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CY1124139T1 - Μη επεμβατικος προσδιορισμος μεθυλωματος ογκου απο πλασμα - Google Patents

Μη επεμβατικος προσδιορισμος μεθυλωματος ογκου απο πλασμα

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Publication number
CY1124139T1
CY1124139T1 CY20211100417T CY211100417T CY1124139T1 CY 1124139 T1 CY1124139 T1 CY 1124139T1 CY 20211100417 T CY20211100417 T CY 20211100417T CY 211100417 T CY211100417 T CY 211100417T CY 1124139 T1 CY1124139 T1 CY 1124139T1
Authority
CY
Cyprus
Prior art keywords
methylation
dna
fetal
tumor
profile
Prior art date
Application number
CY20211100417T
Other languages
English (en)
Inventor
Rossa Wai Kwun Chiu
Kwan Chee CHAN
Yuk-Ming Dennis Lo
Miu Fan LUN
Peiyong Jiang
Wai Man CHAN
Kong Hong
Original Assignee
The Chinese University Of Hong Kong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50340462&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1124139(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/842,209 external-priority patent/US9732390B2/en
Application filed by The Chinese University Of Hong Kong filed Critical The Chinese University Of Hong Kong
Publication of CY1124139T1 publication Critical patent/CY1124139T1/el

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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Apparatus Associated With Microorganisms And Enzymes (AREA)
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Abstract

Συστήματα, μέθοδοι και συσκευές μπορούν να προσδιορίσουν και να χρησιμοποιήσουν προφίλ μεθυλίωσης διάφορων ιστών και δειγμάτων. Δίνονται παραδείγματα. Ένα προφίλ μεθυλίωσης μπορεί να συναχθεί για εμβρυϊκό/καρκινικό ιστό με βάση μια σύγκριση της μεθυλίωσης πλάσματος (ή άλλου δείγματος με Ακυτταρικό DNA) με ένα προφίλ μεθυλίωσης της μητέρας/του ασθενούς. Ένα προφίλ μεθυλίωσης μπορεί να προσδιοριστεί για εμβρυϊκό/καρκινικό ιστό χρησιμοποιώντας αλληλόμορφα ειδικά σε ιστό για τον εντοπισμό DNA για το έμβρυο/όγκο όταν το δείγμα έχει μείγμα DNA. Ένα προφίλ μεθυλίωσης μπορεί να χρησιμοποιηθεί για τον προσδιορισμό των παραλλαγών του αριθμού αντιγράφων στο γονιδίωμα ενός εμβρύου/όγκου. Οι δείκτες μεθυλίωσης για ένα έμβρυο έχουν εντοπιστεί μέσω διαφόρων τεχνικών. Το προφίλ μεθυλίωσης μπορεί να προσδιοριστεί καθορίζοντας μια παράμετρο μεγέθους μιας κατανομής μεγέθους θραυσμάτων DNA, όπου οι τιμές αναφοράς για την παράμετρο μεγέθους μπορούν να χρησιμοποιηθούν για τον προσδιορισμό των επιπέδων μεθυλίωσης. Επιπλέον, ένα επίπεδο μεθυλίωσης μπορεί να χρησιμοποιηθεί για τον προσδιορισμός ενός επιπέδου καρκίνου.
CY20211100417T 2012-09-20 2021-05-14 Μη επεμβατικος προσδιορισμος μεθυλωματος ογκου απο πλασμα CY1124139T1 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261703512P 2012-09-20 2012-09-20
US13/842,209 US9732390B2 (en) 2012-09-20 2013-03-15 Non-invasive determination of methylome of fetus or tumor from plasma
US201361830571P 2013-06-03 2013-06-03
EP13838770.9A EP2898100B9 (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma
PCT/AU2013/001088 WO2014043763A1 (en) 2012-09-20 2013-09-20 Non-invasive determination of methylome of fetus or tumor from plasma

Publications (1)

Publication Number Publication Date
CY1124139T1 true CY1124139T1 (el) 2022-05-27

Family

ID=50340462

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211100417T CY1124139T1 (el) 2012-09-20 2021-05-14 Μη επεμβατικος προσδιορισμος μεθυλωματος ογκου απο πλασμα

Country Status (28)

Country Link
EP (6) EP3354747B1 (el)
JP (6) JP6317354B2 (el)
KR (5) KR102148547B1 (el)
CN (2) CN117757932A (el)
AU (5) AU2013317708C1 (el)
BR (3) BR112015006183B1 (el)
CA (2) CA3122779A1 (el)
CY (1) CY1124139T1 (el)
DK (4) DK2898100T4 (el)
EA (1) EA201500327A1 (el)
ES (4) ES2994426T3 (el)
FI (2) FI3536807T3 (el)
HR (3) HRP20241142T1 (el)
HU (3) HUE066054T2 (el)
IL (4) IL299444B2 (el)
LT (2) LT4056712T (el)
MX (1) MX360034B (el)
MY (2) MY173356A (el)
NZ (2) NZ717423A (el)
PH (2) PH12022552061A1 (el)
PL (4) PL3536807T3 (el)
PT (4) PT4056712T (el)
SG (2) SG10201705198UA (el)
SI (1) SI4056712T1 (el)
SM (1) SMT202100256T1 (el)
TW (5) TWI784258B (el)
WO (1) WO2014043763A1 (el)
ZA (1) ZA201501772B (el)

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