CZ200563A3 - Therapeutical composition containing olanzapin as active component and process for its preparation - Google Patents

Abstract

In the present invention, there is disclosed a pharmaceutical composition containing, as the active agent, antipsychotic suitable for treating schizophrenia i.e. olanzapine and further a filler and auxiliary substances, in the form of tablet obtainable by direct tabletting, the core of the tablet containing olanzapine in an amount of 0.5 to 20 percent by weight and a pharmaceutically acceptable filler in an amount of 35 to 99 percent by weight with the particle sizes ranging from 90 to 360 micrometers, the core being optionally coated, in which case the coating contains 1 to 10 percent by weight of polyethylene glycol after drying wherein the pharmaceutically acceptable filler being represented by microcrystalline cellulose. A process for the preparation of tablets is also disclosed.

Description

Technical field

The invention relates to a tablet containing the active ingredient olanzapine, prepared by direct tabletting, and to a process for its preparation.

BACKGROUND OF THE INVENTION

Olanzapine, a chemical with the chemical name 2-methyl-4- (4-methyl-1-piperazinyl) -10Hthieno [2,3-b] [1,5] benzodiazepine, formula I

belongs to the class of antipsychotics used to treat schizophrenia.

Olanzapine has been described in EP 456 436, where the pharmaceutical form of the substance has also been generally mentioned. A number of excipients which can be used in the manufacture of the dosage form are listed in the patent. The tablet according to the patent is made by granulating a mixture of olanzapine, microcrystalline cellulose, magnesium stearate and starch using povidone as a binder. The granulate is further tableted.

Further information on the olanzapine dosage form is described in EP 733367 B. It is a film-coated tablet containing lactose, hydroxypropyl cellulose,

AKTOOJW microcrystalline cellulose in the core and hydroxypropylmethyl cellulose (HPMC) in the insulation layer of the coating and subsequent coating of the suspensions. For the coating, according to the patent, an insulating layer is important to prevent discoloration of the tablet, which is a particular problem with olanzapine. According to the patent, polyethylene glycol is not suitable for a coating to prevent discolouration.

The tablet of patent EP 733-367B is produced by the wet granulation, drying and tabletting technique. It is clear from the patent (page 4) that the applicant believes that in the case of direct tabletting an insufficiently homogeneous mixture (non-uniformity of batches) is produced and recommends a wet granulation method in a high shear granulation machine.

Indeed, the high shear wet granulation method as proposed in the cited document actually provides better homogeneity and hence uniformity of composition in the individual tablets. On the other hand, it also has negative effects. In particular, the active ingredient is subjected to a wet thermal stress. This can lead to a number of decomposition reactions and ultimately lower product purity.

Wet granulation may also cause discoloration of the tablet, which is then treated with a suitable coating.

Another problem may be the change in the crystalline form of the active ingredient, which also often occurs as a result of wet heating. Changing the crystalline form may lead to a change in the bioavailability of the active ingredient in the dosage form, which in the worst case eventually results in a loss of action. Especially with olanzapine, where a number of crystalline forms are described, and several types of solvates, the risk of switching to another crystalline form is particularly high.

It therefore appears desirable to overcome the problem of insufficient uniformity of dosage in direct tabletting in order to use this gentle method for olanzapine. Such a composition is solved by the present invention.

A medicament comprising olanzapine as an active ingredient, and a filler and excipients in the form of a tablet, characterized in that the composition for its manufacture permits direct tabletting, wherein the tablet core contains olanzapine in an amount of 0.5 to 20% by weight; and a pharmaceutically acceptable filler which is microcrystalline cellulose in an amount of 35 to 99% by weight. % of the particles having a particle size of 90 to 360 µm, optionally the core is coated, the coating after drying containing 1 to 10 wt. polyethylene glycol.

The ratio of filler to active ingredient is 3 to 100: 1, more preferably 5 to 30: 1, most preferably 10 to 25: 1. The medicament composition of the invention preferably comprises a pharmaceutically usable filler in an amount of 60 to 95% by weight. and preferably has a particle size of 180 µm. The content of the active ingredient olanzapine is preferably 2 to 10%.

Microcrystalline cellulose was chosen as a pharmaceutically acceptable filler.

Thus, microcrystalline cellulose is primarily harmless to health and has suitable physical properties for this function. Other useful fillers to be used in combination with microcrystalline cellulose and their properties can be found in various types of pharmaceutical publications, such as the Handbook of Pharmaceutical Excipients by the American Pharmaceutical Association.

The invention also provides a process for the manufacture of a tablet comprising olanzapine as an active ingredient, comprising mixing the olanzapine and filler mixture in a homogenizer, optionally adding a flow modifier and an anti-adhesive agent in the next step and tableting after homogenization.

DETAILED DESCRIPTION OF THE INVENTION

Tablets made by direct tabletting have a number of advantages over tablets, which need to be obtained by alternative methods.

The preparation of the pulp is technologically simple, it is limited to technological and time-saving technological steps. The preparation of the tablet does not include stressful procedures, such as introducing the wetting agent into the active ingredient / excipient mixture and dry granulation by compacting the active ingredient / excipient preparation.

