CY1124427T1 - Συνθεση omecamtiv mecarbil - Google Patents
Συνθεση omecamtiv mecarbilInfo
- Publication number
- CY1124427T1 CY1124427T1 CY20211100714T CY211100714T CY1124427T1 CY 1124427 T1 CY1124427 T1 CY 1124427T1 CY 20211100714 T CY20211100714 T CY 20211100714T CY 211100714 T CY211100714 T CY 211100714T CY 1124427 T1 CY1124427 T1 CY 1124427T1
- Authority
- CY
- Cyprus
- Prior art keywords
- composition
- omecamtiv mecarbil
- omecamtiv
- mecarbil
- formulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Εδώ παρέχεται μια σύνθεση για ένυδρο διϋδροχλωρίδιο omecamtiv mecarbil και διάφορα ενδιάμεσα προϊόντα.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762527174P | 2017-06-30 | 2017-06-30 | |
| US201862664363P | 2018-04-30 | 2018-04-30 | |
| PCT/US2018/040176 WO2019006231A1 (en) | 2017-06-30 | 2018-06-29 | SYNTHESIS OF OMECAMTIV MECARBIL |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124427T1 true CY1124427T1 (el) | 2022-07-22 |
Family
ID=62976317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100714T CY1124427T1 (el) | 2017-06-30 | 2021-08-10 | Συνθεση omecamtiv mecarbil |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US11040956B2 (el) |
| EP (3) | EP3645518B1 (el) |
| JP (2) | JP7181896B2 (el) |
| KR (1) | KR102625774B1 (el) |
| CN (1) | CN110799503B (el) |
| AU (2) | AU2018294254C1 (el) |
| BR (1) | BR112019028205A2 (el) |
| CA (1) | CA3063102A1 (el) |
| CL (2) | CL2019003898A1 (el) |
| CY (1) | CY1124427T1 (el) |
| DK (1) | DK3645518T3 (el) |
| ES (1) | ES2882905T3 (el) |
| GE (2) | GEP20247675B (el) |
| HR (1) | HRP20211290T1 (el) |
| HU (1) | HUE055242T2 (el) |
| IL (2) | IL270663B (el) |
| LT (1) | LT3645518T (el) |
| MD (1) | MD3645518T2 (el) |
| MX (2) | MX2021013326A (el) |
| PH (1) | PH12019502883A1 (el) |
| PL (1) | PL3645518T3 (el) |
| PT (1) | PT3645518T (el) |
| RS (1) | RS62328B1 (el) |
| SG (1) | SG10202111790YA (el) |
| SI (1) | SI3645518T1 (el) |
| SM (1) | SMT202100472T1 (el) |
| TW (2) | TWI847144B (el) |
| UA (1) | UA127517C2 (el) |
| WO (1) | WO2019006231A1 (el) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2970123T1 (sl) | 2013-03-14 | 2019-12-31 | Amgen Inc. | Sol omekamtiv mekarbila in postopek za pripravo soli |
| CA3063102A1 (en) | 2017-06-30 | 2019-01-03 | Amgen Inc. | Synthesis of omecamtiv mecarbil |
| BR112019028046A2 (pt) | 2017-06-30 | 2020-07-07 | Amgen Inc. | métodos de tratamento da insuficiência cardíaca com ativadores de sarcômeros cardíacos |
| IL272573B2 (en) | 2017-09-13 | 2023-10-01 | Amgen Inc | Bisamide sarcomere activating compounds and uses thereof |
| SI3594199T1 (sl) | 2018-07-09 | 2020-10-30 | F.I.S.- Fabbrica Italiana Sintetici S.P.A. | Kristalinični 2-fluoro-3-nitrotoluen in postopek za njegovo pripravo |
| EP3837009A1 (en) | 2018-08-17 | 2021-06-23 | Amgen, Inc | Salts and crystal forms of omecamtiv mecarbil |
| WO2021070124A1 (en) * | 2019-10-09 | 2021-04-15 | Dr. Reddy’S Laboratories Limited | Alternate processes for the preparation of omecamtiv mecarbil |
| US20220402874A1 (en) * | 2019-10-09 | 2022-12-22 | Dr. Reddy's Laboratories Limited | Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof |
| TW202233189A (zh) | 2020-11-12 | 2022-09-01 | 美商安進公司 | 藉由投與奧美卡替莫卡必爾治療心臟衰竭之方法 |
