprednisolone derivatives

1981
- 1981-08-18 DE DE19813133081 patent/DE3133081A1/de not_active Withdrawn
1982
- 1982-07-21 PT PT75294A patent/PT75294B/pt unknown
- 1982-08-10 IL IL66511A patent/IL66511A/xx not_active IP Right Cessation
- 1982-08-10 NZ NZ201544A patent/NZ201544A/en unknown
- 1982-08-13 AT AT82107368T patent/ATE18768T1/de active
- 1982-08-13 DE DE8282107368T patent/DE3270118D1/de not_active Expired
- 1982-08-13 EP EP82107368A patent/EP0072547B1/de not_active Expired
- 1982-08-16 DD DD82242551A patent/DD211566A5/de not_active IP Right Cessation
- 1982-08-16 AU AU87177/82A patent/AU560160B2/en not_active Expired
- 1982-08-17 NO NO822799A patent/NO156203C/no not_active IP Right Cessation
- 1982-08-17 GR GR69050A patent/GR78361B/el unknown
- 1982-08-17 HU HU822640A patent/HU186965B/hu unknown
- 1982-08-17 CA CA000409576A patent/CA1251783A/en not_active Expired
- 1982-08-18 DK DK369482A patent/DK160505C/da not_active IP Right Cessation
- 1982-08-18 FI FI822871A patent/FI72730C/fi not_active IP Right Cessation
- 1982-08-18 JP JP57142212A patent/JPS5874698A/ja active Granted
- 1982-08-18 CS CS826061A patent/CS244115B2/cs unknown
- 1982-08-18 IE IE1988/82A patent/IE53753B1/en not_active IP Right Cessation
- 1982-08-18 ZA ZA826017A patent/ZA826017B/xx unknown
- 1982-08-18 GB GB08223809A patent/GB2105339A/en not_active Withdrawn
- 1982-08-18 ES ES515081A patent/ES515081A0/es active Granted
- 1982-08-18 CS CS829880A patent/CS988082A2/cs unknown
1983
- 1983-10-27 US US06/546,143 patent/US4587236A/en not_active Expired - Lifetime
1992
- 1992-06-29 MX MX9203687A patent/MX9203687A/es unknown
1993
- 1993-06-09 LU LU88289C patent/LU88289I2/fr unknown

Also Published As

Publication number	Publication date
CS988082A2 (da)	1985-08-31
PT75294A (de)	1982-08-01
ES8305380A1 (es)	1983-05-01
DK369482A (da)	1983-02-19
NO156203B (no)	1987-05-04
IL66511A0 (en)	1982-12-31
FI822871L (fi)	1983-02-19
AU560160B2 (en)	1987-04-02
EP0072547B1 (de)	1986-03-26
ES515081A0 (es)	1983-05-01
CS606182A2 (en)	1985-08-15
MX9203687A (es)	1992-08-01
NO156203C (no)	1987-08-12
IE821988L (en)	1983-02-18
DE3270118D1 (en)	1986-04-30
IE53753B1 (en)	1989-02-01
IL66511A (en)	1986-12-31
DE3133081A1 (de)	1983-03-10
AU8717782A (en)	1983-02-24
ATE18768T1 (de)	1986-04-15
US4587236A (en)	1986-05-06
EP0072547A1 (de)	1983-02-23
NO822799L (no)	1983-02-21
GB2105339A (en)	1983-03-23
JPS5874698A (ja)	1983-05-06
ZA826017B (en)	1983-07-27
LU88289I2 (fr)	1994-05-04
GR78361B (da)	1984-09-26
CA1251783A (en)	1989-03-28
DK160505B (da)	1991-03-18
FI72730C (fi)	1987-07-10
HU186965B (en)	1985-10-28
DK160505C (da)	1991-08-26
NZ201544A (en)	1986-01-24
CS244115B2 (en)	1986-07-17
FI822871A0 (fi)	1982-08-18
FI72730B (fi)	1987-03-31
JPH0149278B2 (da)	1989-10-24
PT75294B (de)	1984-07-02

Publication	Publication Date	Title
DD211566A5 (de)	1984-07-18	Verfahren zur herstellung von 6alpha-methylprednisolon-derivaten
EP0110041B1 (de)	1987-07-29	Neue 6alpha-Methylkortikoide, ihre Herstellung und Verwendung
EP0072546B1 (de)	1985-10-09	Neue Hydrocortison-Derivate, ihre Herstellung und Verwendung
EP0054786B1 (de)	1985-03-20	Neue 6-alpha-Methylhydrocortison-Derivate, ihre Herstellung und Verwendung
DE1154102B (de)	1963-09-12	Verfahren zur Herstellung therapeutisch wirksamer Steroidverbindungen
CH618704A5 (da)	1980-08-15
DE3042529A1 (de)	1982-06-24	11-methylen- (delta)(pfeil hoch)1(pfeil hoch)(pfeil hoch)5(pfeil hoch) -steroide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE1059906B (de)	1959-06-25	Verfahren zur Herstellung von 1, 4-Pregnadienen
EP0003341B1 (de)	1984-06-27	11,17-substituierte Pregnane, ihre Herstellung und Verwendung zur Herstellung von pharmazeutischen Präparaten
DD158778A5 (de)	1983-02-02	Verfahren zur herstellung halogenierter steroide
CH633562A5 (de)	1982-12-15	Verfahren zur herstellung neuer kortikoide.
CH623062A5 (da)	1981-05-15
DE2839033A1 (de)	1980-03-13	3-oxo-4-pregnen-20 alpha -carbonsaeure- derivate, ihre herstellung und verwendung
DE2636405C2 (de)	1982-07-08	&Delta;&uarr;1&uarr;&uarr;5&uarr;-17&alpha;-Chloräthinyl- und -Propinylsteroide der Östranreihe, Verfahren zu ihrer Herstellung sowie diese enthaltende pharmazeutische Präparate
EP0149222A2 (de)	1985-07-24	Neue 6alpha, 16alpha-Dimethylkortikoide
EP0032103B1 (de)	1984-06-13	Neue Kortikoid-17-thioacetale, ihre Herstellung und Verwendung
EP0164298A2 (de)	1985-12-11	Neue 6alpha-Methyl-D-homo-kortikoide
EP0033120B1 (de)	1983-06-29	1-Hydroxysteroide, Verfahren zu ihrer Herstellung und pharmazeutische Präparate, die diese Verbindungen enthalten
EP0049783B1 (de)	1986-10-22	D-Homo-kortikoide, ihre Herstellung und Verwendung
EP0013959A1 (de)	1980-08-06	Neue D-Homosteroide, Verfahren zu deren Herstellung und diese D-Homosteroide enthaltende Arzneimittel
DE2855465A1 (de)	1980-07-10	Neue kortikoide, verfahren zu ihrer herstellung, ihre verwendung und diese kortikoide enthaltende pharmazeutische praeparate
EP0078432A1 (de)	1983-05-11	Neue Kortikoide, ihre Herstellung und Verwendung
DE2753839A1 (de)	1979-05-31	Neue kortikoide
DE2059310A1 (de)	1972-06-08	Neue 6alpha,16alpha-Dimethylsteroide
EP0112467A1 (de)	1984-07-04	Neue 6alpha-Methylprednisolon-Derivate ihre Herstellung und Verwendung

Legal Events

Date	Code	Title	Description
1999-10-14	ENJ	Ceased due to non-payment of renewal fee