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Dry blending of the tablet allows the preparation of cores and / or tablets of satisfactory parameters, and the method of preparation and selection of excipients according to the invention also ensure good stability of the formulation and the desired physical properties of the dosage form.

The direct tabletting technique is not only simple, but above all the most environmentally friendly. Thus, it represents a further advance over the previously described wet granulation techniques associated with wetting and dry granulation associated with compacting and the need to apply high pressures which may then cause drug release problems to the patient. Due to such problems, a substantial part of the drug may not be used at all.

For direct tabletting, however, it is necessary to find such a mixture of the active ingredient and excipients which can be tabletted without any modification, producing a tablet meeting all the requirements. The tablet of the medicinal product must be hard enough to withstand various types of transport burden. Further, however, it must disintegrate sufficiently quickly when in contact with water to release the active ingredient into solution before it passes through the patient's upper digestive tract. The hardness value of the tablet and the release (dissolution) of the active substance are therefore two variables which are more or less opposed and the conditions must always be optimized.

Another problem with direct tableting may be the variation in the dosage size in the individual tablets, so the uniformity of the dosage is a problem. As mentioned above, this problem was expected in the preparation of the olanzapine tablet (EP0 733 ^ 67B). Thus, dry mixing may not be sufficiently effective. This was the reason why only wet granulation has been applied so far, preferably in a high shear granulator.

In the direct tabletting technique, the homogeneity and hence uniformity of the doses is influenced by the percentage of active ingredient. While the advantageous properties of the tablet described in the previous paragraph (sufficient hardness and release rate) are better achieved at a lower concentration of active ingredient, on the contrary, the achieved uniformity of doses is better at a higher concentration of active ingredient. Expected Problems ”5 with dose uniformity in the EPO patent

733

67B, can be interpreted as meaning that there was an expectation that a formulation would not be found which, with the desired reasonable concentration of olanzapine, simultaneously met both contradictory aspects.

For the olanzapine medicament of the present invention, the filler, or its proportion in the tablet core, and the particle size of which it is formed are essential.

The olanzapine tablet, which meets both the hardness and release rate of the active ingredient and the homogeneity (uniformity) of the individual doses, has been shown to contain 0.5-20% by weight. the active ingredients in the form of olanzapine; and a pharmaceutically acceptable filler which is microcrystalline cellulose in an amount of 35 to 99% by weight. having a particle size of 90 to 360 µm, but preferably 180 µm.

Further, it has been found that a tablet having a higher filler surplus of between 3 and 100 times the volume of active ingredient has better properties.

The most preferred ratios between the active ingredient and the filler are 1: 5 to 30, especially between 1: 10 to 25.

In a preferred embodiment, the active ingredient content of the tablet core is between 2 and 10% by weight.

For the purposes of the present invention, microcrystalline cellulose has proven to be the most preferred filler. It has good flow properties. Tablets have satisfactory strength and disintegration because microcrystalline cellulose in the compact ensures the maintenance of capillary openings through which water inhibits the binding force efficiency. They provide the product with very good stability. The quality of the selected microcrystalline cellulose is essential for the formulation of the invention. The particle size of the commercially available cellulose for pharmaceutical purposes ranges from about 1 to 1000 µm. For direct tabletting of olanzapine, cellulose in the range of 90 to 360 µm particle size is usable, with a size of 180 µm being most preferred.

In another embodiment, the tabletting composition comprises a substance to improve its flow properties. The most preferred material for the described composition is colloidal silica (colloidalis anhydrica), preferably in an amount of 0.1 to 10%, particularly preferably 0.1 to 4%. These

3 & £ 5-6-6 - The substances are important to prevent variations in tablet weight caused by inappropriate flow of solid mixture through the hopper into the high-performance tablet machine.

In another embodiment, the tabletting composition comprises an anti-adhesive agent to facilitate the tabletting process. The most preferred material for the described composition is magnesium stearate, preferably in an amount of 0.1 to 10%, particularly preferably 0.5 to 4%. From these mixtures it is possible to prepare a tablet or a tablet. tablets by dry route, dry blending and direct tabletting.

The tablets according to the invention guarantee the reproducibility of the manufacturing process.

The advantage is the energy and time-consuming preparation of the pulp.

Said process for the production of olanzapine-containing tablet and solid dosage forms by direct dry blending tableting and the selection of excipients according to the invention make it possible to prepare the tablet and solid dosage forms with excellent physical parameters.

DETAILED DESCRIPTION OF THE INVENTION

Example 1

Fillers microcrystalline cellulose

Olanzapine 10 mg tablets

Starting materials weight in g Olanzapinum 0.01000 g Cellulosum microcrystallinum, size 180 pm 0.17710 g Silicon dioxide colloidale 0.00100 g Magnesii stearas 0.00190 g Total weight tbl. in g 0.19000 g

Description of the technology of preparation of the pulp (dry way, direct tabletting):

1. Mixing I: The active substance and the microcrystalline cellulose are mixed in a homogenizer for 15 minutes.

2. Stirring II: add the finishing agents silica colloidale and magnesii stearas and mix in a homogenizer for 15 minutes.

3. Tableting

Two important quantities were determined for the tablets thus prepared. This was a fracture resistance that is necessary to keep the tablets whole during transport and the rate of release of the active ingredient into the dissolution medium, the value of which indicates the availability of the drug to the patient. Both quantities were measured by standard procedures.