| BR112023018095A2 (pt) | 2021-03-10 | 2023-12-12 | Amgen Inc | Processos para sintetizar 2-fluoro-3-nitrotolueno, 1-(bromometil)-2-fluoro-3-nitrobenzeno e para preparar omecamtiv mecarbil ou um sal do mesmo, um hidrato do mesmo ou um hidrato de sal do mesmo |
| WO2023205291A2 (en) * | 2022-04-21 | 2023-10-26 | The Board Of Regents Of The University Of Oklahoma | Targeting myocardial tissue for delivery of therapeutic and imaging agents |
| US11986474B1 (en) | 2023-06-27 | 2024-05-21 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6492529B1 (en) * | 2000-01-18 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Bis pyrazole-1H-pyrazole intermediates and their synthesis |
| RS53600B1 (en) | 2004-06-17 | 2015-02-27 | Cytokinetics, Inc. | UNITS, PREPARATIONS AND METHODS |
| EP1959960B1 (en) | 2005-12-15 | 2013-04-10 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
| US20070208000A1 (en) | 2005-12-15 | 2007-09-06 | Morgan Bradley P | Certain chemical entities, compositions and methods |
| EP1962852B1 (en) | 2005-12-19 | 2017-01-25 | Cytokinetics, Inc. | Compounds, compositions and methods |
| DE112006004156A5 (de) * | 2006-09-25 | 2009-09-03 | Siemens Aktiengesellschaft | Sammelschienenkontaktierung mit Schienendickenausgleich |
| ME01308B (me) * | 2006-10-18 | 2013-12-20 | Pfizer Prod Inc | Jedinjenja biaril etra uree |
| US20090192168A1 (en) | 2008-01-04 | 2009-07-30 | Alex Muci | Compounds, Compositions and Methods |
| WO2010141817A1 (en) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
| RS59106B1 (sr) | 2010-11-10 | 2019-09-30 | Genentech Inc | Derivati pirazol aminopirimidina kao lrrk2 modulatori |
| CN104271569B (zh) | 2012-05-03 | 2016-08-24 | 霍夫曼-拉罗奇有限公司 | 作为lrrk2调节剂的吡唑氨基嘧啶衍生物 |
| WO2014152198A1 (en) | 2013-03-14 | 2014-09-25 | Amgen Inc. | Heterocyclic compounds and their uses |
| SI2970123T1 (sl) | 2013-03-14 | 2019-12-31 | Amgen Inc. | Sol omekamtiv mekarbila in postopek za pripravo soli |
| WO2015152236A1 (ja) | 2014-03-31 | 2015-10-08 | 株式会社メテク | 血液浄化装置及び血液浄化装置の補液・プライミング方法 |
| CN107108593B (zh) * | 2014-11-24 | 2020-03-24 | 美迪福伦Dbt有限公司 | 作为类香草素受体配体ii的基于取代的恶唑和噻唑的羧酰胺和脲衍生物 |
| EP3250557B1 (en) | 2015-01-29 | 2024-11-20 | Signal Pharmaceuticals, LLC | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| WO2016210240A1 (en) | 2015-06-26 | 2016-12-29 | Amgen Inc. | Combination therapy of cardiac myosin activator and sinus node if current inhibitor |
| BR112019028046A2 (pt) | 2017-06-30 | 2020-07-07 | Amgen Inc. | métodos de tratamento da insuficiência cardíaca com ativadores de sarcômeros cardíacos |
| CA3063102A1 (en) | 2017-06-30 | 2019-01-03 | Amgen Inc. | Synthesis of omecamtiv mecarbil |
| SI3594199T1 (sl) | 2018-07-09 | 2020-10-30 | F.I.S.- Fabbrica Italiana Sintetici S.P.A. | Kristalinični 2-fluoro-3-nitrotoluen in postopek za njegovo pripravo |
| EP3837009A1 (en) | 2018-08-17 | 2021-06-23 | Amgen, Inc | Salts and crystal forms of omecamtiv mecarbil |
| WO2020131574A1 (en) | 2018-12-18 | 2020-06-25 | Amgen Inc. | Method of reducing aromatic nitro compounds |
| WO2021070124A1 (en) | 2019-10-09 | 2021-04-15 | Dr. Reddy’S Laboratories Limited | Alternate processes for the preparation of omecamtiv mecarbil |
| JP2023513249A (ja) | 2020-02-10 | 2023-03-30 | アムジェン インコーポレイテッド | オメカムチブメカルビル製剤 |