The tablets thus produced showed a fracture resistance of at least 60N, indicating that they would not be damaged during normal transport.

The content of Olanzapine 10 mg tablets thus produced was in accordance with the 9.5 - 10.5 mg limit.

In the drug release test, more than 85% of the total content was released in 30 minutes. This was a very good match with the already registered and marketed Zyprexa from Eli Lilly.

Thus, it appears that the tablets produced by this new process are identical in properties to those obtained by known, standard processes.

The same procedure gave olanzapine 20 mg, 15 mg, 7.5 mg, 5 mg, 2.5 mg.

Ingredients:

Olanzapine 20 mg tablets

Starting materials weight in g Olanzapinum 0,02000 g Cellulosum microcrystallinum, size 180 pm 0.35420 g Silicon dioxide colloidale 0.00200 g Magnesii stearas 0.00380 g Total weight tbl. in g 0,38000 g

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Olanzapine 15 mg tablets

Starting materials weight in g Olanzapinum 0.01500 g Cellulosum microcrystallinum, size 180 pm 0.26565 g Silicon dioxide colloidale 0.00150 g Magnesii stearas 0.00285 g Total weight tbl. in g 0,28500 g

Olanzapine 7.5 mg tablets

Starting materials weight in g Olanzapinum 0.007500 g Cellulosum microcrystallinum, size 180 pm 0.132825 g Silicon dioxide colloidale 0.000750 g Magnesii stearas 0.001425 g Total weight tbl. in g 0.142500 g

Olanzapine 5 mg tablets

Starting materials weight in g Olanzapinum 0.00500 g Cellulosum microcrystallinum, size 180 pm 0.08885 g Silicon dioxide colloidale 0.00050 g Magnesii stearas 0.00095 g Total weight tbl. in g 0,09500 g

Olanzapine 2.5 mg tablets

Starting materials weight in g Olanzapinum 0.002500 g Cellulosum microcrystallinum, size 180 pm 0.091050 g Silicon dioxide colloidale 0.000500 g

Magnesii stearas 0.000950 g Total weight tbl. in g 0,095000 g

The content uniformity of the tablets was tested with Olanzapine 2.5 mg tablets (Table 1) (requirement 2.375 to 2.625 mg)

Tab. 1

Tablet no. 1 2 3 4 5 6 7 8 9 10 Content / mg / 2,472 2,455 2,467 2,469 2,431 2,520 2,441 2,452 2,458 2,462

Based on the above results, it can be concluded that the content uniformity of the tablets thus produced is satisfactory and that homogeneous tablets can be produced by the above process.

Example 5

Coated tablets

Olanzapine 10 mg coated tablets

Starting materials weight in g Olanzapinum 0.01000 g Cellulosum microcrystallinum, size 180 pm 0.17710 g Silicon dioxide colloidale 0.00100 g Magnesii stearas 0.00190 g Total core weight in g 0.19000 g Sepifilm White 0.01000 g Poiyethylenglycolum 0.00050 g Aqua purificata 0,03500 g Total weight coated tbl. in g 0.20050 g

The treatment was carried out according to Example 1.

Claims (9)

PATENT CLAIMS A medicament comprising olanzapine as an active ingredient and further a filler and excipients in the form of a tablet, characterized in that the composition for its manufacture permits direct tabletting, wherein the tablet core contains olanzapine in an amount of 0.5 to 20% by weight. and a pharmaceutically usable filler which is microcrystalline cellulose in an amount of 35 to 99 wt. % of the particles having a particle size of 90 to 360 µm, optionally the core is coated, the coating after drying containing 1 to 10 wt. polyethylene glycol. Medicament according to claim 1, characterized in that the ratio of filler to active substance is 3 to 100: 1, more preferably 5 to 30: 1, most preferably 10 to 25: 1. Medicament according to claim 1 or 2, characterized in that it comprises a pharmaceutically usable filler in an amount of 60 to 95% by weight. Medicament according to any one of the preceding claims, characterized in that the microcrystalline cellulose has a particle size of 180 µm. Medicament according to claim 1 or 2, characterized in that the active substance content is 2 to 10% by weight. O Medicament according to any one of the preceding claims, characterized in that it additionally comprises a flow modifier and an anti-adhesive. Medicament according to claim 6, characterized in that it contains 0.1 to 10% by weight, preferably 0.1 to 4% by weight, of a flow modifying agent of the tablet, preferably colloidal silica. Medicament according to claim 6, characterized in that it contains 0.1 to 10% by weight, preferably 0.5 to 4% by weight, of an anti-adhesive substance, preferably magnesium stearate. Process for the manufacture of a tablet containing olanzapine as active ingredient according to claims 1 to 8, characterized in that the mixture of olanzapine and filler is mixed in a homogenizer, optionally in a further step a flow agent and a non-sticking agent are added and after homogenization tablets.