| TW202233189A (zh) | 2020-11-12 | 2022-09-01 | 美商安進公司 | 藉由投與奧美卡替莫卡必爾治療心臟衰竭之方法 |
| BR112023018095A2 (pt) | 2021-03-10 | 2023-12-12 | Amgen Inc | Processos para sintetizar 2-fluoro-3-nitrotolueno, 1-(bromometil)-2-fluoro-3-nitrobenzeno e para preparar omecamtiv mecarbil ou um sal do mesmo, um hidrato do mesmo ou um hidrato de sal do mesmo |
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2018
- 2018-06-29 CA CA3063102A patent/CA3063102A1/en active Pending
- 2018-06-29 BR BR112019028205-0A patent/BR112019028205A2/pt unknown
- 2018-06-29 GE GEAP201816116A patent/GEP20247675B/en unknown
- 2018-06-29 SG SG10202111790YA patent/SG10202111790YA/en unknown
- 2018-06-29 EP EP18743314.9A patent/EP3645518B1/en active Active
- 2018-06-29 DK DK18743314.9T patent/DK3645518T3/da active
- 2018-06-29 UA UAA202000509A patent/UA127517C2/uk unknown
- 2018-06-29 AU AU2018294254A patent/AU2018294254C1/en active Active
- 2018-06-29 GE GEAP201815258A patent/GEP20227340B/en unknown
- 2018-06-29 PH PH1/2019/502883A patent/PH12019502883A1/en unknown
- 2018-06-29 PL PL18743314T patent/PL3645518T3/pl unknown
- 2018-06-29 SI SI201830350T patent/SI3645518T1/sl unknown
- 2018-06-29 TW TW111120441A patent/TWI847144B/zh active
- 2018-06-29 PT PT187433149T patent/PT3645518T/pt unknown
- 2018-06-29 ES ES18743314T patent/ES2882905T3/es active Active
- 2018-06-29 US US16/607,940 patent/US11040956B2/en active Active
- 2018-06-29 EP EP21174262.2A patent/EP3925950B1/en active Active
- 2018-06-29 IL IL270663A patent/IL270663B/en unknown
- 2018-06-29 MD MDE20200486T patent/MD3645518T2/ro unknown
- 2018-06-29 EP EP23189293.6A patent/EP4265597A3/en active Pending
- 2018-06-29 TW TW107122465A patent/TWI769272B/zh active
- 2018-06-29 MX MX2021013326A patent/MX2021013326A/es unknown
- 2018-06-29 JP JP2019561794A patent/JP7181896B2/ja active Active
- 2018-06-29 SM SM20210472T patent/SMT202100472T1/it unknown
- 2018-06-29 KR KR1020207001578A patent/KR102625774B1/ko active Active
- 2018-06-29 CN CN201880043674.6A patent/CN110799503B/zh active Active
- 2018-06-29 WO PCT/US2018/040176 patent/WO2019006231A1/en active Application Filing
- 2018-06-29 IL IL294834A patent/IL294834B2/en unknown
- 2018-06-29 RS RS20210965A patent/RS62328B1/sr unknown
- 2018-06-29 HU HUE18743314A patent/HUE055242T2/hu unknown
- 2018-06-29 LT LTEP18743314.9T patent/LT3645518T/lt unknown
- 2018-06-29 MX MX2021009594A patent/MX2021009594A/es unknown
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2019
- 2019-12-30 CL CL2019003898A patent/CL2019003898A1/es unknown
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2021
- 2021-05-19 US US17/324,867 patent/US11753394B2/en active Active
- 2021-08-10 CY CY20211100714T patent/CY1124427T1/el unknown
- 2021-08-11 HR HRP20211290TT patent/HRP20211290T1/hr unknown
- 2021-08-16 CL CL2021002167A patent/CL2021002167A1/es unknown
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2022
- 2022-06-29 AU AU2022204648A patent/AU2022204648B2/en active Active
- 2022-08-19 JP JP2022130911A patent/JP7522799B2/ja active Active
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2023
- 2023-07-26 US US18/359,467 patent/US20230373955A1/en active Pending
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